JP2015535817A5 - - Google Patents
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- JP2015535817A5 JP2015535817A5 JP2015532148A JP2015532148A JP2015535817A5 JP 2015535817 A5 JP2015535817 A5 JP 2015535817A5 JP 2015532148 A JP2015532148 A JP 2015532148A JP 2015532148 A JP2015532148 A JP 2015532148A JP 2015535817 A5 JP2015535817 A5 JP 2015535817A5
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- Japan
- Prior art keywords
- compound
- formula
- temperature
- group
- dichloro
- Prior art date
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019154299A JP6899413B2 (ja) | 2012-09-17 | 2019-08-27 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261702137P | 2012-09-17 | 2012-09-17 | |
| US61/702,137 | 2012-09-17 | ||
| US201361790432P | 2013-03-15 | 2013-03-15 | |
| US61/790,432 | 2013-03-15 | ||
| PCT/US2013/060177 WO2014043706A1 (en) | 2012-09-17 | 2013-09-17 | Method of synthesizing thyroid hormone analogs and polymorphs thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017249107A Division JP6532931B2 (ja) | 2012-09-17 | 2017-12-26 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2019154299A Division JP6899413B2 (ja) | 2012-09-17 | 2019-08-27 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535817A JP2015535817A (ja) | 2015-12-17 |
| JP2015535817A5 true JP2015535817A5 (https=) | 2016-11-04 |
| JP6616688B2 JP6616688B2 (ja) | 2019-12-04 |
Family
ID=50278769
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532148A Active JP6616688B2 (ja) | 2012-09-17 | 2013-09-17 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2017249107A Active JP6532931B2 (ja) | 2012-09-17 | 2017-12-26 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2018217045A Active JP6765408B2 (ja) | 2012-09-17 | 2018-11-20 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2019154299A Active JP6899413B2 (ja) | 2012-09-17 | 2019-08-27 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2020020343A Active JP7038745B2 (ja) | 2012-09-17 | 2020-02-10 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2022034154A Active JP7436542B2 (ja) | 2012-09-17 | 2022-03-07 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2024016915A Pending JP2024056793A (ja) | 2012-09-17 | 2024-02-07 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2025145966A Pending JP2025179154A (ja) | 2012-09-17 | 2025-09-03 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017249107A Active JP6532931B2 (ja) | 2012-09-17 | 2017-12-26 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2018217045A Active JP6765408B2 (ja) | 2012-09-17 | 2018-11-20 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2019154299A Active JP6899413B2 (ja) | 2012-09-17 | 2019-08-27 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2020020343A Active JP7038745B2 (ja) | 2012-09-17 | 2020-02-10 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2022034154A Active JP7436542B2 (ja) | 2012-09-17 | 2022-03-07 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2024016915A Pending JP2024056793A (ja) | 2012-09-17 | 2024-02-07 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
| JP2025145966A Pending JP2025179154A (ja) | 2012-09-17 | 2025-09-03 | 甲状腺ホルモンアナログ及びその多形体の合成方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (8) | US9266861B2 (https=) |
