JP2015520752A - Ｎａｍｐｔ阻害薬としてのピリダジンおよびピリジン誘導体 - Google Patents

Ｎａｍｐｔ阻害薬としてのピリダジンおよびピリジン誘導体 Download PDF

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JP2015520752A
JP2015520752A JP2015511730A JP2015511730A JP2015520752A JP 2015520752 A JP2015520752 A JP 2015520752A JP 2015511730 A JP2015511730 A JP 2015511730A JP 2015511730 A JP2015511730 A JP 2015511730A JP 2015520752 A JP2015520752 A JP 2015520752A
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carboxamide
phenyl
pyridazin
azetidine
piperidin
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JP2015511730A
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Japanese (ja)
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JP2015520752A5 (enExample
Inventor
ハンセン，トッド・エム
ロングネッカー，ケントン
ヘイマン，ハワード・アール
カーティン，マイケル・エル
クラーク，リチャード・エフ
ソーレンセン，ブライアン
ジー，ジーチン
ドハーティ，ジョージ
フレイ，ロビン
ウォーラー，ケビン
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AbbVie Inc
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AbbVie Inc
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Publication of JP2015520752A publication Critical patent/JP2015520752A/ja
Publication of JP2015520752A5 publication Critical patent/JP2015520752A5/ja
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
JP2015511730A 2012-05-11 2013-05-10 Ｎａｍｐｔ阻害薬としてのピリダジンおよびピリジン誘導体 Pending JP2015520752A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261645692P 2012-05-11 2012-05-11
US61/645,692 2012-05-11
US201261719013P 2012-10-26 2012-10-26
US61/719,013 2012-10-26
US201361779756P 2013-03-13 2013-03-13
US61/779,756 2013-03-13
PCT/US2013/040481 WO2013170115A1 (en) 2012-05-11 2013-05-10 Pyridazine and pyridine derivatives as nampt inhibitors

Publications (2)

Publication Number Publication Date
JP2015520752A true JP2015520752A (ja) 2015-07-23
JP2015520752A5 JP2015520752A5 (enExample) 2016-06-30

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JP2015511730A Pending JP2015520752A (ja) 2012-05-11 2013-05-10 Ｎａｍｐｔ阻害薬としてのピリダジンおよびピリジン誘導体

Country Status (11)

Country Link
US (4) US8975398B2 (enExample)
EP (1) EP2847181A1 (enExample)
JP (1) JP2015520752A (enExample)
CN (1) CN104583194A (enExample)
AR (1) AR091023A1 (enExample)
CA (1) CA2873097A1 (enExample)
HK (1) HK1209739A1 (enExample)
MX (1) MX2014013751A (enExample)
TW (1) TW201350478A (enExample)
UY (1) UY34804A (enExample)
WO (1) WO2013170115A1 (enExample)

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EP3778584A1 (en) 2014-06-19 2021-02-17 ARIAD Pharmaceuticals, Inc. Production process of 2-chloro-4-heteroaryl-pyrimidine derivatives
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US11021514B2 (en) 2016-06-01 2021-06-01 Athira Pharma, Inc. Compounds
MX2018015285A (es) 2016-06-08 2019-09-18 Abbvie Inc Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco.
BR112018075639A2 (pt) 2016-06-08 2019-04-09 Abbvie Inc. conjugados de anticorpo fármaco anti-egfr
AU2017279550A1 (en) 2016-06-08 2019-01-03 Abbvie Inc. Anti-B7-H3 antibodies and antibody drug conjugates
JP2019524651A (ja) 2016-06-08 2019-09-05 アッヴィ・インコーポレイテッド 抗ｃｄ９８抗体及び抗体薬物コンジュゲート
WO2017214322A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
AU2017277534A1 (en) 2016-06-08 2019-01-03 Abbvie Inc. Anti-EGFR antibody drug conjugates
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WO2018124001A1 (ja) 2016-12-27 2018-07-05 国立研究開発法人理化学研究所 Ｂｍｐシグナル阻害化合物
WO2018177993A1 (de) 2017-03-31 2018-10-04 Bayer Cropscience Aktiengesellschaft Pyrazole zur bekämpfung von arthropoden
EP3612567B1 (en) 2017-04-19 2024-09-11 Bluefin Biomedicine, Inc. Anti-vtcn1 antibodies and antibody drug conjugates
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
CA3060206A1 (en) 2017-04-27 2018-11-01 Seattle Genetics, Inc. Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates
CA3066918A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
WO2019133635A1 (en) 2017-12-27 2019-07-04 St. Jude Children's Research Hospital Small molecule modulators of pantothenate kinases
JP7527967B2 (ja) 2017-12-27 2024-08-05 セント ジュード チルドレンズ リサーチ ホスピタル，インコーポレイティド Ｃａｓｔｏｒに関連する障害を治療する方法
EP3746079A1 (en) * 2018-01-31 2020-12-09 Bayer Aktiengesellschaft Antibody drug conjugates (adcs) with nampt inhibitors
CR20200347A (es) 2018-02-13 2020-09-23 Gilead Sciences Inc Inhibidores pd-1/pd-l1
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