JP2014525735A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014525735A5 JP2014525735A5 JP2014516358A JP2014516358A JP2014525735A5 JP 2014525735 A5 JP2014525735 A5 JP 2014525735A5 JP 2014516358 A JP2014516358 A JP 2014516358A JP 2014516358 A JP2014516358 A JP 2014516358A JP 2014525735 A5 JP2014525735 A5 JP 2014525735A5
- Authority
- JP
- Japan
- Prior art keywords
- single variable
- variable domain
- immunoglobulin single
- protein
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108060003951 Immunoglobulin Proteins 0.000 claims 33
- 102000018358 immunoglobulin Human genes 0.000 claims 33
- 108091006027 G proteins Proteins 0.000 claims 15
- 102000030782 GTP binding Human genes 0.000 claims 15
- 108091000058 GTP-Binding Proteins 0.000 claims 15
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 12
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- XOFLBQFBSOEHOG-UUOKFMHZSA-N γS-GTP Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=S)[C@@H](O)[C@H]1O XOFLBQFBSOEHOG-UUOKFMHZSA-N 0.000 claims 2
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 102000034345 heterotrimeric G proteins Human genes 0.000 claims 1
- 108091006093 heterotrimeric G proteins Proteins 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000007781 signaling event Effects 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161571159P | 2011-06-21 | 2011-06-21 | |
| US61/571,159 | 2011-06-21 | ||
| EP11181357.2 | 2011-09-15 | ||
| EP11181357 | 2011-09-15 | ||
| PCT/EP2012/062036 WO2012175643A2 (en) | 2011-06-21 | 2012-06-21 | Binding domains directed against gpcr:g protein complexes and uses derived thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017026632A Division JP2017127306A (ja) | 2011-06-21 | 2017-02-16 | Ｇｐｃｒ：ｇタンパク質複合体に対して作製された結合ドメインおよびそれに由来する使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014525735A JP2014525735A (ja) | 2014-10-02 |
| JP2014525735A5 true JP2014525735A5 (https=) | 2015-08-13 |
| JP6164535B2 JP6164535B2 (ja) | 2017-07-19 |
Family
ID=47423019
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516358A Active JP6164535B2 (ja) | 2011-06-21 | 2012-06-21 | Ｇｐｃｒ：ｇタンパク質複合体に対して作製された結合ドメインおよびそれに由来する使用 |
| JP2017026632A Pending JP2017127306A (ja) | 2011-06-21 | 2017-02-16 | Ｇｐｃｒ：ｇタンパク質複合体に対して作製された結合ドメインおよびそれに由来する使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017026632A Pending JP2017127306A (ja) | 2011-06-21 | 2017-02-16 | Ｇｐｃｒ：ｇタンパク質複合体に対して作製された結合ドメインおよびそれに由来する使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9695227B2 (https=) |
| EP (3) | EP4282882A3 (https=) |
| JP (2) | JP6164535B2 (https=) |
| CN (2) | CN104053667B (https=) |
| AU (1) | AU2012273987B2 (https=) |
| CA (1) | CA2839834A1 (https=) |
| DK (1) | DK2723764T3 (https=) |
| ES (1) | ES2662372T3 (https=) |
| HR (1) | HRP20180443T1 (https=) |
| HU (1) | HUE036982T2 (https=) |
| NO (1) | NO2723764T3 (https=) |
| PL (1) | PL2723764T3 (https=) |
| PT (1) | PT2723764T (https=) |
| WO (1) | WO2012175643A2 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| NO2723764T3 (https=) | 2011-09-15 | 2018-05-26 | ||
| EP2867674B1 (en) | 2012-06-28 | 2018-10-10 | UCB Biopharma SPRL | A method for identifying compounds of therapeutic interest |
| SG11201600853UA (en) | 2013-08-05 | 2016-03-30 | Twist Bioscience Corp | De novo synthesized gene libraries |
| JP2017522906A (ja) * | 2014-07-04 | 2017-08-17 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 抗ｍＧｌｕＲ２構造的単一ドメイン抗体及びその使用 |
| CN107111691B (zh) | 2014-10-27 | 2021-01-26 | 阿卜杜拉国王科技大学 | 识别配体-蛋白质结合位点的方法和系统 |
