JP2016505586A5 - - Google Patents

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Publication number

JP2016505586A5

JP2016505586A5 JP2015548633A JP2015548633A JP2016505586A5 JP 2016505586 A5 JP2016505586 A5 JP 2016505586A5 JP 2015548633 A JP2015548633 A JP 2015548633A JP 2015548633 A JP2015548633 A JP 2015548633A JP 2016505586 A5 JP2016505586 A5 JP 2016505586A5

Authority

JP

Japan

Prior art keywords

group

formula

unit

alkyl

compound according

Prior art date

2013-12-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 150000001875 compounds Chemical class 0.000 claims 21
• 125000000217 alkyl group Chemical group 0.000 claims 14
• 239000003446 ligand Substances 0.000 claims 7
• 125000005647 linker group Chemical group 0.000 claims 7
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
• 125000003342 alkenyl group Chemical group 0.000 claims 6
• 125000004432 carbon atom Chemical group C* 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 6
• -1 methoxy, ethoxy Chemical group 0.000 claims 6
• 125000003118 aryl group Chemical group 0.000 claims 5
• 229910052799 carbon Inorganic materials 0.000 claims 5
• 125000005843 halogen group Chemical group 0.000 claims 5
• 229910052739 hydrogen Inorganic materials 0.000 claims 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 229910052760 oxygen Inorganic materials 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000012453 solvate Substances 0.000 claims 4
• 125000006850 spacer group Chemical group 0.000 claims 4
• 229910052717 sulfur Inorganic materials 0.000 claims 4
• 125000002947 alkylene group Chemical group 0.000 claims 3
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
• 230000002062 proliferating effect Effects 0.000 claims 3
• OMRPLUKQNWNZAV-CONSDPRKSA-N (6as)-3-[3-[[(6as)-2-methoxy-8-(4-methoxyphenyl)-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-8-(4-aminophenyl)-2-methoxy-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical compound C1=CC(OC)=CC=C1C1=CN2C(=O)C3=CC(OC)=C(OCCCOC=4C(=CC=5C(=O)N6C=C(C[C@H]6C=NC=5C=4)C=4C=CC(N)=CC=4)OC)C=C3N=C[C@@H]2C1 OMRPLUKQNWNZAV-CONSDPRKSA-N 0.000 claims 2
• 108010016626 Dipeptides Chemical group 0.000 claims 2
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
• 125000005907 alkyl ester group Chemical group 0.000 claims 2
• 125000000304 alkynyl group Chemical group 0.000 claims 2
• 150000001768 cations Chemical class 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 229910052731 fluorine Inorganic materials 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
• UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
• 125000004076 pyridyl group Chemical group 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• 125000001544 thienyl group Chemical group 0.000 claims 2
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 125000001309 chloro group Chemical group Cl* 0.000 claims 1
• IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 125000005519 fluorenylmethyloxycarbonyl group Chemical group 0.000 claims 1
• 125000001153 fluoro group Chemical group F* 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• 150000002825 nitriles Chemical class 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1