JP2015514128A5 - - Google Patents
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- JP2015514128A5 JP2015514128A5 JP2015505016A JP2015505016A JP2015514128A5 JP 2015514128 A5 JP2015514128 A5 JP 2015514128A5 JP 2015505016 A JP2015505016 A JP 2015505016A JP 2015505016 A JP2015505016 A JP 2015505016A JP 2015514128 A5 JP2015514128 A5 JP 2015514128A5
- Authority
- JP
- Japan
- Prior art keywords
- monomer
- lysenin
- pore
- variant
- substitution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102220076678 rs146651027 Human genes 0.000 claims 40
- 102220483642 Nuclear distribution protein nudE homolog 1_E84Q_mutation Human genes 0.000 claims 39
- 102200075749 rs397514044 Human genes 0.000 claims 38
- 102200101908 rs72554358 Human genes 0.000 claims 38
- 239000000178 monomer Substances 0.000 claims 26
- 101710174798 Lysenin Proteins 0.000 claims 13
- 239000011148 porous material Substances 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 6
- 239000012491 analyte Substances 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 102220530307 Calcium-transporting ATPase type 2C member 1_E50S_mutation Human genes 0.000 claims 2
- 102220591546 Cysteine-rich hydrophobic domain-containing protein 1_E76S_mutation Human genes 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 102220539335 Prostaglandin D2 receptor 2_E71S_mutation Human genes 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 102220493937 26S proteasome complex subunit SEM1_E167A_mutation Human genes 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 102220528081 M1-specific T cell receptor alpha chain_H58S_mutation Human genes 0.000 claims 1
- 102220520572 Osteoclast-stimulating factor 1_N48S_mutation Human genes 0.000 claims 1
- 102220640643 Polyadenylate-binding protein 1_E84S_mutation Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 102220503470 Superoxide dismutase [Cu-Zn]_H81S_mutation Human genes 0.000 claims 1
- 102220566198 Survival motor neuron protein_F70S_mutation Human genes 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- -1 aromatic amino acids Chemical class 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 125000003636 chemical group Chemical group 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 102220198313 rs1057519973 Human genes 0.000 claims 1
- 102200070587 rs763615602 Human genes 0.000 claims 1
- 102220072337 rs794728990 Human genes 0.000 claims 1
- 230000003335 steric effect Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622174P | 2012-04-10 | 2012-04-10 | |
| US61/622,174 | 2012-04-10 | ||
| PCT/GB2013/050667 WO2013153359A1 (en) | 2012-04-10 | 2013-03-15 | Mutant lysenin pores |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017250647A Division JP2018075025A (ja) | 2012-04-10 | 2017-12-27 | 変異体ライセニンポア |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514128A JP2015514128A (ja) | 2015-05-18 |
| JP2015514128A5 true JP2015514128A5 (https=) | 2016-04-28 |
| JP6271505B2 JP6271505B2 (ja) | 2018-01-31 |
Family
ID=47915292
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505016A Active JP6271505B2 (ja) | 2012-04-10 | 2013-03-15 | 変異体ライセニンポア |
| JP2017250647A Pending JP2018075025A (ja) | 2012-04-10 | 2017-12-27 | 変異体ライセニンポア |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017250647A Pending JP2018075025A (ja) | 2012-04-10 | 2017-12-27 | 変異体ライセニンポア |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9777049B2 (https=) |
| EP (2) | EP2836506B1 (https=) |
| JP (2) | JP6271505B2 (https=) |
| KR (1) | KR102083695B1 (https=) |
| CN (2) | CN104350067A (https=) |
| AU (1) | AU2013246702B2 (https=) |
| BR (1) | BR112014025157B1 (https=) |
