AU2013348009C1 - Substituted reverse pyrimidine Bmi-1 inhibitors - Google Patents
Substituted reverse pyrimidine Bmi-1 inhibitors Download PDFInfo
- Publication number
- AU2013348009C1 AU2013348009C1 AU2013348009A AU2013348009A AU2013348009C1 AU 2013348009 C1 AU2013348009 C1 AU 2013348009C1 AU 2013348009 A AU2013348009 A AU 2013348009A AU 2013348009 A AU2013348009 A AU 2013348009A AU 2013348009 C1 AU2013348009 C1 AU 2013348009C1
- Authority
- AU
- Australia
- Prior art keywords
- pyrimidine
- benzimidazol
- fluoro
- diamine
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- KGIIKSDOQLOSJE-UHFFFAOYSA-N CC(Nc(nc1C)nc(N)c1F)=N Chemical compound CC(Nc(nc1C)nc(N)c1F)=N KGIIKSDOQLOSJE-UHFFFAOYSA-N 0.000 description 3
- KCLPPNJIMZDPSS-UHFFFAOYSA-N CC(Nc1nc(C)c(C)c(C)n1)=N Chemical compound CC(Nc1nc(C)c(C)c(C)n1)=N KCLPPNJIMZDPSS-UHFFFAOYSA-N 0.000 description 1
- WRVKMYIXZVKGGK-UHFFFAOYSA-N CCC(Nc(nc1N)nc(C)c1F)=N Chemical compound CCC(Nc(nc1N)nc(C)c1F)=N WRVKMYIXZVKGGK-UHFFFAOYSA-N 0.000 description 1
- UBXVZSMWPYGQKO-UHFFFAOYSA-N Cc([n](c1cc(F)c2)-c(nc3C)nc(Nc(cc4)ccc4OC(F)(F)F)c3F)nc1c2F Chemical compound Cc([n](c1cc(F)c2)-c(nc3C)nc(Nc(cc4)ccc4OC(F)(F)F)c3F)nc1c2F UBXVZSMWPYGQKO-UHFFFAOYSA-N 0.000 description 1
- VAABNOYEIHLZGX-UHFFFAOYSA-N Cc([n](c1cc(F)c2)-c(nc3N)nc(Nc(cc4)ccc4Cl)c3F)nc1c2F Chemical compound Cc([n](c1cc(F)c2)-c(nc3N)nc(Nc(cc4)ccc4Cl)c3F)nc1c2F VAABNOYEIHLZGX-UHFFFAOYSA-N 0.000 description 1
- QFRXRQJZRSSGQO-UHFFFAOYSA-N Cc(cc1O2)ccc1OC2(F)F Chemical compound Cc(cc1O2)ccc1OC2(F)F QFRXRQJZRSSGQO-UHFFFAOYSA-N 0.000 description 1
- APVZCIDOUGWKAI-UHFFFAOYSA-N Cc1nc2ccccc2[n]1-c(nc1N)nc(Nc2ccc(C)c(F)c2)c1F Chemical compound Cc1nc2ccccc2[n]1-c(nc1N)nc(Nc2ccc(C)c(F)c2)c1F APVZCIDOUGWKAI-UHFFFAOYSA-N 0.000 description 1
- QDEYNDOQMMXVRW-UHFFFAOYSA-N FC(c1c(-c2nc(Cl)ccn2)[n](cccc2)c2n1)(F)F Chemical compound FC(c1c(-c2nc(Cl)ccn2)[n](cccc2)c2n1)(F)F QDEYNDOQMMXVRW-UHFFFAOYSA-N 0.000 description 1
- FGSAQRJRWCZLOB-UHFFFAOYSA-N Fc1ccnc(Cl)c1 Chemical compound Fc1ccnc(Cl)c1 FGSAQRJRWCZLOB-UHFFFAOYSA-N 0.000 description 1
- TTYVECQWCUJXCS-UHFFFAOYSA-N Fc1ccncc1 Chemical compound Fc1ccncc1 TTYVECQWCUJXCS-UHFFFAOYSA-N 0.000 description 1
- FCUPBCLWJYVIOT-UHFFFAOYSA-N OCc1n[n](ccc(F)c2)c2c1 Chemical compound OCc1n[n](ccc(F)c2)c2c1 FCUPBCLWJYVIOT-UHFFFAOYSA-N 0.000 description 1
- JQGUMOUQHSVYQG-UHFFFAOYSA-N OCc1n[n](ccc(F)c2)c2c1[IH+] Chemical compound OCc1n[n](ccc(F)c2)c2c1[IH+] JQGUMOUQHSVYQG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hematology (AREA)
- Oncology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728907P | 2012-11-21 | 2012-11-21 | |
| US61/728,907 | 2012-11-21 | ||
| PCT/US2013/071132 WO2014081906A2 (en) | 2012-11-21 | 2013-11-21 | Substituted reverse pyrimidine bmi-1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2013348009A1 AU2013348009A1 (en) | 2015-06-04 |
| AU2013348009B2 AU2013348009B2 (en) | 2018-05-17 |
| AU2013348009C1 true AU2013348009C1 (en) | 2019-08-08 |
Family
ID=50776672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013348009A Active AU2013348009C1 (en) | 2012-11-21 | 2013-11-21 | Substituted reverse pyrimidine Bmi-1 inhibitors |
