|
DE3280400D1
(de)
|
1981-10-23 |
1992-06-04 |
Molecular Biosystems Inc |
Oligonukleotides heilmittel und dessen herstellungsverfahren.
|
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
|
ATE151467T1
(de)
|
1987-11-30 |
1997-04-15 |
Univ Iowa Res Found |
Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene
|
|
US5623065A
(en)
|
1990-08-13 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
|
US6005087A
(en)
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
|
US6753423B1
(en)
|
1990-01-11 |
2004-06-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
|
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
US6395492B1
(en)
|
1990-01-11 |
2002-05-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
|
WO1994008003A1
(en)
|
1991-06-14 |
1994-04-14 |
Isis Pharmaceuticals, Inc. |
ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE
|
|
US5965722A
(en)
|
1991-05-21 |
1999-10-12 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
|
|
US5661134A
(en)
|
1991-10-15 |
1997-08-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
|
|
US6831166B2
(en)
|
1992-10-23 |
2004-12-14 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
US20060270624A1
(en)
|
1991-12-24 |
2006-11-30 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
|
JP3131222B2
(ja)
|
1991-12-24 |
2001-01-31 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
ギャップを有する2′修飾オリゴヌクレオチド
|
|
TW244371B
(https=)
|
1992-07-23 |
1995-04-01 |
Tri Clover Inc |
|
|
US5652355A
(en)
|
1992-07-23 |
1997-07-29 |
Worcester Foundation For Experimental Biology |
Hybrid oligonucleotide phosphorothioates
|
|
US6346614B1
(en)
|
1992-07-23 |
2002-02-12 |
Hybridon, Inc. |
Hybrid oligonucleotide phosphorothioates
|
|
ATE162198T1
(de)
|
1992-07-27 |
1998-01-15 |
Hybridon Inc |
Oligonukleotid alkylphosphonothiate
|
|
US5574142A
(en)
|
1992-12-15 |
1996-11-12 |
Microprobe Corporation |
Peptide linkers for improved oligonucleotide delivery
|
|
ATE138384T1
(de)
|
1993-01-25 |
1996-06-15 |
Hybridon Inc |
Olionukleotidalkylphosphonate und - phosphonothioate
|
|
US5734039A
(en)
*
|
1994-09-15 |
1998-03-31 |
Thomas Jefferson University |
Antisense oligonucleotides targeting cooperating oncogenes
|
|
US6608035B1
(en)
|
1994-10-25 |
2003-08-19 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
NZ331217A
(en)
|
1996-02-14 |
2000-02-28 |
Novartis Ag |
Sugar-modified gapped oligonucleotides for eliciting RNase H activity for strand cleavage in an opposing strand
|
|
US6015710A
(en)
|
1996-04-09 |
2000-01-18 |
The University Of Texas System |
Modulation of mammalian telomerase by peptide nucleic acids
|
|
US20080119427A1
(en)
|
1996-06-06 |
2008-05-22 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US5912332A
(en)
*
|
1996-07-26 |
1999-06-15 |
Hybridon, Inc. |
Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides
|
|
US6383808B1
(en)
|
2000-09-11 |
2002-05-07 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of clusterin expression
|
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
|
EP1071753A2
(en)
|
1998-04-20 |
2001-01-31 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
EP0979869A1
(en)
|
1998-08-07 |
2000-02-16 |
Hoechst Marion Roussel Deutschland GmbH |
Short oligonucleotides for the inhibition of VEGF expression
|
|
US6228642B1
(en)
|
1998-10-05 |
2001-05-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of tumor necrosis factor-(α) (TNF-α) expression
