JP2014534266A5 - - Google Patents
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- Publication number
- JP2014534266A5 JP2014534266A5 JP2014543634A JP2014543634A JP2014534266A5 JP 2014534266 A5 JP2014534266 A5 JP 2014534266A5 JP 2014543634 A JP2014543634 A JP 2014543634A JP 2014543634 A JP2014543634 A JP 2014543634A JP 2014534266 A5 JP2014534266 A5 JP 2014534266A5
- Authority
- JP
- Japan
- Prior art keywords
- tsgl
- polypeptide
- molecule
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 4
- 102000002090 Fibronectin type III Human genes 0.000 claims 2
- 108050009401 Fibronectin type III Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102100026061 Mannan-binding lectin serine protease 1 Human genes 0.000 claims 2
- 101710161855 Methionine aminopeptidase 1 Proteins 0.000 claims 2
- 101710103983 Modulator of apoptosis 1 Proteins 0.000 claims 2
- 102000008212 P-Selectin Human genes 0.000 claims 2
- 108010035766 P-Selectin Proteins 0.000 claims 2
- 102000003800 Selectins Human genes 0.000 claims 2
- 108090000184 Selectins Proteins 0.000 claims 2
- NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 125000001493 tyrosinyl group Chemical class [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161564275P | 2011-11-28 | 2011-11-28 | |
| US61/564,275 | 2011-11-28 | ||
| PCT/US2012/066910 WO2013082200A1 (en) | 2011-11-28 | 2012-11-28 | Novel enhanced selectin antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014534266A JP2014534266A (ja) | 2014-12-18 |
| JP2014534266A5 true JP2014534266A5 (https=) | 2015-12-24 |
| JP6181066B2 JP6181066B2 (ja) | 2017-08-16 |
Family
ID=48467086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543634A Active JP6181066B2 (ja) | 2011-11-28 | 2012-11-28 | 新規な増強型セレクチンアンタゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8889628B2 (https=) |
| EP (1) | EP2785843B1 (https=) |
| JP (1) | JP6181066B2 (https=) |
| CA (1) | CA2857019C (https=) |
| WO (1) | WO2013082200A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10253071B2 (en) | 2013-06-03 | 2019-04-09 | Beth Israel Deaconess Medical Center, Inc. | Selectin inhibitors, composition, and uses related thereto |
| EP3568159A4 (en) | 2017-01-11 | 2020-08-05 | Bristol-Myers Squibb Company | PSGL-1 ANTAGONISTS AND THEIR USES |
| KR102715540B1 (ko) | 2017-03-14 | 2024-10-08 | 파이브 프라임 테라퓨틱스, 인크. | 산성 pH에서 VISTA에 결합하는 항체 |
| US12479904B2 (en) | 2017-12-29 | 2025-11-25 | Gray D Shaw | Methods of treating cytokine release syndrome by administering a molecule comprising a soluble tandem selectin glycoprotein ligand |
| BR112020019083A2 (pt) | 2018-03-21 | 2020-12-29 | Five Prime Therapeutics, Inc. | Anticorpos, ácido nucleico, composições, célula e métodos para preparar um anticorpo, para tratar câncer, para tratar uma doença infecciosa, para tratar uma inflamação, para a identificação de um anticorpo, para melhorar a eficácia antitumoral de um anticorpo, para melhorar a farmacocinética de um anticorpo, para selecionar um anticorpo, para melhorar a eficácia de anticorpos, para isolar anticorpos, para detectar vista em uma amostra e para tratar câncer |
| BR112021000303A2 (pt) | 2018-07-11 | 2021-04-13 | Five Prime Therapeutics, Inc. | Anticorpos que se ligam a vista em ph ácido |
| WO2021183685A2 (en) * | 2020-03-10 | 2021-09-16 | Shaw Gray D | Fusion molecules of psgl-1 or tsgl anionic domains to checkpoint-modulating antibodies and other antibodies |
| EP4404971A1 (en) * | 2021-09-23 | 2024-07-31 | Beth Israel Deaconess Medical Center, Inc. | P-selectin inhibitors and uses thereof |
| WO2026080432A1 (en) * | 2024-10-07 | 2026-04-16 | Beth Israel Deaconess Medical Center, Inc. | Dimeric p-selectin inhibitors and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277975B1 (en) | 1992-10-23 | 2001-08-21 | Genetics Institute, Inc. | Fusions of P-selectin ligand protein and polynucleotides encoding same |
| JP2002542785A (ja) * | 1999-04-23 | 2002-12-17 | セプティア, インコーポレイテッド | Dsp−10二重特異性mapキナーゼホスファターゼ |
| WO2001075107A2 (en) * | 2000-03-31 | 2001-10-11 | Genetics Institute, Llc. | Use of p-selectin glycoprotein ligand-1 (psgl-1) and fragments thereof for the inhibition of thrombosis |
| US20040086519A1 (en) * | 2000-09-12 | 2004-05-06 | Genetics Institute, Llc | Inhibition of stenosis or restenosis by P-selectin ligand antagonists |
| CA2457400A1 (en) * | 2001-08-03 | 2003-02-20 | Genetics Institute, Llc | Modulation of leukocyte-endothelial interactions following ischemia |
| JP2009510102A (ja) * | 2005-09-29 | 2009-03-12 | ヴァイラル ロジック システムズ テクノロジー コーポレーション | 免疫調節組成物およびその使用 |
| CA2748314C (en) * | 2009-02-03 | 2018-10-02 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
-
2012
- 2012-11-28 CA CA2857019A patent/CA2857019C/en active Active
- 2012-11-28 EP EP12854260.2A patent/EP2785843B1/en active Active
- 2012-11-28 US US13/688,187 patent/US8889628B2/en active Active
- 2012-11-28 JP JP2014543634A patent/JP6181066B2/ja active Active
- 2012-11-28 WO PCT/US2012/066910 patent/WO2013082200A1/en not_active Ceased
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