JP2015521166A5 - - Google Patents

Download PDF

Info

Publication number
JP2015521166A5
JP2015521166A5 JP2015509119A JP2015509119A JP2015521166A5 JP 2015521166 A5 JP2015521166 A5 JP 2015521166A5 JP 2015509119 A JP2015509119 A JP 2015509119A JP 2015509119 A JP2015509119 A JP 2015509119A JP 2015521166 A5 JP2015521166 A5 JP 2015521166A5
Authority
JP
Japan
Prior art keywords
cancer
pharmaceutical composition
polymorph
compound
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015509119A
Other languages
English (en)
Japanese (ja)
Other versions
JP6410710B2 (ja
JP2015521166A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/038064 external-priority patent/WO2013163344A1/en
Publication of JP2015521166A publication Critical patent/JP2015521166A/ja
Publication of JP2015521166A5 publication Critical patent/JP2015521166A5/ja
Application granted granted Critical
Publication of JP6410710B2 publication Critical patent/JP6410710B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015509119A 2012-04-27 2013-04-24 バルドキソロンメチルの2,2−ジフルオロプロピオンアミド誘導体、その多形体および使用方法 Active JP6410710B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261687669P 2012-04-27 2012-04-27
US61/687,669 2012-04-27
US201361775288P 2013-03-08 2013-03-08
US61/775,288 2013-03-08
US201361780444P 2013-03-13 2013-03-13
US61/780,444 2013-03-13
PCT/US2013/038064 WO2013163344A1 (en) 2012-04-27 2013-04-24 2.2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018178470A Division JP6637136B2 (ja) 2012-04-27 2018-09-25 バルドキソロンメチルの2,2−ジフルオロプロピオンアミド誘導体、その多形体および使用方法

Publications (3)

Publication Number Publication Date
JP2015521166A JP2015521166A (ja) 2015-07-27
JP2015521166A5 true JP2015521166A5 (enExample) 2016-06-16
JP6410710B2 JP6410710B2 (ja) 2018-10-24

Family

ID=49483867

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015509119A Active JP6410710B2 (ja) 2012-04-27 2013-04-24 バルドキソロンメチルの2,2−ジフルオロプロピオンアミド誘導体、その多形体および使用方法
JP2018178470A Active JP6637136B2 (ja) 2012-04-27 2018-09-25 バルドキソロンメチルの2,2−ジフルオロプロピオンアミド誘導体、その多形体および使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018178470A Active JP6637136B2 (ja) 2012-04-27 2018-09-25 バルドキソロンメチルの2,2−ジフルオロプロピオンアミド誘導体、その多形体および使用方法

Country Status (40)

