RU2012134351A - Способы лечения дисфункции мейбомиевых желез - Google Patents
Способы лечения дисфункции мейбомиевых желез Download PDFInfo
- Publication number
- RU2012134351A RU2012134351A RU2012134351/15A RU2012134351A RU2012134351A RU 2012134351 A RU2012134351 A RU 2012134351A RU 2012134351/15 A RU2012134351/15 A RU 2012134351/15A RU 2012134351 A RU2012134351 A RU 2012134351A RU 2012134351 A RU2012134351 A RU 2012134351A
- Authority
- RU
- Russia
- Prior art keywords
- meibomian glands
- halogen atom
- secretion
- reduced
- nhcor
- Prior art date
Links
- 230000004064 dysfunction Effects 0.000 title claims abstract 3
- 210000004907 gland Anatomy 0.000 title 1
- 210000004175 meibomian gland Anatomy 0.000 claims abstract 15
- 125000005843 halogen group Chemical group 0.000 claims abstract 12
- 230000028327 secretion Effects 0.000 claims abstract 11
- 239000012530 fluid Substances 0.000 claims abstract 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract 8
- 229940127557 pharmaceutical product Drugs 0.000 claims abstract 8
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 150000001204 N-oxides Chemical class 0.000 claims abstract 4
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 4
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- 125000003118 aryl group Chemical group 0.000 claims abstract 4
- 150000002632 lipids Chemical class 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 210000000744 eyelid Anatomy 0.000 claims abstract 3
- 206010065062 Meibomian gland dysfunction Diseases 0.000 claims abstract 2
- 230000002159 abnormal effect Effects 0.000 claims abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract 2
- 229930195729 fatty acid Natural products 0.000 claims abstract 2
- 239000000194 fatty acid Substances 0.000 claims abstract 2
- 150000004665 fatty acids Chemical class 0.000 claims abstract 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002775 capsule Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- -1 elixir Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000002997 ophthalmic solution Substances 0.000 claims 1
- 229940054534 ophthalmic solution Drugs 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 1
- 101150065749 Churc1 gene Proteins 0.000 abstract 1
- 102100038239 Protein Churchill Human genes 0.000 abstract 1
- 0 C[C@](COc(cc1)ccc1C#N)(C(Nc(cc1*=Cl)ccc1C#N)=O)O Chemical compound C[C@](COc(cc1)ccc1C#N)(C(Nc(cc1*=Cl)ccc1C#N)=O)O 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29396610P | 2010-01-11 | 2010-01-11 | |
| US61/293,966 | 2010-01-11 | ||
| PCT/US2011/020871 WO2011085385A1 (en) | 2010-01-11 | 2011-01-11 | Methods of treating meibomian gland dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012134351A true RU2012134351A (ru) | 2014-02-20 |
Family
ID=44259000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012134351/15A RU2012134351A (ru) | 2010-01-11 | 2011-01-11 | Способы лечения дисфункции мейбомиевых желез |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8791158B2 (enExample) |
| EP (1) | EP2523556A4 (enExample) |
| JP (1) | JP2013516501A (enExample) |
| KR (1) | KR20120115380A (enExample) |
| CN (1) | CN103002737A (enExample) |
| AU (1) | AU2011203832A1 (enExample) |
| CA (1) | CA2787114A1 (enExample) |
| MX (1) | MX2012008110A (enExample) |
| RU (1) | RU2012134351A (enExample) |
| WO (1) | WO2011085385A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8915253B2 (en) | 2005-07-18 | 2014-12-23 | Tearscience, Inc. | Method and apparatus for treating gland dysfunction employing heated medium |
| US7981095B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
| US8950405B2 (en) | 2006-05-15 | 2015-02-10 | Tearscience, Inc. | Treatment of obstructive disorders of the eye or eyelid |
| US20070060988A1 (en) * | 2005-07-18 | 2007-03-15 | Grenon Stephen M | Melting meibomian gland obstructions |
| US20090043365A1 (en) | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
| US20080114423A1 (en) | 2006-05-15 | 2008-05-15 | Grenon Stephen M | Apparatus for inner eyelid treatment of meibomian gland dysfunction |
| WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
| US7981145B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
| US8128674B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US8137390B2 (en) | 2006-05-15 | 2012-03-20 | Tearscience, Inc. | System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction |
