JP2016147858A5 - - Google Patents
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- Publication number
- JP2016147858A5 JP2016147858A5 JP2016023658A JP2016023658A JP2016147858A5 JP 2016147858 A5 JP2016147858 A5 JP 2016147858A5 JP 2016023658 A JP2016023658 A JP 2016023658A JP 2016023658 A JP2016023658 A JP 2016023658A JP 2016147858 A5 JP2016147858 A5 JP 2016147858A5
- Authority
- JP
- Japan
- Prior art keywords
- dipiperidinyl
- mycaminosyl
- tylonolide
- composition
- crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000023504 respiratory system disease Diseases 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 241000588807 Bordetella Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 241000606856 Pasteurella multocida Species 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229940051027 pasteurella multocida Drugs 0.000 claims 2
- FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 claims 2
- 241000606748 Actinobacillus pleuropneumoniae Species 0.000 claims 1
- 241001293418 Mannheimia haemolytica Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 1
- 206010034107 Pasteurella infections Diseases 0.000 claims 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims 1
- 201000005115 pasteurellosis Diseases 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07113244.3 | 2007-07-26 | ||
| EP07113244A EP2019112A1 (en) | 2007-07-26 | 2007-07-26 | Macrolide solid-state forms |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013251788A Division JP2014088394A (ja) | 2007-07-26 | 2013-12-05 | マクロライド固体状形態 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018021677A Division JP2018109020A (ja) | 2007-07-26 | 2018-02-09 | マクロライド固体状形態 |
| JP2018021676A Division JP2018104449A (ja) | 2007-07-26 | 2018-02-09 | マクロライド固体状形態 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016147858A JP2016147858A (ja) | 2016-08-18 |
| JP2016147858A5 true JP2016147858A5 (enExample) | 2016-09-29 |
| JP6343624B2 JP6343624B2 (ja) | 2018-06-13 |
Family
ID=39467287
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517412A Active JP5925989B2 (ja) | 2007-07-26 | 2008-07-25 | マクロライド固体状形態 |
| JP2013251788A Pending JP2014088394A (ja) | 2007-07-26 | 2013-12-05 | マクロライド固体状形態 |
| JP2016023658A Active JP6343624B2 (ja) | 2007-07-26 | 2016-02-10 | マクロライド固体状形態 |
| JP2018021677A Pending JP2018109020A (ja) | 2007-07-26 | 2018-02-09 | マクロライド固体状形態 |
| JP2018021676A Pending JP2018104449A (ja) | 2007-07-26 | 2018-02-09 | マクロライド固体状形態 |
| JP2020114652A Pending JP2020172517A (ja) | 2007-07-26 | 2020-07-02 | マクロライド固体状形態 |
| JP2020114648A Pending JP2020172516A (ja) | 2007-07-26 | 2020-07-02 | マクロライド固体状形態 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517412A Active JP5925989B2 (ja) | 2007-07-26 | 2008-07-25 | マクロライド固体状形態 |
| JP2013251788A Pending JP2014088394A (ja) | 2007-07-26 | 2013-12-05 | マクロライド固体状形態 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018021677A Pending JP2018109020A (ja) | 2007-07-26 | 2018-02-09 | マクロライド固体状形態 |
| JP2018021676A Pending JP2018104449A (ja) | 2007-07-26 | 2018-02-09 | マクロライド固体状形態 |
| JP2020114652A Pending JP2020172517A (ja) | 2007-07-26 | 2020-07-02 | マクロライド固体状形態 |