Country Link
US (5) US8993640B2 (enExample)
EP (2) EP3444261B1 (enExample)
JP (2) JP6410710B2 (enExample)
KR (1) KR102101774B1 (enExample)
CN (1) CN104395332B (enExample)
AR (1) AR092823A1 (enExample)
AU (1) AU2013251602B2 (enExample)
BR (1) BR112014026640B1 (enExample)
CA (1) CA2869783C (enExample)
CL (1) CL2014002886A1 (enExample)
CO (1) CO7170182A2 (enExample)
CY (3) CY1119333T1 (enExample)
DK (2) DK2841445T3 (enExample)
DO (1) DOP2014000236A (enExample)
EA (1) EA030468B1 (enExample)
ES (2) ES2634315T3 (enExample)
FI (1) FIC20240012I1 (enExample)
FR (1) FR24C1015I2 (enExample)
HK (1) HK1207085A1 (enExample)
HR (1) HRP20171275T1 (enExample)
HU (3) HUE053113T2 (enExample)
IL (1) IL235275B (enExample)
LT (3) LT2841445T (enExample)
ME (1) ME02926B (enExample)
MX (2) MX357060B (enExample)
MY (1) MY172750A (enExample)
NL (1) NL301276I2 (enExample)
NZ (1) NZ630222A (enExample)
PE (1) PE20150160A1 (enExample)
PL (2) PL3444261T3 (enExample)
PT (2) PT2841445T (enExample)
RS (2) RS61544B1 (enExample)
SG (1) SG11201406868XA (enExample)
SI (2) SI2841445T1 (enExample)
SM (2) SMT202100166T1 (enExample)
TW (2) TWI623548B (enExample)
UA (1) UA116209C2 (enExample)
UY (1) UY34764A (enExample)
WO (1) WO2013163344A1 (enExample)
ZA (1) ZA201407326B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2252283T (lt) 2008-01-11 2019-03-25 Reata Pharmaceuticals, Inc. Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą
KR101735807B1 (ko) 2008-04-18 2017-05-15 리타 파마슈티컬스 잉크. C-17에 아미노 및 기타 변형을 갖는 올레아놀산 유도체를 포함하는 항산화 염증 조절제
CA2721665C (en) 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
HUE038046T2 (hu) 2010-12-17 2018-09-28 Reata Pharmaceuticals Inc Antioxidáns gyulladáscsökkentõ pirazolil és pirimidinil triciklusos enonok
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
ME02926B (me) 2012-04-27 2018-04-20 Reata Pharmaceuticals Inc 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
CR20150117A (es) 2012-09-10 2016-10-10 Reata Pharmaceuticals Inc Derivados c17-alcandilo y alquendilo del ácido oleanólico y sus métodos de uso
UY39092A (es) * 2013-04-24 2021-03-26 Abbvie Inc Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso
WO2016070063A1 (en) 2014-10-31 2016-05-06 The Regents Of The University Of California Compositions and methods for treating hiv-associated cognitive dysfunction
US11059792B2 (en) 2015-02-12 2021-07-13 Reata Pharmaceuticals, Inc. Imidazolyl tricyclic enones as antioxidant inflammation modulators
EA201890767A1 (ru) 2015-09-23 2019-09-30 Рита Фармасьютикалз, Инк. C4-модифицированные производные олеаноловой кислоты для ингибирования il-17 и других применений
MA46749A (fr) 2016-11-08 2019-09-18 Reata Pharmaceuticals Inc Méthodes de traitement du syndrome d'alport à l'aide d'un méthyle de bardoxolone ou d'analogues de ce dernier
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物
CN112384807A (zh) 2018-05-24 2021-02-19 雷尼布斯治疗公司 治疗有风险患有肾损伤和肾衰竭的患者的方法
BR112020025605A2 (pt) 2018-06-15 2021-03-23 Reata Pharmaceuticals, Inc. compostos de pirazol e imidazol para inibição de il-17 e rorgama
EP3810141A1 (en) 2018-06-20 2021-04-28 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
WO2020041169A2 (en) 2018-08-20 2020-02-27 Janssen Pharmaceutica Nv Inhibitors of keap1-nrf2 protein-protein interaction
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
US12370202B2 (en) 2019-02-15 2025-07-29 Triterpenoid Therapeutics, Inc. Methods and compositions for inhibiting the NLRP3 inflammasome and/or LON protease
KR102891865B1 (ko) 2019-07-19 2025-11-26 리아타 파마슈티컬즈, 아이엔씨. C17 극성-치환된 헤테로방향족 합성 트리터페노이드 및 그의 사용 방법
CN115023236A (zh) * 2019-12-03 2022-09-06 贝勒医学院 用于胰岛素抵抗的使用方法的治疗性化合物
KR20220131947A (ko) 2020-01-24 2022-09-29 트발디 테라퓨틱스, 인크. 치료 화합물, 제제 및 이의 용도
WO2022126129A1 (en) 2020-12-11 2022-06-16 Reata Pharmaceuticals, Inc. Synthetic triterpenoids for use in therapy
MX2023008454A (es) 2021-01-18 2023-08-07 Reata Pharmaceuticals Inc Derivados sintéticos de ácido ursólico y métodos de uso de estos.
CN113197905B (zh) * 2021-04-23 2022-04-19 浙江大学 三萜类化合物在制备神经母细胞瘤治疗药物中的应用
CN113358627B (zh) * 2021-06-23 2022-07-01 华中农业大学 一种基于拉曼检测的田间快速测定茶树品质成分的方法
CN114344308A (zh) * 2021-12-22 2022-04-15 山西医科大学第二医院 甲基巴多索隆在制备防治骨关节炎的药物中的应用
CN117050134A (zh) * 2022-05-05 2023-11-14 中国科学院上海有机化学研究所 酰胺化合物的合成及其用途
KR20250023496A (ko) 2022-06-15 2025-02-18 트발디 테라퓨틱스, 인크. Stat3 억제제의 프로드러그
CN115165838B (zh) * 2022-06-23 2025-09-30 中国医学科学院血液病医院(中国医学科学院血液学研究所) 基于拉曼光谱和血清代谢构建mds和aml鉴别模型的方法和试剂盒
US20240124393A1 (en) 2022-09-21 2024-04-18 Sicor - Societa Italiana Corticosteroidi S.R.L. Process and intermediates for preparation of omaveloxolone and salts thereof
WO2025029691A1 (en) * 2023-07-28 2025-02-06 Reata Pharmaceuticals Holdings, LLC Methods for producing triterpenoid derivatives
