|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US4109496A
(en)
|
1977-12-20 |
1978-08-29 |
Norris Industries |
Trapped key mechanism
|
|
US4323546A
(en)
|
1978-05-22 |
1982-04-06 |
Nuc Med Inc. |
Method and composition for cancer detection in humans
|
|
US4411990A
(en)
|
1979-06-13 |
1983-10-25 |
University Patents, Inc. |
Primary bioassay of human tumor stem cells
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4612282A
(en)
|
1981-12-15 |
1986-09-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Monoclonal antibodies reactive with human breast cancer
|
|
US4670393A
(en)
|
1982-03-22 |
1987-06-02 |
Genentech, Inc. |
DNA vectors encoding a novel human growth hormone-variant protein
|
|
US5019497A
(en)
|
1984-11-09 |
1991-05-28 |
Lennart Olsson |
Human squamous lung carcinoma cell specific antigens and antibodies
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5087570A
(en)
|
1988-05-10 |
1992-02-11 |
Weissman Irving L |
Homogeneous mammalian hematopoietic stem cell composition
|
|
US4981785A
(en)
|
1988-06-06 |
1991-01-01 |
Ventrex Laboratories, Inc. |
Apparatus and method for performing immunoassays
|
|
US4968103A
(en)
|
1988-07-22 |
1990-11-06 |
Photofinish Cosmetics Inc. |
Method of making a brush
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5994617A
(en)
|
1988-09-19 |
1999-11-30 |
Hsc Research Development Corporation |
Engraftment of immune-deficient mice with human cells
|
|
US5534617A
(en)
|
1988-10-28 |
1996-07-09 |
Genentech, Inc. |
Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
|
|
US5688666A
(en)
|
1988-10-28 |
1997-11-18 |
Genentech, Inc. |
Growth hormone variants with altered binding properties
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
GB8901778D0
(en)
|
1989-01-27 |
1989-03-15 |
Univ Court Of The University O |
Manipulatory technique
|
|
US6583115B1
(en)
|
1989-10-12 |
2003-06-24 |
Ohio University/Edison Biotechnology Institute |
Methods for treating acromegaly and giantism with growth hormone antagonists
|
|
US5061620A
(en)
|
1990-03-30 |
1991-10-29 |
Systemix, Inc. |
Human hematopoietic stem cell
|
|
US5614396A
(en)
|
1990-06-14 |
1997-03-25 |
Baylor College Of Medicine |
Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
US5856441A
(en)
|
1991-05-03 |
1999-01-05 |
Yale University |
Serrate fragments and derivatives
|
|
IE20030749A1
(en)
|
1991-05-03 |
2003-11-12 |
Indiana University Foundation |
Human notch and delta binding domains in torporythmic proteins, and methods based thereon
|
|
IL101728A
(en)
|
1991-05-03 |
2007-08-19 |
Univ Yale |
Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
|
|
US6429186B1
(en)
|
1991-05-10 |
2002-08-06 |
Genentech, Inc. |
Ligand antagonists for treatment of breast cancer
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
US5750376A
(en)
|
1991-07-08 |
1998-05-12 |
Neurospheres Holdings Ltd. |
In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
US5753229A
(en)
|
1991-09-25 |
1998-05-19 |
Mordoh; Jose |
Monoclonal antibodies reactive with tumor proliferating cells
|
|
US6353150B1
(en)
|
1991-11-22 |
2002-03-05 |
Hsc Research And Development Limited Partnership |
Chimeric mammals with human hematopoietic cells
|
|
US6004924A
(en)
|
1991-12-11 |
1999-12-21 |
Imperial Cancer Research Technology, Ltd. |
Protein sequences of serrate gene products
|
|
US5869282A
(en)
|
1991-12-11 |
1999-02-09 |
Imperial Cancer Research Technology, Ltd. |
Nucleotide and protein sequences of the serrate gene and methods based thereon
|
|
EP0552108B1
(en)
|
1992-01-17 |
1999-11-10 |
Lakowicz, Joseph R. |
Energy transfer phase-modulation fluoro-immunoassay
|
|
US5376313A
(en)
|
1992-03-27 |
1994-12-27 |
Abbott Laboratories |
Injection molding a plastic assay cuvette having low birefringence
|
|
US5786158A
(en)
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US5589376A
(en)
|
1992-07-27 |
1996-12-31 |
California Institute Of Technology |
Mammalian neural crest stem cells
|
|
US5693482A
(en)
|
