CN103360447B - 大环内酯固态晶型 - Google Patents

大环内酯固态晶型 Download PDF

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Publication number
CN103360447B
CN103360447B CN201310280229.0A CN201310280229A CN103360447B CN 103360447 B CN103360447 B CN 103360447B CN 201310280229 A CN201310280229 A CN 201310280229A CN 103360447 B CN103360447 B CN 103360447B
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China
Prior art keywords
tylonolide
mycaminosyl
dipiperidinyl
polymorph
crystalline
Prior art date
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CN201310280229.0A
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English (en)
Chinese (zh)
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CN103360447A (zh
Inventor
F·布拉特尔
M·布伦纳
G·胡
T·拉赫尔
R·瓦拉斯
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Microbial Chemistry Research Foundation
Intervet International BV
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Microbial Chemistry Research Foundation
Intervet International BV
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Publication of CN103360447A publication Critical patent/CN103360447A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epidemiology (AREA)
CN201310280229.0A 2007-07-26 2008-07-25 大环内酯固态晶型 Active CN103360447B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07113244.3 2007-07-26
EP07113244A EP2019112A1 (en) 2007-07-26 2007-07-26 Macrolide solid-state forms
CN2008801005518A CN101778858B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2008801005518A Division CN101778858B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型

Publications (2)

Publication Number Publication Date
CN103360447A CN103360447A (zh) 2013-10-23
CN103360447B true CN103360447B (zh) 2016-04-06

Family

ID=39467287

Family Applications (5)

Application Number Title Priority Date Filing Date
CN201310280229.0A Active CN103360447B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN2008801005518A Active CN101778858B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN201310280228.6A Active CN103360446B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN2013102805250A Pending CN103467548A (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN201310279877.4A Active CN103360445B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型

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CN2008801005518A Active CN101778858B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN201310280228.6A Active CN103360446B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN2013102805250A Pending CN103467548A (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN201310279877.4A Active CN103360445B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型

Country Status (13)

Country Link
EP (3) EP2019112A1 (enExample)
JP (7) JP5925989B2 (enExample)
KR (2) KR102508115B1 (enExample)
CN (5) CN103360447B (enExample)
AU (1) AU2008278969B8 (enExample)
BR (1) BRPI0814318B1 (enExample)
CA (1) CA2693801C (enExample)
ES (2) ES2805534T3 (enExample)
HU (1) HUE031449T2 (enExample)
RU (1) RU2476438C2 (enExample)
TW (1) TWI427083B (enExample)
WO (1) WO2009013351A2 (enExample)
ZA (1) ZA201000188B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5323696B2 (ja) 2006-07-28 2013-10-23 インターベツト・インターナシヨナル・ベー・ベー マクロライド合成方法
EP2019112A1 (en) * 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms
PL2782922T3 (pl) 2011-11-25 2018-07-31 Bayer Intellectual Property Gmbh Przeciwbakteryjne pochodne tylozynowe i sposoby ich wytwarzania
CN102816196A (zh) * 2012-09-10 2012-12-12 河北远征药业有限公司 泰地罗新半抗原、人工抗原及其制备方法
HUE037868T2 (hu) * 2013-05-23 2018-09-28 Bayer Animal Health Gmbh Tilozin-származékok és eljárás elõállításukra
CN103554203A (zh) * 2013-08-17 2014-02-05 齐鲁动物保健品有限公司 一种泰地罗新无定形晶及其制备方法
CN104478974B (zh) * 2014-11-28 2016-08-17 武汉回盛生物科技有限公司 一种20，23-二哌啶基-5-o-碳霉胺糖基-泰乐内酯的合成方法
CN104447919B (zh) * 2014-11-28 2017-03-08 武汉回盛生物科技股份有限公司 一种20，23‑二哌啶基‑5‑o‑碳霉胺糖基‑泰乐内酯原料药的精制方法
CN104497082B (zh) * 2015-01-13 2017-12-12 中国兽医药品监察所 一种泰地罗新的合成方法
CN104774223A (zh) * 2015-03-26 2015-07-15 宁夏泰瑞制药股份有限公司 一种利用泰乐菌素碱生产泰地罗新的方法
CN105254693B (zh) * 2015-11-13 2017-12-22 周金华 一种泰地罗新的合成方法
CN106008629B (zh) * 2016-06-02 2019-11-22 天津大学 泰地罗新1,4-二氧六环溶剂化合物及制备方法
CN106083958B (zh) * 2016-06-02 2019-07-23 天津大学 泰地罗新环己烷溶剂化合物及制备方法
CN106046084B (zh) * 2016-06-02 2019-08-09 天津大学 泰地罗新丙酮溶剂化合物及制备方法
CN109721633A (zh) * 2017-10-31 2019-05-07 齐鲁晟华制药有限公司 一种泰地罗新晶型a及其制备方法
CN112218877B (zh) 2018-08-27 2025-07-25 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
CN111349130A (zh) * 2018-12-21 2020-06-30 齐鲁动物保健品有限公司 一种泰地罗新晶型b及其制备方法
ES3032032T3 (en) 2020-12-03 2025-07-15 Intervet Int Bv Tildipirosin for the treatment of foot rot
CN114213484A (zh) * 2021-12-21 2022-03-22 河北远征药业有限公司 一种泰地罗新1，2-丙二醇溶剂化合物及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87102397A (zh) * 1986-03-31 1987-10-07 伊莱利利公司 制备大环内酯类衍生物的改进方法
US6514946B1 (en) * 1999-08-30 2003-02-04 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Macrolide antibiotics and treatment and prophylaxis of pasteurellosis using the same
CN101506220A (zh) * 2006-07-28 2009-08-12 英特威国际有限公司 大环内酯合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3761588A (en) * 1969-02-06 1973-09-25 Meiji Seika Kaisha Antibiotics and production thereof
AU561147B2 (en) 1982-09-13 1987-04-30 Eli Lilly And Company 20-amino macrolide antibiotics
US4820695A (en) 1982-09-13 1989-04-11 Eli Lilly And Company C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics
SI8311553A8 (en) * 1983-07-18 1995-06-30 Pliva Pharm & Chem Works Process for preparing 7,16-dioxa-2-aza-10-0-cladynosil-12-0-desosaminyl-4,5-dihydroxy-6- ethyl-3,5,9,11,13,15-hexamethylbicyclo (11.2.1.) hexadeca-1(2)-ene-8-ones
US4920103A (en) 1986-09-29 1990-04-24 Eli Lilly And Company Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides
EP3738591A3 (en) * 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
AU2003269473A1 (en) * 2003-08-26 2005-03-10 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
MX2007006119A (es) * 2005-01-05 2007-07-19 Teva Gyogyszergyar Zartkoruen Tacrolimus amorfo y preparacion de el.
JP5323696B2 (ja) * 2006-07-28 2013-10-23 インターベツト・インターナシヨナル・ベー・ベー マクロライド合成方法
EP2019112A1 (en) * 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87102397A (zh) * 1986-03-31 1987-10-07 伊莱利利公司 制备大环内酯类衍生物的改进方法
US6514946B1 (en) * 1999-08-30 2003-02-04 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Macrolide antibiotics and treatment and prophylaxis of pasteurellosis using the same
CN101506220A (zh) * 2006-07-28 2009-08-12 英特威国际有限公司 大环内酯合成方法

