CN101400418B - 保持流体完整性和预先形成梯度的适于液相色谱的溶剂输送系统 - Google Patents
保持流体完整性和预先形成梯度的适于液相色谱的溶剂输送系统 Download PDFInfo
- Publication number
- CN101400418B CN101400418B CN2007800091668A CN200780009166A CN101400418B CN 101400418 B CN101400418 B CN 101400418B CN 2007800091668 A CN2007800091668 A CN 2007800091668A CN 200780009166 A CN200780009166 A CN 200780009166A CN 101400418 B CN101400418 B CN 101400418B
- Authority
- CN
- China
- Prior art keywords
- pump
- gradient
- pressure
- flow velocity
- converter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D11/00—Control of flow ratio
- G05D11/02—Controlling ratio of two or more flows of fluid or fluent material
- G05D11/13—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means
- G05D11/131—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by measuring the values related to the quantity of the individual components
- G05D11/132—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by measuring the values related to the quantity of the individual components by controlling the flow of the individual components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
Abstract
Description
Claims (25)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78361006P | 2006-03-17 | 2006-03-17 | |
US60/783,610 | 2006-03-17 | ||
PCT/US2007/006679 WO2007109157A2 (en) | 2006-03-17 | 2007-03-16 | Solvent delivery system for liquid chromatography that maintains fluid integrity and pre-forms gradients |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101400418A CN101400418A (zh) | 2009-04-01 |
CN101400418B true CN101400418B (zh) | 2012-11-14 |
Family
ID=38522989
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007800091668A Active CN101400418B (zh) | 2006-03-17 | 2007-03-16 | 保持流体完整性和预先形成梯度的适于液相色谱的溶剂输送系统 |
Country Status (6)
Country | Link |
---|---|
US (3) | US9103814B2 (zh) |
EP (1) | EP1996303B1 (zh) |
JP (1) | JP2009530615A (zh) |
CN (1) | CN101400418B (zh) |
HK (1) | HK1130723A1 (zh) |
WO (1) | WO2007109157A2 (zh) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007092798A2 (en) * | 2006-02-08 | 2007-08-16 | Waters Investments Limited | Methods and apparatus for generating solvent gradients in liquid chromatography |
GB2471956B (en) * | 2006-02-08 | 2011-06-01 | Waters Investments Ltd | Control means for improved performance of chromatographic separations |
JP4840015B2 (ja) * | 2006-07-31 | 2011-12-21 | 株式会社島津製作所 | 液体クロマトグラフシステム |
WO2010025777A1 (en) * | 2008-09-08 | 2010-03-11 | Agilent Technologies, Inc. | Method transfer between fluidic devices considering deviations from ideal behavior |
JP2012511723A (ja) * | 2008-12-10 | 2012-05-24 | オールテック・アソシエイツ・インコーポレーテッド | クロマトグラフィーシステムのための溶媒供給システム、及び、その製造と使用の方法 |
EP2401502B1 (en) * | 2009-02-27 | 2018-10-31 | Waters Technologies Corporation | Automated dilution for liquid chromatography |
CN101614711B (zh) * | 2009-04-03 | 2012-07-04 | 天津博纳艾杰尔科技有限公司 | 一种自动三级层析色谱仪 |
CN102858419A (zh) * | 2009-12-15 | 2013-01-02 | 沃特世科技公司 | 实施体积排阻色谱的设备和方法 |
US20130014569A1 (en) * | 2009-12-18 | 2013-01-17 | Waters Technologies Corporation | Thermal-based flow sensing apparatus and method for high-performance liquid chromatography |
CN102713599A (zh) * | 2010-01-25 | 2012-10-03 | 株式会社日立高新技术 | 液相色谱仪以及液相色谱仪用送液装置 |
