JP2015530390A5 - - Google Patents
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- JP2015530390A5 JP2015530390A5 JP2015532042A JP2015532042A JP2015530390A5 JP 2015530390 A5 JP2015530390 A5 JP 2015530390A5 JP 2015532042 A JP2015532042 A JP 2015532042A JP 2015532042 A JP2015532042 A JP 2015532042A JP 2015530390 A5 JP2015530390 A5 JP 2015530390A5
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- 102000004196 processed proteins & peptides Human genes 0.000 claims 25
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- 229940024606 amino acid Drugs 0.000 claims 23
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- 108010056852 Myostatin Proteins 0.000 claims 9
- 229910052731 fluorine Inorganic materials 0.000 claims 9
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- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 3
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
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- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
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- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
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- 102000002090 Fibronectin type III Human genes 0.000 claims 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 claims 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000026072 Motor neurone disease Diseases 0.000 claims 1
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- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 claims 1
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- 235000003704 aspartic acid Nutrition 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
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- 210000004369 blood Anatomy 0.000 claims 1
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- 239000008103 glucose Substances 0.000 claims 1
- 230000004190 glucose uptake Effects 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
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- 102000028557 immunoglobulin binding proteins Human genes 0.000 claims 1
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- 238000000034 method Methods 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 208000018360 neuromuscular disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
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- 239000012581 transferrin Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261700697P | 2012-09-13 | 2012-09-13 | |
| US61/700,697 | 2012-09-13 | ||
| US201361780005P | 2013-03-13 | 2013-03-13 | |
| US61/780,005 | 2013-03-13 | ||
| PCT/US2013/059458 WO2014043344A1 (en) | 2012-09-13 | 2013-09-12 | Fibronectin based scaffold domain proteins that bind to myostatin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018101646A Division JP6793680B2 (ja) | 2012-09-13 | 2018-05-28 | ミオスタチンと結合するフィブロネクチンベースの足場ドメインタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015530390A JP2015530390A (ja) | 2015-10-15 |
| JP2015530390A5 true JP2015530390A5 (enExample) | 2016-10-27 |
| JP6346895B2 JP6346895B2 (ja) | 2018-06-20 |
Family
ID=49253416
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532042A Active JP6346895B2 (ja) | 2012-09-13 | 2013-09-12 | ミオスタチンと結合するフィブロネクチンベースの足場ドメインタンパク質 |
| JP2018101646A Active JP6793680B2 (ja) | 2012-09-13 | 2018-05-28 | ミオスタチンと結合するフィブロネクチンベースの足場ドメインタンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018101646A Active JP6793680B2 (ja) | 2012-09-13 | 2018-05-28 | ミオスタチンと結合するフィブロネクチンベースの足場ドメインタンパク質 |
Country Status (33)
Families Citing this family (76)
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| AU2023250649A1 (en) | 2022-04-04 | 2024-11-14 | The Regents Of The University Of California | Genetic complementation compositions and methods |
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| US20260146076A1 (en) | 2024-11-22 | 2026-05-28 | Smith College | Mesothelin-Binding Engineered Fibronectin Type III Protein Scaffold |
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