CN117964678A (zh) * 2024-01-29 2024-05-03 烟台大学 C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5555153Y2 (enExample) 1975-03-19 1980-12-20
US4395423A (en) 1978-10-10 1983-07-26 Sterling Drug Inc. Polycyclic cyanoketones
NZ191586A (en) 1978-10-10 1981-10-19 Sterling Drug Inc Cyanoketones derived from glycyrrhetinic acid and pharmaceutical compositions
US5064823A (en) 1988-08-24 1991-11-12 Research Triangle Institute Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers
US6025395A (en) 1994-04-15 2000-02-15 Duke University Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US6369101B1 (en) 1999-02-26 2002-04-09 Regents Of The University Of Minnesota Therapeutic method to treat herpes virus infection
DK1178952T5 (da) 1999-05-14 2008-03-17 Univ California Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer
US6649654B1 (en) 1999-11-23 2003-11-18 The Regents Of The University Of California Methods for identifying and using IKK inhibitors
JP2001240573A (ja) 2000-03-01 2001-09-04 Meiji Seika Kaisha Ltd トリテルペン誘導体及び肝疾患治療剤
WO2002003996A1 (en) 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
US6951847B2 (en) 2000-09-29 2005-10-04 Regents Of The University Of Minnesota Methods of treating fungal infections using lupeol
AU2001294953A1 (en) 2000-09-29 2002-04-08 Regents Of The University Of Minnesota Triterpenes having fungicidal activity against yeast
WO2002026762A1 (en) 2000-09-29 2002-04-04 Regents Of The University Of Minnesota Triterpenes having antibacterial activity
US6878751B1 (en) 2000-10-19 2005-04-12 Imperial College Of Science Technology And Medicine Administration of resveratrol to treat inflammatory respiratory disorders
WO2002047611A2 (en) 2000-11-28 2002-06-20 Board Of Regents, The University Of Texas System Cddo-compounds and combination therapies thereof
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
CN1636058B (zh) 2001-05-14 2011-06-08 龚大为 新型丙氨酸转氨酶及其应用方法
US7176237B2 (en) 2002-01-15 2007-02-13 The Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
ATE417857T1 (de) 2002-01-18 2009-01-15 Univ Minnesota Quaternäre terpensalze als biologisch aktive tenside
EP1507541A4 (en) 2002-05-13 2009-06-03 Dartmouth College HEMMER AND APPLICATION METHOD THEREFOR
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
US20050208151A1 (en) 2003-10-30 2005-09-22 Entelos, Inc. Treatment of rheumatoid arthritis with FLIP antagonists
US8288439B2 (en) 2003-11-04 2012-10-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for the inhibition of HIV-1 replication
US20060258752A1 (en) 2004-02-12 2006-11-16 Vander Jagt David L Method and compounds for cancer treatment utilizing NFkB as a direct or ultimate target for small molecule inhibitors
JP2005314381A (ja) 2004-03-30 2005-11-10 Anges Mg Inc 増殖性腎疾患の予防・治療・改善剤
EP1811840B1 (en) 2004-09-07 2016-04-13 May Sung Mak Anti-tumor compounds with angeloyl groups
AU2006265113A1 (en) 2005-07-01 2007-01-11 The Johns Hopkins University Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
US20070232577A1 (en) 2006-03-23 2007-10-04 Advanced Life Sciences, Inc. Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
WO2007127791A2 (en) 2006-04-25 2007-11-08 The Administrators Of The Tulane Educational Fund New pharmacological method for treatment of neuropathic pain
EP2032594B1 (en) 2006-06-27 2015-09-23 Wellington Laboratories Inc. Glycyrrhetinic acid derivatives
JP2008110962A (ja) 2006-08-02 2008-05-15 Santen Pharmaceut Co Ltd Nrf2活性化物質を有効成分として含む角結膜障害の予防または治療剤
WO2008016095A1 (en) 2006-08-02 2008-02-07 Santen Pharmaceutical Co., Ltd. PREVENTIVE OR REMEDY FOR KERATOCONJUNCTIVAL DISORDERS CONTAINING Nrf2 ACTIVATOR AS THE ACTIVE INGREDIENT
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
PT2137537E (pt) 2007-02-08 2013-08-22 Biogen Idec Inc Composições e respectivas utilizações para o tratamento da esclerose múltipla
JP2008247898A (ja) 2007-03-08 2008-10-16 Santen Pharmaceut Co Ltd トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤
US20080254055A1 (en) 2007-04-11 2008-10-16 John Erich Oblong Compositions for Regulation of Hair Growth
WO2008136838A1 (en) 2007-05-04 2008-11-13 Trustees Of Dartmouth College Novel amide derivatives of cddo and methods of use thereof
US8088824B2 (en) 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
US20090048205A1 (en) 2007-08-15 2009-02-19 Colin Meyer Combination therapy with synthetic triterpenoids and gemcitabine
US9012439B2 (en) 2007-10-29 2015-04-21 University Of Rochester Use of electrophilic compounds for inducing platelet production or maintaining platelet function
LT2252283T (lt) 2008-01-11 2019-03-25 Reata Pharmaceuticals, Inc. Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą
CA2721665C (en) 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
