JP2016027050A5 - - Google Patents
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- Publication number
- JP2016027050A5 JP2016027050A5 JP2015177674A JP2015177674A JP2016027050A5 JP 2016027050 A5 JP2016027050 A5 JP 2016027050A5 JP 2015177674 A JP2015177674 A JP 2015177674A JP 2015177674 A JP2015177674 A JP 2015177674A JP 2016027050 A5 JP2016027050 A5 JP 2016027050A5
- Authority
- JP
- Japan
- Prior art keywords
- fsh
- recombinant
- variant
- stimulating hormone
- follicle stimulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 23
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 23
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 23
- 238000000034 method Methods 0.000 claims 13
- 102000003864 Human Follicle Stimulating Hormone Human genes 0.000 claims 5
- 108010082302 Human Follicle Stimulating Hormone Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000000746 purification Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 238000005571 anion exchange chromatography Methods 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000011210 chromatographic step Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000053391 human F Human genes 0.000 claims 1
- 108700031895 human F Proteins 0.000 claims 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims 1
- 208000021267 infertility disease Diseases 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims 1
- 238000004271 weak anion exchange chromatography Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09157133.1 | 2009-04-01 | ||
| EP09157133 | 2009-04-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502514A Division JP5845170B2 (ja) | 2009-04-01 | 2010-04-01 | 組換えｆｓｈを精製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016027050A JP2016027050A (ja) | 2016-02-18 |
| JP2016027050A5 true JP2016027050A5 (enExample) | 2016-03-31 |
| JP6231056B2 JP6231056B2 (ja) | 2017-11-15 |
Family
ID=42153744
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502514A Expired - Fee Related JP5845170B2 (ja) | 2009-04-01 | 2010-04-01 | 組換えｆｓｈを精製する方法 |
| JP2015177674A Expired - Fee Related JP6231056B2 (ja) | 2009-04-01 | 2015-09-09 | 組換えｆｓｈを精製する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502514A Expired - Fee Related JP5845170B2 (ja) | 2009-04-01 | 2010-04-01 | 組換えｆｓｈを精製する方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US9096683B2 (enExample) |
| EP (1) | EP2414380B1 (enExample) |
| JP (2) | JP5845170B2 (enExample) |
| KR (1) | KR101761168B1 (enExample) |
| CN (1) | CN102448979B (enExample) |
| AU (1) | AU2010234028B2 (enExample) |
| BR (1) | BRPI1012647B1 (enExample) |
| CA (1) | CA2755927A1 (enExample) |
| CY (1) | CY1116963T1 (enExample) |
| DK (1) | DK2414380T3 (enExample) |
| EA (1) | EA028065B1 (enExample) |
| ES (1) | ES2552055T3 (enExample) |
| HR (1) | HRP20151086T1 (enExample) |
| HU (1) | HUE025959T2 (enExample) |
| IL (1) | IL215234A (enExample) |
| ME (1) | ME02277B (enExample) |
| MX (1) | MX2011010480A (enExample) |
| NZ (1) | NZ595661A (enExample) |
| PL (1) | PL2414380T3 (enExample) |
| PT (1) | PT2414380E (enExample) |
| RS (1) | RS54318B1 (enExample) |
