TWI427083B - 巨環內酯固態形式 - Google Patents
巨環內酯固態形式 Download PDFInfo
- Publication number
- TWI427083B TWI427083B TW097125698A TW97125698A TWI427083B TW I427083 B TWI427083 B TW I427083B TW 097125698 A TW097125698 A TW 097125698A TW 97125698 A TW97125698 A TW 97125698A TW I427083 B TWI427083 B TW I427083B
- Authority
- TW
- Taiwan
- Prior art keywords
- dipiperidinyl
- mycaminosyl
- tylonolide
- spectrum
- crystalline
- Prior art date
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- 239000005414 inactive ingredient Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
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- 239000007927 intramuscular injection Substances 0.000 description 1
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
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- 230000001737 promoting effect Effects 0.000 description 1
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- ZLIBICFPKPWGIZ-UHFFFAOYSA-N pyrimethanil Chemical compound CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 ZLIBICFPKPWGIZ-UHFFFAOYSA-N 0.000 description 1
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- 230000002829 reductive effect Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
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- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Epidemiology (AREA)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07113244A EP2019112A1 (en) | 2007-07-26 | 2007-07-26 | Macrolide solid-state forms |
Publications (2)
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|---|---|
| TW200918547A TW200918547A (en) | 2009-05-01 |
| TWI427083B true TWI427083B (zh) | 2014-02-21 |
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| JP (7) | JP5925989B2 (enExample) |
| KR (2) | KR102508115B1 (enExample) |
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| ES (2) | ES2805534T3 (enExample) |
| HU (1) | HUE031449T2 (enExample) |
| RU (1) | RU2476438C2 (enExample) |
| TW (1) | TWI427083B (enExample) |
| WO (1) | WO2009013351A2 (enExample) |
| ZA (1) | ZA201000188B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5323696B2 (ja) | 2006-07-28 | 2013-10-23 | インターベツト・インターナシヨナル・ベー・ベー | マクロライド合成方法 |
| EP2019112A1 (en) * | 2007-07-26 | 2009-01-28 | Intervet International BV | Macrolide solid-state forms |
| PL2782922T3 (pl) | 2011-11-25 | 2018-07-31 | Bayer Intellectual Property Gmbh | Przeciwbakteryjne pochodne tylozynowe i sposoby ich wytwarzania |
| CN102816196A (zh) * | 2012-09-10 | 2012-12-12 | 河北远征药业有限公司 | 泰地罗新半抗原、人工抗原及其制备方法 |
| HUE037868T2 (hu) * | 2013-05-23 | 2018-09-28 | Bayer Animal Health Gmbh | Tilozin-származékok és eljárás elõállításukra |
| CN103554203A (zh) * | 2013-08-17 | 2014-02-05 | 齐鲁动物保健品有限公司 | 一种泰地罗新无定形晶及其制备方法 |
| CN104478974B (zh) * | 2014-11-28 | 2016-08-17 | 武汉回盛生物科技有限公司 | 一种20，23-二哌啶基-5-o-碳霉胺糖基-泰乐内酯的合成方法 |
| CN104447919B (zh) * | 2014-11-28 | 2017-03-08 | 武汉回盛生物科技股份有限公司 | 一种20，23‑二哌啶基‑5‑o‑碳霉胺糖基‑泰乐内酯原料药的精制方法 |
| CN104497082B (zh) * | 2015-01-13 | 2017-12-12 | 中国兽医药品监察所 | 一种泰地罗新的合成方法 |
| CN104774223A (zh) * | 2015-03-26 | 2015-07-15 | 宁夏泰瑞制药股份有限公司 | 一种利用泰乐菌素碱生产泰地罗新的方法 |
| CN105254693B (zh) * | 2015-11-13 | 2017-12-22 | 周金华 | 一种泰地罗新的合成方法 |
| CN106008629B (zh) * | 2016-06-02 | 2019-11-22 | 天津大学 | 泰地罗新1,4-二氧六环溶剂化合物及制备方法 |
| CN106083958B (zh) * | 2016-06-02 | 2019-07-23 | 天津大学 | 泰地罗新环己烷溶剂化合物及制备方法 |
| CN106046084B (zh) * | 2016-06-02 | 2019-08-09 | 天津大学 | 泰地罗新丙酮溶剂化合物及制备方法 |
| CN109721633A (zh) * | 2017-10-31 | 2019-05-07 | 齐鲁晟华制药有限公司 | 一种泰地罗新晶型a及其制备方法 |
