JP2015517402A - クロマトグラフィー材料 - Google Patents

クロマトグラフィー材料 Download PDF

Info

Publication number
JP2015517402A
JP2015517402A JP2015512799A JP2015512799A JP2015517402A JP 2015517402 A JP2015517402 A JP 2015517402A JP 2015512799 A JP2015512799 A JP 2015512799A JP 2015512799 A JP2015512799 A JP 2015512799A JP 2015517402 A JP2015517402 A JP 2015517402A
Authority
JP
Japan
Prior art keywords
chromatography
stationary phase
chromatographic
over
runs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015512799A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015517402A5 (enExample
Inventor
ブルースミーシュ，ダリル・ダブリュ
ウィンダム，ケビン・ディー
フェアチャイルド，ジェイコブ・エヌ
イラネタ，パメラ・シー
ヒル，ジェイソン・エフ
Original Assignee
ウオーターズ・テクノロジーズ・コーポレイシヨン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウオーターズ・テクノロジーズ・コーポレイシヨン filed Critical ウオーターズ・テクノロジーズ・コーポレイシヨン
Publication of JP2015517402A publication Critical patent/JP2015517402A/ja
Publication of JP2015517402A5 publication Critical patent/JP2015517402A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/283—Porous sorbents based on silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • B01D15/305—Hydrophilic interaction chromatography [HILIC]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/322—Normal bonded phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/40—Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/02—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography
    • B01D53/025—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography with wetted adsorbents; Chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28042—Shaped bodies; Monolithic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B01J20/28059—Surface area, e.g. B.E.T specific surface area being less than 100 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B01J20/28061—Surface area, e.g. B.E.T specific surface area being in the range 100-500 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B01J20/28064—Surface area, e.g. B.E.T specific surface area being in the range 500-1000 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B01J20/28066—Surface area, e.g. B.E.T specific surface area being more than 1000 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B01J20/28071—Pore volume, e.g. total pore volume, mesopore volume, micropore volume being less than 0.5 ml/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B01J20/28073—Pore volume, e.g. total pore volume, mesopore volume, micropore volume being in the range 0.5-1.0 ml/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B01J20/28076—Pore volume, e.g. total pore volume, mesopore volume, micropore volume being more than 1.0 ml/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28083—Pore diameter being in the range 2-50 nm, i.e. mesopores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/288—Polar phases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3085—Chemical treatments not covered by groups B01J20/3007 - B01J20/3078
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/284—Porous sorbents based on alumina
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3234—Inorganic material layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/80—Aspects related to sorbents specially adapted for preparative, analytical or investigative chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
JP2015512799A 2012-05-15 2013-05-15 クロマトグラフィー材料 Pending JP2015517402A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261647303P 2012-05-15 2012-05-15
US61/647,303 2012-05-15
PCT/US2013/041207 WO2013173494A1 (en) 2012-05-15 2013-05-15 Chromatographic materials

Publications (2)

Publication Number Publication Date
JP2015517402A true JP2015517402A (ja) 2015-06-22
JP2015517402A5 JP2015517402A5 (enExample) 2016-06-30

Family

ID=49584263

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015512799A Pending JP2015517402A (ja) 2012-05-15 2013-05-15 クロマトグラフィー材料
JP2015512802A Expired - Fee Related JP6401151B2 (ja) 2012-05-15 2013-05-15 クロマトグラフィー材料

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015512802A Expired - Fee Related JP6401151B2 (ja) 2012-05-15 2013-05-15 クロマトグラフィー材料

Country Status (8)