WO2009129545A1 (en) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
KR101735807B1 (ko) 2008-04-18 2017-05-15 리타 파마슈티컬스 잉크. C-17에 아미노 및 기타 변형을 갖는 올레아놀산 유도체를 포함하는 항산화 염증 조절제
WO2009146216A2 (en) * 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
HUE033288T2 (en) 2008-04-18 2017-11-28 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: C-17 homologated oleic acid derivatives
AU2009274037B2 (en) 2008-07-22 2015-07-09 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US8778990B2 (en) 2008-11-04 2014-07-15 Trustees Of Dartmouth College Betulinic acid derivatives and methods of use thereof
EP2362770A4 (en) 2008-11-21 2012-05-30 Univ Johns Hopkins COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING RADIATION DAMAGE
ES2646816T3 (es) 2009-02-13 2017-12-18 Reata Pharmaceuticals, Inc. Composiciones de dosificaciones orales de liberación retardada que contienen CDDO-Me amorfo
EP3165606A1 (en) 2009-05-01 2017-05-10 Ophthotech Corporation Methods for treating or preventing ophthalmological diseases
MY163031A (en) 2010-04-12 2017-07-31 Reata Pharmaceuticals Inc Method of treating obesity using antioxidant inflammation modulators
WO2011140078A1 (en) 2010-05-04 2011-11-10 Concert Pharmaceuticals, Inc. Synthetic triterpenoid derivatives
WO2012009171A2 (en) 2010-07-15 2012-01-19 The Schepens Eye Research Institute, Inc. Compositions and methods of treatment of corneal endothelium disorders
CN102079772A (zh) 2010-12-09 2011-06-01 中国药科大学 一类五环三萜-13,28-内酯化合物、其制备方法和用途
CN102070697A (zh) 2010-12-09 2011-05-25 中国药科大学 一种齐墩果酸衍生物、其制备方法及用途
HUE038046T2 (hu) 2010-12-17 2018-09-28 Reata Pharmaceuticals Inc Antioxidáns gyulladáscsökkentõ pirazolil és pirimidinil triciklusos enonok
US8846647B2 (en) 2011-01-31 2014-09-30 Bristol-Myers Squibb Company C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity
CN102093462B (zh) 2011-02-28 2012-11-21 贵州省中国科学院天然产物化学重点实验室 1α,2α-二羟基齐墩果酸的制备方法和应用
CN102153613B (zh) 2011-02-28 2013-08-14 贵州省中国科学院天然产物化学重点实验室 夏枯草酸的制备方法和应用
CN103619866B (zh) * 2011-03-11 2016-06-22 里亚塔医药公司 C4-一甲基三萜系化合物的衍生物及其使用方法
WO2012154554A1 (en) 2011-05-06 2012-11-15 Catabasis Pharmaceuticals, Inc. Fatty acid triterpene derivatives and their uses
CN102250189B (zh) 2011-05-20 2012-08-29 中国药科大学 一种具有1,12-二烯-3-酮骨架的甘草次酸衍生物、其制备方法及医药用途
ME02926B (me) 2012-04-27 2018-04-20 Reata Pharmaceuticals Inc 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US8981144B2 (en) 2012-05-08 2015-03-17 Trustees Of Dartmouth College Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof
WO2013169740A2 (en) 2012-05-08 2013-11-14 Trustees Of Dartmouth College Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
RU2487884C1 (ru) 2012-07-13 2013-07-20 Общество с ограниченной ответственностью "Дакор" (ООО "Дакор") Средство, обладающее антиоксидантной, противовоспалительной, нейропротекторной, гиполипидемической, гипохолестеринемической, гипогликемической, гепатопротекторной, иммуносупрессорной активностями
CN103665087A (zh) 2012-09-03 2014-03-26 上海源力生物技术有限公司 一种萜类化合物及其在医药上的应用
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
CR20150117A (es) 2012-09-10 2016-10-10 Reata Pharmaceuticals Inc Derivados c17-alcandilo y alquendilo del ácido oleanólico y sus métodos de uso
KR102237364B1 (ko) 2012-09-10 2021-04-06 리아타 파마슈티컬즈, 아이엔씨. 올레아놀산의 c17―헤테로아릴 유도체 및 그의 사용 방법
US9278912B2 (en) 2012-09-10 2016-03-08 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
US20140073700A1 (en) 2012-09-10 2014-03-13 Abbvie Inc. Glycyrrhetinic acid derivatives and methods of use thereof
JP5972986B2 (ja) 2012-09-28 2016-08-17 アプライド ファーマシューティカル サイエンス インコーポレイテッド Cddoエチルエステルの多形体及びその用途
CN102887936A (zh) 2012-10-24 2013-01-23 苏州晶云药物科技有限公司 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯晶型
CN102875634B (zh) 2012-10-24 2014-08-20 苏州晶云药物科技有限公司 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯的几种晶型
UY39092A (es) 2013-04-24 2021-03-26 Abbvie Inc Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso
US20150080465A1 (en) 2013-08-23 2015-03-19 Reata Pharmaceuticals, Inc. Methods of treating and preventing endothelial dysfunction using bardoxolone methyl or analogs thereof
EP3097089B1 (en) 2014-01-24 2021-02-24 Reata Pharmaceuticals, Inc. Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
US11059792B2 (en) 2015-02-12 2021-07-13 Reata Pharmaceuticals, Inc. Imidazolyl tricyclic enones as antioxidant inflammation modulators
EA201890767A1 (ru) 2015-09-23 2019-09-30 Рита Фармасьютикалз, Инк. C4-модифицированные производные олеаноловой кислоты для ингибирования il-17 и других применений
MA46749A (fr) 2016-11-08 2019-09-18 Reata Pharmaceuticals Inc Méthodes de traitement du syndrome d'alport à l'aide d'un méthyle de bardoxolone ou d'analogues de ce dernier
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物