| CA (1) | CA2869546C (https=) |
| WO (1) | WO2013153359A1 (https=) |
Families Citing this family (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110121840A1 (en) | 2007-02-20 | 2011-05-26 | Gurdial Singh Sanghera | Lipid Bilayer Sensor System |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| EP2391732B1 (en) | 2009-01-30 | 2015-05-27 | Oxford Nanopore Technologies Limited | Methods using adaptors for nucleic acid constructs in transmembrane sequencing |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| KR101939420B1 (ko) | 2011-02-11 | 2019-01-16 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 세공 |
| EP4737389A2 (en) | 2011-05-27 | 2026-05-06 | Oxford Nanopore Technologies PLC | Coupling method |
| JP6298404B2 (ja) | 2011-07-25 | 2018-03-20 | オックスフォード ナノポール テクノロジーズ リミテッド | 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法 |
| JP6457811B2 (ja) | 2011-09-23 | 2019-01-23 | オックスフォード ナノポール テクノロジーズ リミテッド | ポリマー単位を含むポリマーの解析 |
| CN104039979B (zh) | 2011-10-21 | 2016-08-24 | 牛津纳米孔技术公司 | 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法 |
| AU2012360244B2 (en) | 2011-12-29 | 2018-08-23 | Oxford Nanopore Technologies Limited | Enzyme method |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| IN2014DN06796A (https=) | 2012-02-15 | 2015-05-22 | Oxford Nanopore Tech Ltd | |
| CN104321441B (zh) | 2012-02-16 | 2016-10-19 | 牛津楠路珀尔科技有限公司 | 聚合物的测量的分析 |
| KR102083695B1 (ko) | 2012-04-10 | 2020-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 리세닌 기공 |
| JP6429773B2 (ja) | 2012-07-19 | 2018-11-28 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素構築物 |
| CA2879261C (en) | 2012-07-19 | 2022-12-06 | Oxford Nanopore Technologies Limited | Modified helicases |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| US9551023B2 (en) | 2012-09-14 | 2017-01-24 | Oxford Nanopore Technologies Ltd. | Sample preparation method |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| WO2014072703A1 (en) | 2012-11-06 | 2014-05-15 | Oxford Nanopore Technologies Limited | Quadruplex method |
| GB201222928D0 (en) | 2012-12-19 | 2013-01-30 | Oxford Nanopore Tech Ltd | Analysis of a polynucleotide |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| CA2901545C (en) | 2013-03-08 | 2019-10-08 | Oxford Nanopore Technologies Limited | Use of spacer elements in a nucleic acid to control movement of a helicase |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CN117947149A (zh) | 2013-10-18 | 2024-04-30 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| SI3074534T1 (sl) | 2013-11-26 | 2019-08-30 | Illumina, Inc. | Postopki določanja zaporedja polinukleotidov |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CN111534504B (zh) | 2014-01-22 | 2024-06-21 | 牛津纳米孔科技公开有限公司 | 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法 |
| US10359395B2 (en) | 2014-02-19 | 2019-07-23 | University Of Washington | Nanopore-based analysis of protein characteristics |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| WO2015150786A1 (en) | 2014-04-04 | 2015-10-08 | Oxford Nanopore Technologies Limited | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
| EP3137490B1 (en) | 2014-05-02 | 2021-01-27 | Oxford Nanopore Technologies Limited | Mutant pores |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| ES2846746T3 (es) | 2014-06-03 | 2021-07-29 | Illumina Inc | Composiciones, sistemas y métodos para detectar acontecimientos usando fijaciones ancladas o adyacentes a nanoporos |
| WO2016014822A1 (en) * | 2014-07-25 | 2016-01-28 | Ge Healthcare Uk Limited | Screening and monitoring the progression of type 2 diabetes by the molecular identification of gut flora using fta as a faecal collection device |
