|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
FI903489A7
(fi)
|
1988-11-11 |
1990-07-10 |
Medical Res Council |
Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US6291158B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
PT1024191E
(pt)
|
1991-12-02 |
2008-12-22 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
|
DE69334275D1
(de)
|
1992-08-21 |
2009-05-20 |
Univ Bruxelles |
Immunoglobuline ohne Leichtkette
|
|
CA2145278C
(en)
|
1992-09-25 |
2009-03-10 |
Commonwealth Scientific And Industrial Research Organisation |
Target binding polypeptide
|
|
US20080152586A1
(en)
|
1992-09-25 |
2008-06-26 |
Avipep Pty Limited |
High avidity polyvalent and polyspecific reagents
|
|
CA2126967A1
(en)
|
1992-11-04 |
1994-05-11 |
Anna M. Wu |
Novel antibody construct
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5928939A
(en)
*
|
1995-03-01 |
1999-07-27 |
Ludwig Institute For Cancer Research |
Vascular endothelial growth factor-b and dna coding therefor
|
|
US6113898A
(en)
|
1995-06-07 |
2000-09-05 |
Idec Pharmaceuticals Corporation |
Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
|
|
EP0859841B1
(en)
|
1995-08-18 |
2002-06-19 |
MorphoSys AG |
Protein/(poly)peptide libraries
|
|
US6699658B1
(en)
|
1996-05-31 |
2004-03-02 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
ATE374248T1
(de)
|
1996-06-27 |
2007-10-15 |
Vlaams Interuniv Inst Biotech |
Antikörpermoleküle, die spezifisch mit dem aktiven zentrum oder dem aktiven spalt eines zielmoleküls interagieren
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
AUPP221098A0
(en)
|
1998-03-06 |
1998-04-02 |
Diatech Pty Ltd |
V-like domain binding molecules
|
|
CN101818145A
(zh)
|
1998-03-20 |
2010-09-01 |
联邦科学和工业研究组织 |
控制基因表达
|
|
DK1068311T3
(da)
|
1998-04-08 |
2011-08-08 |
Commw Scient Ind Res Org |
Fremgangsmåder og midler til opnåelse af modificerede fænotyper
|
|
AU776910B2
(en)
|
1998-12-08 |
2004-09-23 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Modifying protein immunogenicity
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7270969B2
(en)
|
1999-05-05 |
2007-09-18 |
Phylogica Limited |
Methods of constructing and screening diverse expression libraries
|
|
US6326193B1
(en)
|
1999-11-05 |
2001-12-04 |
Cambria Biosciences, Llc |
Insect control agent
|
|
EP1332209B1
(en)
|
2000-09-08 |
2009-11-11 |
Universität Zürich |
Collections of repeat proteins comprising repeat modules
|
|
JP4369662B2
(ja)
|
2001-04-26 |
2009-11-25 |
アビディア インコーポレイテッド |
単量体ドメインのコンビナトリアルライブラリー
|
|
AU2002368077B2
(en)
|
2001-07-12 |
2010-03-04 |
Jefferson Foote |
Super humanized antibodies
|
|
WO2003063904A2
(en)
*
|
2002-01-29 |
2003-08-07 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Tissue adhesion formation control
|
|
CA2429483A1
(en)
|
2002-05-17 |
2003-11-17 |
Amrad Operations Pty Ltd. |
Immunointeractive molecules
|
|
US20030232439A1
(en)
|
2002-06-17 |
2003-12-18 |
Isis Pharmaceuticals Inc. |
Antisense modulation of VEGF-B expression
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US7355008B2
(en)
|
2003-01-09 |
2008-04-08 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
AU2004245038A1
(en)
|
2003-06-02 |
2004-12-16 |
Alexion Pharmaceuticals, Inc. |
De-immunized anti-CD3 antibody
|
|
CA2531238C
(en)
|
2003-07-04 |
2015-02-24 |
Affibody Ab |
Polypeptides having binding affinity for her2
|
|
WO2005019255A1
(en)
|
2003-08-25 |
2005-03-03 |
Pieris Proteolab Ag |
Muteins of tear lipocalin
|
|
EP1673395A1
(en)
|
2003-10-15 |
2006-06-28 |
PDL BioPharma, Inc. |
Alteration of fc-fusion protein serum half-lives by mutagenesis of positions 250, 314 and/or 428 of the heavy chain constant region of ig
|
|
BRPI0417302A
(pt)
|
2003-12-05 |
2007-03-06 |
Compound Therapeutics Inc |
inibidores de receptores de fator de crescimento endotelial vascular do tipo 2
|
|
US20050282233A1
(en)
*
|
2004-03-05 |
2005-12-22 |
Ludwig Institute For Cancer Research |
Multivalent antibody materials and methods for VEGF/PDGF family of growth factors
|
|
DK1751181T3
(da)
|
2004-06-02 |
2012-11-26 |
Adalta Pty Ltd |
BINDINGSDELE, DER ER BASERET PÅ HAJ IgNAR-DOMÆNER
|
|
JP5014130B2
(ja)
|
2004-08-02 |
2012-08-29 |
ズィナイス オペレーションズ ピーティーワイ.エルティーディー. |
Vegf−bアンタゴニストを含む癌治療方法
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
WO2007019620A1
(en)
|
2005-08-15 |
2007-02-22 |
Arana Therapeutics Limited |
Engineered antibodies with new world primate framework regions
|
|
WO2007140534A1
(en)
|
2006-06-08 |
2007-12-13 |
Csl Limited |
Vegf-a cross-reactive anti- vegf-b antibodies as antagonists of vegf-a and vegf-b signalling
|
|
ES2918452T3
(es)
*
|
2007-02-19 |
2022-07-15 |
Marine Polymer Tech Inc |
Composiciones hemostáticas y regímenes terapéuticos
|
|
US20100216865A1
(en)
|
2007-09-12 |
2010-08-26 |
Elias Jack A |
MicroRNA COMPOSITIONS IN THE TREATMENT OF VEGF-MEDIATED DISORDERS
|
|
EP2271365A4
(en)
*
|
2008-04-09 |
2011-10-26 |
Ludwig Inst Cancer Res |
REGULATION OF FATTY ACID TRANSPORTERS
|
|
WO2010005527A1
(en)
*
|
2008-06-30 |
2010-01-14 |
Angioblast Systems, Inc. |
Treatment of eye diseases and excessive neovascularization using a combined therapy
|
|
RU2395521C1
(ru)
*
|
2008-11-10 |
2010-07-27 |
Учреждение Российской Академии Наук Институт Биологии Гена Ран |
Наноантитело v9, связывающее vegf, и способ его получения, кодирующая v9 нуклеотидная последовательность и содержащий ее вектор, способ ингибирования пролиферации эндотелиальных клеток
|
|
JP5734201B2
(ja)
|
2008-12-19 |
2015-06-17 |
マクロジェニクス,インコーポレーテッド |
共有結合型ダイアボディ及びその使用
|
|
US9259507B2
(en)
*
|
2009-04-21 |
2016-02-16 |
Warsaw Orthopedic, Inc. |
Tissue augmentation with active agent for wound healing
|
|
EP2367000A1
(en)
|
2010-03-04 |
2011-09-21 |
Charité Universitätsmedizin Berlin |
High throughput analysis of T-cell receptor repertoires
|