JP2015522029A - スタチン療法中の患者における心血管系イベントの危険性を減少させる方法 - Google Patents

スタチン療法中の患者における心血管系イベントの危険性を減少させる方法 Download PDF

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JP2015522029A
JP2015522029A JP2015520566A JP2015520566A JP2015522029A JP 2015522029 A JP2015522029 A JP 2015522029A JP 2015520566 A JP2015520566 A JP 2015520566A JP 2015520566 A JP2015520566 A JP 2015520566A JP 2015522029 A JP2015522029 A JP 2015522029A
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cardiovascular event
cardiovascular
baseline
control
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ソニ パレシュ
ソニ パレシュ
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アマリン ファーマシューティカルス アイルランド リミテッド
アマリン ファーマシューティカルス アイルランド リミテッド
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Application filed by アマリン ファーマシューティカルス アイルランド リミテッド, アマリン ファーマシューティカルス アイルランド リミテッド filed Critical アマリン ファーマシューティカルス アイルランド リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
JP2015520566A 2012-06-29 2013-06-28 スタチン療法中の患者における心血管系イベントの危険性を減少させる方法 Pending JP2015522029A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261666447P 2012-06-29 2012-06-29
US61/666,447 2012-06-29
PCT/US2013/048559 WO2014005013A2 (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy

Related Child Applications (1)

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JP2018144666A Division JP2018184463A (ja) 2012-06-29 2018-08-01 スタチン療法中の患者における心血管系イベントの危険性を減少させる方法

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JP2015522029A true JP2015522029A (ja) 2015-08-03
JP2015522029A5 JP2015522029A5 (https=) 2016-08-04

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JP2015520566A Pending JP2015522029A (ja) 2012-06-29 2013-06-28 スタチン療法中の患者における心血管系イベントの危険性を減少させる方法
JP2018144666A Pending JP2018184463A (ja) 2012-06-29 2018-08-01 スタチン療法中の患者における心血管系イベントの危険性を減少させる方法
JP2019222599A Pending JP2020073492A (ja) 2012-06-29 2019-12-10 スタチン療法中の患者における心血管系イベントの危険性を減少させる方法

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JP2018144666A Pending JP2018184463A (ja) 2012-06-29 2018-08-01 スタチン療法中の患者における心血管系イベントの危険性を減少させる方法
JP2019222599A Pending JP2020073492A (ja) 2012-06-29 2019-12-10 スタチン療法中の患者における心血管系イベントの危険性を減少させる方法

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US (26) US9603826B2 (https=)
EP (6) EP4338805B1 (https=)
JP (3) JP2015522029A (https=)
KR (1) KR20150036252A (https=)
CN (4) CN111840269A (https=)
AU (3) AU2013282394B2 (https=)
BR (1) BR112014032905B1 (https=)
CA (4) CA3292198A1 (https=)
CL (1) CL2014003534A1 (https=)
CO (1) CO7190236A2 (https=)
CR (1) CR20140591A (https=)
CU (1) CU20140151A7 (https=)
CY (1) CY1123749T1 (https=)
DK (4) DK3363433T3 (https=)
DO (1) DOP2014000301A (https=)
EA (2) EA029988B1 (https=)
EC (1) ECSP15002815A (https=)
ES (4) ES3040261T3 (https=)
FI (3) FI3815684T3 (https=)
GE (1) GEP201706768B (https=)
HK (1) HK1204271A1 (https=)
HR (4) HRP20241269T1 (https=)
HU (4) HUE069516T2 (https=)
IL (3) IL275396B2 (https=)
LT (4) LT4338805T (https=)
MA (2) MA50258B2 (https=)
MX (6) MX392694B (https=)
MY (1) MY187464A (https=)
NI (1) NI201400155A (https=)
NZ (5) NZ727849A (https=)
PE (1) PE20150770A1 (https=)
PH (1) PH12014502849A1 (https=)
PL (4) PL4342546T3 (https=)
PT (4) PT3363433T (https=)
RS (4) RS65970B1 (https=)
SG (5) SG10201703867RA (https=)
SI (4) SI4338805T1 (https=)
SM (4) SMT202500325T1 (https=)
TN (1) TN2014000540A1 (https=)
UA (2) UA128280C2 (https=)
WO (1) WO2014005013A2 (https=)
ZA (1) ZA201500040B (https=)

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JP2021510730A (ja) * 2018-09-24 2021-04-30 アマリン ファーマシューティカルズ アイルランド リミテッド 対象の心血管イベントのリスクを低減する方法
JP2021534185A (ja) * 2018-08-17 2021-12-09 アマリン ファーマシューティカルズ アイルランド リミテッド スタチン治療対象における末梢動脈血行再建の必要性を低減する方法
US11986452B2 (en) 2021-04-21 2024-05-21 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure
US12171738B2 (en) 2009-06-15 2024-12-24 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides
US12427134B2 (en) 2019-11-12 2025-09-30 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter

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JP7148605B2 (ja) 2017-10-12 2022-10-05 ノヴォ ノルディスク アー／エス 医学療法におけるセマグルチド
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
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CN113332269A (zh) * 2018-09-24 2021-09-03 阿马里纳药物爱尔兰有限公司 降低受试者的心血管事件的风险的方法
US10813612B2 (en) 2019-01-25 2020-10-27 Cleerly, Inc. Systems and method of characterizing high risk plaques
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US11501436B2 (en) 2020-01-07 2022-11-15 Cleerly, Inc. Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking
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US11969280B2 (en) 2020-01-07 2024-04-30 Cleerly, Inc. Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking
WO2022212655A1 (en) * 2021-03-31 2022-10-06 Amarin Pharmaceuticals Ireland Limited Compositions comprising epa and colchicine and methods of using the same for reducing the risk of cardiovascular events in a subject
US20250143657A1 (en) 2022-03-10 2025-05-08 Cleerly, Inc. Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination
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US20250217981A1 (en) 2022-03-10 2025-07-03 Cleerly, Inc. Systems, methods, and devices for image-based plaque analysis and risk determination
KR20230143081A (ko) 2022-04-04 2023-10-11 삼성전자주식회사 중성지방 측정 장치 및 방법
WO2025100587A1 (ko) * 2023-11-08 2025-05-15 경상국립대학교병원 경피적 관상동맥중재술 이후 예후 예측에 대한 정보 제공 방법

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