JP2013516501A5 - - Google Patents
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- JP2013516501A5 JP2013516501A5 JP2012549006A JP2012549006A JP2013516501A5 JP 2013516501 A5 JP2013516501 A5 JP 2013516501A5 JP 2012549006 A JP2012549006 A JP 2012549006A JP 2012549006 A JP2012549006 A JP 2012549006A JP 2013516501 A5 JP2013516501 A5 JP 2013516501A5
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- Prior art keywords
- pharmaceutical composition
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- 229910052736 halogen Inorganic materials 0.000 claims description 48
- 125000005843 halogen group Chemical group 0.000 claims description 32
- 150000001875 compounds Chemical class 0.000 claims description 20
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 20
- 229940127557 pharmaceutical product Drugs 0.000 claims description 20
- 125000003342 alkenyl group Chemical group 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 150000002367 halogens Chemical group 0.000 claims description 16
- 210000004175 meibomian gland Anatomy 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 230000028327 secretion Effects 0.000 claims description 12
- 206010065062 Meibomian gland dysfunction Diseases 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 5
- 210000000744 eyelid Anatomy 0.000 claims description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 235000021314 Palmitic acid Nutrition 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 239000007963 capsule composition Substances 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- -1 elixirs Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000002997 ophthalmic solution Substances 0.000 claims description 2
- 229940054534 ophthalmic solution Drugs 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000007916 tablet composition Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 32
- 150000004677 hydrates Chemical class 0.000 claims 3
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 63
- 150000001204 N-oxides Chemical class 0.000 description 13
- 210000001508 eye Anatomy 0.000 description 5
- JNGVJMBLXIUVRD-SFHVURJKSA-N C[C@](COc(cc1)ccc1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O Chemical compound C[C@](COc(cc1)ccc1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O JNGVJMBLXIUVRD-SFHVURJKSA-N 0.000 description 4
- JQFMUAOGKUMGNM-SFHVURJKSA-N C[C@](COc(cc1)cc(F)c1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O Chemical compound C[C@](COc(cc1)cc(F)c1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O JQFMUAOGKUMGNM-SFHVURJKSA-N 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 0 *[C@](COc(cc1F)ccc1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O Chemical compound *[C@](COc(cc1F)ccc1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29396610P | 2010-01-11 | 2010-01-11 | |
| US61/293,966 | 2010-01-11 | ||
| PCT/US2011/020871 WO2011085385A1 (en) | 2010-01-11 | 2011-01-11 | Methods of treating meibomian gland dysfunction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013516501A JP2013516501A (ja) | 2013-05-13 |
| JP2013516501A5 true JP2013516501A5 (enExample) | 2014-04-10 |
Family
ID=44259000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549006A Pending JP2013516501A (ja) | 2010-01-11 | 2011-01-11 | マイボーム腺機能障害を治療する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8791158B2 (enExample) |
| EP (1) | EP2523556A4 (enExample) |
| JP (1) | JP2013516501A (enExample) |
| KR (1) | KR20120115380A (enExample) |
| CN (1) | CN103002737A (enExample) |
| AU (1) | AU2011203832A1 (enExample) |
| CA (1) | CA2787114A1 (enExample) |
| MX (1) | MX2012008110A (enExample) |
| RU (1) | RU2012134351A (enExample) |
| WO (1) | WO2011085385A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070060988A1 (en) | 2005-07-18 | 2007-03-15 | Grenon Stephen M | Melting meibomian gland obstructions |
| US20090043365A1 (en) | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
| US7981145B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
| US20080114423A1 (en) | 2006-05-15 | 2008-05-15 | Grenon Stephen M | Apparatus for inner eyelid treatment of meibomian gland dysfunction |
| US8950405B2 (en) | 2006-05-15 | 2015-02-10 | Tearscience, Inc. | Treatment of obstructive disorders of the eye or eyelid |
| US8083787B2 (en) | 2005-07-18 | 2011-12-27 | Tearscience, Inc. | Method and apparatus for treating meibomian gland dysfunction |