| EP (5) | EP4691557A3 (https=) |
| JP (8) | JP6616688B2 (https=) |
| KR (4) | KR101966490B1 (https=) |
| CN (2) | CN108101851A (https=) |
| AR (1) | AR092872A1 (https=) |
| AU (1) | AU2013315017C1 (https=) |
| BR (2) | BR112015005891A2 (https=) |
| CA (3) | CA2884481C (https=) |
| DK (3) | DK2895466T3 (https=) |
| ES (3) | ES2907926T3 (https=) |
| FI (2) | FI4406594T3 (https=) |
| FR (1) | FR26C1009I1 (https=) |
| HR (1) | HRP20251398T1 (https=) |
| IL (7) | IL314360B2 (https=) |
| IN (1) | IN2015DN03133A (https=) |
| LT (2) | LT4406594T (https=) |
| MX (2) | MX395148B (https=) |
| MY (1) | MY170520A (https=) |
| NL (1) | NL301369I2 (https=) |
| NO (1) | NO2026010I1 (https=) |
| NZ (2) | NZ739645A (https=) |
| PL (1) | PL4406594T3 (https=) |
| PT (1) | PT4406594T (https=) |
| RS (1) | RS67728B1 (https=) |
| RU (2) | RU2018128393A (https=) |
| SG (3) | SG10202006058QA (https=) |
| SI (1) | SI4406594T1 (https=) |
| TW (4) | TWI652260B (https=) |
| WO (1) | WO2014043706A1 (https=) |
| ZA (1) | ZA201501795B (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT4406594T (lt) * | 2012-09-17 | 2025-12-29 | Madrigal Pharmaceuticals, Inc. | Skydliaukės hormono analogai |
| IL266054B2 (en) * | 2016-10-18 | 2023-10-01 | Madrigal Pharmaceuticals Inc | Methods for treating liver disorders or lipid disorders using a THR-BETA agonist |
| CN109574995B (zh) * | 2018-01-23 | 2020-07-24 | 深圳市塔吉瑞生物医药有限公司 | 取代的哒嗪酮化合物 |
| CN111801324B (zh) * | 2018-06-12 | 2021-10-22 | 四川海思科制药有限公司 | 甲状腺激素受体激动剂及其用途 |
| CN110627773B (zh) * | 2018-06-22 | 2021-03-19 | 海创药业股份有限公司 | 氘代mgl-3196化合物及其用途 |
| TW202019914A (zh) * | 2018-07-02 | 2020-06-01 | 美商瑪德瑞高製藥公司 | ２-（３，５-二氯-４-（（５-異丙基-６-側氧基-１，６-二氫噠嗪-３-基）氧）苯基）-３，５-二側氧基-２，３，４，５-四氫-１，２，４-三嗪-６-腈之固體型式 |
| US12391677B2 (en) | 2018-10-12 | 2025-08-19 | InventisBio Co., Ltd. | Thyroid hormone receptor agonists |
| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| US12338206B2 (en) | 2019-02-21 | 2025-06-24 | Nanjing Ruijie Pharma Co., Ltd. | Compounds and their uses as thyroid hormone receptor agonists |
| GEP20247637B (en) * | 2019-05-08 | 2024-06-25 | Aligos Therapeutics Inc | Modulators of thr-b and methods of use thereof |
| WO2020228577A1 (zh) * | 2019-05-10 | 2020-11-19 | 深圳微芯生物科技股份有限公司 | 一种哒嗪酮衍生物及其应用 |
| CN114174282A (zh) * | 2019-05-29 | 2022-03-11 | 南京明德新药研发有限公司 | 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用 |
| AU2020336272A1 (en) | 2019-08-23 | 2022-04-14 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| CN112442013B (zh) * | 2019-09-04 | 2022-07-26 | 广东东阳光药业有限公司 | 一种作为甲状腺激素β受体激动剂的化合物及其用途 |
| CN114375193B (zh) | 2019-09-12 | 2024-05-14 | 拓臻制药公司 | 甲状腺激素受体β激动剂化合物 |
| WO2021063367A1 (zh) * | 2019-09-30 | 2021-04-08 | 苏州科睿思制药有限公司 | 一种Resmetirom晶型及其制备方法和用途 |
| CN112707892A (zh) * | 2019-10-24 | 2021-04-27 | 苏州泽璟生物制药股份有限公司 | 哒嗪酮或哒嗪类化合物及其衍生物和药物组合物 |
| EP4083024A4 (en) | 2019-11-26 | 2023-11-01 | KPC Pharmaceuticals, Inc. | 1,2,4-TRIAZINE-3,5-DIONE COMPOUND, METHOD FOR PRODUCTION THEREOF AND USE THEREOF |
| WO2021121210A1 (zh) * | 2019-12-16 | 2021-06-24 | 江苏恒瑞医药股份有限公司 | 并环类衍生物、其制备方法及其在医药上的应用 |
| WO2021129465A1 (zh) * | 2019-12-26 | 2021-07-01 | 苏州科睿思制药有限公司 | 一种Resmetirom晶型及其制备方法和用途 |
