JP2016504290A5 - - Google Patents
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- Publication number
- JP2016504290A5 JP2016504290A5 JP2015544124A JP2015544124A JP2016504290A5 JP 2016504290 A5 JP2016504290 A5 JP 2016504290A5 JP 2015544124 A JP2015544124 A JP 2015544124A JP 2015544124 A JP2015544124 A JP 2015544124A JP 2016504290 A5 JP2016504290 A5 JP 2016504290A5
- Authority
- JP
- Japan
- Prior art keywords
- diamine
- fluoro
- benzimidazol
- pyrimidine
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728907P | 2012-11-21 | 2012-11-21 | |
| US61/728,907 | 2012-11-21 | ||
| PCT/US2013/071132 WO2014081906A2 (en) | 2012-11-21 | 2013-11-21 | Substituted reverse pyrimidine bmi-1 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018183173A Division JP6617186B2 (ja) | 2012-11-21 | 2018-09-28 | 置換逆ピリミジンBmi−1阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016504290A JP2016504290A (ja) | 2016-02-12 |
| JP2016504290A5 true JP2016504290A5 (enExample) | 2017-01-05 |
| JP6412503B2 JP6412503B2 (ja) | 2018-10-24 |
Family
ID=50776672
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544124A Expired - Fee Related JP6412503B2 (ja) | 2012-11-21 | 2013-11-21 | 置換逆ピリミジンBmi−1阻害剤 |
| JP2018183173A Expired - Fee Related JP6617186B2 (ja) | 2012-11-21 | 2018-09-28 | 置換逆ピリミジンBmi−1阻害剤 |
| JP2019203706A Expired - Fee Related JP6918898B2 (ja) | 2012-11-21 | 2019-11-11 | 置換逆ピリミジンBmi−1阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018183173A Expired - Fee Related JP6617186B2 (ja) | 2012-11-21 | 2018-09-28 | 置換逆ピリミジンBmi−1阻害剤 |
| JP2019203706A Expired - Fee Related JP6918898B2 (ja) | 2012-11-21 | 2019-11-11 | 置換逆ピリミジンBmi−1阻害剤 |
Country Status (32)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PH12015501130B1 (en) | 2012-11-21 | 2023-01-27 | Ptc Therapeutics Inc | Substituted reverse pyrimidine bmi-1 inhibitors |
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| CN105593215B (zh) * | 2013-07-11 | 2019-01-15 | 安吉奥斯医药品有限公司 | 用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物 |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| MX370588B (es) * | 2013-08-30 | 2019-12-16 | Ptc Therapeutics Inc | Inhibidores de la bmi-1 de pirimidina sustituida. |
| US10584115B2 (en) | 2013-11-21 | 2020-03-10 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine BMI-1 inhibitors |
| ES3067417T3 (en) | 2015-08-11 | 2026-05-21 | Cognoa Inc | Apparatus to determine developmental progress with artificial intelligence and user input |
| US10851082B2 (en) | 2015-10-28 | 2020-12-01 | Northwestern University | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) |
| US11972336B2 (en) | 2015-12-18 | 2024-04-30 | Cognoa, Inc. | Machine learning platform and system for data analysis |
| WO2017123826A1 (en) * | 2016-01-14 | 2017-07-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| CN118609834A (zh) | 2016-11-14 | 2024-09-06 | 科格诺亚公司 | 用于评估发育状况并提供覆盖度和可靠性控制的方法和装置 |
| JP7324709B2 (ja) * | 2017-02-09 | 2023-08-10 | コグノア,インク. | デジタル個別化医療のためのプラットフォームとシステム |
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| EP3564235A1 (en) * | 2018-05-03 | 2019-11-06 | Northwestern University | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (mnk1) and 2 (mnk2) |
| JP2021535198A (ja) * | 2018-08-17 | 2021-12-16 | ピーティーシー セラピューティクス, インコーポレイテッド | 膵臓癌を治療する方法 |
| CN109988172B (zh) * | 2019-01-10 | 2020-09-29 | 石家庄学院 | 一种吡唑并[1,5-a]嘧啶类杂环化合物及衍生物的合成方法 |
| WO2020150326A1 (en) * | 2019-01-15 | 2020-07-23 | Ptc Therapeutics, Inc. | Method for treating an acute myeloid leukemia |
| AU2020227748A1 (en) * | 2019-02-28 | 2021-09-16 | Ptc Therapeutics, Inc. | Method for treating a multiple myeloma |
| KR20210151061A (ko) * | 2019-03-11 | 2021-12-13 | 피티씨 테라퓨틱스, 인크. | 향상된 생체이용률을 갖는 화합물 형태 및 이의 제형 |
| CN113873935B (zh) | 2019-03-22 | 2024-11-22 | 科格诺亚公司 | 个性化数字化治疗方法和装置 |
| CA3134648A1 (en) * | 2019-03-27 | 2020-10-01 | Ptc Therapeutics, Inc. | Combinations useful in a method for treating sarcoma |
