JP2015517310A5 - - Google Patents
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- JP2015517310A5 JP2015517310A5 JP2015511775A JP2015511775A JP2015517310A5 JP 2015517310 A5 JP2015517310 A5 JP 2015517310A5 JP 2015511775 A JP2015511775 A JP 2015511775A JP 2015511775 A JP2015511775 A JP 2015511775A JP 2015517310 A5 JP2015517310 A5 JP 2015517310A5
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- polypeptide
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- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 17
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 10
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 10
- 150000001413 amino acids Chemical group 0.000 claims 9
- 229940024606 amino acid Drugs 0.000 claims 8
- 230000000813 microbial effect Effects 0.000 claims 8
- QPRQEDXDYOZYLA-UHFFFAOYSA-N 2-methylbutan-1-ol Chemical compound CCC(C)CO QPRQEDXDYOZYLA-UHFFFAOYSA-N 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 6
- WTLNOANVTIKPEE-UHFFFAOYSA-N 2-acetyloxypropanoic acid Chemical compound OC(=O)C(C)OC(C)=O WTLNOANVTIKPEE-UHFFFAOYSA-N 0.000 claims 4
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- CTMXBOCTJPQVDZ-UHFFFAOYSA-N 2,2-dihydroxy-3-methylbutanoic acid Chemical compound CC(C)C(O)(O)C(O)=O CTMXBOCTJPQVDZ-UHFFFAOYSA-N 0.000 claims 2
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102220313176 rs749459367 Human genes 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims 1
- JTEYKUFKXGDTEU-UHFFFAOYSA-N 2,3-dihydroxy-3-methylbutanoic acid Chemical compound CC(C)(O)C(O)C(O)=O JTEYKUFKXGDTEU-UHFFFAOYSA-N 0.000 claims 1
- KSAIICDEQGEQBK-UHFFFAOYSA-N 3-hydroxy-2,2-dimethylbutanedioic acid Chemical compound OC(=O)C(C)(C)C(O)C(O)=O KSAIICDEQGEQBK-UHFFFAOYSA-N 0.000 claims 1
- 239000005695 Ammonium acetate Substances 0.000 claims 1
- 102220522807 Brain acid soluble protein 1_S86A_mutation Human genes 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 101150096607 Fosl2 gene Proteins 0.000 claims 1
- 102220630801 Interferon alpha-8_A68E_mutation Human genes 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 102220480756 Nucleotide pyrophosphatase_I13L_mutation Human genes 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 102220469877 Protein argonaute-3_F50A_mutation Human genes 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 102200163308 c.158T>C Human genes 0.000 claims 1
- 102200108209 c.205G>A Human genes 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000000446 fuel Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229960003136 leucine Drugs 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 229940014662 pantothenate Drugs 0.000 claims 1
- 235000019161 pantothenic acid Nutrition 0.000 claims 1
- 239000011713 pantothenic acid Substances 0.000 claims 1
- 102200071829 rs34620296 Human genes 0.000 claims 1
- 102200140931 rs794727301 Human genes 0.000 claims 1
- 102220099823 rs878853788 Human genes 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 229960004295 valine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645832P | 2012-05-11 | 2012-05-11 | |
| US61/645,832 | 2012-05-11 | ||
| US201361787480P | 2013-03-15 | 2013-03-15 | |
| US61/787,480 | 2013-03-15 | ||
| PCT/US2013/040627 WO2013176909A2 (en) | 2012-05-11 | 2013-05-10 | Ketol-acid reductoisomerase enzymes and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517310A JP2015517310A (ja) | 2015-06-22 |
| JP2015517310A5 true JP2015517310A5 (cg-RX-API-DMAC7.html) | 2016-06-23 |
| JP6321631B2 JP6321631B2 (ja) | 2018-05-09 |
Family
