KR20120115380A - 마이봄선 기능 장애의 치료 방법 - Google Patents

마이봄선 기능 장애의 치료 방법 Download PDF

Info

Publication number
KR20120115380A
KR20120115380A KR1020127020961A KR20127020961A KR20120115380A KR 20120115380 A KR20120115380 A KR 20120115380A KR 1020127020961 A KR1020127020961 A KR 1020127020961A KR 20127020961 A KR20127020961 A KR 20127020961A KR 20120115380 A KR20120115380 A KR 20120115380A
Authority
KR
South Korea
Prior art keywords
compound
halogen
nhcor
formula
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020127020961A
Other languages
English (en)
Korean (ko)
Inventor
제임스 티. 달튼
지텐드라 에스와라카
Original Assignee
지티엑스, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 지티엑스, 인코포레이티드 filed Critical 지티엑스, 인코포레이티드
Publication of KR20120115380A publication Critical patent/KR20120115380A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020127020961A 2010-01-11 2011-01-11 마이봄선 기능 장애의 치료 방법 Withdrawn KR20120115380A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29396610P 2010-01-11 2010-01-11
US61/293,966 2010-01-11

Publications (1)

Publication Number Publication Date
KR20120115380A true KR20120115380A (ko) 2012-10-17

Family

ID=44259000

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127020961A Withdrawn KR20120115380A (ko) 2010-01-11 2011-01-11 마이봄선 기능 장애의 치료 방법

Country Status (10)

Country Link
US (1) US8791158B2 (enExample)
EP (1) EP2523556A4 (enExample)
JP (1) JP2013516501A (enExample)
KR (1) KR20120115380A (enExample)
CN (1) CN103002737A (enExample)
AU (1) AU2011203832A1 (enExample)
CA (1) CA2787114A1 (enExample)
MX (1) MX2012008110A (enExample)
RU (1) RU2012134351A (enExample)
WO (1) WO2011085385A1 (enExample)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8523928B2 (en) 2006-05-15 2013-09-03 Tearscience, Inc. System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8617229B2 (en) 2006-05-15 2013-12-31 Tearscience, Inc. System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8628504B2 (en) 2005-07-18 2014-01-14 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction employing fluid jet
US8632578B2 (en) 2006-05-15 2014-01-21 Tearscience, Inc. System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction
US8685073B2 (en) 2005-07-18 2014-04-01 Tearscience, Inc. Apparatus for treating meibomian gland dysfunction
US8950405B2 (en) 2006-05-15 2015-02-10 Tearscience, Inc. Treatment of obstructive disorders of the eye or eyelid
KR20150126405A (ko) * 2013-03-12 2015-11-11 피지션즈 레커멘디드 뉴트리슈티컬즈, 엘엘씨 마이봄선을 표적화하는 영양 보충물
US9216028B2 (en) 2005-07-18 2015-12-22 Tearscience, Inc. Apparatuses for treatment of meibomian glands
US9314369B2 (en) 2006-05-15 2016-04-19 Tearscience, Inc. System for inner eyelid treatment of meibomian gland dysfunction
KR101714710B1 (ko) 2015-09-17 2017-03-10 고려대학교 산학협력단 마이봄샘 압출기
US9719977B2 (en) 2005-07-18 2017-08-01 Tearscience, Inc. Methods and systems for treating meibomian gland dysfunction using radio-frequency energy
US9913678B2 (en) 2005-07-18 2018-03-13 Tearscience, Inc. Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma
US10842670B2 (en) 2012-08-22 2020-11-24 Johnson & Johnson Vision Care, Inc. Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices
US10940074B2 (en) 2005-07-18 2021-03-09 Tearscience Inc Melting meibomian gland obstructions
US10952896B2 (en) 2006-05-15 2021-03-23 Tearscience Inc Methods and apparatuses for treatment of meibomian gland dysfunction