Country Link
US (9) US9925521B2 (enExample)
EP (1) EP3113857B1 (enExample)
JP (2) JP2015517402A (enExample)
CN (3) CN107754776B (enExample)
DE (2) DE112013002519T5 (enExample)
GB (3) GB2515984A (enExample)
HK (1) HK1211258A1 (enExample)
WO (3) WO2013173494A1 (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111644164B (zh) * 2012-05-15 2024-03-08 沃特世科技公司 用于分离不饱和分子的色谱材料
WO2013173494A1 (en) 2012-05-15 2013-11-21 Waters Technologies Corporation Chromatographic materials
WO2014085486A2 (en) * 2012-11-30 2014-06-05 Waters Technologies Corporation Methods and apparatus for the analysis of vitamin d metabolites
EP3007792A4 (en) * 2013-06-11 2017-05-03 Waters Technologies Corporation Chromatographic columns and separation devices comprising a superficially porous material; and use thereof for supercritical fluid chromatography and other chromatography
US9518960B2 (en) * 2013-10-02 2016-12-13 Waters Technologies Corporation System and method for rapid analysis of polycyclic aromatic hydrocarbons
US11092574B2 (en) 2013-12-24 2021-08-17 Waters Technologies Corporation Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
US10119944B2 (en) 2013-12-24 2018-11-06 Waters Technologies Corporation Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
JP6821435B2 (ja) * 2014-03-01 2021-01-27 ウオーターズ・テクノロジーズ・コーポレイシヨン 不飽和分子を分離するためのクロマトグラフィー材料
WO2016011427A1 (en) * 2014-07-17 2016-01-21 Azyp, Llc High efficiency, ultra-stable, bonded hydrophilic interaction chromatography (hilic) matrix on superficially porous particles (spps)
US10246410B2 (en) 2014-12-03 2019-04-02 Life Technologies Corporation Hydrazinyl and aminooxy compounds and their methods of use
US10309959B2 (en) 2014-12-03 2019-06-04 Life Technologies Corporation Charged reactive oligomers
US20180057553A1 (en) * 2015-03-05 2018-03-01 The University Of Tokyo Conjugate and use thereof
CN108136275A (zh) * 2015-04-29 2018-06-08 沃特世科技公司 用于超临界流体色谱法的包含离子配对键合相的高纯度色谱材料
CN105536747B (zh) * 2016-01-14 2018-02-02 重庆大学 一种智能响应液相色谱填料及其制备方法
EP3426388A1 (en) 2016-03-06 2019-01-16 Waters Technologies Corporation Superficially porous materials comprising a coated core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
EP3435079B1 (en) * 2016-03-23 2020-07-29 Daicel Corporation Chromatography stationary phase
CN105727912B (zh) * 2016-04-07 2018-08-17 湖北省农业科学院农业质量标准与检测技术研究所 一种新型胆固醇键合硅胶固定相及其制备方法和应用
EP4559924A3 (en) * 2016-04-24 2025-08-06 Waters Technologies Corporation Isolation of glycans modified with amphipathic, strongly basic moieties, using charged surface reversed phase chromatopgraphic materials
EP4443155A3 (en) 2016-07-28 2025-01-22 Waters Technologies Corporation Encapsulated pre-analytic workflows for flow-through devices, liquid chromatography and mass spectrometric analysis
RU2638660C1 (ru) * 2016-12-19 2017-12-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Сорбент для определения соединений ионной и гидрофильной природы
CN110383060A (zh) 2017-03-08 2019-10-25 沃特世科技公司 使用色谱法确定极性农药
CN110418795B (zh) * 2017-03-16 2023-05-23 沃特世科技公司 色谱组合物