| US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
| US8128673B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| CN101528214B (zh) * | 2006-08-24 | 2013-06-05 | 田纳西大学研究基金会 | 取代的n-酰基苯胺及其使用方法 |
| US9381183B2 (en) * | 2012-07-18 | 2016-07-05 | Physicians Recommended Nutriceuticals, Llc | Methods for improving the quality of the meibum composition of meibomian glands |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| PL2872482T3 (pl) | 2012-07-13 | 2021-03-08 | Oncternal Therapeutics, Inc. | Sposób leczenia raków sutka z użyciem selektywnego modulatora receptora androgenowego (sarm) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US10842670B2 (en) | 2012-08-22 | 2020-11-24 | Johnson & Johnson Vision Care, Inc. | Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices |
| US10064818B2 (en) * | 2013-08-28 | 2018-09-04 | Presbyopia Therapies, LLC | Compositions and methods for the treatment of presbyopia |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| RU2567829C1 (ru) * | 2014-10-22 | 2015-11-10 | Елизавета Геннадьевна Полунина | Способ оценки морфофункционального состояния мейбомиевых желез - биометрия мейбомиевых желез |
| KR101714710B1 (ko) | 2015-09-17 | 2017-03-10 | 고려대학교 산학협력단 | 마이봄샘 압출기 |
| BR112018070852B1 (pt) * | 2016-04-14 | 2024-01-16 | Azura Ophthalmics Ltd | Composições de dissulfeto de selênio |
| US20210251970A1 (en) | 2018-10-10 | 2021-08-19 | Presbyopia Therapies Inc | Compositions and methods for storage stable ophthalmic drugs |
| EP4433053A4 (en) | 2021-11-17 | 2025-09-17 | Lenz Therapeutics Operations Inc | ACECLIDINE DERIVATIVES, THEIR COMPOSITIONS AND METHODS OF USE |
| US20230168157A1 (en) * | 2021-11-29 | 2023-06-01 | Petróleo Brasileiro S.A. - Petrobras | System and method for evaluation of the deposition in tubes of the furnaces of a delayed coking unit |
| US11648247B1 (en) | 2021-12-16 | 2023-05-16 | Lenz Therapeutics, Inc. | Compositions and methods for the treatment of presbyopia |
| US12414942B1 (en) | 2024-03-15 | 2025-09-16 | Lenz Therapeutics Operations, Inc. | Compositions, methods, and systems for treating presbyopia |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| LU88769I2 (fr) * | 1982-07-23 | 1996-11-05 | Zeneca Ltd | Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R)) |
| US20050038110A1 (en) * | 2000-08-24 | 2005-02-17 | Steiner Mitchell S. | Selective androgen receptor modulators and methods of use thereof |
| US6492554B2 (en) * | 2000-08-24 | 2002-12-10 | The University Of Tennessee Research Corporation | Selective androgen receptor modulators and methods of use thereof |
| US6838484B2 (en) * | 2000-08-24 | 2005-01-04 | University Of Tennessee Research Foundation | Formulations comprising selective androgen receptor modulators |
| US7645898B2 (en) * | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US7026500B2 (en) * | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| US7855229B2 (en) * | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| US7622503B2 (en) * | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8445534B2 (en) * | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
| US20070173546A1 (en) * | 2000-08-24 | 2007-07-26 | Dalton James T | Selective androgen receptor modulators and method of use thereof |
| US6998500B2 (en) * | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US20040260108A1 (en) * | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| US7919647B2 (en) * | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| EP1325914A4 (en) * | 2000-09-14 | 2004-11-17 | Kaken Pharma Co Ltd | TETRAHYDROQUINOLINE COMPOUNDS |
| US8853266B2 (en) * | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US20070161608A1 (en) * | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| WO2003074449A2 (en) | 2002-02-28 | 2003-09-12 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| AU2003217303A1 (en) | 2002-02-28 | 2003-09-16 | University Of Tennessee Research Foundation | Haloacetamide and azide substituted compounds and methods of use thereof |
| US7772433B2 (en) * | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
| KR20040101251A (ko) * | 2002-02-28 | 2004-12-02 | 유니버시티 오브 테네시 리서치 파운데이션 | 다치환된 선택적 안드로겐 수용체 모듈레이터 및 이를사용하는 방법 |
| US7803970B2 (en) * | 2002-02-28 | 2010-09-28 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| HRP20050038A2 (en) | 2002-06-17 | 2005-08-31 | University Of Tennessee Research Foundation | N-bridged selective androgen receptor modulators and methods of use thereof |
