JP2014506452A5 - - Google Patents
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- JP2014506452A5 JP2014506452A5 JP2013550573A JP2013550573A JP2014506452A5 JP 2014506452 A5 JP2014506452 A5 JP 2014506452A5 JP 2013550573 A JP2013550573 A JP 2013550573A JP 2013550573 A JP2013550573 A JP 2013550573A JP 2014506452 A5 JP2014506452 A5 JP 2014506452A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- fusion protein
- fragment
- derivative
- derived therefrom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 44
- 108020001507 fusion proteins Proteins 0.000 claims description 27
- 102000037865 fusion proteins Human genes 0.000 claims description 27
- 239000012634 fragment Substances 0.000 claims description 25
- 239000000816 peptidomimetic Substances 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 11
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 238000001542 size-exclusion chromatography Methods 0.000 claims description 3
- 101800001415 Bri23 peptide Proteins 0.000 claims description 2
- 102400000107 C-terminal peptide Human genes 0.000 claims description 2
- 101800000655 C-terminal peptide Proteins 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 230000013595 glycosylation Effects 0.000 claims 6
- 238000006206 glycosylation reaction Methods 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 208000007502 anemia Diseases 0.000 claims 5
- 102000008154 Bone Morphogenetic Protein 6 Human genes 0.000 claims 4
- 108010049974 Bone Morphogenetic Protein 6 Proteins 0.000 claims 4
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 238000005534 hematocrit Methods 0.000 claims 4
- 239000000710 homodimer Substances 0.000 claims 4
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 102000001554 Hemoglobins Human genes 0.000 claims 2
- 108010054147 Hemoglobins Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 2
- 230000013632 homeostatic process Effects 0.000 claims 2
- 230000000921 morphogenic effect Effects 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 239000002510 pyrogen Substances 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 230000019491 signal transduction Effects 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 150000001945 cysteines Chemical class 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000010438 iron metabolism Effects 0.000 description 1
- 230000001483 mobilizing effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161434405P | 2011-01-19 | 2011-01-19 | |
| US61/434,405 | 2011-01-19 | ||
| PCT/US2012/021829 WO2012150973A1 (en) | 2011-01-19 | 2012-01-19 | Compositions for regulating iron homeostasis and methods of using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016158787A Division JP6466376B2 (ja) | 2011-01-19 | 2016-08-12 | 鉄恒常性を制御するための組成物およびそれを用いる方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014506452A JP2014506452A (ja) | 2014-03-17 |
| JP2014506452A5 true JP2014506452A5 (enExample) | 2015-03-05 |
Family
ID=47107987
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550573A Pending JP2014506452A (ja) | 2011-01-19 | 2012-01-19 | 鉄恒常性を制御するための組成物およびそれを用いる方法 |
| JP2016158787A Expired - Fee Related JP6466376B2 (ja) | 2011-01-19 | 2016-08-12 | 鉄恒常性を制御するための組成物およびそれを用いる方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016158787A Expired - Fee Related JP6466376B2 (ja) | 2011-01-19 | 2016-08-12 | 鉄恒常性を制御するための組成物およびそれを用いる方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9708379B2 (enExample) |
| EP (1) | EP2665752B1 (enExample) |
| JP (2) | JP2014506452A (enExample) |
| KR (1) | KR102035357B1 (enExample) |
| CN (2) | CN103649126B (enExample) |
| AU (3) | AU2012251919B2 (enExample) |
| CA (1) | CA2825163C (enExample) |
| WO (1) | WO2012150973A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110070242A1 (en) * | 2009-09-01 | 2011-03-24 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for Diagnosing and Treating Iron Dysregulation |
| JP6336397B2 (ja) | 2011-12-14 | 2018-06-06 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | 鉄関連障害を診断および治療するための組成物および方法 |
| EP3800200A1 (en) | 2011-12-14 | 2021-04-07 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