| SI (1) | SI2414380T1 (enExample) |
| SM (1) | SMT201500276B (enExample) |
| UA (1) | UA106369C2 (enExample) |
| WO (1) | WO2010115586A2 (enExample) |
| ZA (1) | ZA201106800B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102448979B (zh) * | 2009-04-01 | 2015-03-04 | 拉蒂奥法姆有限责任公司 | 纯化重组促卵泡激素的方法 |
| CN103570820B (zh) * | 2012-08-06 | 2015-11-18 | 齐鲁制药有限公司 | 一种重组人促卵泡激素的纯化方法 |
| KR101516054B1 (ko) * | 2012-11-21 | 2015-05-06 | 씨제이헬스케어 주식회사 | 신규한 지속형 인간 성장호르몬 단량체를 제조하는 방법 |
| CN103059125B (zh) * | 2012-12-27 | 2015-08-12 | 浙江海正药业股份有限公司 | 重组人促卵泡激素的纯化方法 |
| WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CN103539860B (zh) * | 2013-11-01 | 2014-12-03 | 广州优联康医药科技有限公司 | 一种长效重组人促卵泡激素融合蛋白 |
| CN103539861B (zh) * | 2013-11-01 | 2015-02-18 | 广州联康生物科技有限公司 | 长效重组人促卵泡激素融合蛋白 |
| SG11201608513WA (en) * | 2014-04-18 | 2016-11-29 | Cadila Healthcare Ltd | Novel purification process of gonadotropin |
| CN104479005B (zh) * | 2014-09-05 | 2017-10-31 | 上海丽珠制药有限公司 | 一种促性腺激素纯化的方法 |
| CN105461799A (zh) * | 2015-12-31 | 2016-04-06 | 哈药集团技术中心 | 一种重组人促卵泡生成素的纯化方法 |
| CN106117342B (zh) * | 2016-07-07 | 2020-01-03 | 江西浩然生物医药有限公司 | 一种高纯度尿促卵泡素的制备方法 |
| RU2694598C1 (ru) * | 2018-08-07 | 2019-07-16 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Клеточная линия huFSHKKc6 - продуцент рекомбинантного человеческого фолликулостимулирующего гормона (ФСГ) и способ получения ФСГ с использованием данной линии |
| CN114867741A (zh) * | 2019-12-26 | 2022-08-05 | 株式会社Lg化学 | 纯化促卵泡激素的方法 |
| KR102283871B1 (ko) * | 2021-03-02 | 2021-08-02 | 한국원자력연구원 | 크로마토그래피를 이용한 무담체 홀뮴-166의 분리 방법, 분리 장치 및 이에 의하여 분리된 무담체 홀뮴-166 |
| CN113372433B (zh) * | 2021-03-12 | 2022-10-11 | 上海景泽生物技术有限公司 | 纯化fsh方法 |
| CN114591414A (zh) * | 2022-03-24 | 2022-06-07 | 江西浩然生物制药有限公司 | 一种人绒毛膜促性腺激素的制备方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4840896A (en) | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
| US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| US6455282B1 (en) * | 1983-11-02 | 2002-09-24 | Genzyme Corporation | Cells, vectors and methods for producing biologically active TSH |
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| CA2018676C (en) | 1989-06-20 | 2003-05-06 | Christie A. Kelton | Novel heteropolymeric protein production methods |
| US5021160A (en) * | 1990-01-09 | 1991-06-04 | Gelman Sciences, Inc. | Strongly acidic microporous membranes for cation exchange |
| DE4440587A1 (de) | 1994-11-14 | 1996-05-15 | Fliether Karl Gmbh & Co | Basquill-Schloß |
| US6261823B1 (en) * | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| CN100404551C (zh) | 1997-06-25 | 2008-07-23 | 雪兰诺实验室有限公司 | 二硫键交联的糖蛋白激素类似物及其制备和应用 |
| US5990288A (en) * | 1997-10-21 | 1999-11-23 | Vitro Diagnostics, Inc. | Method for purifying FSH |
| US6414123B1 (en) * | 1997-10-21 | 2002-07-02 | Vitro Diagnostics, Inc. | Method for purifying FSH |
| JP4574865B2 (ja) * | 1999-04-16 | 2010-11-04 | インスチチュート マッソーネ エス．エイ． | 高度に精製されたゴナドトロピン組成物およびそれらの製造方法 |
| WO2001058493A1 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | Conjugates of follicle stimulating hormones |
