JP2015515478A - Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法 - Google Patents

Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法 Download PDF

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Publication number
JP2015515478A
JP2015515478A JP2015504748A JP2015504748A JP2015515478A JP 2015515478 A JP2015515478 A JP 2015515478A JP 2015504748 A JP2015504748 A JP 2015504748A JP 2015504748 A JP2015504748 A JP 2015504748A JP 2015515478 A JP2015515478 A JP 2015515478A
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cancer
aliphatic
compound
compounds
agent
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JP2015515478A5 (enExample
Inventor
ジョン ロバート ポラード，
ジョン ロバート ポラード，
フィリップ マイケル リーパー，
フィリップ マイケル リーパー，
モハメド アスマル，
モハメド アスマル，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of JP2015515478A5 publication Critical patent/JP2015515478A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2015504748A 2012-04-05 2013-04-05 Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法 Withdrawn JP2015515478A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261620717P 2012-04-05 2012-04-05
US61/620,717 2012-04-05
PCT/US2013/035466 WO2013152298A1 (en) 2012-04-05 2013-04-05 Compounds useful as inhibitors of atr kinase and combination therapies thereof

Related Child Applications (1)

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JP2017143696A Division JP6770490B2 (ja) 2012-04-05 2017-07-25 Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法

Publications (2)

Publication Number Publication Date
JP2015515478A true JP2015515478A (ja) 2015-05-28
JP2015515478A5 JP2015515478A5 (enExample) 2016-06-02

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JP2015504748A Withdrawn JP2015515478A (ja) 2012-04-05 2013-04-05 Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法
JP2017143696A Expired - Fee Related JP6770490B2 (ja) 2012-04-05 2017-07-25 Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法
JP2018110161A Withdrawn JP2018150379A (ja) 2012-04-05 2018-06-08 Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法
JP2020143455A Withdrawn JP2020196748A (ja) 2012-04-05 2020-08-27 Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法

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JP2017143696A Expired - Fee Related JP6770490B2 (ja) 2012-04-05 2017-07-25 Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法
JP2018110161A Withdrawn JP2018150379A (ja) 2012-04-05 2018-06-08 Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法
JP2020143455A Withdrawn JP2020196748A (ja) 2012-04-05 2020-08-27 Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法

Country Status (22)

Country Link
US (4) US20140044802A1 (enExample)
EP (2) EP3311816A1 (enExample)
JP (4) JP2015515478A (enExample)
CN (2) CN104582795B (enExample)
AU (2) AU2013243291B2 (enExample)
CA (1) CA2869309C (enExample)
DK (1) DK2833973T3 (enExample)
ES (1) ES2654670T3 (enExample)
HK (1) HK1205028A1 (enExample)
HR (1) HRP20171915T1 (enExample)
HU (1) HUE035253T2 (enExample)
IN (1) IN2014KN02410A (enExample)
LT (1) LT2833973T (enExample)
MX (1) MX358818B (enExample)
NO (1) NO2885404T3 (enExample)
NZ (3) NZ720511A (enExample)
PL (1) PL2833973T3 (enExample)
PT (1) PT2833973T (enExample)
RS (1) RS56673B1 (enExample)
SI (1) SI2833973T1 (enExample)
TW (2) TWI644672B (enExample)
WO (1) WO2013152298A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019501203A (ja) * 2016-01-08 2019-01-17 ザ インスティチュート オブ キャンサー リサーチ，ロイヤル キャンサー ホスピタル 癌を治療する方法における使用のための毛細血管拡張性運動失調症の変異したＲａｄ３関連タンパク質キナーゼ（ＡＴＲ）の阻害剤

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EP2376485B1 (en) 2008-12-19 2017-12-06 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
WO2011143425A2 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US9630956B2 (en) 2010-05-12 2017-04-25 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
BR112014007721B1 (pt) 2011-09-30 2022-11-01 Vertex Pharmaceuticals Incorporated Processos para preparar compostos úteis como inibidores de atr quinase
KR102056586B1 (ko) 2011-09-30 2019-12-18 버텍스 파마슈티칼스 인코포레이티드 Ａｔｒ 억제제를 이용한 췌장암 및 비소세포 폐암의 치료
AU2013243291B2 (en) 2012-04-05 2018-02-01 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase and combination therapies thereof
US8999632B2 (en) 2012-10-04 2015-04-07 Vertex Pharmaceuticals Incorporated Method for measuring ATR inhibition mediated increases in DNA damage
LT3486245T (lt) 2012-12-07 2021-08-25 Vertex Pharmaceuticals Incorporated 2-amino-n-(piperidin-1-il-piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamidas, kaip atr kinazės inhibitorius
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JP2019501203A (ja) * 2016-01-08 2019-01-17 ザ インスティチュート オブ キャンサー リサーチ，ロイヤル キャンサー ホスピタル 癌を治療する方法における使用のための毛細血管拡張性運動失調症の変異したＲａｄ３関連タンパク質キナーゼ（ＡＴＲ）の阻害剤
JP2022050493A (ja) * 2016-01-08 2022-03-30 ザ インスティチュート オブ キャンサー リサーチ，ロイヤル キャンサー ホスピタル 癌を治療する方法における使用のための毛細血管拡張性運動失調症の変異したＲａｄ３関連タンパク質キナーゼ（ＡＴＲ）の阻害剤
JP7560026B2 (ja) 2016-01-08 2024-10-02 ザ インスティチュート オブ キャンサー リサーチ，ロイヤル キャンサー ホスピタル 癌を治療する方法における使用のための毛細血管拡張性運動失調症の変異したＲａｄ３関連タンパク質キナーゼ（ＡＴＲ）の阻害剤
US12233060B2 (en) 2016-01-08 2025-02-25 The Institute Of Cancer Research: Royal Cancer Hospital Inhibitors of Ataxia-Telangiectasia Mutated and Rad3-related protein kinase (ATR) for use in methods of treating cancer

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