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101264820B1 (ko) * 2006-08-24 2013-05-22 유니버시티 오브 테네시 리서치 파운데이션 치환된 아실아닐리드 및 그의 사용 방법
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
JP6226978B2 (ja) 2012-07-13 2017-11-08 ジーティーエックス・インコーポレイテッド 選択的アンドロゲン受容体モジュレーター(sarm)によりアンドロゲン受容体(ar)陽性乳癌を処置する方法
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10064818B2 (en) * 2013-08-28 2018-09-04 Presbyopia Therapies, LLC Compositions and methods for the treatment of presbyopia
US9463201B2 (en) 2014-10-19 2016-10-11 M.G. Therapeutics Ltd Compositions and methods for the treatment of meibomian gland dysfunction
RU2567829C1 (ru) * 2014-10-22 2015-11-10 Елизавета Геннадьевна Полунина Способ оценки морфофункционального состояния мейбомиевых желез - биометрия мейбомиевых желез
CA3019349A1 (en) 2016-04-14 2017-10-19 Azura Ophthalmics Ltd. Selenium disulfide compositions for use in treating meibomian gland dysfunction
US20210251970A1 (en) 2018-10-10 2021-08-19 Presbyopia Therapies Inc Compositions and methods for storage stable ophthalmic drugs
WO2023091439A1 (en) 2021-11-17 2023-05-25 Lenz Therapeutics, Inc. Aceclidine derivatives, compositions thereof and methods of use thereof
US20230168157A1 (en) * 2021-11-29 2023-06-01 Petróleo Brasileiro S.A. - Petrobras System and method for evaluation of the deposition in tubes of the furnaces of a delayed coking unit
US11648247B1 (en) 2021-12-16 2023-05-16 Lenz Therapeutics, Inc. Compositions and methods for the treatment of presbyopia
US12414942B1 (en) 2024-03-15 2025-09-16 Lenz Therapeutics Operations, Inc. Compositions, methods, and systems for treating presbyopia