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
US6465628B1
(en)
|
1999-02-04 |
2002-10-15 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
KR20000065690A
(ko)
|
1999-04-08 |
2000-11-15 |
박종구 |
반응 특이성 및 안정성을 개선시킨 안티센스 올리고 뉴클레오타이드, 안티센스 dna 및 그 제조방법
|
|
US6677445B1
(en)
|
1999-08-27 |
2004-01-13 |
Chiron Corporation |
Chimeric antisense oligonucleotides and cell transfecting formulations thereof
|
|
AU7406700A
(en)
|
1999-10-04 |
2001-05-10 |
Exiqon A/S |
Design of high affinity rnase h recruiting oligonucleotide
|
|
IL149694A0
(en)
|
1999-12-23 |
2002-11-10 |
Exiqon As |
Therapeutic uses of lna-modified oligonucleotides
|
|
US6602857B1
(en)
|
2000-01-18 |
2003-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US6727355B2
(en)
|
2000-08-25 |
2004-04-27 |
Jcr Pharmaceuticals Co., Ltd. |
Pharmaceutical composition for treatment of Duchenne muscular dystrophy
|
|
EP1315807B1
(en)
|
2000-09-06 |
2005-04-20 |
McGILL UNIVERSITY |
Chimeric antisense oligonucleotides of arabinofuranose analogues and deoxyribose nucleotides
|
|
CA2437942C
(en)
|
2000-11-09 |
2013-06-11 |
Cold Spring Harbor Laboratory |
Chimeric molecules to modulate gene expression
|
|
CA2465129A1
(en)
*
|
2001-10-29 |
2003-05-08 |
Mcgill University |
Acyclic linker-containing oligonucleotides and uses thereof
|
|
CN101044154A
(zh)
*
|
2002-02-14 |
2007-09-26 |
威廉·J·鲁特 |
治疗宿主中切割的嵌合分子
|
|
US20080207542A1
(en)
|
2002-03-26 |
2008-08-28 |
Sirna Therapeutics, Inc. |
RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
|
|
AU2003225495B2
(en)
|
2002-04-05 |
2009-01-15 |
Roche Innovation Center Copenhagen A/S |
Oligomeric compounds for the modulation HIF-1alpha expression
|
|
US20030228690A1
(en)
|
2002-06-10 |
2003-12-11 |
Isis Pharmaceuticals Inc. |
Antisense modulation of IL-1 receptor-associated kinase-1 expression
|
|
US7507808B2
(en)
|
2002-12-12 |
2009-03-24 |
Isis Pharmaceuticals, Inc. |
Modulation of endothelial lipase expression
|
|
US20050130924A1
(en)
|
2002-06-26 |
2005-06-16 |
Monia Brett P. |
Antisense inhibition via RNAse H-independent reduction in mRNA
|
|
AU2003291755A1
(en)
|
2002-11-05 |
2004-06-07 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
|
WO2004046160A2
(en)
|
2002-11-18 |
2004-06-03 |
Santaris Pharma A/S |
Amino-lna, thio-lna and alpha-l-oxy-ln
|
|
JP2006518197A
(ja)
|
2003-02-10 |
2006-08-10 |
サンタリス・ファルマ・アクティーゼルスカブ |
ラス発現の改変のためのオリゴマー化合物
|
|
FR2853663B1
(fr)
|
2003-04-14 |
2007-08-31 |
Aventis Pharma Sa |
Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine
|
|
WO2004112565A2
(en)
|
2003-06-25 |
2004-12-29 |
Quark Biotech, Inc. |
Diagnosis and treatment of liver, pulmonary and cardiac fibrosis
|
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
EP1678303A2
(en)
|
2003-10-30 |
2006-07-12 |
Coley Pharmaceutical GmbH |
C-class oligonucleotide analogs with enhanced immunostimulatory potency
|
|
US7431915B2
(en)
*
|
2003-10-31 |
2008-10-07 |
The Regents Of The University Of California |
Peptides whose uptake by cells is controllable
|
|
WO2005061710A1
(en)
*
|
2003-12-23 |
2005-07-07 |
Santaris Pharma A/S |
Oligomeric compounds for the modulation of bcl-2
|
|
CA2553104A1
(en)
|
2004-01-23 |
2005-08-11 |
Avi Biopharma, Inc. |
Antisense oligomers and methods for inducing immune tolerance and immunosuppression
|
|
WO2005072057A2
(en)
|
2004-01-30 |
2005-08-11 |
Quark Biotech, Inc. |
Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
|
|
WO2005094370A2
(en)