EP2529214A4 (en) * | 2010-01-26 | 2014-04-16 | Alltech Associates Inc | METHOD FOR OPTIMIZING GRADIENTS USED IN LIQUID-LIQUID CHROMATOGRAPHY SYSTEMS |
US8746270B2 (en) * | 2010-02-10 | 2014-06-10 | Brg Industries Incorporated | Precision low flow rate fluid delivery system and methods for controlling same |
JP5659969B2 (ja) * | 2011-07-05 | 2015-01-28 | 株式会社島津製作所 | 低圧グラジエント装置 |
US9546987B2 (en) * | 2011-07-15 | 2017-01-17 | Shimadzu Corporation | System and program for controlling liquid chromatograph |
US20140345372A1 (en) * | 2012-02-01 | 2014-11-27 | Waters Technologies Corporation | Managing fluidic connections to microfluidic devices |
JP6401151B2 (ja) * | 2012-05-15 | 2018-10-03 | ウオーターズ・テクノロジーズ・コーポレイシヨン | クロマトグラフィー材料 |
JP5861569B2 (ja) * | 2012-06-21 | 2016-02-16 | 株式会社島津製作所 | 移動相送液装置及び液体クロマトグラフ |
WO2014031070A1 (en) | 2012-08-24 | 2014-02-27 | Ge Healthcare Bio-Sciences Ab | System and method for controlling a liquid chromatography system |
US9086426B2 (en) | 2012-09-12 | 2015-07-21 | Dionex Corporation | Multi-component eluent generating system and method |
CN104813164B (zh) | 2012-11-30 | 2018-05-22 | 安捷伦科技有限公司 | 用于液相色谱的混合器旁路样品注射 |
JP6207872B2 (ja) * | 2013-04-18 | 2017-10-04 | 株式会社日立ハイテクノロジーズ | 液体クロマトグラフ装置および液体クロマトグラフ分析方法 |
JP2014215125A (ja) * | 2013-04-24 | 2014-11-17 | 株式会社日立ハイテクノロジーズ | 高圧力定流量ポンプ及び高圧力定流量送液方法 |
DE102013212540A1 (de) | 2013-06-27 | 2014-12-31 | Agilent Technologies Inc. | Konditionieren eines nachfolgenden Probenpakets in einer Probentrennstufe während Prozessierens eines vorangehenden Probenpakets in einer Probenweiterverarbeitungsstufe |
GB2524147B (en) * | 2014-02-06 | 2016-02-10 | Waters Technologies Corp | Method for high pressure gradient chromatography using pump stroke control |
WO2015123309A1 (en) * | 2014-02-11 | 2015-08-20 | Alltech Associates, Inc. | Apparatus and methods for controlling pressure limits and flow rates in a chromatographic system |
JP6331484B2 (ja) * | 2014-03-04 | 2018-05-30 | 株式会社島津製作所 | 液体クロマトグラフ制御装置及び液体クロマトグラフ制御方法 |
EP3148664B1 (en) * | 2014-05-29 | 2019-11-13 | Agilent Technologies, Inc. | Apparatus and method for introducing a sample into a separation unit of a chromatography system |
CN104784990B (zh) * | 2015-04-24 | 2017-07-11 | 中国能源建设集团广东省电力设计研究院有限公司 | 反冲洗装置的调度方法和系统 |
EP3093335A1 (de) * | 2015-05-13 | 2016-11-16 | Bayer Technology Services GmbH | Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten |
US9683511B2 (en) * | 2015-05-14 | 2017-06-20 | Ford Global Technologies, Llc | Method and system for supplying fuel to an engine |
CN106290675B (zh) * | 2015-05-22 | 2020-03-31 | 达耐科学有限公司 | 谱峰终点调整方法及具有谱峰终点调整功能的色谱工作站 |
WO2017066630A1 (en) * | 2015-10-16 | 2017-04-20 | Lonza Ltd. | System and method for regulating cell culture based production of biologics |
US11275062B2 (en) * | 2016-05-30 | 2022-03-15 | Agilent Technologies, Inc | Sample injection with fluidic connection between fluid drive unit and sample accommodation volume |
JP6696578B2 (ja) * | 2016-09-26 | 2020-05-20 | 株式会社島津製作所 | 切替バルブ、バイナリポンプ及びそのバイナリポンプを備えた液体クロマトグラフ |
US20200041467A1 (en) * | 2016-09-28 | 2020-02-06 | Evosep Aps | Chromatographic analysis with low pressure dual gradient refocusing |
DE102016121512A1 (de) * | 2016-11-10 | 2018-05-17 | Dionex Softron Gmbh | System, Verfahren und Verwendung der Flüssigkeitschromatografie |