1992-07-27 |
1997-12-02 |
California Institute Of Technology |
Neural chest stem cell assay
|
|
US5654183A
(en)
|
1992-07-27 |
1997-08-05 |
California Institute Of Technology |
Genetically engineered mammalian neural crest stem cells
|
|
US5849553A
(en)
|
1992-07-27 |
1998-12-15 |
California Institute Of Technology |
Mammalian multipotent neural stem cells
|
|
WO1994002593A1
(en)
|
1992-07-27 |
1994-02-03 |
California Institute Of Technology |
Mammalian multipotent neural stem cells
|
|
DE69333969T2
(de)
|
1992-10-30 |
2006-09-14 |
The General Hospital Corp., Boston |
Wechselwirkendes Fallensystem zur Isolierung von Proteinen
|
|
GB9223084D0
(en)
|
1992-11-04 |
1992-12-16 |
Imp Cancer Res Tech |
Compounds to target cells
|
|
JP3106021B2
(ja)
|
1992-11-30 |
2000-11-06 |
キヤノン株式会社 |
パターンデータの圧縮方法及び装置と出力方法及び装置
|
|
EP0685234B1
(en)
|
1993-02-19 |
2000-05-10 |
Nippon Shinyaku Company, Limited |
Drug composition containing nucleic acid copolymer
|
|
US5643765A
(en)
|
1993-04-06 |
1997-07-01 |
University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5639606A
(en)
|
1993-04-06 |
1997-06-17 |
The University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5876978A
(en)
|
1993-04-06 |
1999-03-02 |
Medical College Of Ohio |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5538848A
(en)
|
1994-11-16 |
1996-07-23 |
Applied Biosystems Division, Perkin-Elmer Corp. |
Method for detecting nucleic acid amplification using self-quenching fluorescence probe
|
|
US5599677A
(en)
|
1993-12-29 |
1997-02-04 |
Abbott Laboratories |
Immunoassays for prostate specific antigen
|
|
ATE336587T1
(de)
|
1994-06-10 |
2006-09-15 |
Genvec Inc |
Adenoviren-vektor systeme und zelllinien
|
|
US6156305A
(en)
|
1994-07-08 |
2000-12-05 |
Baxter International Inc. |
Implanted tumor cells for the prevention and treatment of cancer
|
|
US5650317A
(en)
|
1994-09-16 |
1997-07-22 |
Michigan State University |
Human breast epithelial cell type with stem cell and luminal epithelial cell characteristics
|
|
PT787200E
(pt)
|
1994-10-28 |
2005-08-31 |
Univ Pennsylvania |
Adenovirus melhorado e metodos para a sua utilizacao
|
|
US6218166B1
(en)
|
1994-12-09 |
2001-04-17 |
John Wayne Cancer Institute |
Adjuvant incorporation into antigen carrying cells: compositions and methods
|
|
US5736396A
(en)
|
1995-01-24 |
1998-04-07 |
Case Western Reserve University |
Lineage-directed induction of human mesenchymal stem cell differentiation
|
|
US5872154A
(en)
|
1995-02-24 |
1999-02-16 |
The Trustees Of The University Of Pennsylvania |
Method of reducing an immune response to a recombinant adenovirus
|
|
US5707618A
(en)
|
1995-03-24 |
1998-01-13 |
Genzyme Corporation |
Adenovirus vectors for gene therapy
|
|
US5633161A
(en)
|
1995-03-29 |
1997-05-27 |
Millennium Pharmaceuticals, Inc. |
Murine gene fomy030 coding for tumor progression inhibitor
|
|
US5821108A
(en)
|
1995-04-07 |
1998-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US6019978A
(en)
|
1995-06-05 |
2000-02-01 |
The Wistar Institute Of Anatomy And Biology |
Replication-defective adenovirus human type 5 recombinant as a vaccine carrier
|
|
ATE445705T1
(de)
|
1995-06-15 |
2009-10-15 |
Crucell Holland Bv |
Verpackungssysteme für humane rekombinante adenoviren zur gentherapie
|
|
US6117985A
(en)
|
1995-06-16 |
2000-09-12 |
Stemcell Technologies Inc. |
Antibody compositions for preparing enriched cell preparations
|
|
ATE442373T1
(de)
|
1995-06-28 |
2009-09-15 |
Imp Cancer Res Tech |
Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
|
|
JP3628333B2
(ja)
|
1995-09-21 |
2005-03-09 |
ジェネンテック インコーポレーテッド |
ヒト成長ホルモン変異体
|
|
US5780300A
(en)
|
1995-09-29 |
1998-07-14 |
Yale University |
Manipulation of non-terminally differentiated cells using the notch pathway
|
|
US5986170A
(en)
|
1995-11-13 |
1999-11-16 |
Corixa Corporation |
Murine model for human carcinoma
|
|
US6337387B1
(en)
|
1995-11-17 |
2002-01-08 |
Asahi Kasei Kabushiki Kaisha |
Differentiation-suppressive polypeptide