| JP2020114648A Pending JP2020172516A (ja) | 2007-07-26 | 2020-07-02 | マクロライド固体状形態 |
Country Status (13)
| Country | Link |
|---|---|
| EP (3) | EP2019112A1 (enExample) |
| JP (7) | JP5925989B2 (enExample) |
| KR (2) | KR102508115B1 (enExample) |
| CN (5) | CN103360447B (enExample) |
| AU (1) | AU2008278969B8 (enExample) |
| BR (1) | BRPI0814318B1 (enExample) |
| CA (1) | CA2693801C (enExample) |
| ES (2) | ES2805534T3 (enExample) |
| HU (1) | HUE031449T2 (enExample) |
| RU (1) | RU2476438C2 (enExample) |
| TW (1) | TWI427083B (enExample) |
| WO (1) | WO2009013351A2 (enExample) |
| ZA (1) | ZA201000188B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5323696B2 (ja) | 2006-07-28 | 2013-10-23 | インターベツト・インターナシヨナル・ベー・ベー | マクロライド合成方法 |
| EP2019112A1 (en) * | 2007-07-26 | 2009-01-28 | Intervet International BV | Macrolide solid-state forms |
| PL2782922T3 (pl) | 2011-11-25 | 2018-07-31 | Bayer Intellectual Property Gmbh | Przeciwbakteryjne pochodne tylozynowe i sposoby ich wytwarzania |
| CN102816196A (zh) * | 2012-09-10 | 2012-12-12 | 河北远征药业有限公司 | 泰地罗新半抗原、人工抗原及其制备方法 |
| HUE037868T2 (hu) * | 2013-05-23 | 2018-09-28 | Bayer Animal Health Gmbh | Tilozin-származékok és eljárás elõállításukra |
| CN103554203A (zh) * | 2013-08-17 | 2014-02-05 | 齐鲁动物保健品有限公司 | 一种泰地罗新无定形晶及其制备方法 |
| CN104478974B (zh) * | 2014-11-28 | 2016-08-17 | 武汉回盛生物科技有限公司 | 一种20，23-二哌啶基-5-o-碳霉胺糖基-泰乐内酯的合成方法 |
| CN104447919B (zh) * | 2014-11-28 | 2017-03-08 | 武汉回盛生物科技股份有限公司 | 一种20，23‑二哌啶基‑5‑o‑碳霉胺糖基‑泰乐内酯原料药的精制方法 |
| CN104497082B (zh) * | 2015-01-13 | 2017-12-12 | 中国兽医药品监察所 | 一种泰地罗新的合成方法 |
| CN104774223A (zh) * | 2015-03-26 | 2015-07-15 | 宁夏泰瑞制药股份有限公司 | 一种利用泰乐菌素碱生产泰地罗新的方法 |
| CN105254693B (zh) * | 2015-11-13 | 2017-12-22 | 周金华 | 一种泰地罗新的合成方法 |
| CN106008629B (zh) * | 2016-06-02 | 2019-11-22 | 天津大学 | 泰地罗新1,4-二氧六环溶剂化合物及制备方法 |
| CN106083958B (zh) * | 2016-06-02 | 2019-07-23 | 天津大学 | 泰地罗新环己烷溶剂化合物及制备方法 |
| CN106046084B (zh) * | 2016-06-02 | 2019-08-09 | 天津大学 | 泰地罗新丙酮溶剂化合物及制备方法 |
| CN109721633A (zh) * | 2017-10-31 | 2019-05-07 | 齐鲁晟华制药有限公司 | 一种泰地罗新晶型a及其制备方法 |
| CN112218877B (zh) | 2018-08-27 | 2025-07-25 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| CN111349130A (zh) * | 2018-12-21 | 2020-06-30 | 齐鲁动物保健品有限公司 | 一种泰地罗新晶型b及其制备方法 |
| ES3032032T3 (en) | 2020-12-03 | 2025-07-15 | Intervet Int Bv | Tildipirosin for the treatment of foot rot |
| CN114213484A (zh) * | 2021-12-21 | 2022-03-22 | 河北远征药业有限公司 | 一种泰地罗新1，2-丙二醇溶剂化合物及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3761588A (en) * | 1969-02-06 | 1973-09-25 | Meiji Seika Kaisha | Antibiotics and production thereof |
| AU561147B2 (en) | 1982-09-13 | 1987-04-30 | Eli Lilly And Company | 20-amino macrolide antibiotics |
| US4820695A (en) | 1982-09-13 | 1989-04-11 | Eli Lilly And Company | C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics |
| SI8311553A8 (en) * | 1983-07-18 | 1995-06-30 | Pliva Pharm & Chem Works | Process for preparing 7,16-dioxa-2-aza-10-0-cladynosil-12-0-desosaminyl-4,5-dihydroxy-6- ethyl-3,5,9,11,13,15-hexamethylbicyclo (11.2.1.) hexadeca-1(2)-ene-8-ones |
| US4921947A (en) * | 1986-03-31 | 1990-05-01 | Eli Lilly And Company | Process for preparing macrolide derivatives |
