JP2016507472A5 - - Google Patents
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- Publication number
- JP2016507472A5 JP2016507472A5 JP2015542290A JP2015542290A JP2016507472A5 JP 2016507472 A5 JP2016507472 A5 JP 2016507472A5 JP 2015542290 A JP2015542290 A JP 2015542290A JP 2015542290 A JP2015542290 A JP 2015542290A JP 2016507472 A5 JP2016507472 A5 JP 2016507472A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical product
- methyl
- soft chewable
- oral administration
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 isoxazoline compound Chemical class 0.000 claims 48
- 239000000825 pharmaceutical preparation Substances 0.000 claims 21
- 229940127557 pharmaceutical product Drugs 0.000 claims 21
- 238000000034 method Methods 0.000 claims 15
- 241001465754 Metazoa Species 0.000 claims 11
- 239000008186 active pharmaceutical agent Substances 0.000 claims 9
- 238000000465 moulding Methods 0.000 claims 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 4
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 4
- 125000004970 halomethyl group Chemical group 0.000 claims 4
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 3
- 241000238876 Acari Species 0.000 claims 2
- 241000244206 Nematoda Species 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000003125 aqueous solvent Substances 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 claims 2
- 125000004672 ethylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C(*)=O 0.000 claims 2
- 229920005555 halobutyl Polymers 0.000 claims 2
- 125000004968 halobutyl group Chemical group 0.000 claims 2
- 125000004969 haloethyl group Chemical group 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 2
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 244000045947 parasite Species 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 125000004673 propylcarbonyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- XNTFQMKXUFFUQO-UHFFFAOYSA-N C[n]1nccc1CN Chemical compound C[n]1nccc1CN XNTFQMKXUFFUQO-UHFFFAOYSA-N 0.000 description 1
- HRVLXTZHPZXHTR-UHFFFAOYSA-N NC1(CC1)c1ccccn1 Chemical compound NC1(CC1)c1ccccn1 HRVLXTZHPZXHTR-UHFFFAOYSA-N 0.000 description 1
- YFEQTUUFQKDATK-UHFFFAOYSA-N NCc1c[s]cn1 Chemical compound NCc1c[s]cn1 YFEQTUUFQKDATK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728379P | 2012-11-20 | 2012-11-20 | |
| US61/728,379 | 2012-11-20 | ||
| US201361791385P | 2013-03-15 | 2013-03-15 | |
| US61/791,385 | 2013-03-15 | ||
| PCT/EP2013/074127 WO2014079825A1 (en) | 2012-11-20 | 2013-11-19 | Manufacturing of semi-plastic pharmaceutical dosage units |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149603A Division JP6695938B2 (ja) | 2012-11-20 | 2018-08-08 | 半可塑性医薬投与単位の製造 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016507472A JP2016507472A (ja) | 2016-03-10 |
| JP2016507472A5 true JP2016507472A5 (enExample) | 2016-12-28 |
| JP6408476B2 JP6408476B2 (ja) | 2018-10-17 |
Family
ID=49622822
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015542290A Active JP6408476B2 (ja) | 2012-11-20 | 2013-11-19 | 半可塑性医薬投与単位の製造 |
| JP2018149603A Active JP6695938B2 (ja) | 2012-11-20 | 2018-08-08 | 半可塑性医薬投与単位の製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149603A Active JP6695938B2 (ja) | 2012-11-20 | 2018-08-08 | 半可塑性医薬投与単位の製造 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US9532946B2 (enExample) |
| EP (2) | EP2922526B1 (enExample) |
| JP (2) | JP6408476B2 (enExample) |
| KR (4) | KR20240060876A (enExample) |
| CN (2) | CN110897889B (enExample) |
| AU (5) | AU2013349850A1 (enExample) |
| BR (2) | BR112015011383B1 (enExample) |
| CA (1) | CA2891688C (enExample) |
| DK (1) | DK2922526T3 (enExample) |
| ES (1) | ES2898376T3 (enExample) |
| HU (1) | HUE057510T2 (enExample) |