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4407791A (en) * 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
EP0100172B1 (en) * 1982-07-23 1987-08-12 Imperial Chemical Industries Plc Amide derivatives
US20050038110A1 (en) * 2000-08-24 2005-02-17 Steiner Mitchell S. Selective androgen receptor modulators and methods of use thereof
US6492554B2 (en) * 2000-08-24 2002-12-10 The University Of Tennessee Research Corporation Selective androgen receptor modulators and methods of use thereof
US6838484B2 (en) * 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US7026500B2 (en) * 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US7622503B2 (en) * 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8445534B2 (en) * 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US7855229B2 (en) * 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
US6998500B2 (en) * 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7645898B2 (en) * 2000-08-24 2010-01-12 University Of Tennessee Research Foundation Selective androgen receptor modulators and method of use thereof
US20040260108A1 (en) * 2001-06-25 2004-12-23 Dalton James T. Metabolites of selective androgen receptor modulators and methods of use thereof
US7919647B2 (en) * 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US20070173546A1 (en) * 2000-08-24 2007-07-26 Dalton James T Selective androgen receptor modulators and method of use thereof
AU2001286243A1 (en) * 2000-09-14 2002-03-26 Kaken Pharmaceutical Co., Ltd. Tetrahydroquinoline compounds
US8853266B2 (en) * 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US20070161608A1 (en) * 2001-12-06 2007-07-12 Dalton James T Selective androgen receptor modulators for treating muscle wasting
US7772433B2 (en) * 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7803970B2 (en) * 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
US7214693B2 (en) * 2002-10-15 2007-05-08 University Of Tennessee Research Foundation Heterocyclic selective androgen receptor modulators and methods of use thereof
CA2477737C (en) 2002-02-28 2012-08-07 The University Of Tennessee Research Corporation Multi-substituted selective androgen receptor modulators and methods of use thereof
ES2528764T3 (es) * 2002-02-28 2015-02-12 University Of Tennessee Research Foundation Moduladores selectivos multisustituidos del receptor de andrógeno y métodos de uso de los mismos
EP1487780A4 (en) * 2002-02-28 2005-11-16 Univ Tennessee Res Foundation HALOACETAMIDE AND AZID SUBSTITUTED COMPOUNDS AND METHODS OF USE THEREOF
US7022870B2 (en) 2002-06-17 2006-04-04 University Of Tennessee Research Foundation N-bridged selective androgen receptor modulators and methods of use thereof
US20040265916A1 (en) * 2002-10-15 2004-12-30 Dalton James T. Method for detecting selective androgen receptor modulators
US20040197928A1 (en) * 2002-10-15 2004-10-07 Dalton James T. Method for detecting selective androgen receptor modulators
AU2003287075A1 (en) * 2002-10-15 2004-05-04 Gtx, Inc. Treating obesity with selective androgen receptor modulators
CN1726034A (zh) 2002-10-15 2006-01-25 田纳西大学研究基金会 亚甲基桥连的选择性雄激素受体调节剂及其应用方法
WO2004035739A2 (en) 2002-10-16 2004-04-29 Gtx, Inc. Treating androgen decline in aging male (adam)-associated conditions with sarms
US20060276539A1 (en) * 2002-10-16 2006-12-07 Dalton James T Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS
US20040087810A1 (en) * 2002-10-23 2004-05-06 Dalton James T. Irreversible selective androgen receptor modulators and methods of use thereof
US8309603B2 (en) * 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
MXPA05007536A (es) * 2003-01-13 2005-10-20 Gtx Inc Sintesis a gran escala de moduladores de receptor de androgeno selectivos.
CN1771031A (zh) 2003-01-22 2006-05-10 Gtx公司 用sarms治疗与女性雄激素缺乏(ad if)相关的疾病
EA200501761A1 (ru) * 2003-12-16 2006-04-28 Джи Ти Икс, ИНК. Пролекарственные формы селективных модуляторов андрогеновых рецепторов и способы их применения
WO2005067892A1 (en) * 2004-01-10 2005-07-28 Biolipid, Inc. Lipid compositions and methods of use
US20130034562A1 (en) * 2004-06-07 2013-02-07 Dalton James T Selective androgen receptor modulators for treating diabetes
US20110237664A1 (en) * 2004-06-07 2011-09-29 Dalton James T Selective androgen receptor modulators for treating diabetes
AU2005251781C1 (en) 2004-06-07 2008-02-21 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
EA200800710A1 (ru) 2005-08-31 2008-06-30 Юниверсити Оф Теннесси Рисерч Фаундейшн Лечение почечной недостаточности, ожогов, ран и повреждений спинного мозга селективными модуляторами андрогенового рецептора
JP4899625B2 (ja) * 2006-05-12 2012-03-21 スズキ株式会社 鞍乗型不整地走行車両
AR061980A1 (es) 2006-07-12 2008-08-10 Univ Tennessee Res Foundation Acilanilidas sustituidas y metodos para su utilizacion
MX2009000714A (es) * 2006-07-19 2009-07-27 Osurf Moduladores de receptor de androgeno selectivos, analogos y derivados de los mismos.
KR101264820B1 (ko) * 2006-08-24 2013-05-22 유니버시티 오브 테네시 리서치 파운데이션 치환된 아실아닐리드 및 그의 사용 방법
US20080312194A1 (en) * 2007-02-28 2008-12-18 Ousler Iii George W Methods and compositions for normalizing meibomian gland secretions
CA2886501C (en) * 2007-09-11 2018-03-27 Gtx, Inc. Solid forms of selective androgen receptor modulators
US7968603B2 (en) * 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
PL2285364T3 (pl) * 2008-05-07 2015-04-30 Univ California Terapeutyczne uzupełnienie i wzbogacenie smarowania powierzchni oka

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719977B2 (en) 2005-07-18 2017-08-01 Tearscience, Inc. Methods and systems for treating meibomian gland dysfunction using radio-frequency energy
US9913678B2 (en) 2005-07-18 2018-03-13 Tearscience, Inc. Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma
US8628504B2 (en) 2005-07-18 2014-01-14 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction employing fluid jet
US9216028B2 (en) 2005-07-18 2015-12-22 Tearscience, Inc. Apparatuses for treatment of meibomian glands
US8685073B2 (en) 2005-07-18 2014-04-01 Tearscience, Inc. Apparatus for treating meibomian gland dysfunction
US8915253B2 (en) 2005-07-18 2014-12-23 Tearscience, Inc. Method and apparatus for treating gland dysfunction employing heated medium
US10940074B2 (en) 2005-07-18 2021-03-09 Tearscience Inc Melting meibomian gland obstructions
US9060843B2 (en) 2005-07-18 2015-06-23 Tearscience, Inc. Method and apparatus for treating gland dysfunction employing heated medium
US10905898B2 (en) 2005-07-18 2021-02-02 Tearscience, Inc. Methods and apparatuses for treating gland dysfunction
US10376273B2 (en) 2005-07-18 2019-08-13 Tearscience, Inc. Methods and apparatuses for treatment of meibomian glands
US8632578B2 (en) 2006-05-15 2014-01-21 Tearscience, Inc. System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction
US8523928B2 (en) 2006-05-15 2013-09-03 Tearscience, Inc. System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US9314369B2 (en) 2006-05-15 2016-04-19 Tearscience, Inc. System for inner eyelid treatment of meibomian gland dysfunction
US8617229B2 (en) 2006-05-15 2013-12-31 Tearscience, Inc. System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8950405B2 (en) 2006-05-15 2015-02-10 Tearscience, Inc. Treatment of obstructive disorders of the eye or eyelid
US10952896B2 (en) 2006-05-15 2021-03-23 Tearscience Inc Methods and apparatuses for treatment of meibomian gland dysfunction
US10842670B2 (en) 2012-08-22 2020-11-24 Johnson & Johnson Vision Care, Inc. Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices
KR20150126405A (ko) * 2013-03-12 2015-11-11 피지션즈 레커멘디드 뉴트리슈티컬즈, 엘엘씨 마이봄선을 표적화하는 영양 보충물
KR101714710B1 (ko) 2015-09-17 2017-03-10 고려대학교 산학협력단 마이봄샘 압출기