US11123656B2 (en) 2017-06-22 2021-09-21 Showa Denko K.K. Separation/analysis method for mixture of oligonucleotides
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
WO2019067632A1 (en) 2017-09-26 2019-04-04 Waters Technologies Corporation LIQUID CHROMATOGRAPHY SEPARATION OF GLUCIDIC TAUTOMERS
CN108061773B (zh) * 2018-02-02 2019-04-12 湖南山水检测有限公司 高效液相色谱技术测定维生素a的方法
CN110412139A (zh) 2018-04-27 2019-11-05 株式会社岛津制作所 一种分析系统
EP3821238B1 (en) 2018-07-11 2022-08-31 Waters Technologies Corporation Chromatographic system and method for trap-elute mixed mode chromatography
CN109692501B (zh) * 2018-12-29 2021-02-09 武汉谱立科技有限公司 一种色谱柱及其制备方法和应用
CN113507971A (zh) 2019-02-27 2021-10-15 沃特世科技公司 用于最大程度减少分析物吸附的色谱密封件和经涂覆的流动路径
EP3930868B1 (en) * 2019-02-27 2024-07-17 Waters Technologies Corporation Coated flow path components for chromatographic effects
JP7156146B2 (ja) * 2019-04-10 2022-10-19 株式会社島津製作所 親水性材料の疎水化方法
EP3744683A1 (en) * 2019-05-29 2020-12-02 Nouryon Chemicals International B.V. Porous silica particles
EP3744684A1 (en) 2019-05-29 2020-12-02 Nouryon Chemicals International B.V. Porous silica particles
US11786842B2 (en) 2019-05-30 2023-10-17 Restek Corporation Hybrid ligand and liquid chromatography stationary phase including hybrid ligand
CN111250064A (zh) * 2019-10-10 2020-06-09 浙江海洋大学 一种支化聚乙烯亚胺修饰贻贝壳粉的制备方法及应用
CN110938459B (zh) * 2019-11-19 2021-09-28 中海油天津化工研究设计院有限公司 一种石脑油生产石油醚及轻质白油的方法
CN110938458B (zh) * 2019-11-19 2021-11-23 中海油天津化工研究设计院有限公司 一种生产高品质工业白油的方法
CN111013557B (zh) * 2019-12-27 2023-04-07 纳谱分析技术（苏州）有限公司 一种疏水层析介质及其制备方法和应用
US20210255196A1 (en) * 2020-01-17 2021-08-19 Waters Technologies Corporation Low binding surfaces for peptide mapping
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
US20210348154A1 (en) * 2020-05-08 2021-11-11 Waters Technologies Corporation Hetero-functional coating for conjugating biomolecules on a solid support and use thereof for bio analysis
US12411064B2 (en) 2020-05-08 2025-09-09 Waters Technologies Corporation Methods for heat-assisted enzyme digestion
CN116391122A (zh) 2020-09-24 2023-07-04 沃特世科技公司 用于反应性分子分离的色谱硬件改进
CN112147249B (zh) * 2020-09-25 2022-04-12 安徽瑞思威尔科技有限公司 一种杨梅酒中31种有效成分的UPC2-PDA-Q-Tof/MS检测方法
JP7503755B2 (ja) 2020-11-25 2024-06-21 パナソニックＩｐマネジメント株式会社 イオン選択性電極およびその製造方法
CN112755985B (zh) * 2020-12-28 2023-08-25 纳谱分析技术（苏州）有限公司 一种液相色谱分离介质及其制备方法和应用
GB202108373D0 (en) * 2021-06-11 2021-07-28 Johnson Matthey Plc Separation of base metals
CN116139839B (zh) * 2021-11-19 2025-01-07 中国科学院大连化学物理研究所 一种巯基吡啶键合色谱固定相及其制备方法和应用
CN114377566B (zh) * 2021-12-25 2022-09-20 广东台泉环保科技有限公司 一种盐湖提锂用纳滤膜及其制备方法
US20240286110A1 (en) * 2023-02-25 2024-08-29 Chrom6 Technologies, LLC Carbon microsphere chromatographic material
CN116440874B (zh) * 2023-04-25 2025-02-18 北京市农林科学院 一种基于核酸适配体功能化磁性疏水聚合物的交链孢酚吸附剂及其应用
CN117269375B (zh) * 2023-11-22 2024-02-13 湖南科锐斯医药科技有限公司 一种测定维生素a醋酸酯粉中有关物质的方法
US12434218B2 (en) 2023-11-28 2025-10-07 Phenomenex, Inc. Pore structure for separation of adeno-associated viruses (AAVS) from their aggregates