| CN116056709A (zh) * | 2020-08-27 | 2023-05-02 | 益方生物科技(上海)股份有限公司 | 哒嗪酮化合物 |
| US12595254B2 (en) | 2020-09-10 | 2026-04-07 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of Resmetirom, preparation method therefor, and use thereof |
| WO2022086894A1 (en) | 2020-10-19 | 2022-04-28 | Teva Pharmaceuticals International Gmbh | Solid state forms of resmetirom |
| CN114437042A (zh) * | 2020-11-03 | 2022-05-06 | 深圳微芯生物科技股份有限公司 | 酞嗪类化合物的晶型及其制备方法 |
| CN114437034A (zh) * | 2020-11-06 | 2022-05-06 | 深圳微芯生物科技股份有限公司 | 一种酞嗪类化合物的可药用盐、晶型及其制备方法 |
| KR20230142523A (ko) * | 2021-02-01 | 2023-10-11 | 마드리갈 파마슈티칼스, 인크. | 간 장애 또는 지질 장애의 치료를 위한 로수바스타틴 및 레스메티롬의 치료용 조합 |
| CN114907327A (zh) * | 2021-02-10 | 2022-08-16 | 杭州领业医药科技有限公司 | Resmetirom的晶型及其制备方法和用途 |
| CN115073429A (zh) * | 2021-03-15 | 2022-09-20 | 昆药集团股份有限公司 | 一种1，2，4-三嗪-3，5-二酮类化合物的盐型、晶型及其制备方法 |
| CA3233319A1 (en) | 2021-09-27 | 2023-03-30 | Rebecca Taub | Resmetirom for reducing liver volume |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| US20240398794A1 (en) | 2023-04-07 | 2024-12-05 | Terns Pharmaceuticals, Inc. | COMBINATIONS OF GLP-1R AND THRß AGONISTS AND METHODS OF USE THEREOF |
| CN116768802B (zh) * | 2023-05-25 | 2025-11-21 | 杭州科巢生物科技有限公司 | 一种瑞司美替罗的合成方法 |
| WO2024263714A1 (en) | 2023-06-22 | 2024-12-26 | Madrigal Pharmaceuticals, Inc. | BIOMARKERS FOR TREATING LIVER DISORDERS WITH THR-β AGONISTS AND RELATED USES |
| CN119613386A (zh) * | 2023-09-14 | 2025-03-14 | 杭州科巢生物科技有限公司 | 一种瑞司美替罗1,4-二氧六环溶剂化合物及其制备方法 |
| CN117263870B (zh) * | 2023-09-21 | 2026-02-06 | 江西同和药业股份有限公司 | 一种Resmetirom关键中间体III的制备方法 |
| WO2025083699A2 (en) | 2023-10-16 | 2025-04-24 | Cipla Limited | Resmetirom polymorphs and process thereof |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| EP4686757A1 (en) | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025164161A1 (ja) * | 2024-01-29 | 2025-08-07 | シオノギファーマ株式会社 | カンナビジオールの溶媒和物及びカンナビジオールの精製方法 |
| WO2025171032A1 (en) | 2024-02-06 | 2025-08-14 | Madrigal Pharmaceuticals, Inc. | Methods for treating a fatty liver disease |
| US12377104B1 (en) | 2024-02-06 | 2025-08-05 | Madrigal Pharmaceuticals, Inc. | Methods for treating a fatty liver disease |
| WO2025191457A1 (en) * | 2024-03-13 | 2025-09-18 | Morepen Laboratories Limited | Process for the preparation of pyridazinone derivative |
| CN119019375A (zh) * | 2024-08-14 | 2024-11-26 | 奥锐特药业(天津)有限公司 | 一种瑞司美替罗新晶型及其制备方法 |
| WO2026067708A1 (zh) * | 2024-09-30 | 2026-04-02 | 齐鲁制药有限公司 | 瑞司美替罗晶型及其制备方法和用途 |
| WO2026074443A1 (en) | 2024-10-01 | 2026-04-09 | Assia Chemical Industries Ltd. | Solid state forms of resmetirom |
| CN119306670A (zh) * | 2024-10-12 | 2025-01-14 | 北京海美桐医药科技有限公司 | 瑞司美替罗中间体、其合成方法和瑞司美替罗的合成方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5615272A (en) * | 1979-07-17 | 1981-02-14 | Ishihara Sangyo Kaisha Ltd | N-benzoyl-n'-phenylurea compound, its preparation, and insecticide containing the same |
| GB0028429D0 (en) | 2000-11-22 | 2001-01-10 | Astrazeneca Ab | Therapy |
| ATE435870T1 (de) | 2003-01-28 | 2009-07-15 | Academisch Ziekenhuis Leiden | Aus ll-37 abgeleiteten peptidinhibitoren von toxinen |
| BRPI0408704A (pt) | 2003-03-24 | 2006-03-07 | Hoffmann La Roche | benzil-piridazinonas como inibidores de transcriptase reversa |