|
|
CA2239957A1
(en)
|
1995-12-22 |
1997-07-03 |
Abbott Laboratories |
Fluorescence polarization immunoassay diagnostic method
|
|
US5994316A
(en)
|
1996-02-21 |
1999-11-30 |
The Immune Response Corporation |
Method of preparing polynucleotide-carrier complexes for delivery to cells
|
|
AU2160297A
(en)
|
1996-03-30 |
1997-10-22 |
Boehringer Mannheim Gmbh |
Method for the production of activated marked tumor-specific t cells and use thereof in treatment of tumors
|
|
US5753506A
(en)
|
1996-05-23 |
1998-05-19 |
Cns Stem Cell Technology, Inc. |
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
|
|
JP2000512134A
(ja)
|
1996-05-31 |
2000-09-19 |
ザ ナショナル アメリカン レッド クロス |
Ｊａｇｇｅｄ／Ｎｏｔｃｈタンパク質および核酸に基づく治療および診断の方法および組成物
|
|
US6716974B1
(en)
|
1996-05-31 |
2004-04-06 |
Maine Medical Center Research Institute |
Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
|
|
US5885529A
(en)
|
1996-06-28 |
1999-03-23 |
Dpc Cirrus, Inc. |
Automated immunoassay analyzer
|
|
FR2751986B1
(fr)
|
1996-08-01 |
1998-12-31 |
Inst Nat Sante Rech Med |
Gene implique dans le cadasil, methode de diagnostic et application therapeutique
|
|
CA2263883C
(en)
|
1996-08-29 |
2003-07-08 |
The Regents Of The University Of California |
Kuz, a novel family of metalloproteases
|
|
WO1998013493A2
(en)
|
1996-09-24 |
1998-04-02 |
Lxr Biotechnology, Inc. |
A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
|
|
CA2267157C
(en)
|
1996-10-11 |
2005-05-31 |
The Regents Of The University Of California |
Cancer immunotherapy using tumor cells combined with mixed lymphocytes
|
|
US5994132A
(en)
|
1996-10-23 |
1999-11-30 |
University Of Michigan |
Adenovirus vectors
|
|
DE69739673D1
(de)
|
1996-11-27 |
2009-12-31 |
Genentech Inc |
Affinitätsreinigung von Polypeptid-Proteinen auf einer Protein A Matrix
|
|
US5859535A
(en)
|
1997-02-12 |
1999-01-12 |
The United States Of America As Represented By The Secretary Of The Navy |
System for determining size and location of defects in material by use of microwave radiation
|
|
WO1998039636A1
(en)
|
1997-03-07 |
1998-09-11 |
Clare Chemical Research Llc |
Fluorometric detection using visible light
|
|
US6080912A
(en)
|
1997-03-20 |
2000-06-27 |
Wisconsin Alumni Research Foundation |
Methods for creating transgenic animals
|
|
US5861832A
(en)
|
1997-03-27 |
1999-01-19 |
Lucent Technologies Inc. |
Analog-to-digital converter having amplifier and comparator stages
|
|
US20020137890A1
(en)
|
1997-03-31 |
2002-09-26 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US20030180784A1
(en)
|
1997-04-04 |
2003-09-25 |
Millennium Pharmaceuticals, Inc. |
Novel human Delta3 compositions and therapeutic and diagnostic uses therefor
|
|
US6121045A
(en)
|
1997-04-04 |
2000-09-19 |
Millennium Biotherapeutics, Inc. |
Human Delta3 nucleic acid molecules
|
|
AU6952498A
(en)
|
1997-04-04 |
1998-10-30 |
Millenium Pharmaceuticals, Inc. |
Novel human delta3 compositions and therapeutic and diagnostic uses therefor
|
|
US5830730A
(en)
|
1997-05-08 |
1998-11-03 |
The Regents Of The University Of California |
Enhanced adenovirus-assisted transfection composition and method
|
|
EP1004669B1
(en)
|
1997-05-14 |
2007-04-18 |
Asahi Kasei Kabushiki Kaisha |
Novel differentiation inhibitor
|
|
US6479255B1
(en)
|
1997-05-29 |
2002-11-12 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Polynucleotides encoding human FRP and fragments thereof
|
|
AU8162898A
(en)
|
1997-06-18 |
1999-01-04 |
Trustees Of Columbia University In The City Of New York, The |
Angiogenic modulation by notch signal transduction
|
|
US6379925B1
(en)
|
1997-06-18 |
2002-04-30 |
The Trustees Of Columbia University In The City Of New York |
Angiogenic modulation by notch signal transduction
|
|
US6136952A
(en)
|
1997-06-25 |
2000-10-24 |
University Of Washington |
Human jagged polypeptide, encoding nucleic acids and methods of use
|
|
CA2290736A1
(en)
|
1997-07-11 |
1999-01-21 |
Introgene B.V. |
Interleukin-3 gene therapy for cancer
|
|
US7361336B1