US10823712B2 (en) * | 2017-01-06 | 2020-11-03 | Waters Technologies Corporation | Modifier stream elution of trap column for multidimensional compressible fluid-based chromatography |
CN106824006B (zh) * | 2017-02-16 | 2018-09-04 | 中国科学院半导体研究所 | 一种防止交叉污染的多试剂顺序进液装置 |
CN107121504B (zh) * | 2017-04-12 | 2019-08-20 | 岛津企业管理(中国)有限公司 | 多功能加温加压萃取-捕集-色谱分离在线联用设备 |
CN108614033A (zh) * | 2017-06-14 | 2018-10-02 | 中国科学院过程工程研究所 | 一种可移动的具有双梯度调节功能的流动相控制系统及其处理方法和用途 |
DE102017115242A1 (de) * | 2017-07-07 | 2019-01-10 | Dionex Softron Gmbh | Pumpenbetriebsverfahren, Verwendung des Verfahrens bei HPLC, Pumpe, Pumpensystem und HPLC-System |
US10976289B2 (en) * | 2017-08-30 | 2021-04-13 | Agilent Technologies, Inc. | Corrected flow reporting under dynamic conditions by system modeling |
EP3687652A1 (en) * | 2017-09-26 | 2020-08-05 | Waters Technologies Corporation | High purity chromatographic materials comprising an ionizable modifier for retention of acidic analytes |
CN108037233B (zh) * | 2017-12-28 | 2024-05-03 | 大连博迈科技发展有限公司 | 基于同一检测器的全在线检测的多维液相色谱分离系统 |
US11879877B2 (en) * | 2018-03-16 | 2024-01-23 | Shimadzu Corporation | Binary pump and liquid chromatograph provided with same |
EP3803380B1 (en) * | 2018-05-30 | 2023-10-25 | Waters Technologies Corporation | System and method for controlling fluid flow within a chromatography system |
US20220003722A1 (en) * | 2018-10-15 | 2022-01-06 | Shimadzu Corporation | Chromatographic control device, chromatographic system, chromatographic control method and chromatographic control program |
US11709085B2 (en) * | 2019-08-21 | 2023-07-25 | Waters Technologies Corporation | Method for determining a dwell volume of a chromatographic system |
EP4065972A1 (en) * | 2019-11-27 | 2022-10-05 | Waters Technologies Corporation | Passive dampening gradient proportioning valve |
CN111538959B (zh) * | 2020-04-22 | 2023-09-01 | 常州三泰科技有限公司 | 基于机器学习技术的液相色谱分离仪的梯度推荐方法 |
WO2021226043A1 (en) * | 2020-05-07 | 2021-11-11 | Waters Technologies Corporation | Multidimensional liquid chromatography system |
WO2021250919A1 (ja) * | 2020-06-09 | 2021-12-16 | 株式会社島津製作所 | 液体クロマトグラフィ分析システム |
US20220168668A1 (en) * | 2020-11-30 | 2022-06-02 | PAK Biosolutions Inc. | End-to-End Continuous Purification System |
WO2022190066A1 (en) * | 2021-03-12 | 2022-09-15 | Dh Technologies Development Pte. Ltd. | Flow module selector |
CN220913059U (zh) * | 2022-06-17 | 2024-05-07 | 特拉珍科学澳大利亚私人有限公司 | 毛细管液相色谱系统及用于其的光学检测器模块 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5217590A (en) * | 1990-09-11 | 1993-06-08 | Lauer Labs B.V. | Method and apparatus for the introduction of a volume of at least one fluid in a tube in particular suitable for capillary electrophoresis systems and method and apparatus for separating and/or analyzing a fluid material |
US6610201B2 (en) * | 1999-10-29 | 2003-08-26 | Waters Investments Limited | High pressure capillary liquid chromatography solvent delivery system |
CN1511256A (zh) * | 2001-06-07 | 2004-07-07 | 纳诺斯特利姆有限公司 | 具有柱上样品注射的微流体分离装置 |
CN1630557A (zh) * | 2002-02-13 | 2005-06-22 | 纳诺斯特利姆有限公司 | 微流体分离柱装置及其制备方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1441462A (en) * | 1973-02-14 | 1976-06-30 | Univ Edinburgh University Cour | Method and apapratus for liquid chromotography |
NL7600264A (nl) * | 1975-02-14 | 1976-08-17 | Foxboro Co | Inrichting voor het verwarmen en op constante temperatuur houden van een bepaald toestel. |