| CA2959220A1 (en) | 2014-09-01 | 2016-03-10 | Vib Vzw | Mutant csgg pores |
| EP3204511B1 (en) | 2014-10-07 | 2021-07-28 | Oxford Nanopore Technologies Limited | Mutant pores |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| EP4397972A3 (en) | 2014-10-16 | 2024-10-09 | Oxford Nanopore Technologies PLC | Alignment mapping estimation |
| US10480026B2 (en) | 2014-10-17 | 2019-11-19 | Oxford Nanopore Technologies Ltd. | Method for nanopore RNA characterisation |
| GB201418469D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
| CN112816679B (zh) | 2015-02-05 | 2024-05-28 | 哈佛大学校长及研究员协会 | 一种用于感测分子穿过纳米孔的移位的方法 |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| GB201502810D0 (en) * | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| WO2016166232A1 (en) | 2015-04-14 | 2016-10-20 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| GB201508003D0 (en) | 2015-05-11 | 2015-06-24 | Oxford Nanopore Tech Ltd | Apparatus and methods for measuring an electrical current |
| GB201508669D0 (en) | 2015-05-20 | 2015-07-01 | Oxford Nanopore Tech Ltd | Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown |
| AU2016270887C1 (en) | 2015-06-03 | 2025-01-16 | Illumina, Inc. | Compositions, systems, and methods for sequencing polynucleotides using tethers anchored to polymerases adjacent to nanopores |
| AU2016369071B2 (en) | 2015-12-08 | 2022-05-19 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Modified nanopores, compositions comprising the same, and uses thereof |
| JP6579948B2 (ja) * | 2015-12-24 | 2019-09-25 | 株式会社日立ハイテクノロジーズ | 生体ポリマを分析するための測定試薬及び分析デバイス |
| CN116200476A (zh) * | 2016-03-02 | 2023-06-02 | 牛津纳米孔科技公开有限公司 | 靶分析物测定方法、突变CsgG单体及其构筑体、及聚核苷酸和寡聚孔 |
| EP4397970A3 (en) * | 2016-04-06 | 2024-10-09 | Oxford Nanopore Technologies PLC | Mutant pore |
| CN109196116B (zh) | 2016-05-25 | 2022-09-27 | 牛津纳米孔科技公开有限公司 | 一种表征靶多核苷酸的方法 |
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| GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
| GB201616590D0 (en) | 2016-09-29 | 2016-11-16 | Oxford Nanopore Technologies Limited | Method |
| GB201617886D0 (en) | 2016-10-21 | 2016-12-07 | Oxford Nanopore Technologies Limited | Method |
| GB201619930D0 (en) | 2016-11-24 | 2017-01-11 | Oxford Nanopore Tech | Apparatus and methods for controlling insertion of a membrane channel into a membrane |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
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| WO2018152050A1 (en) | 2017-02-14 | 2018-08-23 | Axbio Inc. | Apparatus and methods for continuous diagnostics of macromolecules |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201707138D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Machine learning analysis of nanopore measurements |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| CN117106038B (zh) | 2017-06-30 | 2025-12-09 | 弗拉芒区生物技术研究所 | 新颖蛋白孔 |
| GB2568895B (en) | 2017-11-29 | 2021-10-27 | Oxford Nanopore Tech Ltd | Microfluidic device |
| GB2569630B (en) | 2017-12-21 | 2022-10-12 | Sharp Life Science Eu Ltd | Droplet Interfaces in Electro-wetting Devices |
| GB201801768D0 (en) | 2018-02-02 | 2018-03-21 | Oxford Nanopore Tech Ltd | Synthesis method |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| KR102796115B1 (ko) | 2018-05-24 | 2025-04-14 | 옥스포드 나노포어 테크놀로지즈 피엘씨 | 전기 습윤 소자 내 액적 계면 |
| GB201808556D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| GB2574048B (en) | 2018-05-24 | 2021-06-16 | Oxford Nanopore Tech Ltd | Nanopore sensor component with electrostatic discharge protection |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| GB201814369D0 (en) | 2018-09-04 | 2018-10-17 | Oxford Nanopore Tech Ltd | Method for determining a polymersequence |