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011017418A1 (en) * 2009-08-04 2011-02-10 Waters Technologies Corporation High purity chromatrographic materials comprising an ionizable modifier

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2357184A1 (de) 1973-11-16 1975-05-22 Merck Patent Gmbh Verfahren zur herstellung von organisch modifizierten siliciumdioxiden
ZA814216B (en) * 1980-06-27 1982-07-28 Akzo Nv Porous inorganic support material coated with an organic stationary phase for use in chromatography and process for its preparation
JP2504005B2 (ja) * 1986-11-17 1996-06-05 東ソー株式会社 充填剤およびその製法
US4767670A (en) 1987-01-21 1988-08-30 E. I. Du Pont De Nemours And Company Chromatographic supports for separation of oligonucleotides
US5374755A (en) 1992-07-17 1994-12-20 Millipore Corporation Liquid chromatography stationary phases with reduced silanol interactions
US6686035B2 (en) 1999-02-05 2004-02-03 Waters Investments Limited Porous inorganic/organic hybrid particles for chromatographic separations and process for their preparation
WO2000045951A1 (en) * 1999-02-05 2000-08-10 Waters Investments Limited Porous inorganic/organic hybrid particles for chromatographic separations and process for its preparation
SE0004932D0 (sv) 2000-12-31 2000-12-31 Apbiotech Ab A method for mixed mode adsorption and mixed mode adsorbents
US6528167B2 (en) 2001-01-31 2003-03-04 Waters Investments Limited Porous hybrid particles with organic groups removed from the surface
US7250214B2 (en) 2001-08-09 2007-07-31 Waters Investments Limited Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation
DE10393599T5 (de) 2002-10-30 2005-10-27 Waters Investments Ltd., New Castle Poröse anorganische/organische Homogene copolymerische Hybridmaterialien für chromatographische Auftrennungen und Verfahren für deren Herstellung
GB2413507B (en) 2003-02-07 2007-01-31 Waters Investments Ltd Polymeric solid supports for chromatography nanocolumns
DE112004000906T5 (de) 2003-05-28 2006-10-19 Waters Investments Ltd., New Castle Neue Nanoverbundstoffe und ihre Anwendung als Monolithsäulen
US20040251188A1 (en) 2003-06-10 2004-12-16 Skinner Charles E. Immoblized alkylated amine functional macromolecules, alkylated ammonium salt functional macromolecules, and alkylated quaternary ammonium salt functional macromolecules, process for their preparation and methods for their use
US7074491B2 (en) 2003-11-04 2006-07-11 Dionex Corporation Polar silanes for binding to substrates and use of the bound substrates
US7125488B2 (en) * 2004-02-12 2006-10-24 Varian, Inc. Polar-modified bonded phase materials for chromatographic separations
GB2427611A (en) 2004-02-17 2007-01-03 Waters Investments Ltd Porous hybrid monolith materials with organic groups removed from the surface
US20050242038A1 (en) * 2004-04-30 2005-11-03 Wu Chen Novel stationary phases for use in high-performance liquid chromatography
CN100548428C (zh) * 2004-08-19 2009-10-14 沃特世科技公司 用于执行分离的设备、方法和装置
US7402243B2 (en) * 2004-09-10 2008-07-22 Dionex Corporation Organosilanes and substrate bonded with same
US20070090052A1 (en) * 2005-10-20 2007-04-26 Broske Alan D Chromatographic stationary phase
WO2007095158A2 (en) 2006-02-13 2007-08-23 Advanced Materials Technology, Inc. Process for preparing substrates with porous surface
EP1996303B1 (en) * 2006-03-17 2018-05-02 Waters Technologies Corporation Solvent delivery system for liquid chromatography that maintains fluid integrity and pre-forms gradients
CN101152624B (zh) * 2006-10-01 2010-09-29 中国科学院大连化学物理研究所 一种醇羟基亲水色谱固定相及其制备方法
JP5152600B2 (ja) 2007-02-21 2013-02-27 ウオーターズ・テクノロジーズ・コーポレイシヨン 高い有機物含有量および向上性細孔形状を有するクロマトグラフィー分離用の多孔質無機／有機ハイブリッド粒子
US7651762B2 (en) * 2007-03-13 2010-01-26 Varian, Inc. Methods and devices using a shrinkable support for porous monolithic materials
US7557232B2 (en) * 2007-05-25 2009-07-07 Dionex Corporation Compositions useful as chromatography stationary phases
CN101249426B (zh) * 2007-11-26 2011-04-06 福州大学 一种反相阴离子交换电色谱整体柱的原料配方及制备方法
US9248383B2 (en) * 2008-04-08 2016-02-02 Waters Technologies Corporation Composite materials containing nanoparticles and their use in chromatography
DE102008032687B4 (de) 2008-07-02 2021-05-06 Hansgrohe Se Befestigungsanordnung für wasserdurchflossene Sanitärbauteile
US20100061367A1 (en) 2008-09-11 2010-03-11 Pradeep Sindhu Methods and apparatus related to lossless operation within a data center
AU2009321174A1 (en) 2008-11-26 2011-07-14 University College Cork - National University Of Ireland, Cork A process for preparing silica microparticles
EP3964287A1 (en) * 2009-06-01 2022-03-09 Waters Technologies Corporation Hybrid material for chromatographic separations
GB2473814B (en) * 2009-09-16 2014-06-11 Spheritech Ltd Hollow particulate support
EP2488544B1 (en) * 2009-10-15 2015-03-18 Monash University Affinity ligands and methods for protein purification
US20130135610A1 (en) * 2009-12-15 2013-05-30 Waters Technologies Corporation Device and methods for performing size exclusion chromatography
JP6199184B2 (ja) 2010-07-26 2017-09-20 ウオーターズ・テクノロジーズ・コーポレイシヨン 粒度分布の狭い実質的に非多孔質のコアを含む表面多孔質材料、その製造方法及びクロマトグラフィー分離用としてのその使用
AU2011285520A1 (en) 2010-08-06 2013-03-07 Molycorp Minerals Llc Agglomeration of high surface area rare earths
WO2013173494A1 (en) * 2012-05-15 2013-11-21 Waters Technologies Corporation Chromatographic materials