|
2004-03-29 |
2005-10-13 |
The General Hospital Corporation |
Oligonucleotide complex compositions and methods of use as gene alteration tools
|
|
WO2005116204A1
(ja)
|
2004-05-11 |
2005-12-08 |
Rnai Co., Ltd. |
Rna干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法
|
|
US7879992B2
(en)
|
2005-01-31 |
2011-02-01 |
Isis Pharmaceuticals, Inc. |
Modification of MyD88 splicing using modified oligonucleotides
|
|
EP1855694B1
(en)
|
2005-02-09 |
2020-12-02 |
Sarepta Therapeutics, Inc. |
Antisense composition for treating muscle atrophy
|
|
DE102005036654A1
(de)
|
2005-08-04 |
2007-02-15 |
Bayer Materialscience Ag |
Selbstvernetzende PUR-Dispersionen mit Uretdionstruktur
|
|
EP1951736A4
(en)
|
2005-11-21 |
2009-12-16 |
Johnson & Johnson Res Pty Ltd |
INTERFERING MULTICIBLATION RNA AND METHODS OF USE AND DESIGN
|
|
WO2007133812A2
(en)
|
2005-12-30 |
2007-11-22 |
Philadelphia Health & Education Corporation, D/B/A Drexel University College Of Medicine |
Improved carriers for delivery of nucleic acid agents to cells and tissues
|
|
AU2007211082B2
(en)
|
2006-01-27 |
2012-09-27 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of microRNAs
|
|
EP1989307B1
(en)
|
2006-02-08 |
2012-08-08 |
Quark Pharmaceuticals, Inc. |
NOVEL TANDEM siRNAS
|
|
EP2007888A2
(en)
|
2006-04-03 |
2008-12-31 |
Santaris Pharma A/S |
Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
|
|
JP2009536222A
(ja)
|
2006-05-05 |
2009-10-08 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
Pcsk9の発現を調節するための化合物および方法
|
|
WO2008029619A1
(fr)
|
2006-09-07 |
2008-03-13 |
Daiichi Sankyo Company, Limited |
Oligonucléotide antisens ena ayant une action spécifique de la séquence
|
|
ES2526295T5
(es)
|
2006-10-18 |
2021-05-04 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido
|
|
US20080311040A1
(en)
|
2007-03-06 |
2008-12-18 |
Flagship Ventures |
METHODS AND COMPOSITIONS FOR IMPROVED THERAPEUTIC EFFECTS WITH siRNA
|
|
DK2149605T3
(da)
|
2007-03-22 |
2013-09-30 |
Santaris Pharma As |
Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
|
|
JP2010536787A
(ja)
|
2007-08-15 |
2010-12-02 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Toll様受容体モジュレータ
|
|
EP2623599B1
(en)
|
2007-10-04 |
2019-01-02 |
Roche Innovation Center Copenhagen A/S |
Micromirs
|
|
AU2008308499A1
(en)
|
2007-10-04 |
2009-04-09 |
Board Of Regents, The University Of Texas System |
Modulating gene expression with agRNA and gapmers targeting antisense transcripts
|
|
WO2009090182A1
(en)
|
2008-01-14 |
2009-07-23 |
Santaris Pharma A/S |
C4'-substituted - dna nucleotide gapmer oligonucleotides
|
|
CA2717792A1
(en)
|
2008-03-07 |
2009-09-11 |
Santaris Pharma A/S |
Pharmaceutical compositions for treatment of microrna related diseases
|
|
EP2274423A2
(en)
|
2008-04-04 |
2011-01-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
|
AU2009235941A1
(en)
|
2008-04-07 |
2009-10-15 |
Riken |
RNA molecules and uses thereof
|
|
CA2635187A1
(en)
|
2008-06-05 |
2009-12-05 |
The Royal Institution For The Advancement Of Learning/Mcgill University |
Oligonucleotide duplexes and uses thereof
|
|
US20110172292A1
(en)
|
2008-06-30 |
2011-07-14 |
Hansen Jens Bo Rode |
Antidote oligomers
|
|
CN102239260B
(zh)
|
2008-10-03 |
2017-04-12 |
库尔纳公司 |
通过抑制针对载脂蛋白‑a1的天然反义转录物治疗载脂蛋白‑a1相关疾病
|
|
JP2012505913A
(ja)
|
2008-10-16 |
2012-03-08 |
マリーナ バイオテック,インコーポレイテッド |
遺伝子発現を抑制する治療におけるリポソームによる効率的な送達のプロセスおよび組成物
|
|
US20100249214A1
(en)
|