| US7981095B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
| WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
| US8137390B2 (en) | 2006-05-15 | 2012-03-20 | Tearscience, Inc. | System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction |
| US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
| US8128673B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US8128674B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| AU2007287070C1 (en) * | 2006-08-24 | 2013-02-14 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
| US9381183B2 (en) * | 2012-07-18 | 2016-07-05 | Physicians Recommended Nutriceuticals, Llc | Methods for improving the quality of the meibum composition of meibomian glands |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US12685719B2 (en) | 2012-07-13 | 2026-07-21 | University Of Tennessee Research Foundation | Treatment of breast cancer with selective androgen receptor modulators and cyclin-dependent kinase 4/6 inhibitors |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| EP3733170A1 (en) | 2012-07-13 | 2020-11-04 | Oncternal Therapeutics, Inc. | A method of treating androgen receptor (ar) -positive breast cancers with selective androgen receptor modulator (sarms) |
| US10842670B2 (en) | 2012-08-22 | 2020-11-24 | Johnson & Johnson Vision Care, Inc. | Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices |
| US10064818B2 (en) * | 2013-08-28 | 2018-09-04 | Presbyopia Therapies, LLC | Compositions and methods for the treatment of presbyopia |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| RU2567829C1 (ru) * | 2014-10-22 | 2015-11-10 | Елизавета Геннадьевна Полунина | Способ оценки морфофункционального состояния мейбомиевых желез - биометрия мейбомиевых желез |
| US12653779B2 (en) | 2015-06-18 | 2026-06-16 | Lenz Therapeutics Operations, Inc. | Compositions and methods for the treatment of presbyopia |
| KR101714710B1 (ko) | 2015-09-17 | 2017-03-10 | 고려대학교 산학협력단 | 마이봄샘 압출기 |
| WO2017178892A2 (en) | 2016-04-14 | 2017-10-19 | M.G. Therapeutics Ltd. | Selenium disulfide compositions for use in treating meibomian gland dysfunction |
| US20210251970A1 (en) | 2018-10-10 | 2021-08-19 | Presbyopia Therapies Inc | Compositions and methods for storage stable ophthalmic drugs |
| WO2023091439A1 (en) | 2021-11-17 | 2023-05-25 | Lenz Therapeutics, Inc. | Aceclidine derivatives, compositions thereof and methods of use thereof |
| CN116183427A (zh) * | 2021-11-29 | 2023-05-30 | 巴西石油公司 | 用于评估延迟焦化装置的炉的管中的沉积的系统和方法 |
| US11648247B1 (en) | 2021-12-16 | 2023-05-16 | Lenz Therapeutics, Inc. | Compositions and methods for the treatment of presbyopia |
| US12414942B1 (en) | 2024-03-15 | 2025-09-16 | Lenz Therapeutics Operations, Inc. | Compositions, methods, and systems for treating presbyopia |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| DE3372965D1 (en) | 1982-07-23 | 1987-09-17 | Ici Plc | Amide derivatives |
| US20050038110A1 (en) | 2000-08-24 | 2005-02-17 | Steiner Mitchell S. | Selective androgen receptor modulators and methods of use thereof |
| US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US20040260108A1 (en) | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8445534B2 (en) | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
| US20070173546A1 (en) | 2000-08-24 | 2007-07-26 | Dalton James T | Selective androgen receptor modulators and method of use thereof |
| US6998500B2 (en) | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7026500B2 (en) | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| IL154425A0 (en) | 2000-08-24 | 2003-09-17 | Univ Tennessee Res H Corp | Selective androgen receptor modulators and methods of use thereof |
| US6838484B2 (en) | 2000-08-24 | 2005-01-04 | University Of Tennessee Research Foundation | Formulations comprising selective androgen receptor modulators |
| US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| WO2002022585A1 (en) | 2000-09-14 | 2002-03-21 | Kaken Pharmaceutical Co., Ltd. | Tetrahydroquinoline compounds |
| US8853266B2 (en) * | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US20070066568A1 (en) * | 2005-08-31 | 2007-03-22 | Dalton James T | Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators |
| US20070161608A1 (en) | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| HRP20040818A2 (en) | 2002-02-28 | 2005-02-28 | University Of Tennessee Research Foundation | Haloacetamide and azide substituted compounds and methods of use thereof |
