JP2014505089A5 - - Google Patents
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- Publication number
- JP2014505089A5 JP2014505089A5 JP2013552962A JP2013552962A JP2014505089A5 JP 2014505089 A5 JP2014505089 A5 JP 2014505089A5 JP 2013552962 A JP2013552962 A JP 2013552962A JP 2013552962 A JP2013552962 A JP 2013552962A JP 2014505089 A5 JP2014505089 A5 JP 2014505089A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mono
- group
- cyano
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 229910052757 nitrogen Inorganic materials 0.000 claims 28
- -1 C 1 -C 6 -alkoxy Chemical group 0.000 claims 24
- 229910052736 halogen Inorganic materials 0.000 claims 20
- 150000002367 halogens Chemical class 0.000 claims 20
- 125000004093 cyano group Chemical group *C#N 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 9
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 9
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 8
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 8
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 8
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 7
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 229940124530 sulfonamide Drugs 0.000 claims 7
- 150000003456 sulfonamides Chemical class 0.000 claims 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims 4
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 244000045947 parasite Species 0.000 claims 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 2
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 2
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000004749 (C1-C6) haloalkylsulfinyl group Chemical group 0.000 claims 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 1
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical compound [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 claims 1
- CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000002053 thietanyl group Chemical group 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH00247/11 | 2011-02-10 | ||
| CH2472011 | 2011-02-10 | ||
| PCT/EP2012/052241 WO2012107533A1 (en) | 2011-02-10 | 2012-02-09 | Isoxazoline derivatives for controlling invertebrate pests |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014505089A JP2014505089A (ja) | 2014-02-27 |
| JP2014505089A5 true JP2014505089A5 (enExample) | 2015-03-12 |
Family
ID=45607737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552962A Ceased JP2014505089A (ja) | 2011-02-10 | 2012-02-09 | 無脊椎有害動物を防除するためのイソオキサゾリン誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20130324538A1 (enExample) |
| EP (1) | EP2673273A1 (enExample) |
| JP (1) | JP2014505089A (enExample) |
| CN (1) | CN103347880B (enExample) |
| AR (1) | AR085354A1 (enExample) |
| AU (1) | AU2012215440B2 (enExample) |
| BR (1) | BR112013020520A2 (enExample) |
| CA (1) | CA2826067A1 (enExample) |
| CL (1) | CL2013002296A1 (enExample) |
| CO (1) | CO6731114A2 (enExample) |
| MX (1) | MX2013009211A (enExample) |
| RU (1) | RU2013141413A (enExample) |
| TW (1) | TWI511966B (enExample) |
| WO (1) | WO2012107533A1 (enExample) |
| ZA (1) | ZA201305226B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY33403A (es) * | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| AR086113A1 (es) * | 2011-04-30 | 2013-11-20 | Abbott Lab | Isoxazolinas como agentes terapeuticos |
| WO2012155352A1 (en) * | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
| HU231098B1 (hu) | 2012-02-06 | 2020-08-28 | Boehringer Ingelheim Animal Health USA Inc. | Szisztémás hatóanyagokat tartalmazó, parazitaellenes hatású, orális állatgyógyászati készítmények, eljárások és alkalmazásuk |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| BR112015018311B1 (pt) | 2013-02-06 | 2021-01-05 | Bayer Animal Health Gmbh | compostos derivados de pirazol substituídos por halogêneo como agentes de controle de pragas, composição farmacêutica e uso dos mesmos, processo para a preparação de composições de proteção de colheitas e método para o controle de pragas |
| EP3013822B1 (en) | 2013-06-24 | 2017-11-01 | Merial, Inc. | Thiophene- or furan-substituted isothiazoline compounds as pesticides |
| US9447084B2 (en) | 2013-11-01 | 2016-09-20 | Merial, Inc. | Antiparisitic and pesticidal isoxazoline compounds |
| EP3878281B1 (en) * | 2013-12-20 | 2023-05-24 | Intervet International B.V. | Use of isoxazoline compounds in poultry |
| JP6581586B2 (ja) | 2013-12-20 | 2019-09-25 | インターベット インターナショナル ベー． フェー． | イソオキサゾリン組成物および動物における寄生虫侵襲の予防または処置におけるその使用 |
| CN106061965A (zh) | 2014-01-03 | 2016-10-26 | 拜耳动物保健有限责任公司 | 作为农药的新型吡唑基杂芳基酰胺 |
| US10857121B2 (en) | 2014-04-17 | 2020-12-08 | Merial Inc. | Use of malononitrile compounds for protecting animals from parasites |
| AU2015289246B2 (en) | 2014-07-15 | 2019-07-25 | Elanco Animal Health Gmbh | Aryl-triazolyl pyridines as pest control agents |
| US20170232024A1 (en) | 2014-08-04 | 2017-08-17 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| EP3018129A1 (en) * | 2014-11-10 | 2016-05-11 | Novartis Tiergesundheit AG | Diaryl isoxazoline compound |
| UY36570A (es) * | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| KR102593069B1 (ko) * | 2015-04-08 | 2023-10-23 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 이속사졸린 활성제를 포함하는 서방형 주사 제형, 이의 방법 및 용도 |