| CA3118808A1 (en) | 2018-11-08 | 2020-05-14 | Oxford Nanopore Technologies Limited | Pore |
| GB201818216D0 (en) | 2018-11-08 | 2018-12-26 | Oxford Nanopore Tech Ltd | Pore |
| CN113164954B (zh) | 2018-11-28 | 2023-10-20 | 牛津纳米孔科技公开有限公司 | 感测系统和操作方法 |
| GB201819378D0 (en) | 2018-11-28 | 2019-01-09 | Oxford Nanopore Tech Ltd | Analysis of nanopore signal using a machine-learning technique |
| GB201821155D0 (en) | 2018-12-21 | 2019-02-06 | Oxford Nanopore Tech Ltd | Method |
| JP7492200B2 (ja) | 2019-03-12 | 2024-05-29 | オックスフォード ナノポール テクノロジーズ ピーエルシー | ナノ細孔センシングデバイスと操作方法およびその成形方法 |
| GB2580988B (en) | 2019-03-19 | 2022-04-13 | Oxford Nanopore Tech Ltd | Current measurement apparatus, molecular entity sensing apparatus, method of measuring a current, method of sensing a molecular entity |
| CN110093399A (zh) * | 2019-04-22 | 2019-08-06 | 武汉大学 | 一种利用二磷酸尿嘧啶脱氧核苷酸检测核酸中腺嘌呤n6位发生甲基化修饰的方法 |
| GB201907243D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Sensing interactions between molecular entities and nanapores |
| GB201907246D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| GB201907244D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| GB201915480D0 (en) | 2019-10-25 | 2019-12-11 | Oxford Nanopore Tech Ltd | Improved nanopore sensing device, components and method of manufacture |
| GB201917060D0 (en) | 2019-11-22 | 2020-01-08 | Oxford Nanopore Tech Ltd | Method |
| CN114761799A (zh) | 2019-12-02 | 2022-07-15 | 牛津纳米孔科技公开有限公司 | 使用纳米孔表征靶多肽的方法 |
| GB201917742D0 (en) | 2019-12-04 | 2020-01-15 | Oxford Nanopore Tech Ltd | Method |
| GB202004944D0 (en) | 2020-04-03 | 2020-05-20 | King S College London | Method |
| GB202016874D0 (en) | 2020-10-23 | 2020-12-09 | Oxford Nanopore Tech Ltd | Nanopore support structure and manufacture thereof |
| JP2023530155A (ja) | 2020-06-18 | 2023-07-13 | オックスフォード ナノポール テクノロジーズ ピーエルシー | ナノポアを通って移動するポリヌクレオチドを特徴付ける方法 |
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| GB202009349D0 (en) | 2020-06-18 | 2020-08-05 | Oxford Nanopore Tech Ltd | Method |
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| US12535457B2 (en) | 2020-07-22 | 2026-01-27 | Oxford Nanopore Technologies Plc | Solid state nanopore formation |
| WO2022069022A1 (en) | 2020-09-29 | 2022-04-07 | Ecole Polytechnique Federale De Lausanne (Epfl) | Systems and methods for digital information decoding and data storage in hybrid macromolecules |
| GB202015993D0 (en) | 2020-10-08 | 2020-11-25 | Oxford Nanopore Tech Ltd | Method |
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| GB202107192D0 (en) | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
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| GB202107354D0 (en) | 2021-05-24 | 2021-07-07 | Oxford Nanopore Tech Ltd | Method |
| GB2610380A (en) | 2021-08-23 | 2023-03-08 | Cambridge Entpr Ltd | Nucleic acid detection |
| GB202112235D0 (en) | 2021-08-26 | 2021-10-13 | Oxford Nanopore Tech Ltd | Nanopore |
| US20230090867A1 (en) | 2021-09-22 | 2023-03-23 | Illumina, Inc. | Sequencing polynucleotides using nanopores |
| GB202113935D0 (en) | 2021-09-29 | 2021-11-10 | Cambridge Entpr Ltd | Nucleic acid characterisation |
| WO2023081031A1 (en) | 2021-11-08 | 2023-05-11 | Illumina, Inc. | Identifying nucleotides using changes in impedance between electrodes |
| WO2023094806A1 (en) | 2021-11-29 | 2023-06-01 | Oxford Nanopore Technologies Plc | Nanopore measurement signal analysis |
| GB202118906D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| GB202118908D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