2009-02-11 |
2010-09-30 |
Dicerna Pharmaceuticals |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
US9023820B2
(en)
|
2009-01-26 |
2015-05-05 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein C-III expression
|
|
JP5529895B2
(ja)
|
2009-02-04 |
2014-06-25 |
ソンギュングヮン ユニバーシティ ファウンデーション フォー コーポレート コラボレーション |
細胞内の伝達能が増加した低分子干渉rna複合体
|
|
WO2010120969A1
(en)
*
|
2009-04-15 |
2010-10-21 |
Board Of Regents, The University Of Texas System |
Targeting of the mir-30 family and let-7 family as a treatment for heart disease
|
|
JP2012533587A
(ja)
|
2009-07-22 |
2012-12-27 |
セニックス バイオサイエンス ゲーエムベーハー |
自然に存在する細胞内輸送経路を介して化合物を送達するための送達システム及びコンジュゲート
|
|
EP2470656B1
(en)
*
|
2009-08-27 |
2015-05-06 |
Idera Pharmaceuticals, Inc. |
Composition for inhibiting gene expression and uses thereof
|
|
EP2490699A1
(en)
|
2009-10-20 |
2012-08-29 |
Santaris Pharma A/S |
Oral delivery of therapeutically effective lna oligonucleotides
|
|
WO2011078672A1
(en)
|
2009-12-24 |
2011-06-30 |
Prosensa Technologies B.V. |
Molecule for treating an inflammatory disorder
|
|
WO2011117353A1
(en)
*
|
2010-03-24 |
2011-09-29 |
Mirrx Therapeutics A/S |
Bivalent antisense oligonucleotides
|
|
US9145556B2
(en)
|
2010-04-13 |
2015-09-29 |
Life Technologies Corporation |
Compositions and methods for inhibition of nucleic acids function
|
|
KR101860963B1
(ko)
*
|
2010-04-23 |
2018-05-24 |
제넨테크, 인크. |
이종다량체 단백질의 생산
|
|
PL2563920T3
(pl)
|
2010-04-29 |
2017-08-31 |
Ionis Pharmaceuticals, Inc. |
Modulacja ekspresji transtyretyny
|
|
US9518259B2
(en)
|
2010-06-15 |
2016-12-13 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating interaction between proteins and target nucleic acids
|
|
GB201010557D0
(en)
|
2010-06-23 |
2010-08-11 |
Mina Therapeutics Ltd |
RNA molecules and uses thereof
|
|
EP2595663A4
(en)
|
2010-07-19 |
2014-03-05 |
Isis Pharmaceuticals Inc |
MODULATION OF DYSTROPHIA MYOTONICA PROTEIN KINASE (DMPK) EXPRESSION
|
|
US10000752B2
(en)
|
2010-11-18 |
2018-06-19 |
Curna, Inc. |
Antagonat compositions and methods of use
|
|
US8557787B2
(en)
|
2011-05-13 |
2013-10-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Diagnostic, prognostic and therapeutic uses of long non-coding RNAs for cancer and regenerative medicine
|
|
AU2012308320C1
(en)
|
2011-09-14 |
2018-08-23 |
Translate Bio Ma, Inc. |
Multimeric oligonucleotide compounds
|
|
EP2824184B1
(en)
|
2012-03-04 |
2017-09-27 |
Bonac Corporation |
micro-RNA INHIBITOR
|
|
WO2013173652A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating gene expression
|
|
EA201492116A1
(ru)
|
2012-05-16 |
2015-05-29 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии mecp2
|
|
AU2013262699A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating ATP2A2 expression
|
|
BR112014028645A2
(pt)
|
2012-05-16 |
2017-06-27 |
Rana Therapeutics Inc |
composições e métodos para modulação da expressão de apoa1 e abca1.
|
|
CA2873776A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating pten expression
|
|
US9567581B2
(en)
*
|
2012-08-07 |
2017-02-14 |
The General Hospital Corporation |
Selective reactivation of genes on the inactive X chromosome
|
|
US20150247141A1
(en)
|
2012-09-14 |
2015-09-03 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
|
CN104837996A
(zh)
|
2012-11-15 |
2015-08-12 |
罗氏创新中心哥本哈根有限公司 |
抗apob反义缀合物化合物
|
|
CA2964979A1
(en)
|
2014-11-14 |
2016-05-19 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of proteins
|