Country Status (32)
Families Citing this family (25)
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| JP6412503B2 (ja) * | 2012-11-21 | 2018-10-24 | ピーティーシー セラピューティクス， インコーポレイテッド | 置換逆ピリミジンＢｍｉ−１阻害剤 |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US10376510B2 (en) * | 2013-07-11 | 2019-08-13 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| KR102232595B1 (ko) | 2013-08-30 | 2021-03-26 | 피티씨 테라퓨틱스, 인크. | 치환된 피리미딘 bmi-1 저해제 |
| EP3071553A4 (en) | 2013-11-21 | 2017-08-02 | PTC Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| CN108351862B (zh) | 2015-08-11 | 2023-08-22 | 科格诺亚公司 | 利用人工智能和用户输入来确定发育进展的方法和装置 |
| US10851082B2 (en) | 2015-10-28 | 2020-12-01 | Northwestern University | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) |
| US11972336B2 (en) | 2015-12-18 | 2024-04-30 | Cognoa, Inc. | Machine learning platform and system for data analysis |
| CA3010615C (en) * | 2016-01-14 | 2024-02-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| WO2018090009A1 (en) | 2016-11-14 | 2018-05-17 | Cognoa, Inc. | Methods and apparatus for evaluating developmental conditions and providing control over coverage and reliability |
| WO2018148365A1 (en) * | 2017-02-09 | 2018-08-16 | Cognoa, Inc. | Platform and system for digital personalized medicine |
| KR20200035292A (ko) | 2017-08-01 | 2020-04-02 | 피티씨 테라퓨틱스, 인크. | 혈액 암 치료에 사용하기 위한 dhodh 억제제 |
| EP3564235A1 (en) * | 2018-05-03 | 2019-11-06 | Northwestern University | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (mnk1) and 2 (mnk2) |
| JP2021535198A (ja) * | 2018-08-17 | 2021-12-16 | ピーティーシー セラピューティクス， インコーポレイテッド | 膵臓癌を治療する方法 |
| CN109988172B (zh) * | 2019-01-10 | 2020-09-29 | 石家庄学院 | 一种吡唑并[1,5-a]嘧啶类杂环化合物及衍生物的合成方法 |
| AU2020209767B2 (en) * | 2019-01-15 | 2025-03-06 | Ptc Therapeutics, Inc. | Method for treating an acute myeloid leukemia |
| MX2021010398A (es) * | 2019-02-28 | 2022-01-18 | Ptc Therapeutics Inc | Metodo para tratar un mieloma multiple. |
| MX2021010906A (es) * | 2019-03-11 | 2021-10-01 | Ptc Therapeutics Inc | Forma de un compuesto que tiene biodisponibilidad mejorada y formulaciones de las mismas. |
| AU2020248351B2 (en) | 2019-03-22 | 2025-09-25 | Cognoa, Inc. | Personalized digital therapy methods and devices |
| EA202192349A1 (ru) * | 2019-03-27 | 2022-02-01 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Комбинации, пригодные в способе лечения саркомы |
| JP2022527925A (ja) * | 2019-04-02 | 2022-06-07 | ヒノバ ファーマシューティカルズ インコーポレイテッド | 芳香族アミン系化合物と、該化合物のａｒおよびｂｒｄ４二重阻害剤ならびに調節剤の製造における使用 |
| CA3153086A1 (en) | 2019-09-06 | 2021-03-11 | Cognoa, Inc. | Methods, systems, and devices for the diagnosis of behavioral disorders, developmental delays, and neurologic impairments |
| US12245355B2 (en) | 2021-02-19 | 2025-03-04 | Mevion Medical Systems, Inc. | Gantry for a particle therapy system |
| US20240120050A1 (en) * | 2022-10-07 | 2024-04-11 | Insight Direct Usa, Inc. | Machine learning method for predicting a health outcome of a patient using video and audio analytics |
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