| ITRM20030363A1 (it) | 2003-07-24 | 2005-01-25 | Fernando Goglia | Composizioni comprendenti la 3, 5diiodotironina e uso farmaceutico di esse. |
| US7807647B2 (en) * | 2004-06-01 | 2010-10-05 | Pronai Therapeutics, Inc. | Methods and compositions for cancer therapy |
| US7498315B2 (en) | 2004-06-01 | 2009-03-03 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| JP5337375B2 (ja) | 2004-11-02 | 2013-11-06 | ノースウェスタン ユニバーシティ | ピリダジン化合物、組成物および方法 |
| PL1919878T3 (pl) | 2005-07-21 | 2011-03-31 | Hoffmann La Roche | Pochodne pirydazynonu jako agoniści receptora hormonu tarczycy |
| RS51501B (sr) | 2007-06-06 | 2011-04-30 | Torrent Pharmaceuticals Ltd | Nova jedinjenja |
| US8076334B2 (en) * | 2007-09-20 | 2011-12-13 | Hoffmann-La Roche Inc. | Prodrugs of thyroid hormone analogs |
| LT4406594T (lt) | 2012-09-17 | 2025-12-29 | Madrigal Pharmaceuticals, Inc. | Skydliaukės hormono analogai |
| US8858502B2 (en) | 2012-10-10 | 2014-10-14 | Alcon Research, Ltd. | Systems and methods for external pressure sensing |
| RU2016133471A (ru) | 2014-02-14 | 2018-03-19 | Семпра Фармасьютикалс, Инк. | Композиции и способы для лечения диабета и заболеваний печени |
| IL266054B2 (en) | 2016-10-18 | 2023-10-01 | Madrigal Pharmaceuticals Inc | Methods for treating liver disorders or lipid disorders using a THR-BETA agonist |
| CN111801324B (zh) | 2018-06-12 | 2021-10-22 | 四川海思科制药有限公司 | 甲状腺激素受体激动剂及其用途 |
| TW202019914A (zh) | 2018-07-02 | 2020-06-01 | 美商瑪德瑞高製藥公司 | ２-（３，５-二氯-４-（（５-異丙基-６-側氧基-１，６-二氫噠嗪-３-基）氧）苯基）-３，５-二側氧基-２，３，４，５-四氫-１，２，４-三嗪-６-腈之固體型式 |
| US12391677B2 (en) | 2018-10-12 | 2025-08-19 | InventisBio Co., Ltd. | Thyroid hormone receptor agonists |
| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
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2013
- 2013-09-17 LT LTEP24173563.8T patent/LT4406594T/lt unknown
- 2013-09-17 IL IL314360A patent/IL314360B2/en unknown
- 2013-09-17 KR KR1020157009807A patent/KR101966490B1/ko active Active
- 2013-09-17 MX MX2018014924A patent/MX395148B/es unknown
- 2013-09-17 ES ES20157696T patent/ES2907926T3/es active Active
- 2013-09-17 CN CN201810077707.0A patent/CN108101851A/zh active Pending
- 2013-09-17 ES ES24173563T patent/ES3053122T3/es active Active
- 2013-09-17 ES ES13837402T patent/ES2795450T3/es active Active
- 2013-09-17 BR BR112015005891A patent/BR112015005891A2/pt not_active Application Discontinuation
- 2013-09-17 EP EP25200792.7A patent/EP4691557A3/en active Pending
- 2013-09-17 SG SG10202006058QA patent/SG10202006058QA/en unknown
- 2013-09-17 FI FIEP24173563.8T patent/FI4406594T3/fi active
- 2013-09-17 TW TW102133687A patent/TWI652260B/zh active
- 2013-09-17 SI SI201332113T patent/SI4406594T1/sl unknown
- 2013-09-17 TW TW107137798A patent/TWI681957B/zh active
- 2013-09-17 NZ NZ73964513A patent/NZ739645A/en unknown
- 2013-09-17 AU AU2013315017A patent/AU2013315017C1/en active Active
- 2013-09-17 TW TW108132827A patent/TWI755628B/zh active
- 2013-09-17 EP EP13837402.0A patent/EP2895466B1/en active Active
- 2013-09-17 MX MX2015003418A patent/MX364661B/es active IP Right Grant
- 2013-09-17 TW TW110117935A patent/TWI804870B/zh active
- 2013-09-17 MY MYPI2015000591A patent/MY170520A/en unknown
- 2013-09-17 EP EP21209827.1A patent/EP4023641B1/en active Active