ID=48877508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511775A Active JP6321631B2 (ja) | 2012-05-11 | 2013-05-10 | ケトール酸レダクトイソメラーゼ酵素及び使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9169467B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2847326A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6321631B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20150014953A (cg-RX-API-DMAC7.html) |
| CN (1) | CN104619835B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2013266727A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014028153A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2873109A1 (cg-RX-API-DMAC7.html) |
| MX (2) | MX2014013446A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ701099A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013176909A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201407713B (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| EP2543721A1 (en) | 2007-04-18 | 2013-01-09 | Butamax (TM) Advanced Biofuels LLC | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| AU2009296224B2 (en) | 2008-09-29 | 2015-02-12 | Butamax(Tm) Advanced Biofuels Llc | Increased heterologous Fe-S enzyme actiivty in yeast |
| MX2012007583A (es) | 2009-12-29 | 2012-07-30 | Butamax Tm Advanced Biofuels | Alcohol deshidrogenasas (adh) utiles para la produccion fermentativa de alcoholes alquilicos de cadena corta. |
| CA2788842C (en) | 2010-02-17 | 2019-03-19 | Butamax(Tm) Advanced Biofuels Llc | Improving activity of fe-s cluster requiring proteins |
| CN103080298A (zh) | 2010-09-07 | 2013-05-01 | 布特马斯先进生物燃料有限责任公司 | 整合编码催化丙酮酸至乙酰乳酸的转化的多肽的多核苷酸 |
| AU2012230737B2 (en) | 2011-03-24 | 2017-02-23 | Butamax (Tm) Advanced Biofuels Llc | Host cells and methods for production of isobutanol |
| KR20140099224A (ko) | 2011-07-28 | 2014-08-11 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 케토-아이소발레레이트 데카르복실라제 효소 및 이의 이용 방법 |
| EP2798072A2 (en) | 2011-12-30 | 2014-11-05 | Butamax Advanced Biofuels LLC | Fermentative production of alcohols |
| CN104284981A (zh) | 2012-03-23 | 2015-01-14 | 布特马斯先进生物燃料有限责任公司 | 在针对产丁醇生物的培养基中补充乙酸盐 |
| CN104619835B (zh) | 2012-05-11 | 2018-06-19 | 布特马斯先进生物燃料有限责任公司 | 酮醇酸还原异构酶及其使用方法 |
| US9593349B2 (en) | 2012-08-22 | 2017-03-14 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
| US9840724B2 (en) | 2012-09-21 | 2017-12-12 | Butamax Advanced Biofuels Llc | Production of renewable hydrocarbon compositions |
| CA2886157A1 (en) | 2012-09-26 | 2014-04-03 | Butamax Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| US9650624B2 (en) | 2012-12-28 | 2017-05-16 | Butamax Advanced Biofuels Llc | DHAD variants for butanol production |
| CA2905912A1 (en) | 2013-03-14 | 2014-10-02 | E. I. Du Pont De Nemours And Company | Glycerol 3- phosphate dehydrogenase for butanol production |
| US9580705B2 (en) | 2013-03-15 | 2017-02-28 | Butamax Advanced Biofuels Llc | DHAD variants and methods of screening |
| US9771602B2 (en) | 2013-03-15 | 2017-09-26 | Butamax Advanced Biofuels Llc | Competitive growth and/or production advantage for butanologen microorganism |
| CA2957920A1 (en) | 2014-08-11 | 2016-02-18 | Butamax Advanced Biofuels Llc | Yeast preparations and methods of making the same |
| CN110177801B (zh) | 2016-11-09 | 2024-02-23 | 丹尼斯科美国公司 | 具有改善的醇生产的酵母 |
| CN108728477B (zh) * | 2017-04-24 | 2022-02-22 | 华东理工大学 | 一种高效的转座突变系统及构建方法 |
| KR101960501B1 (ko) * | 2017-09-15 | 2019-03-21 | 고려대학교 산학협력단 | Ｎａｄｈ 친화적인 신규 케톨산 리덕토아이소머라제 |
| US11308274B2 (en) | 2019-05-17 | 2022-04-19 | International Business Machines Corporation | Word grouping using a plurality of models |
| CN113278568B (zh) * | 2020-05-27 | 2022-10-21 | 安徽华恒生物科技股份有限公司 | 生产l-缬氨酸的重组大肠杆菌及其应用 |
| EP4674950A1 (en) * | 2023-03-30 | 2026-01-07 | Anhui Huaheng Biotechnology Co., Ltd. | Recombinant microorganism for producing pantoic acid and use thereof |