| MX (1) | MX2015006288A (enExample) |
| NZ (3) | NZ748326A (enExample) |
| PL (1) | PL2922526T3 (enExample) |
| PT (1) | PT2922526T (enExample) |
| RU (1) | RU2695360C2 (enExample) |
| SI (1) | SI2922526T1 (enExample) |
| WO (1) | WO2014079825A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4577C1 (ro) | 2012-02-06 | 2019-02-28 | Merial Inc. | Compoziţii masticabile de uz veterinar care conţin agent activ izoxazolinic şi utilizarea acestora în tratamentul sau prevenirea unei infestări sau infecţii parazitare |
| RU2632965C2 (ru) | 2012-04-04 | 2017-10-11 | Интервет Интернэшнл Б.В. | Мягкие жевательные фармацевтические продукты |
| CN106551804B (zh) * | 2015-09-30 | 2022-04-26 | 董玲 | 一种使用滚模制备冻干赋形制剂的方法及其产品 |
| EP3389628A4 (en) | 2015-12-19 | 2019-08-07 | Dixit, Manesh A. | PHARMACEUTICAL FORMULATIONS OF MOUSE CHEESE TABLETS |
| US20190022013A1 (en) * | 2015-12-19 | 2019-01-24 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
| WO2017151571A1 (en) * | 2016-02-29 | 2017-09-08 | First Time Us Generics Llc | Abuse deterrent soft chewable drug formulations |
| CN107260557A (zh) * | 2016-04-07 | 2017-10-20 | 董玲 | 一种滚模法制备冻干制剂的方法及其产品 |
| CN108926540A (zh) * | 2017-05-25 | 2018-12-04 | 北京欧博方医药科技有限公司 | 一种用于制造药物递送的软咀嚼剂型的方法 |
| AU2018316531B2 (en) | 2017-08-17 | 2024-05-02 | Ceva Sante Animale | Oral compositions and the preparation methods thereof |
| US12194144B2 (en) | 2018-09-22 | 2025-01-14 | Florida Research Group Llc | Soft chews with low water activity and methods of manufacturing same |
| JP7442540B2 (ja) | 2019-02-20 | 2024-03-04 | ゾエティス・サービシーズ・エルエルシー | 旨味製剤 |
| CN114144172A (zh) * | 2019-07-22 | 2022-03-04 | 英特维特国际股份有限公司 | 软咀嚼兽用剂型 |
| BR112022012269A2 (pt) | 2019-12-18 | 2022-08-30 | Elanco Tiergesundheit Ag | Derivados de isoxazolina como pesticidas |
| US11894130B2 (en) * | 2019-12-26 | 2024-02-06 | Augmenticon Gmbh | Pharmaceutical manufacturing process control, support and analysis |
| USD941985S1 (en) * | 2020-04-07 | 2022-01-25 | Nutramax Laboratories, Inc. | Dietary supplement |
| USD941457S1 (en) | 2020-04-07 | 2022-01-18 | Nutramax Laboratories, Inc. | Dietary supplement |
| CN116194450A (zh) | 2020-07-24 | 2023-05-30 | 礼蓝美国公司 | 用于制备异噁唑啉化合物及其中间体的工艺 |
| USD941458S1 (en) | 2020-08-11 | 2022-01-18 | Nutramax Laboratories, Inc. | Dietary supplement |
| USD942609S1 (en) | 2020-08-11 | 2022-02-01 | Nutramax Laboratories, Inc. | Dietary supplement |
| US20220160628A1 (en) * | 2020-11-24 | 2022-05-26 | Florida Research Group Llc | Process for manufacturing improved semi-soft solid dosage forms and soft chews produced thereby |
| IT202100016310A1 (it) * | 2021-06-22 | 2022-12-22 | Alaia Idea S R L | Metodo per la produzione di compresse |
| CN118368990A (zh) | 2021-12-23 | 2024-07-19 | 维克公司 | 基于大米淀粉的软咀嚼物 |
| WO2023198476A1 (en) * | 2022-04-15 | 2023-10-19 | Krka, D.D., Novo Mesto | Soft chewable veterinary dosage form |
| FR3138315A1 (fr) | 2022-07-27 | 2024-02-02 | Virbac | Produit à usage vétérinaire et procédé pour sa fabrication |
| PE20251178A1 (es) * | 2023-12-29 | 2025-04-23 | Agrovet Market S A | Procedimiento para la fabricacion de tabletas blandas |
| WO2025240494A1 (en) | 2024-05-13 | 2025-11-20 | Lumen Bioscience, Inc. | Leptin compositions and methods of making and using the same to support weight loss and/or maintenance |
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| RU2632965C2 (ru) | 2012-04-04 | 2017-10-11 | Интервет Интернэшнл Б.В. | Мягкие жевательные фармацевтические продукты |
-
2013
- 2013-11-18 US US14/082,813 patent/US9532946B2/en active Active
- 2013-11-19 CN CN201911336784.4A patent/CN110897889B/zh active Active
- 2013-11-19 CN CN201380060526.2A patent/CN104780908B/zh active Active
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