RU2012134351A - Способы лечения дисфункции мейбомиевых желез - Google Patents
Способы лечения дисфункции мейбомиевых желез Download PDFInfo
- Publication number
- RU2012134351A RU2012134351A RU2012134351/15A RU2012134351A RU2012134351A RU 2012134351 A RU2012134351 A RU 2012134351A RU 2012134351/15 A RU2012134351/15 A RU 2012134351/15A RU 2012134351 A RU2012134351 A RU 2012134351A RU 2012134351 A RU2012134351 A RU 2012134351A
- Authority
- RU
- Russia
- Prior art keywords
- meibomian glands
- halogen atom
- secretion
- reduced
- nhcor
- Prior art date
Links
- 230000004064 dysfunction Effects 0.000 title claims abstract 3
- 210000004907 gland Anatomy 0.000 title 1
- 210000004175 meibomian gland Anatomy 0.000 claims abstract 15
- 125000005843 halogen group Chemical group 0.000 claims abstract 12
- 230000028327 secretion Effects 0.000 claims abstract 11
- 239000012530 fluid Substances 0.000 claims abstract 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract 8
- 229940127557 pharmaceutical product Drugs 0.000 claims abstract 8
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 150000001204 N-oxides Chemical class 0.000 claims abstract 4
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 4
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- 125000003118 aryl group Chemical group 0.000 claims abstract 4
- 150000002632 lipids Chemical class 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 210000000744 eyelid Anatomy 0.000 claims abstract 3
- 206010065062 Meibomian gland dysfunction Diseases 0.000 claims abstract 2
- 230000002159 abnormal effect Effects 0.000 claims abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract 2
- 229930195729 fatty acid Natural products 0.000 claims abstract 2
- 239000000194 fatty acid Substances 0.000 claims abstract 2
- 150000004665 fatty acids Chemical class 0.000 claims abstract 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002775 capsule Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- -1 elixir Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000002997 ophthalmic solution Substances 0.000 claims 1
- 229940054534 ophthalmic solution Drugs 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 1
- 101150065749 Churc1 gene Proteins 0.000 abstract 1
- 102100038239 Protein Churchill Human genes 0.000 abstract 1
- 0 C[C@](COc(cc1)ccc1C#N)(C(Nc(cc1*=Cl)ccc1C#N)=O)O Chemical compound C[C@](COc(cc1)ccc1C#N)(C(Nc(cc1*=Cl)ccc1C#N)=O)O 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29396610P | 2010-01-11 | 2010-01-11 | |
| US61/293,966 | 2010-01-11 | ||
| PCT/US2011/020871 WO2011085385A1 (en) | 2010-01-11 | 2011-01-11 | Methods of treating meibomian gland dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012134351A true RU2012134351A (ru) | 2014-02-20 |
Family
ID=44259000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012134351/15A RU2012134351A (ru) | 2010-01-11 | 2011-01-11 | Способы лечения дисфункции мейбомиевых желез |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8791158B2 (enExample) |
| EP (1) | EP2523556A4 (enExample) |
| JP (1) | JP2013516501A (enExample) |
| KR (1) | KR20120115380A (enExample) |
| CN (1) | CN103002737A (enExample) |
| AU (1) | AU2011203832A1 (enExample) |
| CA (1) | CA2787114A1 (enExample) |
| MX (1) | MX2012008110A (enExample) |
| RU (1) | RU2012134351A (enExample) |
| WO (1) | WO2011085385A1 (enExample) |
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|---|---|---|---|---|
| US20070060988A1 (en) | 2005-07-18 | 2007-03-15 | Grenon Stephen M | Melting meibomian gland obstructions |
| US20090043365A1 (en) | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
| US7981145B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
| US20080114423A1 (en) | 2006-05-15 | 2008-05-15 | Grenon Stephen M | Apparatus for inner eyelid treatment of meibomian gland dysfunction |
| US8950405B2 (en) | 2006-05-15 | 2015-02-10 | Tearscience, Inc. | Treatment of obstructive disorders of the eye or eyelid |
| US8083787B2 (en) | 2005-07-18 | 2011-12-27 | Tearscience, Inc. | Method and apparatus for treating meibomian gland dysfunction |
| US7981095B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
| WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
| US8137390B2 (en) | 2006-05-15 | 2012-03-20 | Tearscience, Inc. | System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction |
| US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