| CN117417949B (zh) * | 2023-10-19 | 2024-12-20 | 云南农业大学 | 雪胆细胞色素氧化酶HcCYP81Q58转基因酵母工程菌及其应用 |
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| RU2012138943A (ru) | 2010-02-12 | 2014-03-20 | Джево, Инк. | Дрожжевые микроорганизмы с пониженным накоплением побочных продуктов для улучшенного производства топлив, химикатов и аминокислот |
| CA2788842C (en) | 2010-02-17 | 2019-03-19 | Butamax(Tm) Advanced Biofuels Llc | Improving activity of fe-s cluster requiring proteins |
| CA2801576A1 (en) | 2010-06-17 | 2011-12-22 | Butamax(Tm) Advanced Biofuels Llc | Yeast production culture for the production of butanol |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| CN103080298A (zh) * | 2010-09-07 | 2013-05-01 | 布特马斯先进生物燃料有限责任公司 | 整合编码催化丙酮酸至乙酰乳酸的转化的多肽的多核苷酸 |
| AU2012230737B2 (en) | 2011-03-24 | 2017-02-23 | Butamax (Tm) Advanced Biofuels Llc | Host cells and methods for production of isobutanol |
| US20120258873A1 (en) | 2011-04-06 | 2012-10-11 | Butamax(Tm) Advanced Biofuels Llc | Reduction of 2,3-dihydroxy-2-methyl butyrate (dhmb) in butanol production |
| US20130035515A1 (en) | 2011-06-17 | 2013-02-07 | Butamax(Tm) Advanced Biofuels Llc | Lignocellulosic hydrolysates as feedstocks for isobutanol fermentation |
| KR20140099224A (ko) | 2011-07-28 | 2014-08-11 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 케토-아이소발레레이트 데카르복실라제 효소 및 이의 이용 방법 |
| EP2798072A2 (en) | 2011-12-30 | 2014-11-05 | Butamax Advanced Biofuels LLC | Fermentative production of alcohols |
| BR112014016005A8 (pt) | 2011-12-30 | 2017-07-04 | Butamax Advanced Biofuels Llc | alterações genéticas para produção de butanol |
| CN104284981A (zh) | 2012-03-23 | 2015-01-14 | 布特马斯先进生物燃料有限责任公司 | 在针对产丁醇生物的培养基中补充乙酸盐 |
| CN104619835B (zh) | 2012-05-11 | 2018-06-19 | 布特马斯先进生物燃料有限责任公司 | 酮醇酸还原异构酶及其使用方法 |
| CA2886157A1 (en) | 2012-09-26 | 2014-04-03 | Butamax Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| US9650624B2 (en) | 2012-12-28 | 2017-05-16 | Butamax Advanced Biofuels Llc | DHAD variants for butanol production |
| US20140186911A1 (en) | 2012-12-28 | 2014-07-03 | Butamax Advanced Biofuels Llc | Recombinant host cells and methods for producing butanol |
| CA2905912A1 (en) | 2013-03-14 | 2014-10-02 | E. I. Du Pont De Nemours And Company | Glycerol 3- phosphate dehydrogenase for butanol production |
| US9580705B2 (en) | 2013-03-15 | 2017-02-28 | Butamax Advanced Biofuels Llc | DHAD variants and methods of screening |
-
2013
- 2013-05-10 CN CN201380036539.6A patent/CN104619835B/zh not_active Expired - Fee Related
- 2013-05-10 NZ NZ701099A patent/NZ701099A/en not_active IP Right Cessation
- 2013-05-10 AU AU2013266727A patent/AU2013266727A1/en not_active Abandoned
- 2013-05-10 JP JP2015511775A patent/JP6321631B2/ja active Active
- 2013-05-10 WO PCT/US2013/040627 patent/WO2013176909A2/en not_active Ceased
- 2013-05-10 BR BR112014028153-0A patent/BR112014028153A2/pt not_active Application Discontinuation
- 2013-05-10 EP EP13742293.7A patent/EP2847326A2/en not_active Withdrawn
- 2013-05-10 US US13/891,963 patent/US9169467B2/en active Active
- 2013-05-10 MX MX2014013446A patent/MX2014013446A/es unknown
- 2013-05-10 MX MX2018004620A patent/MX370134B/es unknown
- 2013-05-10 KR KR1020147034485A patent/KR20150014953A/ko not_active Withdrawn
- 2013-05-10 CA CA2873109A patent/CA2873109A1/en not_active Abandoned
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2014
- 2014-10-23 ZA ZA2014/07713A patent/ZA201407713B/en unknown
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2015
- 2015-09-14 US US14/853,108 patent/US9388392B2/en active Active
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