(en)
|
1997-09-18 |
2008-04-22 |
Ivan Bergstein |
Methods of cancer therapy targeted against a cancer stem line
|
|
US6004528A
(en)
|
1997-09-18 |
1999-12-21 |
Bergstein; Ivan |
Methods of cancer diagnosis and therapy targeted against the cancer stemline
|
|
US6197523B1
(en)
|
1997-11-24 |
2001-03-06 |
Robert A. Levine |
Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
US6551795B1
(en)
|
1998-02-18 |
2003-04-22 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
|
|
US5981225A
(en)
|
1998-04-16 |
1999-11-09 |
Baylor College Of Medicine |
Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
|
|
US6252050B1
(en)
|
1998-06-12 |
2001-06-26 |
Genentech, Inc. |
Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
|
|
WO2000006726A2
(en)
|
1998-07-27 |
2000-02-10 |
Amgen Inc. |
Delta-related polypeptides
|
|
CA2340682A1
(en)
|
1998-08-14 |
2000-02-24 |
Aventis Pharmaceuticals Products Inc. |
Adenovirus formulations for gene therapy
|
|
JP2002523105A
(ja)
|
1998-08-27 |
2002-07-30 |
アバンテイス・フアルマ・エス・アー |
異種遺伝子の運搬用の標的化アデノウイルスベクター
|
|
GB9819681D0
(en)
|
1998-09-09 |
1998-11-04 |
Smithkline Beecham Plc |
Novel compounds
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
EP1133519B1
(en)
|
1998-11-02 |
2008-08-13 |
Curis, Inc. |
Functional antagonists of hedgehog activity
|
|
US6291516B1
(en)
|
1999-01-13 |
2001-09-18 |
Curis, Inc. |
Regulators of the hedgehog pathway, compositions and uses related thereto
|
|
US20030003572A1
(en)
|
1999-03-05 |
2003-01-02 |
David J. Anderson |
Isolation and enrichment of neural stem cells from uncultured tissue based on cell-surface marker expression
|
|
US20030119029A1
(en)
|
1999-04-30 |
2003-06-26 |
Regents Of The University Of Michigan |
Compositions and methods relating to novel benzodiazepine compounds and targets thereof
|
|
AU782493B2
(en)
|
1999-06-01 |
2005-08-04 |
Curis, Inc. |
Polymer conjugates of hedgehog proteins and uses
|
|
WO2001002568A2
(en)
|
1999-07-02 |
2001-01-11 |
Chiron Corporation |
Human genes and gene expression products
|
|
US6703221B1
(en)
|
1999-08-19 |
2004-03-09 |
Chiron Corporation |
Notch receptor ligands and uses thereof
|
|
AU7721500A
(en)
|
1999-09-29 |
2001-04-30 |
Human Genome Sciences, Inc. |
Colon and colon cancer associated polynucleotides and polypeptides
|
|
AU1194501A
(en)
|
1999-10-14 |
2001-04-23 |
Wistar Institute, The |
Inhibition of tumorigenic properties of melanoma cells
|
|
US6380362B1
(en)
|
1999-12-23 |
2002-04-30 |
Genesis Research & Development Corporation Ltd. |
Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use
|
|
US20040048249A1
(en)
|
2000-01-21 |
2004-03-11 |
Tang Y. Tom |
Novel nucleic acids and secreted polypeptides
|
|
AU779875B2
(en)
|
2000-01-24 |
2005-02-17 |
Merck Sharp & Dohme Limited |
Gamma-secretase inhibitors
|
|
DK1252192T3
(da)
|
2000-02-11 |
2006-11-20 |
Merck Patent Gmbh |
Forbedring af antistofbaserede fusionsproteiners serumhalveringstid
|
|
US7115653B2
(en)
|
2000-03-30 |
2006-10-03 |
Curis, Inc. |
Small organic molecule regulators of cell proliferation
|
|
US7060436B2
(en)
|
2000-06-17 |
2006-06-13 |
Third Wave Technologies, Inc. |
Nucleic acid accessible hybridization sites
|
|
WO2001098354A2
(en)
|
2000-06-21 |
2001-12-27 |
Incyte Genomics, Inc. |
Human receptors
|
|
US6632620B1
(en)
|
2000-06-22 |
2003-10-14 |
Andrew N. Makarovskiy |
Compositions for identification and isolation of stem cells
|
|
DE10031380A1
(de)
|
2000-06-28 |
2002-01-10 |
Merck Patent Gmbh |
Verfahren zur Übertragung von Alkyliden-Gruppen auf organischen Verbindungen
|
|
GB0016681D0
(en)
|
2000-07-06 |
2000-08-23 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
AU2001278076A1
(en)
|
2000-07-26 |
2002-02-05 |
Applied Genomics, Inc. |
Bstp-5 proteins and related reagents and methods of use thereof
|
|
US20050089518A1
(en)
|
2001-12-07 |
2005-04-28 |
Clarke Michael F. |
Prospective identification and characterization of breast cancer stem cells
|
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