| US8128673B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US8128674B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| AU2007287070C1 (en) * | 2006-08-24 | 2013-02-14 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
| US9381183B2 (en) * | 2012-07-18 | 2016-07-05 | Physicians Recommended Nutriceuticals, Llc | Methods for improving the quality of the meibum composition of meibomian glands |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US12685719B2 (en) | 2012-07-13 | 2026-07-21 | University Of Tennessee Research Foundation | Treatment of breast cancer with selective androgen receptor modulators and cyclin-dependent kinase 4/6 inhibitors |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| EP3733170A1 (en) | 2012-07-13 | 2020-11-04 | Oncternal Therapeutics, Inc. | A method of treating androgen receptor (ar) -positive breast cancers with selective androgen receptor modulator (sarms) |
| US10842670B2 (en) | 2012-08-22 | 2020-11-24 | Johnson & Johnson Vision Care, Inc. | Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices |
| US10064818B2 (en) * | 2013-08-28 | 2018-09-04 | Presbyopia Therapies, LLC | Compositions and methods for the treatment of presbyopia |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| RU2567829C1 (ru) * | 2014-10-22 | 2015-11-10 | Елизавета Геннадьевна Полунина | Способ оценки морфофункционального состояния мейбомиевых желез - биометрия мейбомиевых желез |
| US12653779B2 (en) | 2015-06-18 | 2026-06-16 | Lenz Therapeutics Operations, Inc. | Compositions and methods for the treatment of presbyopia |
| KR101714710B1 (ko) | 2015-09-17 | 2017-03-10 | 고려대학교 산학협력단 | 마이봄샘 압출기 |
| WO2017178892A2 (en) | 2016-04-14 | 2017-10-19 | M.G. Therapeutics Ltd. | Selenium disulfide compositions for use in treating meibomian gland dysfunction |
| US20210251970A1 (en) | 2018-10-10 | 2021-08-19 | Presbyopia Therapies Inc | Compositions and methods for storage stable ophthalmic drugs |
| WO2023091439A1 (en) | 2021-11-17 | 2023-05-25 | Lenz Therapeutics, Inc. | Aceclidine derivatives, compositions thereof and methods of use thereof |
| CN116183427A (zh) * | 2021-11-29 | 2023-05-30 | 巴西石油公司 | 用于评估延迟焦化装置的炉的管中的沉积的系统和方法 |
| US11648247B1 (en) | 2021-12-16 | 2023-05-16 | Lenz Therapeutics, Inc. | Compositions and methods for the treatment of presbyopia |
| US12414942B1 (en) | 2024-03-15 | 2025-09-16 | Lenz Therapeutics Operations, Inc. | Compositions, methods, and systems for treating presbyopia |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| DE3372965D1 (en) | 1982-07-23 | 1987-09-17 | Ici Plc | Amide derivatives |
| US20050038110A1 (en) | 2000-08-24 | 2005-02-17 | Steiner Mitchell S. | Selective androgen receptor modulators and methods of use thereof |
| US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US20040260108A1 (en) | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8445534B2 (en) | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
| US20070173546A1 (en) | 2000-08-24 | 2007-07-26 | Dalton James T | Selective androgen receptor modulators and method of use thereof |
| US6998500B2 (en) | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7026500B2 (en) | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| IL154425A0 (en) | 2000-08-24 | 2003-09-17 | Univ Tennessee Res H Corp | Selective androgen receptor modulators and methods of use thereof |
| US6838484B2 (en) | 2000-08-24 | 2005-01-04 | University Of Tennessee Research Foundation | Formulations comprising selective androgen receptor modulators |
| US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| WO2002022585A1 (en) | 2000-09-14 | 2002-03-21 | Kaken Pharmaceutical Co., Ltd. | Tetrahydroquinoline compounds |
| US8853266B2 (en) * | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US20070066568A1 (en) * | 2005-08-31 | 2007-03-22 | Dalton James T | Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators |
| US20070161608A1 (en) | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| HRP20040818A2 (en) | 2002-02-28 | 2005-02-28 | University Of Tennessee Research Foundation | Haloacetamide and azide substituted compounds and methods of use thereof |
| US7803970B2 (en) | 2002-02-28 | 2010-09-28 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| WO2003074449A2 (en) | 2002-02-28 | 2003-09-12 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
| JP5113979B2 (ja) | 2002-02-28 | 2013-01-09 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 複数置換の選択的アンドロゲンレセプタ修飾因子及びその使用方法 |
