JP2016513122A5 - - Google Patents
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- Publication number
- JP2016513122A5 JP2016513122A5 JP2015558938A JP2015558938A JP2016513122A5 JP 2016513122 A5 JP2016513122 A5 JP 2016513122A5 JP 2015558938 A JP2015558938 A JP 2015558938A JP 2015558938 A JP2015558938 A JP 2015558938A JP 2016513122 A5 JP2016513122 A5 JP 2016513122A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- aryl
- alkynyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 8
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 150000002596 lactones Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- -1 NR 5 Chemical compound 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical group [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910003002 lithium salt Inorganic materials 0.000 claims 2
- 159000000002 lithium salts Chemical class 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767212P | 2013-02-20 | 2013-02-20 | |
| US61/767,212 | 2013-02-20 | ||
| PCT/US2014/017284 WO2014130618A1 (en) | 2013-02-20 | 2014-02-20 | Cyclohexenone compositions and process for making thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019028852A Division JP2019142854A (ja) | 2013-02-20 | 2019-02-20 | シクロヘキセノン組成物およびその作製のためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513122A JP2016513122A (ja) | 2016-05-12 |
| JP2016513122A5 true JP2016513122A5 (enExample) | 2017-03-16 |
| JP6706018B2 JP6706018B2 (ja) | 2020-06-03 |
Family
ID=51391788
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558938A Active JP6706018B2 (ja) | 2013-02-20 | 2014-02-20 | シクロヘキセノン組成物およびその作製のためのプロセス |
| JP2019028852A Pending JP2019142854A (ja) | 2013-02-20 | 2019-02-20 | シクロヘキセノン組成物およびその作製のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019028852A Pending JP2019142854A (ja) | 2013-02-20 | 2019-02-20 | シクロヘキセノン組成物およびその作製のためのプロセス |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9365481B2 (enExample) |
| EP (1) | EP2958883B1 (enExample) |
| JP (2) | JP6706018B2 (enExample) |
| CN (1) | CN105263893A (enExample) |
| CA (1) | CA2901581C (enExample) |
| ES (1) | ES2713181T3 (enExample) |
| HK (1) | HK1220174A1 (enExample) |
| TW (1) | TWI612026B (enExample) |
| WO (1) | WO2014130618A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI612026B (zh) * | 2013-02-20 | 2018-01-21 | 國鼎生物科技股份有限公司 | 環己烯酮組成物及其製造方法 |
| TW201632491A (zh) * | 2014-09-09 | 2016-09-16 | 翁慶豐 | 安卓奎諾爾於治療肥胖的用途及製備安卓奎諾爾的方法 |
| US20160237012A1 (en) * | 2015-02-17 | 2016-08-18 | Golden Biotechnology Corporation | Anticancer agents and process of making thereof |
| KR102399856B1 (ko) * | 2016-02-17 | 2022-05-20 | 골든 바이오테크놀러지 코포레이션 | 간암 치료용 조성물 및 방법 |
| TW201831436A (zh) * | 2017-02-24 | 2018-09-01 | 郭盈妤 | 分離自牛樟芝的化合物及其用途 |
| AU2018247249B2 (en) | 2017-12-20 | 2023-10-19 | Golden Biotechnology Corporation | Therapeutic compositions for treating pancreatic cancer |
| US11406605B2 (en) | 2017-12-20 | 2022-08-09 | Golden Biotechnology Corporation | Therapeutic compositions for treating pancreatic cancer |
| CN111018686B (zh) * | 2019-11-19 | 2020-09-22 | 南通大学 | 6-苄亚基-2-芳基乙炔基环己烯酮衍生物及其制备方法和医药用途 |
| CA3168432A1 (en) | 2020-05-08 | 2021-11-11 | Golden Biotechnology Corporation | Methods and compositions for treating an rna virus induced disease |
| WO2025165622A1 (en) * | 2024-01-31 | 2025-08-07 | Golden Biotechnology Corporation | Therapeutic compositions for treating liver cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200829234A (en) * | 2007-01-08 | 2008-07-16 | Golden Biotechnology Corp | Antrodia camphorata isophorone extract |
| CN101417934B (zh) * | 2007-10-24 | 2012-04-18 | 国鼎生物科技股份有限公司 | 分离自牛樟芝萃取物的化合物 |
| TWI389699B (zh) * | 2009-02-13 | 2013-03-21 | 高雄醫學大學 | 用於誘導細胞凋亡之樟芝子實體乙醇萃取物及其製備方法 |
| TW201109013A (en) * | 2009-09-09 | 2011-03-16 | Golden Biotechnology Corp | Cyclohexenone chemical compounds of Antrodia cinnamomea for suppressing the growth of the Lymphoma tumor cell |
| TWI394566B (zh) * | 2009-09-09 | 2013-05-01 | 國鼎生物科技股份有限公司 | Used to inhibit the growth of ovarian cancer tumor cells of the cattle camphor cyclohexene ketone compounds |
| TW201109023A (en) * | 2009-09-09 | 2011-03-16 | Golden Biotechnology Corp | Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of colorectal cancer |
| US8309611B2 (en) * | 2010-09-20 | 2012-11-13 | Golden Biotechnology Corporation | Methods and compositions for treating lung cancer |
| TWI444189B (zh) * | 2011-05-31 | 2014-07-11 | 財團法人台灣基督長老教會馬偕紀念社會事業基金會馬偕紀念醫院 | 羊毛甾醇－８，２４－二烯－３β，１５α，２１－三醇抑制腫瘤細胞生長之用途 |
| CN103796647A (zh) * | 2011-06-10 | 2014-05-14 | 国鼎生物科技股份有限公司 | 用于治疗脑癌的方法和组合物 |
| TWI612026B (zh) * | 2013-02-20 | 2018-01-21 | 國鼎生物科技股份有限公司 | 環己烯酮組成物及其製造方法 |
-
2014
- 2014-02-19 TW TW103105417A patent/TWI612026B/zh active
- 2014-02-20 WO PCT/US2014/017284 patent/WO2014130618A1/en not_active Ceased
- 2014-02-20 JP JP2015558938A patent/JP6706018B2/ja active Active
- 2014-02-20 EP EP14754902.6A patent/EP2958883B1/en not_active Not-in-force
- 2014-02-20 CN CN201480022436.9A patent/CN105263893A/zh active Pending
- 2014-02-20 US US14/184,954 patent/US9365481B2/en active Active
- 2014-02-20 ES ES14754902T patent/ES2713181T3/es active Active
- 2014-02-20 HK HK16108277.9A patent/HK1220174A1/zh unknown
- 2014-02-20 CA CA2901581A patent/CA2901581C/en not_active Expired - Fee Related
-
2016
- 2016-05-09 US US15/149,564 patent/US20160251308A1/en not_active Abandoned
-
2019
- 2019-02-20 JP JP2019028852A patent/JP2019142854A/ja active Pending
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