AU2001288628A1
(en)
|
2000-08-31 |
2002-03-13 |
Loyola University Chicago |
Method and reagents for treatment of skin disorders by modulating the notch pathway
|
|
US6689744B2
(en)
|
2000-09-22 |
2004-02-10 |
Genentech, Inc. |
Notch receptor agonists and uses
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
BR0116138A
(pt)
|
2000-12-13 |
2003-09-23 |
Borean Pharma As |
Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c
|
|
US7413873B2
(en)
|
2001-01-30 |
2008-08-19 |
The Regents Of The University Of California |
Method of detection and treatment of colon cancer
|
|
US20020169300A1
(en)
|
2001-01-30 |
2002-11-14 |
Waterman Marian L. |
Method of detection and treatment of colon cancer by analysis of beta-catenin-sensitive isoforms of lymphoid enhancer factor-1
|
|
US20030064384A1
(en)
|
2001-04-02 |
2003-04-03 |
Mien-Chie Hung |
Beta-catenin is a strong and independent prognostic factor for cancer
|
|
IL142481A0
(en)
|
2001-04-05 |
2002-03-10 |
Yissum Res Dev Co |
A method for identifying consitutively active mutants of mitogen activated protein kinases (mapk) and uses thereof
|
|
DE60237969D1
(de)
|
2001-04-24 |
2010-11-25 |
Bayer Corp |
Menschliche antikörper gegen timp-1
|
|
US7713526B2
(en)
|
2001-05-01 |
2010-05-11 |
The Regents Of The University Of California |
Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
|
|
AU2002308557A1
(en)
|
2001-05-01 |
2002-11-11 |
The Regents Of The University Of California |
Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
|
|
US20030044409A1
(en)
|
2001-05-01 |
2003-03-06 |
Carson Dennis A. |
Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
|
|
US7514594B2
(en)
*
|
2001-05-11 |
2009-04-07 |
Wyeth |
Transgenic animal model of bone mass modulation
|
|
JP2005500303A
(ja)
|
2001-06-15 |
2005-01-06 |
ジェネンテック・インコーポレーテッド |
ヒト成長ホルモンアンタゴニスト
|
|
US7171311B2
(en)
|
2001-06-18 |
2007-01-30 |
Rosetta Inpharmatics Llc |
Methods of assigning treatment to breast cancer patients
|
|
US20040023244A1
(en)
|
2001-06-21 |
2004-02-05 |
Griffin Jennifer A |
Receptors
|
|
ES2292772T3
(es)
|
2001-06-22 |
2008-03-16 |
Stemcells, Inc. |
Celulas de injerto de higado, analisis, y sus usos.
|
|
WO2003000893A2
(en)
|
2001-06-26 |
2003-01-03 |
Decode Genetics Ehf. |
Nucleic acids encoding g protein-coupled receptors
|
|
JP2004536045A
(ja)
|
2001-07-02 |
2004-12-02 |
タシ、シナン |
基底細胞癌及び他の腫瘍の治療におけるシクロパミンの使用方法
|
|
EP1411938B1
(en)
|
2001-07-02 |
2005-07-06 |
Tas, Sinan |
Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis
|
|
AU2002317105A1
(en)
|
2001-07-05 |
2003-01-21 |
University Of British Columbia |
Methods for identifying therapeutic agents for treating diseases involving wnt polypeptides and wnt receptors
|
|
CA2453810A1
(en)
|
2001-07-18 |
2003-07-03 |
American Red Cross |
Mutant proteinase inhibitors and uses thereof
|
|
AU2002355477B2
(en)
|
2001-08-03 |
2008-09-25 |
Medical Research Council |
Method of identifying a consensus sequence for intracellular antibodies
|
|
ATE515495T1
(de)
|
2001-08-03 |
2011-07-15 |
Schering Corp |
Gamma sekretase inhibitoren
|
|
US7138370B2
(en)
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
|
AU2002339157A1
(en)
|
2001-11-14 |
2003-05-26 |
Lorantis Limited |
Inhibitors of the notch signalling pathway for use in the treatment of cancer
|
|
US7053547B2
(en)
|
2001-11-29 |
2006-05-30 |
Universal Display Corporation |
Increased emission efficiency in organic light-emitting devices on high-index substrates
|
|
US20070237770A1
(en)
|
2001-11-30 |
2007-10-11 |
Albert Lai |
Novel compositions and methods in cancer
|
|
JP2005514030A
(ja)
|
2001-12-26 |
2005-05-19 |
イミューノメディクス、インコーポレイテッド |
Ｖｈおよびｖｌドメインから多重特異性多価薬剤を製造する方法
|
|
US6713206B2
(en)
|
2002-01-14 |
2004-03-30 |
Board Of Trustees Of University Of Illinois |
Electrochemical cells comprising laminar flow induced dynamic conducting interfaces, electronic devices comprising such cells, and methods employing same
|
|
GB0201674D0
(en)
|
2002-01-25 |