| AU2003241583B2 (en) | 2002-06-17 | 2009-05-21 | University Of Tennessee Research Foundation | N-bridged selective androgen receptor modulators and methods of use thereof |
| US20040265916A1 (en) | 2002-10-15 | 2004-12-30 | Dalton James T. | Method for detecting selective androgen receptor modulators |
| EP1562594A4 (en) | 2002-10-15 | 2008-12-17 | Univ Tennessee Res Foundation | SELECTIVE ANDROGEN RECEPTOR MODULATORS WITH METHYLENE BRIDGES AND METHOD OF USE THEREOF |
| AU2003287075A1 (en) | 2002-10-15 | 2004-05-04 | Gtx, Inc. | Treating obesity with selective androgen receptor modulators |
| US20040197928A1 (en) | 2002-10-15 | 2004-10-07 | Dalton James T. | Method for detecting selective androgen receptor modulators |
| JP2006518328A (ja) | 2002-10-15 | 2006-08-10 | ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション | 複素環選択的アンドロゲン受容体調節剤及びその使用方法 |
| US20060276539A1 (en) | 2002-10-16 | 2006-12-07 | Dalton James T | Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS |
| CN1726020A (zh) | 2002-10-16 | 2006-01-25 | Gtx公司 | 用sarm治疗老年男性雄激素缺乏(adam)相关的疾病 |
| US20040087810A1 (en) | 2002-10-23 | 2004-05-06 | Dalton James T. | Irreversible selective androgen receptor modulators and methods of use thereof |
| US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| EP2457892A1 (en) | 2003-01-13 | 2012-05-30 | University of Tennessee Research Foundation | Large-scale synthesis of selective androgen receptor modulators |
| EP1594490A4 (en) | 2003-01-22 | 2006-03-22 | Gtx Inc | TREATMENT OF WOMEN ANDROGEN DISEASE ASSOCIATED DISORDERS (ADIF) USING ANDROGENIC RECEPTOR MODULATORS (SARM) |
| AU2004305061A1 (en) * | 2003-12-16 | 2005-07-07 | Gtx, Inc. | Prodrugs of selective androgen receptor modulators and methods of use thereof |
| JP2007517893A (ja) * | 2004-01-10 | 2007-07-05 | バイオリピッド インコーポレイテッド | 脂質組成物及び該脂質組成物の使用方法 |
| US20130034562A1 (en) | 2004-06-07 | 2013-02-07 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| DK2289872T3 (en) | 2004-06-07 | 2017-10-09 | Univ Tennessee Res Found | Medical use of a selective androgen receptor modulator |
| US20110237664A1 (en) | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| JP4899625B2 (ja) * | 2006-05-12 | 2012-03-21 | スズキ株式会社 | 鞍乗型不整地走行車両 |
| ES2780193T3 (es) | 2006-07-12 | 2020-08-24 | Univ Tennessee Res Found | Compuesto para tratar el cáncer de mama y afecciones dependientes de la progestina |
| WO2008011072A2 (en) | 2006-07-19 | 2008-01-24 | Osurf (Ohio State University Research Foundation) | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof |
| AU2007287070C1 (en) | 2006-08-24 | 2013-02-14 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
| US20080312194A1 (en) * | 2007-02-28 | 2008-12-18 | Ousler Iii George W | Methods and compositions for normalizing meibomian gland secretions |
| CA2886498C (en) | 2007-09-11 | 2017-09-26 | Gtx, Inc. | Solid forms of selective androgen receptor modulators |
| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| HRP20150097T1 (hr) * | 2008-05-07 | 2015-03-27 | The Regents Of The University Of California | Terapijska nadopuna i poboljšanje vlaženja površine oka |
-
2011
- 2011-01-11 US US13/004,764 patent/US8791158B2/en active Active
- 2011-01-11 RU RU2012134351/15A patent/RU2012134351A/ru not_active Application Discontinuation
- 2011-01-11 JP JP2012549006A patent/JP2013516501A/ja active Pending
- 2011-01-11 KR KR1020127020961A patent/KR20120115380A/ko not_active Withdrawn
- 2011-01-11 MX MX2012008110A patent/MX2012008110A/es not_active Application Discontinuation
- 2011-01-11 CN CN2011800134439A patent/CN103002737A/zh active Pending
- 2011-01-11 CA CA2787114A patent/CA2787114A1/en not_active Abandoned
- 2011-01-11 AU AU2011203832A patent/AU2011203832A1/en not_active Abandoned
- 2011-01-11 EP EP11732323.8A patent/EP2523556A4/en not_active Withdrawn
- 2011-01-11 WO PCT/US2011/020871 patent/WO2011085385A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2523556A4 (en) | 2013-08-28 |
| CA2787114A1 (en) | 2011-07-14 |
| AU2011203832A1 (en) | 2012-08-23 |
| CN103002737A (zh) | 2013-03-27 |
| US20110172302A1 (en) | 2011-07-14 |
| MX2012008110A (es) | 2012-10-03 |
| JP2013516501A (ja) | 2013-05-13 |
| EP2523556A1 (en) | 2012-11-21 |
| KR20120115380A (ko) | 2012-10-17 |
| WO2011085385A1 (en) | 2011-07-14 |
| US8791158B2 (en) | 2014-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150803 |