| US7803970B2 (en) | 2002-02-28 | 2010-09-28 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| WO2003074449A2 (en) | 2002-02-28 | 2003-09-12 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
| JP5113979B2 (ja) | 2002-02-28 | 2013-01-09 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 複数置換の選択的アンドロゲンレセプタ修飾因子及びその使用方法 |
| AU2003241583B2 (en) | 2002-06-17 | 2009-05-21 | University Of Tennessee Research Foundation | N-bridged selective androgen receptor modulators and methods of use thereof |
| US20040265916A1 (en) | 2002-10-15 | 2004-12-30 | Dalton James T. | Method for detecting selective androgen receptor modulators |
| EP1562594A4 (en) | 2002-10-15 | 2008-12-17 | Univ Tennessee Res Foundation | SELECTIVE ANDROGEN RECEPTOR MODULATORS WITH METHYLENE BRIDGES AND METHOD OF USE THEREOF |
| AU2003287075A1 (en) | 2002-10-15 | 2004-05-04 | Gtx, Inc. | Treating obesity with selective androgen receptor modulators |
| US20040197928A1 (en) | 2002-10-15 | 2004-10-07 | Dalton James T. | Method for detecting selective androgen receptor modulators |
| JP2006518328A (ja) | 2002-10-15 | 2006-08-10 | ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション | 複素環選択的アンドロゲン受容体調節剤及びその使用方法 |
| US20060276539A1 (en) | 2002-10-16 | 2006-12-07 | Dalton James T | Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS |
| CN1726020A (zh) | 2002-10-16 | 2006-01-25 | Gtx公司 | 用sarm治疗老年男性雄激素缺乏(adam)相关的疾病 |
| US20040087810A1 (en) | 2002-10-23 | 2004-05-06 | Dalton James T. | Irreversible selective androgen receptor modulators and methods of use thereof |
| US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| EP2457892A1 (en) | 2003-01-13 | 2012-05-30 | University of Tennessee Research Foundation | Large-scale synthesis of selective androgen receptor modulators |
| EP1594490A4 (en) | 2003-01-22 | 2006-03-22 | Gtx Inc | TREATMENT OF WOMEN ANDROGEN DISEASE ASSOCIATED DISORDERS (ADIF) USING ANDROGENIC RECEPTOR MODULATORS (SARM) |
| AU2004305061A1 (en) * | 2003-12-16 | 2005-07-07 | Gtx, Inc. | Prodrugs of selective androgen receptor modulators and methods of use thereof |
| JP2007517893A (ja) * | 2004-01-10 | 2007-07-05 | バイオリピッド インコーポレイテッド | 脂質組成物及び該脂質組成物の使用方法 |
| US20130034562A1 (en) | 2004-06-07 | 2013-02-07 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| DK2289872T3 (en) | 2004-06-07 | 2017-10-09 | Univ Tennessee Res Found | Medical use of a selective androgen receptor modulator |
| US20110237664A1 (en) | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| JP4899625B2 (ja) * | 2006-05-12 | 2012-03-21 | スズキ株式会社 | 鞍乗型不整地走行車両 |
| ES2780193T3 (es) | 2006-07-12 | 2020-08-24 | Univ Tennessee Res Found | Compuesto para tratar el cáncer de mama y afecciones dependientes de la progestina |
| WO2008011072A2 (en) | 2006-07-19 | 2008-01-24 | Osurf (Ohio State University Research Foundation) | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof |
| AU2007287070C1 (en) | 2006-08-24 | 2013-02-14 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
| US20080312194A1 (en) * | 2007-02-28 | 2008-12-18 | Ousler Iii George W | Methods and compositions for normalizing meibomian gland secretions |
| CA2886498C (en) | 2007-09-11 | 2017-09-26 | Gtx, Inc. | Solid forms of selective androgen receptor modulators |
| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| HRP20150097T1 (hr) * | 2008-05-07 | 2015-03-27 | The Regents Of The University Of California | Terapijska nadopuna i poboljšanje vlaženja površine oka |
-
2011
- 2011-01-11 US US13/004,764 patent/US8791158B2/en active Active
- 2011-01-11 RU RU2012134351/15A patent/RU2012134351A/ru not_active Application Discontinuation
- 2011-01-11 JP JP2012549006A patent/JP2013516501A/ja active Pending
- 2011-01-11 KR KR1020127020961A patent/KR20120115380A/ko not_active Withdrawn
- 2011-01-11 MX MX2012008110A patent/MX2012008110A/es not_active Application Discontinuation
- 2011-01-11 CN CN2011800134439A patent/CN103002737A/zh active Pending
- 2011-01-11 CA CA2787114A patent/CA2787114A1/en not_active Abandoned
- 2011-01-11 AU AU2011203832A patent/AU2011203832A1/en not_active Abandoned
- 2011-01-11 EP EP11732323.8A patent/EP2523556A4/en not_active Withdrawn
- 2011-01-11 WO PCT/US2011/020871 patent/WO2011085385A1/en not_active Ceased
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