| UY36449A (es) | 2014-12-19 | 2016-07-29 | Novartis Ag | Composiciones y métodos para anticuerpos dirigidos a bmp6 |
| WO2017123642A1 (en) * | 2016-01-12 | 2017-07-20 | The Trustees Of The University Of Pennsylvania | Methods and uses of osteoclast associated receptor (oscar) for prevention and treatment of osteoarthritis |
| CN110381988A (zh) | 2016-06-15 | 2019-10-25 | 诺华股份有限公司 | 使用骨形态发生蛋白6(bmp6)的抑制剂治疗疾病的方法 |
| WO2019136043A1 (en) * | 2018-01-03 | 2019-07-11 | Acceleron Pharma Inc. | Single-arm co-receptor fusion proteins and uses thereof |
| CA3156007A1 (en) | 2019-09-27 | 2021-04-01 | Disc Medicine, Inc. | METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS |
| US20230061804A1 (en) * | 2020-01-23 | 2023-03-02 | The Rockefeller University | Phase separation sensors and uses thereof |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| WO2022271716A2 (en) * | 2021-06-21 | 2022-12-29 | Keros Therapeutics, Inc. | Methods of using activin receptor type ii signaling inhibitors |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US7459540B1 (en) * | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| AU2004231122B2 (en) * | 2003-04-15 | 2010-04-08 | Xenon Pharmaceuticals Inc. | Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof |
| CA2597925A1 (en) * | 2005-02-16 | 2006-08-24 | The General Hospital Corporation | Use of a human hemojuvelin product to regulate hepcidin-mediated iron metabolism |
| US7534764B2 (en) * | 2005-06-29 | 2009-05-19 | The Regents Of The University Of California | Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin |
| EP1806365A1 (en) * | 2006-01-05 | 2007-07-11 | Boehringer Ingelheim International GmbH | Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them |
| US7528111B2 (en) * | 2006-05-12 | 2009-05-05 | Bristol-Myers Squibb Company | Method of vaccinating subjects receiving immune modulating therapy |
| EP1862555A1 (en) * | 2006-05-29 | 2007-12-05 | Klinikum der Universität Regensburg | Means and methods for diagnosing cancer or a corresponding predisposition |
| US8895002B2 (en) * | 2007-04-09 | 2014-11-25 | The General Hospital Corporation | Hemojuvelin fusion proteins and uses thereof |
| CN101307085B (zh) * | 2007-08-01 | 2012-06-13 | 香港理工大学深圳研究院 | 抑制铁调素调节蛋白的siRNA、重组慢病毒及其应用 |
| EP2033971A1 (de) * | 2007-09-06 | 2009-03-11 | Abbott GmbH & Co. KG | Bone Morphogenetic Protein (BMP)-bindende Domänen von Proteinen der Repulsive Guidance Molecule (RGM) Proteinfamilie und funktionale Fragmente davon sowie deren Verwendung |
| JP2011505821A (ja) * | 2007-12-13 | 2011-03-03 | メルク セローノ ソシエテ アノニム | Ｓａｒｐ−１融合タンパク質およびその使用 |
| WO2009152944A1 (en) | 2008-05-29 | 2009-12-23 | Hanall Pharmaceutical Co., Ltd | Modified erythropoietin (epo)polypeptides that exhibit increased protease resistance and pharmaceutical compositions thereof |
| ES2766257T3 (es) * | 2008-11-13 | 2020-06-12 | Massachusetts Gen Hospital | Métodos y composiciones para regular la homeostasis del hierro mediante la modulación de bmp-6 |
-
2012
- 2012-01-19 KR KR1020137021394A patent/KR102035357B1/ko not_active Expired - Fee Related
- 2012-01-19 EP EP12779784.3A patent/EP2665752B1/en not_active Not-in-force
- 2012-01-19 WO PCT/US2012/021829 patent/WO2012150973A1/en not_active Ceased
- 2012-01-19 CN CN201280013021.6A patent/CN103649126B/zh not_active Expired - Fee Related
- 2012-01-19 JP JP2013550573A patent/JP2014506452A/ja active Pending
- 2012-01-19 US US13/980,666 patent/US9708379B2/en not_active Expired - Fee Related
- 2012-01-19 CA CA2825163A patent/CA2825163C/en not_active Expired - Fee Related
- 2012-01-19 AU AU2012251919A patent/AU2012251919B2/en not_active Ceased
- 2012-01-19 CN CN201610908297.0A patent/CN107022032A/zh active Pending
-
2016
- 2016-08-12 JP JP2016158787A patent/JP6466376B2/ja not_active Expired - Fee Related
-
2017
- 2017-03-15 AU AU2017201782A patent/AU2017201782B2/en not_active Ceased
- 2017-07-17 US US15/651,988 patent/US10273273B2/en not_active Expired - Fee Related
-
2019
- 2019-04-16 AU AU2019202913A patent/AU2019202913A1/en not_active Abandoned
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