KR102508115B1 - 마크롤리드 고체상 형태 - Google Patents

마크롤리드 고체상 형태 Download PDF

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KR102508115B1
KR102508115B1 KR1020107003939A KR20107003939A KR102508115B1 KR 102508115 B1 KR102508115 B1 KR 102508115B1 KR 1020107003939 A KR1020107003939 A KR 1020107003939A KR 20107003939 A KR20107003939 A KR 20107003939A KR 102508115 B1 KR102508115 B1 KR 102508115B1
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dipiperidinyl
tylonolide
micaminosyl
polymorph
crystalline
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KR20100044864A (ko
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프리츠 블라터
마인라트 브레너
귀시앙 후
티모 라거
랄프 바라스
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인터벳 인터내셔널 비.브이.
자이단호진 비세이부쯔 가가꾸 겡뀨까이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
KR1020107003939A 2007-07-26 2008-07-25 마크롤리드 고체상 형태 Active KR102508115B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07113244.3 2007-07-26
EP07113244A EP2019112A1 (en) 2007-07-26 2007-07-26 Macrolide solid-state forms
PCT/EP2008/059775 WO2009013351A2 (en) 2007-07-26 2008-07-25 Macrolide solid-state forms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020157036690A Division KR20160003899A (ko) 2007-07-26 2008-07-25 마크롤리드 고체상 형태

Publications (2)

Publication Number Publication Date
KR20100044864A KR20100044864A (ko) 2010-04-30
KR102508115B1 true KR102508115B1 (ko) 2023-03-08

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ID=39467287

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020107003939A Active KR102508115B1 (ko) 2007-07-26 2008-07-25 마크롤리드 고체상 형태
KR1020157036690A Ceased KR20160003899A (ko) 2007-07-26 2008-07-25 마크롤리드 고체상 형태

Family Applications After (1)

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KR1020157036690A Ceased KR20160003899A (ko) 2007-07-26 2008-07-25 마크롤리드 고체상 형태

Country Status (13)

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EP (3) EP2019112A1 (enExample)
JP (7) JP5925989B2 (enExample)
KR (2) KR102508115B1 (enExample)
CN (5) CN103467548A (enExample)
AU (1) AU2008278969B8 (enExample)
BR (1) BRPI0814318B1 (enExample)
CA (1) CA2693801C (enExample)
ES (2) ES2608978T3 (enExample)
HU (1) HUE031449T2 (enExample)
RU (1) RU2476438C2 (enExample)
TW (1) TWI427083B (enExample)
WO (1) WO2009013351A2 (enExample)
ZA (1) ZA201000188B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2019112A1 (en) * 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms
KR101538599B1 (ko) 2006-07-28 2015-07-21 인터벳 인터내셔널 비.브이. 마크롤라이드 합성 방법
AU2012342548B2 (en) 2011-11-25 2017-08-24 Elanco Animal Health Gmbh Antibacterial tylosin derivatives and methods for their preparation
CN102816196A (zh) * 2012-09-10 2012-12-12 河北远征药业有限公司 泰地罗新半抗原、人工抗原及其制备方法
SI2999707T1 (en) * 2013-05-23 2018-07-31 Bayer Animal Health Gmbh Tylosin derivatives and their preparation process
CN103554203A (zh) * 2013-08-17 2014-02-05 齐鲁动物保健品有限公司 一种泰地罗新无定形晶及其制备方法
CN104478974B (zh) * 2014-11-28 2016-08-17 武汉回盛生物科技有限公司 一种20，23-二哌啶基-5-o-碳霉胺糖基-泰乐内酯的合成方法
CN104447919B (zh) * 2014-11-28 2017-03-08 武汉回盛生物科技股份有限公司 一种20，23‑二哌啶基‑5‑o‑碳霉胺糖基‑泰乐内酯原料药的精制方法
CN104497082B (zh) * 2015-01-13 2017-12-12 中国兽医药品监察所 一种泰地罗新的合成方法
CN104774223A (zh) * 2015-03-26 2015-07-15 宁夏泰瑞制药股份有限公司 一种利用泰乐菌素碱生产泰地罗新的方法
CN105254693B (zh) * 2015-11-13 2017-12-22 周金华 一种泰地罗新的合成方法
CN106008629B (zh) * 2016-06-02 2019-11-22 天津大学 泰地罗新1,4-二氧六环溶剂化合物及制备方法
CN106083958B (zh) * 2016-06-02 2019-07-23 天津大学 泰地罗新环己烷溶剂化合物及制备方法
CN106046084B (zh) * 2016-06-02 2019-08-09 天津大学 泰地罗新丙酮溶剂化合物及制备方法
CN109721633A (zh) * 2017-10-31 2019-05-07 齐鲁晟华制药有限公司 一种泰地罗新晶型a及其制备方法
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
CN111349130A (zh) * 2018-12-21 2020-06-30 齐鲁动物保健品有限公司 一种泰地罗新晶型b及其制备方法
CA3202396A1 (en) 2020-12-03 2022-06-09 Intervet International B.V. A method of treating foot rot
CN114213484A (zh) * 2021-12-21 2022-03-22 河北远征药业有限公司 一种泰地罗新1，2-丙二醇溶剂化合物及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001139592A (ja) 1999-08-30 2001-05-22 Microbial Chem Res Found マイカミノシルタイロノライド誘導体およびそれらの抗パスツレラ菌剤としての用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL33732A (en) * 1969-02-06 1973-05-31 Meiji Seika Kaisha The new antibiotics sf-837,sf-837-a2,sf-837-a3 and sf-837-a4 and their production
US4820695A (en) 1982-09-13 1989-04-11 Eli Lilly And Company C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics
AU561147B2 (en) 1982-09-13 1987-04-30 Eli Lilly And Company 20-amino macrolide antibiotics
YU43658B (en) * 1983-07-18 1989-10-31 Pliva Pharm & Chem Works Process for preparing 7,16-dioxa-2-aza-10-0-cladinosyl-12,0-desosaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethyl-bicyclo(11.2.1)hexadeca-1(2)-ene-8
US4921947A (en) * 1986-03-31 1990-05-01 Eli Lilly And Company Process for preparing macrolide derivatives
US4920103A (en) 1986-09-29 1990-04-24 Eli Lilly And Company Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides
CA2529817C (en) * 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
AU2003269473A1 (en) * 2003-08-26 2005-03-10 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
MX2007006119A (es) * 2005-01-05 2007-07-19 Teva Gyogyszergyar Zartkoruen Tacrolimus amorfo y preparacion de el.
UA98303C2 (ru) * 2006-07-28 2012-05-10 Интервет Интернешонал Б.В. Способ синтеза макролидов
KR101538599B1 (ko) * 2006-07-28 2015-07-21 인터벳 인터내셔널 비.브이. 마크롤라이드 합성 방법
EP2019112A1 (en) * 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001139592A (ja) 1999-08-30 2001-05-22 Microbial Chem Res Found マイカミノシルタイロノライド誘導体およびそれらの抗パスツレラ菌剤としての用途