| CN112218877B (zh) | 2018-08-27 | 2025-07-25 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| CN111349130A (zh) * | 2018-12-21 | 2020-06-30 | 齐鲁动物保健品有限公司 | 一种泰地罗新晶型b及其制备方法 |
| ES3032032T3 (en) | 2020-12-03 | 2025-07-15 | Intervet Int Bv | Tildipirosin for the treatment of foot rot |
| CN114213484A (zh) * | 2021-12-21 | 2022-03-22 | 河北远征药业有限公司 | 一种泰地罗新1，2-丙二醇溶剂化合物及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514946B1 (en) * | 1999-08-30 | 2003-02-04 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Macrolide antibiotics and treatment and prophylaxis of pasteurellosis using the same |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3761588A (en) * | 1969-02-06 | 1973-09-25 | Meiji Seika Kaisha | Antibiotics and production thereof |
| AU561147B2 (en) | 1982-09-13 | 1987-04-30 | Eli Lilly And Company | 20-amino macrolide antibiotics |
| US4820695A (en) | 1982-09-13 | 1989-04-11 | Eli Lilly And Company | C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics |
| SI8311553A8 (en) * | 1983-07-18 | 1995-06-30 | Pliva Pharm & Chem Works | Process for preparing 7,16-dioxa-2-aza-10-0-cladynosil-12-0-desosaminyl-4,5-dihydroxy-6- ethyl-3,5,9,11,13,15-hexamethylbicyclo (11.2.1.) hexadeca-1(2)-ene-8-ones |
| US4921947A (en) * | 1986-03-31 | 1990-05-01 | Eli Lilly And Company | Process for preparing macrolide derivatives |
| US4920103A (en) | 1986-09-29 | 1990-04-24 | Eli Lilly And Company | Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides |
| EP3738591A3 (en) * | 2003-03-10 | 2021-03-24 | Merck Sharp & Dohme Corp. | Novel antibacterial agents |
| AU2003269473A1 (en) * | 2003-08-26 | 2005-03-10 | Biocon Limited | A process for the recovery of substantially pure tricyclic macrolide |
| MX2007006119A (es) * | 2005-01-05 | 2007-07-19 | Teva Gyogyszergyar Zartkoruen | Tacrolimus amorfo y preparacion de el. |
| JP5323696B2 (ja) * | 2006-07-28 | 2013-10-23 | インターベツト・インターナシヨナル・ベー・ベー | マクロライド合成方法 |
| UA98303C2 (ru) * | 2006-07-28 | 2012-05-10 | Интервет Интернешонал Б.В. | Способ синтеза макролидов |
| EP2019112A1 (en) * | 2007-07-26 | 2009-01-28 | Intervet International BV | Macrolide solid-state forms |
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2007
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2008
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- 2008-07-25 CN CN2008801005518A patent/CN101778858B/zh active Active
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- 2008-07-25 CN CN201310280228.6A patent/CN103360446B/zh active Active
- 2008-07-25 KR KR1020107003939A patent/KR102508115B1/ko active Active
- 2008-07-25 WO PCT/EP2008/059775 patent/WO2009013351A2/en not_active Ceased
- 2008-07-25 ES ES16197385T patent/ES2805534T3/es active Active
- 2008-07-25 EP EP08786436.9A patent/EP2181117B1/en active Active
- 2008-07-25 EP EP16197385.4A patent/EP3170833B1/en active Active
- 2008-07-25 CA CA2693801A patent/CA2693801C/en active Active
- 2008-07-25 HU HUE08786436A patent/HUE031449T2/en unknown
- 2008-07-25 KR KR1020157036690A patent/KR20160003899A/ko not_active Ceased
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2010
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- 2020-07-02 JP JP2020114652A patent/JP2020172517A/ja active Pending
- 2020-07-02 JP JP2020114648A patent/JP2020172516A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514946B1 (en) * | 1999-08-30 | 2003-02-04 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Macrolide antibiotics and treatment and prophylaxis of pasteurellosis using the same |
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