US4917575A (en) * | 1986-05-02 | 1990-04-17 | The Dow Chemical Company | Liquid chromatographic pump |
US4767279A (en) * | 1987-06-02 | 1988-08-30 | Millipore Corporation | Fluid composition and volumetric delivery control |
US5240603A (en) * | 1990-03-02 | 1993-08-31 | Hewlett-Packard Company | Decoupled flow and pressure setpoints in an extraction instrument using compressible fluids |
EP0682749B1 (de) * | 1992-10-28 | 1999-04-14 | FLUX Instruments AG | Hochdruckpumpe zur flüssigkeits-feindosierung |
JP2002071657A (ja) | 2000-08-29 | 2002-03-12 | Jasco Corp | グラジェント液体クロマトグラム測定装置および測定方法 |
JP3764421B2 (ja) | 2000-10-03 | 2006-04-05 | ダイオネックス コーポレイション | 液体クロマトグラフィ−質量分析計(lc−ms)分析におけるピークパーキングのための方法及びシステム |
US6743356B1 (en) * | 2000-10-27 | 2004-06-01 | Johnson & Johnson | High throughput high performance chromatography system |
US7465382B2 (en) * | 2001-06-13 | 2008-12-16 | Eksigent Technologies Llc | Precision flow control system |
JP3865119B2 (ja) * | 2001-06-29 | 2007-01-10 | 株式会社島津製作所 | 移動相グラジエント装置及びそれを用いた高速液体クロマトグラフ |
JP2003185646A (ja) * | 2001-12-13 | 2003-07-03 | Moore Kk | 高圧ステップワイズグラジエント送液システム |
US6958119B2 (en) * | 2002-02-26 | 2005-10-25 | Agilent Technologies, Inc. | Mobile phase gradient generation microfluidic device |
US6780315B2 (en) * | 2002-12-09 | 2004-08-24 | Waters Investments Limited | Backflow prevention for high pressure gradient systems |
JP3823092B2 (ja) * | 2003-03-11 | 2006-09-20 | 株式会社日立ハイテクノロジーズ | 分離分析装置 |
JP3898688B2 (ja) * | 2003-11-07 | 2007-03-28 | 株式会社日立ハイテクノロジーズ | グラジエント送液装置 |
US7186336B2 (en) * | 2003-11-26 | 2007-03-06 | Waters Investments Limited | Flow sensing apparatus |
GB0624707D0 (en) * | 2004-05-21 | 2007-01-17 | Waters Investments Ltd | Closed loop flow control of a hplc constant flow pump to enable low-flow operation |
US7144502B2 (en) * | 2004-06-04 | 2006-12-05 | Johnson & Johnson | Chromatography system with gradient storage and method for operating the same |
US7670480B2 (en) * | 2005-03-31 | 2010-03-02 | Agilent Technologies, Inc. | Solvent supply with correction of piston movement |
-
2007
- 2007-03-16 JP JP2009500516A patent/JP2009530615A/ja active Pending
- 2007-03-16 EP EP07753315.6A patent/EP1996303B1/en active Active
- 2007-03-16 US US12/280,585 patent/US9103814B2/en active Active
- 2007-03-16 WO PCT/US2007/006679 patent/WO2007109157A2/en active Application Filing
- 2007-03-16 CN CN2007800091668A patent/CN101400418B/zh active Active
-
2009
- 2009-09-17 HK HK09108537.4A patent/HK1130723A1/xx not_active IP Right Cessation
-
2015
- 2015-08-10 US US14/822,527 patent/US20150346168A1/en not_active Abandoned
-
2021
- 2021-01-07 US US17/143,814 patent/US20210123891A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5217590A (en) * | 1990-09-11 | 1993-06-08 | Lauer Labs B.V. | Method and apparatus for the introduction of a volume of at least one fluid in a tube in particular suitable for capillary electrophoresis systems and method and apparatus for separating and/or analyzing a fluid material |
US6610201B2 (en) * | 1999-10-29 | 2003-08-26 | Waters Investments Limited | High pressure capillary liquid chromatography solvent delivery system |
CN1511256A (zh) * | 2001-06-07 | 2004-07-07 | 纳诺斯特利姆有限公司 | 具有柱上样品注射的微流体分离装置 |