| US4920103A (en) | 1986-09-29 | 1990-04-24 | Eli Lilly And Company | Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides |
| DE122011100013I1 (de) * | 1999-08-30 | 2011-09-15 | Zaidan Hojin Biseibutsu | Makrolid-antibiotika und behandlung von pasteurellosis. |
| EP3738591A3 (en) * | 2003-03-10 | 2021-03-24 | Merck Sharp & Dohme Corp. | Novel antibacterial agents |
| AU2003269473A1 (en) * | 2003-08-26 | 2005-03-10 | Biocon Limited | A process for the recovery of substantially pure tricyclic macrolide |
| MX2007006119A (es) * | 2005-01-05 | 2007-07-19 | Teva Gyogyszergyar Zartkoruen | Tacrolimus amorfo y preparacion de el. |
| JP5323696B2 (ja) * | 2006-07-28 | 2013-10-23 | インターベツト・インターナシヨナル・ベー・ベー | マクロライド合成方法 |
| UA98303C2 (ru) * | 2006-07-28 | 2012-05-10 | Интервет Интернешонал Б.В. | Способ синтеза макролидов |
| EP2019112A1 (en) * | 2007-07-26 | 2009-01-28 | Intervet International BV | Macrolide solid-state forms |
-
2007
- 2007-07-26 EP EP07113244A patent/EP2019112A1/en not_active Withdrawn
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2008
- 2008-07-08 TW TW097125698A patent/TWI427083B/zh active
- 2008-07-25 CN CN201310280229.0A patent/CN103360447B/zh active Active
- 2008-07-25 CN CN2008801005518A patent/CN101778858B/zh active Active
- 2008-07-25 BR BRPI0814318-8A patent/BRPI0814318B1/pt active IP Right Grant
- 2008-07-25 RU RU2010107057/04A patent/RU2476438C2/ru active
- 2008-07-25 AU AU2008278969A patent/AU2008278969B8/en active Active
- 2008-07-25 CN CN201310280228.6A patent/CN103360446B/zh active Active
- 2008-07-25 KR KR1020107003939A patent/KR102508115B1/ko active Active
- 2008-07-25 WO PCT/EP2008/059775 patent/WO2009013351A2/en not_active Ceased
- 2008-07-25 ES ES16197385T patent/ES2805534T3/es active Active
- 2008-07-25 EP EP08786436.9A patent/EP2181117B1/en active Active
- 2008-07-25 EP EP16197385.4A patent/EP3170833B1/en active Active
- 2008-07-25 CA CA2693801A patent/CA2693801C/en active Active
- 2008-07-25 HU HUE08786436A patent/HUE031449T2/en unknown
- 2008-07-25 KR KR1020157036690A patent/KR20160003899A/ko not_active Ceased
- 2008-07-25 CN CN2013102805250A patent/CN103467548A/zh active Pending
- 2008-07-25 ES ES08786436.9T patent/ES2608978T3/es active Active
- 2008-07-25 CN CN201310279877.4A patent/CN103360445B/zh active Active
- 2008-07-25 JP JP2010517412A patent/JP5925989B2/ja active Active
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2010
- 2010-01-11 ZA ZA201000188A patent/ZA201000188B/xx unknown
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2013
- 2013-12-05 JP JP2013251788A patent/JP2014088394A/ja active Pending
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2016
- 2016-02-10 JP JP2016023658A patent/JP6343624B2/ja active Active
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2018
- 2018-02-09 JP JP2018021677A patent/JP2018109020A/ja active Pending
- 2018-02-09 JP JP2018021676A patent/JP2018104449A/ja active Pending
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2020
- 2020-07-02 JP JP2020114652A patent/JP2020172517A/ja active Pending
- 2020-07-02 JP JP2020114648A patent/JP2020172516A/ja active Pending