2002-03-13 |
Lorantis Ltd |
Medical treatment
|
|
US20030185829A1
(en)
|
2002-03-12 |
2003-10-02 |
Erich Koller |
Jagged 2 inhibitors for inducing apoptosis
|
|
CN1305905C
(zh)
|
2002-03-22 |
2007-03-21 |
Aprogen株式会社 |
人源化抗体及其制备方法
|
|
EP1554392A4
(en)
|
2002-05-06 |
2007-08-08 |
Us Gov Health & Human Serv |
IDENTIFICATION OF NEW NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES WITH WIDE CROSS-REACTIVITY USING SEQUENTIAL ANTIGEN PANNING OF PHAG DISPLAY LIBRARIES
|
|
WO2003099781A2
(en)
|
2002-05-24 |
2003-12-04 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
METHODS FOR THE IDENTIFICATION OF IKKα FUNCTION AND OTHER GENES USEFUL FOR TREATMENT OF INFLAMMATORY DISEASES
|
|
AU2003278161A1
(en)
|
2002-06-21 |
2004-01-06 |
Johns Hopkins University School Of Medicine |
Membrane associated tumor endothelium markers
|
|
US7803370B2
(en)
|
2002-08-30 |
2010-09-28 |
Oncotherapy Science, Inc. |
Method for treating synovial sarcoma
|
|
AU2003256079A1
(en)
|
2002-08-30 |
2004-03-19 |
Japan As Represented By President Of The University Of Tokyo |
Method for treating synovial sarcoma
|
|
GB0221952D0
(en)
|
2002-09-20 |
2002-10-30 |
Novartis Forschungsstiftung |
Wnt mediated ErbB1 signalling,compositions and uses related thereto
|
|
US20040058217A1
(en)
|
2002-09-20 |
2004-03-25 |
Ohlsen Leroy J. |
Fuel cell systems having internal multistream laminar flow
|
|
US20040247593A1
(en)
|
2002-10-04 |
2004-12-09 |
Regents Of The University Of California, |
Methods for treating cancer by inhibiting Wnt signaling
|
|
US7365168B2
(en)
|
2002-10-15 |
2008-04-29 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
CA2507581A1
(en)
|
2002-12-06 |
2004-06-24 |
The Board Of Trustees Of The Leland Stanford Junior University |
Protection of stem cells from cytotoxic agents by modulation of .beta.-catenin signaling pathways
|
|
US7803783B2
(en)
|
2002-12-06 |
2010-09-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Use of WNT inhibitors to augment therapeutic index of chemotherapy
|
|
US20040219579A1
(en)
|
2003-02-19 |
2004-11-04 |
Natasha Aziz |
Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
EP2003196A3
(en)
|
2003-06-09 |
2009-01-07 |
The Regents of the University of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
ATE545658T1
(de)
|
2003-07-11 |
2012-03-15 |
Oncotherapy Science Inc |
Verfahren zur behandlung von synovialsarkom
|
|
US20050130199A1
(en)
|
2003-09-22 |
2005-06-16 |
Regents Of The University Of California |
Mutations in WNT-frizzled signaling pathways associated with osteoarthritis
|
|
US6894522B2
(en)
|
2003-10-06 |
2005-05-17 |
International Business Machines Corporation |
Specific site backside underlaying and micromasking method for electrical characterization of semiconductor devices
|
|
CA2545603A1
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto
|
|
CN1981054A
(zh)
|
2004-05-14 |
2007-06-13 |
加利福尼亚大学董事会 |
用抗wnt2单克隆抗体和sirna治疗癌症的方法
|
|
WO2006031977A2
(en)
|
2004-09-13 |
2006-03-23 |
The Regents Of The University Of California |
Inhibition of pancreatic cancer cell growth
|
|
WO2006036175A2
(en)
|
2004-09-21 |
2006-04-06 |
Rhode Island Hospital, A Lifespan-Partner |
Wnt proteins and detection and treatment of cancer
|
|
WO2006036179A2
(en)
|
2004-09-21 |
2006-04-06 |
Rhode Island Hospital, A Lifespan-Partner |
Frizzled proteins and detection and treatment of cancer
|
|
JP5025475B2
(ja)
|
2004-09-21 |
2012-09-12 |
ロード アイランド ホスピタル エー ライフスパン−パートナー |
Ｗｎｔタンパク質ならびに癌の検出および治療の方法
|
|
CN101103045B
(zh)
|
2004-09-24 |
2015-11-25 |
安姆根有限公司 |
修饰的Fc分子
|
|
DE102004050620A1
(de)
|
2004-10-13 |
2006-04-20 |
Eberhard-Karls-Universität Tübingen |
Monoklonaler Antikörper gegen Frizzled-Rezeptoren
|
|
WO2006055635A2
(en)
|
2004-11-15 |
2006-05-26 |
Mount Sinai School Of Medicine Of New York University |
Compositions and methods for altering wnt autocrine signaling
|
|
ES2350231T3
(es)
|
2004-11-24 |
2011-01-20 |
F. Hoffmann-La Roche Ag |
Método para determinar la genotoxicidad.