Also Published As

Publication number Publication date
AU2008278969B2 (en) 2011-11-17
EP3170833A1 (en) 2017-05-24
ES2805534T3 (es) 2021-02-12
WO2009013351A3 (en) 2009-04-02
JP2020172516A (ja) 2020-10-22
JP2014088394A (ja) 2014-05-15
EP2181117A2 (en) 2010-05-05
CN103360447A (zh) 2013-10-23
AU2008278969A1 (en) 2009-01-29
JP5925989B2 (ja) 2016-05-25
TWI427083B (zh) 2014-02-21
CN101778858B (zh) 2013-12-04
CN103360447B (zh) 2016-04-06
AU2008278969B8 (en) 2012-03-15
EP3170833B1 (en) 2020-05-20
JP6343624B2 (ja) 2018-06-13
KR20100044864A (ko) 2010-04-30
ES2608978T3 (es) 2017-04-17
CN103360446B (zh) 2016-04-06
JP2010534635A (ja) 2010-11-11
JP2018104449A (ja) 2018-07-05
JP2020172517A (ja) 2020-10-22
BRPI0814318B1 (pt) 2021-04-06
HUE031449T2 (en) 2017-07-28
JP2016147858A (ja) 2016-08-18
CN103360445A (zh) 2013-10-23
WO2009013351A2 (en) 2009-01-29
CN101778858A (zh) 2010-07-14
EP2019112A1 (en) 2009-01-28
BRPI0814318A2 (pt) 2015-01-06
RU2476438C2 (ru) 2013-02-27
TW200918547A (en) 2009-05-01
EP2181117B1 (en) 2016-11-09
JP2018109020A (ja) 2018-07-12
CN103467548A (zh) 2013-12-25
ZA201000188B (en) 2010-09-29
CN103360445B (zh) 2016-05-18
CA2693801A1 (en) 2009-01-29
CA2693801C (en) 2018-08-14
CN103360446A (zh) 2013-10-23
KR20160003899A (ko) 2016-01-11
RU2010107057A (ru) 2011-09-10

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