CN1630557A (zh) * | 2002-02-13 | 2005-06-22 | 纳诺斯特利姆有限公司 | 微流体分离柱装置及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2007109157A2 (en) | 2007-09-27 |
HK1130723A1 (en) | 2010-01-08 |
EP1996303B1 (en) | 2018-05-02 |
US20090205409A1 (en) | 2009-08-20 |
JP2009530615A (ja) | 2009-08-27 |
US20150346168A1 (en) | 2015-12-03 |
EP1996303A2 (en) | 2008-12-03 |
CN101400418A (zh) | 2009-04-01 |
US20210123891A1 (en) | 2021-04-29 |
EP1996303A4 (en) | 2011-09-28 |
US9103814B2 (en) | 2015-08-11 |
WO2007109157A3 (en) | 2008-03-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101400418B (zh) | 保持流体完整性和预先形成梯度的适于液相色谱的溶剂输送系统 | |
US6962658B2 (en) | Variable flow rate injector | |
US9279788B2 (en) | Apparatus and methods for preparative liquid chromatography | |
Noga et al. | A practical guide to nano‐LC troubleshooting | |
US6404193B1 (en) | Solvent susceptibility compensation for coupled LC-NMR | |
US4971915A (en) | Simulated distillation of petroleum residues by capillary SFC | |
US9746450B2 (en) | Online gas chromatograph operation with reduced usage of calibration gas | |
LaCourse et al. | General instrumentation in HPLC | |
US20160136544A1 (en) | Methodology for scaling methods between supercritical fluid chromatography systems | |
US20050214130A1 (en) | Multidimensional pump apparatus and method for fully automated complex mixtures separation, identification, and quantification | |
De Vos et al. | Advances in ultra‐high‐pressure and multi‐dimensional liquid chromatography instrumentation and workflows | |
US10018603B2 (en) | Two-dimensional liquid chromatography system for heart-cut method | |
Niezen et al. | Thermal modulation to enhance two-dimensional liquid chromatography separations of polymers | |
KR101359941B1 (ko) | 신속측정을 위한 액체 크로마토그래피 장치 | |
Deguchi et al. | Nanoflow gradient generator for capillary high-performance liquid chromatography | |
JP5063149B2 (ja) | 液体クロマトグラフ装置 | |
Siviero et al. | In‐depth performance investigation of a nano‐LC gradient generator | |
WO2013134485A1 (en) | Modular solenoid valve kits and associated methods | |
CN112672799B (zh) | 具有推挽调制的二维流体分离 | |
Roche | Cost effective, automated portable high performance liquid chromatograph for on-site analysis of organic pollutants in river and ground water systems | |
WO2004083848A1 (en) | Gas chromatograph with fast btu analysis | |
Swartz | HPLC systems and components introduced at Pittcon 2010: a brief review | |
Mostert et al. | Coupled high-performance liquid chromatography—gas chromatography for the determination of pesticide residues in biological matrices | |
Xu et al. | Analysis of alkylbenzene samples by comprehensive capillary liquid chromatography× capillary gas chromatography | |
US20040149011A1 (en) | Valve-less on-line process gas chromatograph |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: WATERS TECHNOLOGIES CORPORATION Free format text: FORMER OWNER: WATERS INVESTMENTS LIMITED Effective date: 20090612 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20090612 Address after: Massachusetts Applicant after: Waters Technologies Corporation Address before: The United States Delaware Applicant before: Waters Investments Ltd. |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1130723 Country of ref document: HK |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1130723 Country of ref document: HK |