| US7157277B2 (en) * | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| EP1509959A2 (en) | 2002-05-31 | 2005-03-02 | E. I. du Pont de Nemours and Company | Copolymers having tunable energy levels and color of emission |
| MXPA05010635A (es) | 2003-04-02 | 2005-12-12 | Ares Trading Sa | Formulaciones farmaceuticas liquidas de hormona estimulante de foliculos y hormona luteinizante junto con un surfactante no ionico. |
| US7754860B2 (en) * | 2003-12-22 | 2010-07-13 | Ares Trading S.A. | Method for purifying FSH |
| US7741455B2 (en) * | 2004-11-09 | 2010-06-22 | Ares Trading Sa | Method for purifying FSH |
| TW200728316A (en) * | 2005-12-09 | 2007-08-01 | Ares Trading Sa | Method for purifying FSH or a FSH mutant |
| US8604175B2 (en) * | 2005-12-09 | 2013-12-10 | Ares Trading S.A. | Method for purifying FSH or a FSH mutant |
| KR101522217B1 (ko) | 2007-06-28 | 2015-05-21 | 바이오제너릭스 게엠베하 | Ｆｓｈ 제조 세포 클론 |
| AR067536A1 (es) * | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea |
| CN102448979B (zh) * | 2009-04-01 | 2015-03-04 | 拉蒂奥法姆有限责任公司 | 纯化重组促卵泡激素的方法 |
-
2010
- 2010-04-01 CN CN201080022681.1A patent/CN102448979B/zh active Active
- 2010-04-01 HU HUE10713424A patent/HUE025959T2/en unknown
- 2010-04-01 EA EA201171199A patent/EA028065B1/ru not_active IP Right Cessation
- 2010-04-01 DK DK10713424.9T patent/DK2414380T3/en active
- 2010-04-01 PL PL10713424T patent/PL2414380T3/pl unknown
- 2010-04-01 WO PCT/EP2010/002111 patent/WO2010115586A2/en not_active Ceased
- 2010-04-01 SI SI201031050T patent/SI2414380T1/sl unknown
- 2010-04-01 KR KR1020117025974A patent/KR101761168B1/ko not_active Expired - Fee Related
- 2010-04-01 RS RS20150682A patent/RS54318B1/sr unknown
- 2010-04-01 BR BRPI1012647-3A patent/BRPI1012647B1/pt not_active IP Right Cessation
- 2010-04-01 HR HRP20151086TT patent/HRP20151086T1/hr unknown
- 2010-04-01 PT PT107134249T patent/PT2414380E/pt unknown
- 2010-04-01 ME MEP-2015-172A patent/ME02277B/me unknown
- 2010-04-01 US US13/262,622 patent/US9096683B2/en not_active Expired - Fee Related
- 2010-04-01 NZ NZ595661A patent/NZ595661A/xx not_active IP Right Cessation
- 2010-04-01 JP JP2012502514A patent/JP5845170B2/ja not_active Expired - Fee Related
- 2010-04-01 AU AU2010234028A patent/AU2010234028B2/en not_active Ceased
- 2010-04-01 UA UAA201112796A patent/UA106369C2/ru unknown
- 2010-04-01 MX MX2011010480A patent/MX2011010480A/es unknown
- 2010-04-01 ES ES10713424.9T patent/ES2552055T3/es active Active
- 2010-04-01 EP EP10713424.9A patent/EP2414380B1/en active Active
- 2010-04-01 CA CA2755927A patent/CA2755927A1/en not_active Abandoned
-
2011
- 2011-09-15 ZA ZA2011/06800A patent/ZA201106800B/en unknown
- 2011-09-19 IL IL215234A patent/IL215234A/en active IP Right Grant
-
2015
- 2015-06-15 US US14/739,935 patent/US20150353599A1/en not_active Abandoned
- 2015-09-09 JP JP2015177674A patent/JP6231056B2/ja not_active Expired - Fee Related
- 2015-10-30 CY CY20151100971T patent/CY1116963T1/el unknown
- 2015-11-04 SM SM201500276T patent/SMT201500276B/it unknown
-
2016
- 2016-07-01 US US15/200,714 patent/US20160304575A1/en not_active Abandoned
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