| EP1562906A4 (en) * | 2002-10-15 | 2009-12-02 | Univ Tennessee Res Foundation | HETEROCYCLIC SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHOD FOR THEIR USE |
| US20040197928A1 (en) * | 2002-10-15 | 2004-10-07 | Dalton James T. | Method for detecting selective androgen receptor modulators |
| US20040265916A1 (en) * | 2002-10-15 | 2004-12-30 | Dalton James T. | Method for detecting selective androgen receptor modulators |
| EP1558232A4 (en) | 2002-10-15 | 2008-07-02 | Gtx Inc | TREATMENT OF FAT SUPPORT WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS |
| JP2006506369A (ja) | 2002-10-15 | 2006-02-23 | ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション | メチレン架橋選択的アンドロゲン受容体調節剤及びその使用方法 |
| US20060276539A1 (en) * | 2002-10-16 | 2006-12-07 | Dalton James T | Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS |
| CA2501874A1 (en) | 2002-10-16 | 2004-04-29 | Gtx, Inc. | Treating androgen decline in aging male (adam)-associated conditions with sarms |
| US20040087810A1 (en) * | 2002-10-23 | 2004-05-06 | Dalton James T. | Irreversible selective androgen receptor modulators and methods of use thereof |
| US8309603B2 (en) * | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| AU2004204800B8 (en) * | 2003-01-13 | 2011-05-26 | University Of Tennessee Research Foundation | Large-scale synthesis of selective androgen receptor modulators |
| JP2006516286A (ja) | 2003-01-22 | 2006-06-29 | ジーティーエックス・インコーポレイテッド | Sarmによる女性のアンドロゲン減少に関連する病気の治療 |
| EA200501761A1 (ru) * | 2003-12-16 | 2006-04-28 | Джи Ти Икс, ИНК. | Пролекарственные формы селективных модуляторов андрогеновых рецепторов и способы их применения |
| CA2552524A1 (en) * | 2004-01-10 | 2005-07-28 | Biolipid, Inc. | Lipid compositions and methods of use |
| US20110237664A1 (en) | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| US20130034562A1 (en) * | 2004-06-07 | 2013-02-07 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| MXPA06013958A (es) | 2004-06-07 | 2007-03-15 | Univ Tennessee Res Foundation | Moduladores del receptor de androgenos selectivo metodos para utilizar los mismos. |
| EP2425715B1 (en) * | 2005-08-31 | 2014-03-05 | University of Tennessee Research Foundation | Treating symptoms of renal disease with selective androgen receptor modulators (SARM) |
| JP4899625B2 (ja) * | 2006-05-12 | 2012-03-21 | スズキ株式会社 | 鞍乗型不整地走行車両 |
| WO2008008433A2 (en) * | 2006-07-12 | 2008-01-17 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
| WO2008011072A2 (en) * | 2006-07-19 | 2008-01-24 | Osurf (Ohio State University Research Foundation) | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof |
| CN101528214B (zh) * | 2006-08-24 | 2013-06-05 | 田纳西大学研究基金会 | 取代的n-酰基苯胺及其使用方法 |
| CN101668511A (zh) * | 2007-02-28 | 2010-03-10 | 阿西克斯医疗公司 | 正常化睑板腺分泌的方法和化合物 |
| US7968603B2 (en) * | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| WO2009036206A1 (en) * | 2007-09-11 | 2009-03-19 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| EP2915529B1 (en) | 2008-05-07 | 2017-06-14 | The Regents of The University of California | Therapeutic replenishment and enrichment of ocular surface lubrication |
-
2011
- 2011-01-11 MX MX2012008110A patent/MX2012008110A/es not_active Application Discontinuation
- 2011-01-11 WO PCT/US2011/020871 patent/WO2011085385A1/en not_active Ceased
- 2011-01-11 CA CA2787114A patent/CA2787114A1/en not_active Abandoned
- 2011-01-11 KR KR1020127020961A patent/KR20120115380A/ko not_active Withdrawn
- 2011-01-11 EP EP11732323.8A patent/EP2523556A4/en not_active Withdrawn
- 2011-01-11 CN CN2011800134439A patent/CN103002737A/zh active Pending
- 2011-01-11 RU RU2012134351/15A patent/RU2012134351A/ru not_active Application Discontinuation
- 2011-01-11 AU AU2011203832A patent/AU2011203832A1/en not_active Abandoned
- 2011-01-11 US US13/004,764 patent/US8791158B2/en active Active
- 2011-01-11 JP JP2012549006A patent/JP2013516501A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011203832A1 (en) | 2012-08-23 |
| US8791158B2 (en) | 2014-07-29 |
| CN103002737A (zh) | 2013-03-27 |
| JP2013516501A (ja) | 2013-05-13 |
| US20110172302A1 (en) | 2011-07-14 |
| CA2787114A1 (en) | 2011-07-14 |
| KR20120115380A (ko) | 2012-10-17 |
| WO2011085385A1 (en) | 2011-07-14 |
| MX2012008110A (es) | 2012-10-03 |
| EP2523556A1 (en) | 2012-11-21 |
| EP2523556A4 (en) | 2013-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150803 |