Also Published As

Publication number Publication date
WO2011085385A1 (en) 2011-07-14
MX2012008110A (es) 2012-10-03
EP2523556A4 (en) 2013-08-28
EP2523556A1 (en) 2012-11-21
JP2013516501A (ja) 2013-05-13
CN103002737A (zh) 2013-03-27
US20110172302A1 (en) 2011-07-14
CA2787114A1 (en) 2011-07-14
RU2012134351A (ru) 2014-02-20
US8791158B2 (en) 2014-07-29
AU2011203832A1 (en) 2012-08-23

Similar Documents

Publication Publication Date Title
US8791158B2 (en) Methods of treating meibomian gland dysfunction
CN114667147B (zh) 用四氢萘衍生物作为雌激素受体降解剂的治疗乳腺癌的方法
KR100865503B1 (ko) 신규한 아포르핀 에스테르 및 치료 요법에서의 그 용도
KR20140056280A (ko) 비마토프로스트 및 브리모니딘의 고정된 용량 조합
JP6692371B2 (ja) ピロリジンカルボキサミド誘導体ならびにその調製および使用方法
JP6335927B2 (ja) フェントラミンの水性点眼液およびそれらの医学的用途
US20120122866A1 (en) Topical pharmaceutical composition including rel-n-[6-[(2r,6s)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
JP4933897B2 (ja) 眼内移行性促進水性点眼剤
TW201338777A (zh) 用於治療金屬過載之經口調配物
JP6935393B2 (ja) セバコイルジナルブフィンエステルの徐放のための医薬製剤
US20060093632A1 (en) Compositions for controlled delivery of pharmaceutically active compounds
JP2010514733A (ja) 高眼圧症の治療のためのイソソルビドモノニトレート誘導体
EP4520752A1 (en) Carebastine salt and use thereof
JP6509244B2 (ja) 水晶体硬化抑制剤
EP4309675A1 (en) Prodrug of celecoxib, preparation method therefor and application thereof
JP4843824B2 (ja) 外用剤
JP2005047909A (ja) ピペリジン誘導体を有効成分とする掻痒治療剤
US20200030305A1 (en) Local anesthetic-containing acidic emulsion composition
TW202016065A (zh) 萘普生(naproxen)及普加巴林(pregabalin)之1-(醯氧基)-烷基胺甲酸酯之藥物結合物的結晶型
JP2021523924A (ja) Kor受容体アゴニストの医薬組成物
JP2020514347A (ja) チオトロピウムを有効成分として含有する近視予防、近視治療および/または近視進行抑制剤
KR101733189B1 (ko) 손톱 또는 발톱 성장 촉진용 조성물
JP2018534358A (ja) Vegf阻害剤の局所投与による皮膚障害の処置
WO2021207816A1 (en) Benzimidazole compound for the treatment of metabolic disorders
JP2022125347A (ja) エピナスチン又はその塩を含有する水性組成物

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PC1203 Withdrawal of no request for examination

St.27 status event code: N-1-6-B10-B12-nap-PC1203

WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid
R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R18 Changes to party contact information recorded

Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R18-OTH-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000