Similar Documents

Publication Publication Date Title
JP2015521166A5 (enExample)
ME02926B (me) 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu
RU2015150069A (ru) 2,2-дифторопропионамидные производные бардоксолон-метила, полиморфные формы и способы их пременения
ES2391382T3 (es) Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos
TWI634888B (zh) 治療帕金森疾病的新穎高穿透性藥物和醫藥組合物
CN104219954B (zh) 苯甲酰胺衍生物
EA024563B1 (ru) Применение с-мет-модуляторов в комбинированной терапии рака
CN103946231B (zh) 齐墩果酸酰胺化衍生物、及其制备方法和应用
JP2013516501A5 (enExample)
TW201026700A (en) Compositions useful for treating disorders related to TRPA1
CN104119330B (zh) 小檗碱衍生物的合成及其在制备抗肿瘤药物和协同阿霉素抗肿瘤药物组合物中的应用
CN113402543B (zh) 丁苯酞开环衍生物及其制备方法和用途
CN108822126A (zh) 噻吩并噻喃甲酰基哌嗪类化合物及其医药用途
WO2009146871A1 (en) 5-lipoxygenase inhibitors
CN114344313A (zh) 用于预防或治疗神经系统退行性疾病的白桦脂酸衍生物
CN103755695B (zh) 一种具有抗肿瘤活性的酰胺类化合物及其应用
TW202246254A (zh) 聯芳組成物和調控激酶級聯之方法
CN118178369A (zh) 氨基硫醇类化合物作为脑神经或心脏保护剂的用途
CN111763164B (zh) 一类邻位羰基氨基取代苯衍生物的制备方法和用途
TW202235071A (zh) 小分子化合物及組成物
JP2022532186A (ja) 非晶質のpi3k阻害剤及びこれを含有する医薬組成物
CN108484635A (zh) 4H-噻吩并[2,3-b]噻喃-4-酮类化合物及其应用
CN112661738B (zh) 二氢黄酮类化合物及其制备方法和应用
CN108586485A (zh) 1-(4-羟亚胺基噻吩并[2,3-b]噻喃甲酰基)哌嗪类化合物及其应用
US20240092831A1 (en) Proteasome Inhibitors