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| WO2015051378A1 (en) | 2013-10-04 | 2015-04-09 | University Of Washington Through Its Center For Commercialization | Systems and methods for nanopore-based analysis of nucleic acids |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CN117947149A (zh) | 2013-10-18 | 2024-04-30 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| SI3074534T1 (sl) | 2013-11-26 | 2019-08-30 | Illumina, Inc. | Postopki določanja zaporedja polinukleotidov |
| WO2015097289A1 (en) | 2013-12-24 | 2015-07-02 | Vib Vzw | Secretion and functional display of chimeric polypeptides |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CN111534504B (zh) | 2014-01-22 | 2024-06-21 | 牛津纳米孔科技公开有限公司 | 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法 |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| WO2015150786A1 (en) | 2014-04-04 | 2015-10-08 | Oxford Nanopore Technologies Limited | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
| EP3137490B1 (en) | 2014-05-02 | 2021-01-27 | Oxford Nanopore Technologies Limited | Mutant pores |
| FR3023394B1 (fr) | 2014-07-02 | 2017-12-29 | Adn Access Data Networks | Dispositif permettant de faciliter l'enseignement de la langue amharique et d'en normaliser l'ecriture |
| CA2959220A1 (en) | 2014-09-01 | 2016-03-10 | Vib Vzw | Mutant csgg pores |
| EP3204511B1 (en) | 2014-10-07 | 2021-07-28 | Oxford Nanopore Technologies Limited | Mutant pores |
| US10480026B2 (en) | 2014-10-17 | 2019-11-19 | Oxford Nanopore Technologies Ltd. | Method for nanopore RNA characterisation |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| WO2016166232A1 (en) | 2015-04-14 | 2016-10-20 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| AU2016369071B2 (en) | 2015-12-08 | 2022-05-19 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Modified nanopores, compositions comprising the same, and uses thereof |
| CN116200476A (zh) | 2016-03-02 | 2023-06-02 | 牛津纳米孔科技公开有限公司 | 靶分析物测定方法、突变CsgG单体及其构筑体、及聚核苷酸和寡聚孔 |
| EP4397970A3 (en) | 2016-04-06 | 2024-10-09 | Oxford Nanopore Technologies PLC | Mutant pore |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| CN117106038B (zh) | 2017-06-30 | 2025-12-09 | 弗拉芒区生物技术研究所 | 新颖蛋白孔 |
| CA3118808A1 (en) | 2018-11-08 | 2020-05-14 | Oxford Nanopore Technologies Limited | Pore |
-
2013
- 2013-03-15 KR KR1020147031143A patent/KR102083695B1/ko active Active
- 2013-03-15 EP EP13711464.1A patent/EP2836506B1/en active Active
- 2013-03-15 BR BR112014025157-6A patent/BR112014025157B1/pt active IP Right Grant
- 2013-03-15 US US14/391,660 patent/US9777049B2/en active Active
- 2013-03-15 EP EP17157441.1A patent/EP3192804B1/en active Active
- 2013-03-15 CA CA2869546A patent/CA2869546C/en active Active
- 2013-03-15 CN CN201380030527.2A patent/CN104350067A/zh active Pending
- 2013-03-15 WO PCT/GB2013/050667 patent/WO2013153359A1/en not_active Ceased
- 2013-03-15 AU AU2013246702A patent/AU2013246702B2/en active Active
- 2013-03-15 CN CN202011579254.5A patent/CN112646019B/zh active Active
- 2013-03-15 JP JP2015505016A patent/JP6271505B2/ja active Active
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2017
- 2017-08-31 US US15/692,498 patent/US10882889B2/en active Active
- 2017-12-27 JP JP2017250647A patent/JP2018075025A/ja active Pending
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2020
- 2020-12-01 US US17/108,536 patent/US11845780B2/en active Active
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2023
- 2023-11-08 US US18/504,590 patent/US12258375B2/en active Active
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