| US20220177459A1 (en) * | 2019-04-02 | 2022-06-09 | Hinova Pharmaceuticals Inc. | Aromatic amine compound and use thereof in preparation of ar and brd4 dual inhibitors and regulators |
| WO2021046412A1 (en) | 2019-09-06 | 2021-03-11 | Cognoa, Inc. | Methods, systems, and devices for the diagnosis of behavioral disorders, developmental delays, and neurologic impairments |
| US12245355B2 (en) | 2021-02-19 | 2025-03-04 | Mevion Medical Systems, Inc. | Gantry for a particle therapy system |
| US20240120050A1 (en) * | 2022-10-07 | 2024-04-11 | Insight Direct Usa, Inc. | Machine learning method for predicting a health outcome of a patient using video and audio analytics |
| US20260188467A1 (en) * | 2024-12-27 | 2026-07-02 | Center for Social Dynamics, LLC | Parallel Processing Systems and Methods For Real-Time Multimodal Behavioral Classification Using Neural Networks With Dynamic Content Adaptation |
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-
2013
- 2013-11-21 PH PH1/2015/501130A patent/PH12015501130B1/en unknown
- 2013-11-21 CN CN202010080540.0A patent/CN111423417B/zh active Active
- 2013-11-21 AU AU2013348009A patent/AU2013348009C1/en not_active Ceased
- 2013-11-21 NZ NZ70890913A patent/NZ708909A/en unknown
- 2013-11-21 BR BR112015011760-0A patent/BR112015011760B1/pt active IP Right Grant
- 2013-11-21 CU CU2015000053A patent/CU24387B1/es unknown
- 2013-11-21 CA CA2892045A patent/CA2892045C/en active Active
- 2013-11-21 JP JP2015544124A patent/JP6412503B2/ja not_active Expired - Fee Related
- 2013-11-21 WO PCT/US2013/071132 patent/WO2014081906A2/en not_active Ceased
- 2013-11-21 KR KR1020217020963A patent/KR102356487B1/ko active Active
- 2013-11-21 EA EA201890142A patent/EA035349B1/ru not_active IP Right Cessation
- 2013-11-21 EA EA201590992A patent/EA031405B1/ru unknown
- 2013-11-21 US US14/443,911 patent/US10428050B2/en active Active
- 2013-11-21 UA UAA201505533A patent/UA118094C2/uk unknown
- 2013-11-21 CN CN201380070973.6A patent/CN104918919A/zh active Pending
- 2013-11-21 KR KR1020157016184A patent/KR102275676B1/ko not_active Expired - Fee Related
- 2013-11-21 KR KR1020227002513A patent/KR102455889B1/ko not_active Expired - Fee Related
- 2013-11-21 EP EP13857326.6A patent/EP2922828B1/en active Active
- 2013-11-21 KR KR1020227035587A patent/KR20220143164A/ko not_active Ceased
- 2013-11-21 SG SG10201600149VA patent/SG10201600149VA/en unknown
- 2013-11-21 PE PE2015000665A patent/PE20151413A1/es unknown
- 2013-11-21 PL PL13857326T patent/PL2922828T3/pl unknown
- 2013-11-21 ES ES13857326T patent/ES2821529T3/es active Active
- 2013-11-21 HK HK16103069.2A patent/HK1215032A1/zh unknown
- 2013-11-21 PT PT138573266T patent/PT2922828T/pt unknown
- 2013-11-21 DK DK13857326.6T patent/DK2922828T3/da active
- 2013-11-21 AR ARP130104300A patent/AR093579A1/es active IP Right Grant
- 2013-11-21 MA MA38208A patent/MA38208B1/fr unknown
- 2013-11-21 TW TW102142555A patent/TWI623531B/zh not_active IP Right Cessation
- 2013-11-21 NZ NZ74660713A patent/NZ746607A/en unknown
- 2013-11-21 MX MX2015006469A patent/MX385385B/es unknown
- 2013-11-21 SG SG11201503982XA patent/SG11201503982XA/en unknown
-
2015
- 2015-05-18 IL IL238871A patent/IL238871B/en active IP Right Grant
- 2015-05-20 CL CL2015001377A patent/CL2015001377A1/es unknown
- 2015-05-21 SA SA517381847A patent/SA517381847B1/ar unknown
- 2015-05-21 NI NI201500072A patent/NI201500072A/es unknown
- 2015-05-21 EC ECIEPI201519948A patent/ECSP15019948A/es unknown
- 2015-05-21 MX MX2021009892A patent/MX2021009892A/es unknown
- 2015-05-22 ZA ZA2015/03642A patent/ZA201503642B/en unknown
- 2015-06-05 CR CR20150294A patent/CR20150294A/es unknown
-
2018
- 2018-09-28 JP JP2018183173A patent/JP6617186B2/ja not_active Expired - Fee Related
-
2019
- 2019-03-10 IL IL265253A patent/IL265253A/en unknown
- 2019-09-26 US US16/583,442 patent/US11180483B2/en not_active Expired - Fee Related
- 2019-11-11 JP JP2019203706A patent/JP6918898B2/ja not_active Expired - Fee Related
-
2021
- 2021-11-10 US US17/523,480 patent/US20220064150A1/en not_active Abandoned
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