- 2013-09-17 IN IN3133DEN2015 patent/IN2015DN03133A/en unknown
- 2013-09-17 CA CA2884481A patent/CA2884481C/en active Active
- 2013-09-17 CN CN201380059943.5A patent/CN105008335B/zh active Active
- 2013-09-17 CA CA3111317A patent/CA3111317C/en active Active
- 2013-09-17 PL PL24173563.8T patent/PL4406594T3/pl unknown
- 2013-09-17 JP JP2015532148A patent/JP6616688B2/ja active Active
- 2013-09-17 AR ARP130103332A patent/AR092872A1/es active IP Right Grant
- 2013-09-17 KR KR1020217019940A patent/KR102363776B1/ko active Active
- 2013-09-17 WO PCT/US2013/060177 patent/WO2014043706A1/en not_active Ceased
- 2013-09-17 DK DK13837402.0T patent/DK2895466T3/da active
- 2013-09-17 RU RU2018128393A patent/RU2018128393A/ru unknown
- 2013-09-17 IL IL320269A patent/IL320269A/en unknown
- 2013-09-17 RS RS20251117A patent/RS67728B1/sr unknown
- 2013-09-17 EP EP24173563.8A patent/EP4406594B1/en active Active
- 2013-09-17 CA CA3090070A patent/CA3090070C/en active Active
- 2013-09-17 HR HRP20251398TT patent/HRP20251398T1/hr unknown
- 2013-09-17 DK DK20157696.4T patent/DK3689853T3/da active
- 2013-09-17 IL IL288133A patent/IL288133B2/en unknown
- 2013-09-17 BR BR122021024202-0A patent/BR122021024202B1/pt active IP Right Grant
- 2013-09-17 EP EP20157696.4A patent/EP3689853B1/en active Active
- 2013-09-17 RU RU2015114327A patent/RU2668960C2/ru active
- 2013-09-17 KR KR1020207005528A patent/KR20200023528A/ko not_active Ceased
- 2013-09-17 SG SG11201501907YA patent/SG11201501907YA/en unknown
- 2013-09-17 NZ NZ705827A patent/NZ705827A/en unknown
- 2013-09-17 KR KR1020187034908A patent/KR102138750B1/ko active Active
- 2013-09-17 PT PT241735638T patent/PT4406594T/pt unknown
- 2013-09-17 DK DK24173563.8T patent/DK4406594T3/da active
- 2013-09-17 SG SG10201705984XA patent/SG10201705984XA/en unknown
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2015
- 2015-03-09 IL IL237628A patent/IL237628B/en active IP Right Grant
- 2015-03-16 ZA ZA2015/01795A patent/ZA201501795B/en unknown
- 2015-03-17 US US14/660,720 patent/US9266861B2/en active Active
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2016
- 2016-02-17 US US15/046,213 patent/US9968612B2/en active Active
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2017
- 2017-12-26 JP JP2017249107A patent/JP6532931B2/ja active Active
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2018
- 2018-04-10 US US15/949,389 patent/US10376517B2/en active Active
- 2018-05-27 IL IL259610A patent/IL259610B/en active IP Right Grant
- 2018-11-20 JP JP2018217045A patent/JP6765408B2/ja active Active
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2019
- 2019-02-25 IL IL265030A patent/IL265030B/en active IP Right Grant
- 2019-07-01 US US16/458,546 patent/US10894050B2/en active Active
- 2019-08-27 JP JP2019154299A patent/JP6899413B2/ja active Active
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2020
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2022
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2023
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2024
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2025
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2026
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