| CA2986478C (en) | 2015-05-20 | 2023-08-08 | Merial, Inc. | Anthelmintic depsipeptide compounds |
| UY37137A (es) * | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| AU2017309725A1 (en) * | 2016-08-10 | 2019-02-21 | Bayer Cropscience Aktiengesellschaft | Substituted 2-heterocyclyl imidazolyl-carboxamides as pest control agents |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| CA3044038A1 (en) | 2016-11-16 | 2018-05-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| BR112020003217A2 (pt) | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| CN119174758A (zh) | 2017-12-15 | 2024-12-24 | 塔苏斯制药有限公司 | 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法 |
| TWI812673B (zh) * | 2018-02-12 | 2023-08-21 | 美商富曼西公司 | 用於防治無脊椎害蟲之萘異噁唑啉化合物 |
| BR112021000257A2 (pt) | 2018-07-09 | 2021-04-06 | Boehringer Ingelheim Animal Health USA Inc. | Compostos heterocíclicos anti-helmínticos |
| EP3846793B1 (en) | 2018-09-07 | 2024-01-24 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| PE20220281A1 (es) | 2019-03-19 | 2022-02-25 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de aza-benzotiofeno y aza-benzofurano como antihelminticos |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| AU2020295570A1 (en) * | 2019-06-19 | 2022-02-10 | Tarsus Pharmaceuticals, Inc. | Isoxazoline parasiticide formulations and methods for treating blepharitis |
| US20220249445A1 (en) * | 2019-06-19 | 2022-08-11 | Tarsus Pharmaceuticals, Inc. | Isoxazoline parasiticide formulations and methods for treating blepharitis |
| MX2022009240A (es) * | 2020-01-29 | 2022-08-16 | Bayer Animal Health Gmbh | Composicion farmaceutica para el control de parasitos en organismos no humanos. |
| TW202146393A (zh) | 2020-03-03 | 2021-12-16 | 美商皮克醫療公司 | Eif4e抑制劑及其用途 |
| WO2021242581A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic heterocyclic compounds |
| CA3209562A1 (en) | 2021-01-27 | 2022-08-04 | Intervet International B.V. | Cyclopropylamide compounds against parasites in fish |
| US20240116854A1 (en) | 2021-01-27 | 2024-04-11 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
| IL310924A (en) | 2021-08-25 | 2024-04-01 | Pic Therapeutics Inc | Eif4e inhibitors and uses thereof |
| WO2023028238A1 (en) | 2021-08-25 | 2023-03-02 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
| WO2023073641A1 (en) | 2021-11-01 | 2023-05-04 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic pyrrolopyridazine compounds |
| CN118715163A (zh) | 2022-02-17 | 2024-09-27 | 勃林格殷格翰动物保健有限公司 | 用于提供流体制品邮寄封的方法和系统 |
| CN114853748A (zh) * | 2022-05-06 | 2022-08-05 | 武汉工程大学 | 一种含三氟甲烷异噁唑啉类衍生物、其制备方法和应用 |
| NO20240925A1 (en) | 2023-09-15 | 2025-03-17 | Evah Atlantic Inc | Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4026018A1 (de) * | 1990-08-17 | 1992-02-20 | Hoechst Ag | Isoxazoline oder isothiazoline enthaltende pflanzenschuetzende mittel und neue isoxazoline und isothiazoline |
| DE4331448A1 (de) * | 1993-09-16 | 1995-03-23 | Hoechst Schering Agrevo Gmbh | Substituierte Isoxazoline, Verfahren zu deren Herstellung, diese enthaltende Mittel und deren Verwendung als Safener |
| DE19935218A1 (de) * | 1999-07-27 | 2001-02-01 | Aventis Cropscience Gmbh | Isoxazolyl-substituierte Benzoylcyclohexandione, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| KR100606083B1 (ko) | 2004-11-04 | 2006-07-31 | 삼성전자주식회사 | 광대역 무선 접속 통신 시스템에서 부채널 할당 시스템 및 방법 |
| CA2621228C (en) * | 2005-09-02 | 2014-05-27 | Nissan Chemical Industries, Ltd. | Isoxazoline-substituted benzamide compound and pesticide |
| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI600639B (zh) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備５-鹵烷基-４，５-二氫異唑衍生物之化合物 |
| WO2009071500A2 (en) | 2007-12-03 | 2009-06-11 | Novartis Ag | Organic compounds |
| PT2379537E (pt) * | 2008-12-19 | 2012-12-27 | Novartis Ag | Compostos orgânicos |
-
2012
- 2012-02-09 EP EP12704256.2A patent/EP2673273A1/en not_active Withdrawn
- 2012-02-09 AU AU2012215440A patent/AU2012215440B2/en not_active Ceased
- 2012-02-09 US US13/984,701 patent/US20130324538A1/en not_active Abandoned
- 2012-02-09 WO PCT/EP2012/052241 patent/WO2012107533A1/en not_active Ceased
- 2012-02-09 AR ARP120100434A patent/AR085354A1/es unknown
- 2012-02-09 CN CN201280008309.4A patent/CN103347880B/zh not_active Expired - Fee Related
- 2012-02-09 JP JP2013552962A patent/JP2014505089A/ja not_active Ceased
- 2012-02-09 MX MX2013009211A patent/MX2013009211A/es not_active Application Discontinuation
- 2012-02-09 BR BR112013020520A patent/BR112013020520A2/pt not_active IP Right Cessation
- 2012-02-09 RU RU2013141413/04A patent/RU2013141413A/ru not_active Application Discontinuation
- 2012-02-09 CA CA2826067A patent/CA2826067A1/en not_active Abandoned
- 2012-02-10 TW TW101104306A patent/TWI511966B/zh not_active IP Right Cessation
-
2013
- 2013-07-11 ZA ZA2013/05226A patent/ZA201305226B/en unknown
- 2013-07-12 CO CO13165984A patent/CO6731114A2/es unknown
- 2013-08-07 CL CL2013002296A patent/CL2013002296A1/es unknown
-
2015
- 2015-10-01 US US14/872,669 patent/US20160024062A1/en not_active Abandoned
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