|
|
US7635530B2
(en)
|
2005-03-21 |
2009-12-22 |
The Board Of Trustees Of The University Of Illinois |
Membraneless electrochemical cell and microfluidic device without pH constraint
|
|
US20090311243A1
(en)
|
2005-05-30 |
2009-12-17 |
Astrazeneca Ab |
Methods for Identifying FZD8 Modulators and the Use of such Modulators for Treating Osteoarthritis
|
|
US20070014776A1
(en)
|
2005-06-09 |
2007-01-18 |
Gimeno Ruth E |
Identification of adiponutrin-related proteins as esterases and methods of use for the same
|
|
EP2295570A1
(en)
|
2005-07-27 |
2011-03-16 |
Oncotherapy Science, Inc. |
Method of diagnosing small cell lung cancer
|
|
US20070072239A1
(en)
|
2005-09-26 |
2007-03-29 |
Wyeth |
Pharmaceutical compositions and methods of using secreted frizzled related protein
|
|
US20070238658A1
(en)
|
2005-09-28 |
2007-10-11 |
Levin Steven D |
IL-17A and IL-17F Antagonists and Methods of Using the Same
|
|
PT2500360E
(pt)
|
2005-10-31 |
2015-10-15 |
Oncomed Pharm Inc |
Composições e métodos para diagnóstico e tratamento do cancro
|
|
US7723477B2
(en)
|
2005-10-31 |
2010-05-25 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
|
|
DOP2006000277A
(es)
|
2005-12-12 |
2007-08-31 |
Bayer Pharmaceuticals Corp |
Anticuerpos anti mn y métodos para su utilización
|
|
AR060017A1
(es)
*
|
2006-01-13 |
2008-05-21 |
Novartis Ag |
Composiciones y metodos de uso para anticuerpos de dickkopf -1
|
|
CA2641315A1
(en)
*
|
2006-02-06 |
2007-08-16 |
Tethys Bioscience, Inc. |
Osteoporosis associated markers and methods of use thereof
|
|
KR20080101888A
(ko)
|
2006-02-09 |
2008-11-21 |
다이이찌 산쿄 가부시키가이샤 |
항암 의약 조성물
|
|
GB0603683D0
(en)
|
2006-02-23 |
2006-04-05 |
Novartis Ag |
Organic compounds
|
|
MX2008014910A
(es)
|
2006-05-24 |
2009-01-23 |
Bayer Schering Pharma Ag |
Anticuerpos bloqueantes de la funcion de la integrina ?5?1 humanos y humanizados de gran afinidad con inmunogenicidad reducida.
|
|
CN101573383B
(zh)
|
2006-06-21 |
2015-05-13 |
肿瘤疗法科学股份有限公司 |
靶向肿瘤的针对卷曲同源物10的单克隆抗体及其用途
|
|
TW200815469A
(en)
|
2006-06-23 |
2008-04-01 |
Astrazeneca Ab |
Compounds
|
|
EP2526969A1
(en)
|
2006-09-07 |
2012-11-28 |
Stemline Therapeutics, Inc. |
Monitoring cancer stem cells
|
|
US7947277B2
(en)
|
2006-09-08 |
2011-05-24 |
Genentech, Inc. |
Wnt antagonists and their use in the diagnosis and treatment of Wnt-mediated disorders
|
|
CN101541977A
(zh)
|
2006-09-19 |
2009-09-23 |
诺瓦提斯公司 |
用于raf抑制剂的靶向调节、效力、诊断和/或预后的生物标志物
|
|
EP2084296B1
(en)
|
2006-09-29 |
2015-08-05 |
Agendia N.V. |
High-throughput diagnostic testing using arrays
|
|
EP2083861A4
(en)
|
2006-11-07 |
2010-11-24 |
Merck Sharp & Dohme |
ANTAGONISTS OF PCSK9
|
|
WO2008061020A2
(en)
|
2006-11-14 |
2008-05-22 |
Novartis Ag |
Methods of treating, diagnosing or detecting cancer
|
|
US8178099B2
(en)
*
|
2006-12-29 |
2012-05-15 |
Osteogenex Inc. |
Methods of altering bone growth by administration of sost or wise antagonist or agonist
|
|
JP5363350B2
(ja)
|
2007-03-19 |
2013-12-11 |
武田薬品工業株式会社 |
Ｍａｐｋ／ｅｒｋキナーゼ阻害剤
|
|
US20090082328A1
(en)
|
2007-05-11 |
2009-03-26 |
Bayer Schering Pharma Aktiengesellschaft |
Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity
|
|
WO2008157179A2
(en)
|
2007-06-12 |
2008-12-24 |
Genentech, Inc. |
N-substituted azaindoles and methods of use
|
|
KR20100049073A
(ko)
|
2007-07-18 |
2010-05-11 |
노파르티스 아게 |
비시클릭 헤테로아릴 화합물 및 키나제 억제제로서의 그의 용도
|
|
CA2924436A1
(en)
|
2007-07-30 |
2009-02-05 |
Ardea Biosciences, Inc. |
Pharmaceutical combinations of n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide as inhibitors of mek and methods of use
|
|
JP2010535232A
(ja)
|
2007-07-30 |
2010-11-18 |
アルディア バイオサイエンス，インク． |
Ｍｅｋの阻害剤としての多形体を含む、ｎ−（アリールアミノ）スルホンアミドの誘導体、および組成物、使用方法、ならびにその調製方法
|
|
ES2614402T3
(es)
|
2007-09-26 |
2017-05-31 |
Intrexon Corporation |