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011017418A1 (en) * 2009-08-04 2011-02-10 Waters Technologies Corporation High purity chromatrographic materials comprising an ionizable modifier

Also Published As

Publication number Publication date
JP6401151B2 (ja) 2018-10-03
US10265679B2 (en) 2019-04-23
GB2553727B (en) 2018-12-05
US20210331138A1 (en) 2021-10-28
GB201420328D0 (en) 2014-12-31
WO2013173501A2 (en) 2013-11-21
CN104428045A (zh) 2015-03-18
DE112013002532T5 (de) 2015-03-12
CN106457066B (zh) 2020-08-14
GB2521524B (en) 2018-12-05
GB2553727A (en) 2018-03-14
EP3113857A4 (en) 2017-11-15
US10092894B2 (en) 2018-10-09
GB201420330D0 (en) 2014-12-31
US10744484B2 (en) 2020-08-18
US11992824B2 (en) 2024-05-28
EP3113857A1 (en) 2017-01-11
US20150133294A1 (en) 2015-05-14
WO2013173501A3 (en) 2014-03-06
CN106457066A (zh) 2017-02-22
GB2515984A (en) 2015-01-07
WO2013173494A1 (en) 2013-11-21
HK1211258A1 (en) 2016-05-20
GB2521524A (en) 2015-06-24
US20180326399A1 (en) 2018-11-15
WO2013173501A8 (en) 2014-10-09
CN107754776B (zh) 2021-09-21
GB201718598D0 (en) 2017-12-27
WO2015134317A8 (en) 2015-11-26
WO2015134317A1 (en) 2015-09-11
US20150136700A1 (en) 2015-05-21
US9925521B2 (en) 2018-03-27
US20190217273A1 (en) 2019-07-18
US20180345248A1 (en) 2018-12-06
EP3113857B1 (en) 2020-12-02
JP2015523905A (ja) 2015-08-20
US20140319057A1 (en) 2014-10-30
US11059026B2 (en) 2021-07-13
US20240293799A1 (en) 2024-09-05
CN104428045B (zh) 2017-12-01
US12083498B2 (en) 2024-09-10
US20210023531A1 (en) 2021-01-28
WO2015134317A9 (en) 2016-08-04
CN107754776A (zh) 2018-03-06
WO2013173494A4 (en) 2014-02-06
DE112013002519T5 (de) 2015-01-29

Similar Documents

Publication Publication Date Title
JP6401151B2 (ja) クロマトグラフィー材料
JP6557306B2 (ja) サイズ排除クロマトグラフィーを行うための装置および方法
JP6768790B2 (ja) 超臨界流体クロマトグラフィーのための、イオン対結合相を含む高純度クロマトグラフィー材料
JP6125230B2 (ja) イオン性修飾剤を含有する高純度クロマトグラフィー材料
EP3491374B1 (en) Encapsulated pre-analytic workflow reagents for flow-through devices, liquid chromatography and mass spectrometric analysis
US10241117B2 (en) Methods for quantifying polypeptides using mass spectrometry
JP6821435B2 (ja) 不飽和分子を分離するためのクロマトグラフィー材料
HK40002484A (en) Device and methods for performing size exclusion chromatography
HK1179202A (en) Device and methods of performing size exclusion chromatography

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A525

Effective date: 20150108

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160509

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160509

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20170222

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170314

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170608

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170912

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180116