ATE552235T1 - Selektive androgen-rezeptor-modulator und anwendungsverfahren dafür - Google Patents

Selektive androgen-rezeptor-modulator und anwendungsverfahren dafür

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Publication number
ATE552235T1
ATE552235T1 AT05758756T AT05758756T ATE552235T1 AT E552235 T1 ATE552235 T1 AT E552235T1 AT 05758756 T AT05758756 T AT 05758756T AT 05758756 T AT05758756 T AT 05758756T AT E552235 T1 ATE552235 T1 AT E552235T1
Authority
AT
Austria
Prior art keywords
bone
disorder
androgen receptor
receptor modulator
promoting
Prior art date
Application number
AT05758756T
Other languages
English (en)
Inventor
James Dalton
Duane Miller
Karen Veverka
Original Assignee
Univ Tennessee Res Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/861,923 external-priority patent/US8008348B2/en
Priority claimed from US10/863,524 external-priority patent/US20050038110A1/en
Priority claimed from US10/961,380 external-priority patent/US20060019931A1/en
Application filed by Univ Tennessee Res Foundation filed Critical Univ Tennessee Res Foundation
Application granted granted Critical
Publication of ATE552235T1 publication Critical patent/ATE552235T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
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  • Biomedical Technology (AREA)
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  • Cardiology (AREA)
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  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
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  • Addiction (AREA)
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AT05758756T 2004-06-07 2005-06-07 Selektive androgen-rezeptor-modulator und anwendungsverfahren dafür ATE552235T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/861,923 US8008348B2 (en) 2001-12-06 2004-06-07 Treating muscle wasting with selective androgen receptor modulators
US10/863,524 US20050038110A1 (en) 2000-08-24 2004-06-09 Selective androgen receptor modulators and methods of use thereof
US10/961,380 US20060019931A1 (en) 2003-10-14 2004-10-12 Treating bone-related disorders with selective androgen receptor modulators
PCT/US2005/019788 WO2005120483A2 (en) 2004-06-07 2005-06-07 Selective androgen receptor modulators and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE552235T1 true ATE552235T1 (de) 2012-04-15

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AT05758756T ATE552235T1 (de) 2004-06-07 2005-06-07 Selektive androgen-rezeptor-modulator und anwendungsverfahren dafür

Country Status (14)

Country Link
EP (2) EP2289872B1 (de)
JP (2) JP4201818B2 (de)
AT (1) ATE552235T1 (de)
AU (1) AU2005251781C1 (de)
BR (1) BRPI0511308B8 (de)
CA (1) CA2543827C (de)
CY (1) CY1120469T1 (de)
DK (1) DK2289872T3 (de)
EA (2) EA018699B1 (de)
GE (1) GEP20094851B (de)
IL (1) IL178716A (de)
MX (1) MXPA06013958A (de)
PL (2) PL2289872T3 (de)
WO (1) WO2005120483A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8853266B2 (en) * 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
WO2005120483A2 (en) * 2004-06-07 2005-12-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
WO2007027582A2 (en) * 2005-08-31 2007-03-08 University Of Tennessee Research Foundation Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators
US20090234150A1 (en) * 2006-07-14 2009-09-17 Peter Carmeliet Use of ppar-alpha agonists to treat skeletal muscle wasting disorders
CA2660570C (en) 2006-08-24 2016-08-09 University Of Tennessee Research Foundation Substituted acylanilides and methods of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US9284345B2 (en) 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
EP2176220B1 (de) 2007-08-07 2013-03-27 Takeda Pharmaceutical Company Limited Pyrrolidin-2-on-Derivate als Androgenrezeptormodulatoren
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
AU2009215843B2 (en) 2008-02-22 2011-09-08 Ellipses Pharma Ltd Selective androgen receptor modulators
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
WO2011085385A1 (en) 2010-01-11 2011-07-14 Gtx, Inc. Methods of treating meibomian gland dysfunction
CA2788907A1 (en) 2010-02-04 2011-08-11 Radius Health, Inc. Selective androgen receptor modulators
SI2568806T1 (sl) 2010-05-12 2016-09-30 Radius Health, Inc. Režimi zdravljenja
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
US9133182B2 (en) 2010-09-28 2015-09-15 Radius Health, Inc. Selective androgen receptor modulators
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
MX375256B (es) 2012-07-13 2025-03-06 Gtx Inc Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms).
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
WO2014012050A2 (en) * 2012-07-13 2014-01-16 Indiana University Research & Technology Corporation Compounds for treatment of spinal muscular atrophy
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
MX2017004819A (es) * 2014-10-16 2018-06-12 Gtx Inc Metodos de tratamiento de transtornos urológicos usando sarm.
RU2769527C2 (ru) 2016-06-22 2022-04-01 Эллипсес Фарма Лтд Способы лечения ar+ рака молочной железы
US11529323B2 (en) 2017-09-13 2022-12-20 Ohio State Innovation Foundation Methods and compositions for the treatment of cancer cachexia

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE28864T1 (de) * 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
US6071957A (en) * 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US6995284B2 (en) 2000-08-24 2006-02-07 The University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US6160011A (en) * 1997-05-30 2000-12-12 The University Of Tennessee Research Corporation Non-steroidal agonist compounds and their use in male hormone therapy
CA2420279C (en) * 2000-08-24 2011-07-19 The University Of Tennessee Research Corporation Selective androgen receptor modulators and methods of use thereof
US7547728B2 (en) * 2001-12-06 2009-06-16 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US20060019931A1 (en) * 2003-10-14 2006-01-26 Dalton James T Treating bone-related disorders with selective androgen receptor modulators
US7026500B2 (en) * 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US20030232792A1 (en) * 2000-08-24 2003-12-18 Dalton James T. Selective androgen receptor modulators and methods of use thereof
US6838484B2 (en) * 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
AU2003216174C1 (en) * 2002-02-07 2010-01-28 University Of Tennessee Research Foundation Treating benign prostate hyperplasia with SARMs
GEP20074209B (en) * 2002-02-28 2007-10-10 , Multi-substitued selective androgen receptor modulators and methods of use thereof
US20040087810A1 (en) * 2002-10-23 2004-05-06 Dalton James T. Irreversible selective androgen receptor modulators and methods of use thereof
FI20030958A0 (fi) * 2003-06-27 2003-06-27 Orion Corp Uusia yhdisteitä
CN1805921A (zh) * 2003-12-16 2006-07-19 Gtx公司 选择性雄激素受体调节剂的前药及其使用方法
WO2005120483A2 (en) * 2004-06-07 2005-12-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof

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