5'UTR sintéticas, vectores de expresión y métodos para aumentar la expresión transgénica
|
|
TWI489993B
(zh)
|
2007-10-12 |
2015-07-01 |
Novartis Ag |
骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法
|
|
PL2567709T3
(pl)
*
|
2007-11-02 |
2018-06-29 |
Novartis Ag |
Cząsteczki i sposoby modulowania białka związanego z receptorem dla lipoproteiny o niskiej gęstości 6 (LRP6)
|
|
US20100267626A1
(en)
|
2007-11-05 |
2010-10-21 |
Novartis Ag |
Methods and compositions for measuring wnt activation and for treating wnt-related cancers
|
|
CA2705452C
(en)
|
2007-11-12 |
2016-05-31 |
Takeda Pharmaceutical Company Limited |
Mapk/erk kinase inhibitors
|
|
US20110020368A1
(en)
|
2008-03-25 |
2011-01-27 |
Nancy Hynes |
Treating cancer by down-regulating frizzled-4 and/or frizzled-1
|
|
DE202008004821U1
(de)
|
2008-04-07 |
2008-06-12 |
Heil, Roland |
Siebdruckform
|
|
FR2936255B1
(fr)
|
2008-09-19 |
2010-10-15 |
Galderma Res & Dev |
Modulateurs de fzd2 dans le traitement de l'alopecie
|
|
ES2663536T3
(es)
|
2008-09-26 |
2018-04-13 |
Oncomed Pharmaceuticals, Inc. |
Agentes que se unen a receptores frizzled y usos de los mismos
|
|
US20130295106A1
(en)
|
2008-09-26 |
2013-11-07 |
Oncomed Pharmaceuticals, Inc. |
Frizzled-Binding Agents And Uses Thereof
|
|
WO2010038756A1
(ja)
|
2008-09-30 |
2010-04-08 |
協和発酵キリン株式会社 |
Frizzled1、Frizzled2又はFrizzled7細胞外システインリッチドメインを含む蛋白質を含有する骨疾患治療用医薬組成物
|
|
US20100169025A1
(en)
|
2008-10-10 |
2010-07-01 |
Arthur William T |
Methods and gene expression signature for wnt/b-catenin signaling pathway
|
|
WO2010101793A2
(en)
|
2009-03-06 |
2010-09-10 |
University Of South Alabama |
Methods and compositions for the diagnosis, prognosis and treatment of cancer
|
|
AU2010224044A1
(en)
|
2009-03-11 |
2011-09-22 |
Ardea Biosciences, Inc. |
Pharmaceutical combinations comprising RDEA119/BAY 869766 for the treatment of specific cancers
|
|
TWI535445B
(zh)
|
2010-01-12 |
2016-06-01 |
安可美德藥物股份有限公司 |
Ｗｎｔ拮抗劑及治療和篩選方法
|
|
UY33227A
(es)
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
|
CN103038364A
(zh)
|
2010-03-09 |
2013-04-10 |
达纳－法伯癌症研究所公司 |
诊断和治疗具有或发展对于第一种癌症治疗的抗性的患者中的癌症的方法
|
|
CN102971337B
(zh)
|
2010-04-01 |
2016-09-21 |
昂考梅德药品有限公司 |
卷曲蛋白结合药剂及其应用
|
|
US8431532B2
(en)
|
2010-06-28 |
2013-04-30 |
Five Prime Therepeutics, Inc. |
FZD8 extracellular domains and FZD8 extracellular domain fusion molecules and treatments using same
|
|
UY33469A
(es)
|
2010-06-29 |
2012-01-31 |
Irm Llc Y Novartis Ag |
Composiciones y metodos para modular la via de señalizacion de wnt
|
|
WO2012037551A2
(en)
|
2010-09-17 |
2012-03-22 |
Irx Therapeutics, Inc. |
Primary cell-derived biologic and wt1 synthetic long peptide vaccine
|
|
ES2863626T3
(es)
|
2010-10-27 |
2021-10-11 |
Amgen Inc |
Anticuerpos DKK1 y métodos de uso
|
|
WO2013086260A2
(en)
|
2011-12-09 |
2013-06-13 |
Oncomed Pharmaceuticals, Inc. |
Combination therapy for treatment of cancer
|
|
US20150190505A1
(en)
|
2012-07-30 |
2015-07-09 |
Alex Wah Hin Yeung |
Live and in-vivo tumor specific cancer vaccine system developed by co-administration of either at least two or all three of the following components such as tumor cells, an oncolytic virus vector with transgenic expression of gm-csf and an immune checkpoint modulator
|
|
HK1212216A1
(en)
|
2012-10-23 |
2016-06-10 |
Oncomed Pharmaceuticals, Inc. |
Methods of treating neuroendocrine tumors using wnt pathway-binding agents
|
|
JP2016510411A
(ja)
|
2013-02-04 |
2016-04-07 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
|
|
HK1223657A1
(zh)
|
2013-12-02 |
2017-08-04 |
Oncomed Pharmaceuticals, Inc. |
與wnt途徑抑制劑有關的預測性生物標記物的鑒別
|
|
US20170044268A1
(en)
|
2013-12-23 |
2017-02-16 |
OncoMed Pharmaceuticals |
Immunotherapy with Binding Agents
|
|
MA40364A
(fr)
|
2014-08-27 |
2016-03-03 |
Oncomed Pharm Inc |
Polythérapie pour le traitement du cancer
|