Also Published As

Publication number Publication date
CN103360446B (zh) 2016-04-06
WO2009013351A2 (en) 2009-01-29
CN101778858B (zh) 2013-12-04
JP2010534635A (ja) 2010-11-11
JP5925989B2 (ja) 2016-05-25
EP2019112A1 (en) 2009-01-28
ZA201000188B (en) 2010-09-29
WO2009013351A3 (en) 2009-04-02
BRPI0814318B1 (pt) 2021-04-06
AU2008278969B2 (en) 2011-11-17
ES2805534T3 (es) 2021-02-12
RU2010107057A (ru) 2011-09-10
JP2018104449A (ja) 2018-07-05
CA2693801A1 (en) 2009-01-29
KR20160003899A (ko) 2016-01-11
JP2020172517A (ja) 2020-10-22
EP3170833B1 (en) 2020-05-20
KR20100044864A (ko) 2010-04-30
EP2181117A2 (en) 2010-05-05
CN103467548A (zh) 2013-12-25
EP2181117B1 (en) 2016-11-09
JP2016147858A (ja) 2016-08-18
CN103360445A (zh) 2013-10-23
EP3170833A1 (en) 2017-05-24
ES2608978T3 (es) 2017-04-17
HUE031449T2 (en) 2017-07-28
RU2476438C2 (ru) 2013-02-27
CA2693801C (en) 2018-08-14
KR102508115B1 (ko) 2023-03-08
JP6343624B2 (ja) 2018-06-13
CN101778858A (zh) 2010-07-14
AU2008278969A1 (en) 2009-01-29
TW200918547A (en) 2009-05-01
JP2018109020A (ja) 2018-07-12
JP2014088394A (ja) 2014-05-15
CN103360446A (zh) 2013-10-23
CN103360447A (zh) 2013-10-23
BRPI0814318A2 (pt) 2015-01-06
CN103360445B (zh) 2016-05-18
TWI427083B (zh) 2014-02-21
JP2020172516A (ja) 2020-10-22
AU2008278969B8 (en) 2012-03-15

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