PE20070406A1 - Aciltriptofanoles como antagonistas del receptor de la hormona foliculo estimulante (fsh) - Google Patents

Aciltriptofanoles como antagonistas del receptor de la hormona foliculo estimulante (fsh)

Info

Publication number
PE20070406A1
PE20070406A1 PE2006000971A PE2006000971A PE20070406A1 PE 20070406 A1 PE20070406 A1 PE 20070406A1 PE 2006000971 A PE2006000971 A PE 2006000971A PE 2006000971 A PE2006000971 A PE 2006000971A PE 20070406 A1 PE20070406 A1 PE 20070406A1
Authority
PE
Peru
Prior art keywords
ethyl
fsh
antagonists
stimulating hormone
trimetoxifenil
Prior art date
Application number
PE2006000971A
Other languages
English (en)
Inventor
Lars Wortmann
Arwed Cleve
Peter Muhn
Anna Schrey
Marcus Koppitz
Dirk Kosemund
Ronald Kuhne
Gernot Langer
Bernd Menzenbach
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20070406A1 publication Critical patent/PE20070406A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C6), ALQUENILO(C3-C6), CICLOALQUILO(C3-C7), ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON F, CN, AMINO, ENTRE OTROS SUSTITUYENTES; R2 ES H, HALOGENO, CN, ALQUILO(C1-C6), ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON F; R3 ES H, OH, HALOGENO, NITRO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON F, CN, OH, ENTRE OTROS SUSTITUYENTES; R4, R5 Y R6 SON CADA UNO H, OH, AMINO, FENILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON F, CN, ENTRE OTROS SUSTITUYENTES; R7 Y R8 SON CADA UNO H, METILO O ETILO; Q Y W SON ARILO O HETEROARILO; X ES UN ENLACE, ALQUILENO(C1-C4), ALQUENILENO(C2-C4), ENTRE OTROS; Y ES UN ENLACE O ALQUILENO(C1-C4). SON COMPUESTOS PREFERIDOS: N-[(R,S)-2-(5-BROMO-1H-INDOL-3-IL)-1-(HIDROXIMETIL)ETIL]-2-(3,4,5-TRIMETOXIFENIL)QUINOLIN-4-CARBOXAMIDA, N-[(R,S)-1-(HIDROXIMETIL)-2-(5-METIL-1H-INDOL-3-IL)ETIL]-2-(3,4,5-TRIMETOXIFENIL)QUINOLIN-4-CARBOXAMIDA, N-[(R,S)-1-(HIDROXIMETIL)-2-(4-METIL-1H-INDOL-3-IL)ETIL]-2-(3,4,5-TRIMETOXIFENIL)QUINOLIN-4-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE LA HORMONA FOLICULO ESTIMULANTE (FSH) SIENDO UTILES EN EL TRATAMIENTO DE OSTEOPOROSIS, CONTROL DE LA FERTILIDAD
PE2006000971A 2005-08-10 2006-08-10 Aciltriptofanoles como antagonistas del receptor de la hormona foliculo estimulante (fsh) PE20070406A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005038632A DE102005038632B4 (de) 2005-08-10 2005-08-10 Acyltryptophanole

Publications (1)

Publication Number Publication Date
PE20070406A1 true PE20070406A1 (es) 2007-05-12

Family

ID=37681170

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000971A PE20070406A1 (es) 2005-08-10 2006-08-10 Aciltriptofanoles como antagonistas del receptor de la hormona foliculo estimulante (fsh)

Country Status (7)

Country Link
AR (1) AR056190A1 (es)
DE (1) DE102005038632B4 (es)
DO (1) DOP2006000187A (es)
GT (1) GT200600365A (es)
PE (1) PE20070406A1 (es)
TW (1) TW200716098A (es)
UY (1) UY29737A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008025893B4 (de) * 2008-05-26 2014-09-18 Technische Universität Dresden Verfahren zur Herstellung von Fettsäureamiden mit gesättigten, ungesättigten oder Hydroxy-Fettsäuren

Also Published As

Publication number Publication date
GT200600365A (es) 2007-04-02
UY29737A1 (es) 2007-02-28
AR056190A1 (es) 2007-09-26
DE102005038632B4 (de) 2008-03-27
DE102005038632A1 (de) 2007-02-15
DOP2006000187A (es) 2007-03-15
TW200716098A (en) 2007-05-01

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