| US10669304B2 (en) | 2015-02-04 | 2020-06-02 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| EP3350314A4 (en) | 2015-09-18 | 2019-02-06 | Twist Bioscience Corporation | OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF |
| KR102794025B1 (ko) | 2015-09-22 | 2025-04-09 | 트위스트 바이오사이언스 코포레이션 | 핵산 합성을 위한 가요성 기판 |
| CN115920796A (zh) | 2015-12-01 | 2023-04-07 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| CN105802970A (zh) * | 2016-05-30 | 2016-07-27 | 东北师范大学 | 靶向沉默Gβ1的shRNA |
| EP3500672A4 (en) | 2016-08-22 | 2020-05-20 | Twist Bioscience Corporation | DE NOVO SYNTHETIZED NUCLEIC ACID LIBRARIES |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CN107037116B (zh) * | 2016-12-01 | 2019-04-23 | 白波 | 检测gpcr之间相互作用及其交界面的方法 |
| GB2573069A (en) | 2016-12-16 | 2019-10-23 | Twist Bioscience Corp | Variant libraries of the immunological synapse and synthesis thereof |
| EP4556433A3 (en) | 2017-02-22 | 2025-08-06 | Twist Bioscience Corporation | Nucleic acid based data storage |
| WO2018170169A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| WO2018231872A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| US11407837B2 (en) * | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| KR20200091400A (ko) * | 2017-10-31 | 2020-07-30 | 브이아이비 브이지더블유 | 신규한 항원-결합 키메라 단백질 및 이의 방법 및 용도 |
| SG11202001226PA (en) * | 2017-12-21 | 2020-03-30 | Firmenich & Cie | Method for identifying positive allosteric modulators for odorant receptors |
| KR102804057B1 (ko) | 2018-01-04 | 2025-05-07 | 트위스트 바이오사이언스 코포레이션 | Dna 기반 디지털 정보 저장 |
| WO2019155041A1 (en) * | 2018-02-12 | 2019-08-15 | Vib Vzw | Gβγ COMPLEX ANTIBODIES AND USES THEREOF |
| CN108586620B (zh) * | 2018-05-10 | 2021-11-23 | 山东大学 | 筛选昆虫性信息素受体的配体的传感器分子以及筛选方法 |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| FR3084365B1 (fr) * | 2018-07-27 | 2020-10-23 | Cisbio Bioassays | Anticorps a domaine unique qui se lient a la proteine g alpha |
| JP7627910B2 (ja) * | 2018-12-21 | 2025-02-07 | フエー・イー・ベー・フエー・ゼツト・ウエー | サイトカイン及び足場タンパク質を含む融合タンパク質 |
| WO2020139871A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| FR3092172B1 (fr) * | 2019-01-30 | 2021-02-12 | Cisbio Bioassays | Méthode pour mesurer la modulation de l’activation d’un récepteur couplé à une protéine G avec des analogues du GTP |
| JP2022522668A (ja) | 2019-02-26 | 2022-04-20 | ツイスト バイオサイエンス コーポレーション | 抗体を最適化するための変異体核酸ライブラリ |
| CN113766930B (zh) | 2019-02-26 | 2025-07-22 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
| WO2020221769A1 (en) | 2019-04-29 | 2020-11-05 | Confo Therapeutics N.V. | Screening methods and assays for use with transmembrane proteins, in particular with gpcrs |
| US12123814B1 (en) * | 2019-06-14 | 2024-10-22 | Pierce Biotechnology, Inc. | G- protein coupled receptor extraction formulations |
| EP3986437A4 (en) * | 2019-06-18 | 2023-06-07 | Musc Foundation for Research Development | COMPOSITIONS TARGETED AGAINST THE NUCLEOTIDE-FREE STATE OF RAS AND METHODS FOR BLOCKING ONCOGENIC SIGNALING AND TRANSFORMATION |
| US11332738B2 (en) | 2019-06-21 | 2022-05-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| JP2022548783A (ja) | 2019-09-23 | 2022-11-21 | ツイスト バイオサイエンス コーポレーション | 単一ドメイン抗体のバリアント核酸ライブラリー |
| EP4034566A4 (en) | 2019-09-23 | 2024-01-24 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID BANKS FOR CRTH2 |
| BR112022011235A2 (pt) | 2019-12-09 | 2022-12-13 | Twist Bioscience Corp | Bibliotecas de variantes de ácido nucleico para receptores de adenosina |
| FR3106830B1 (fr) | 2020-01-30 | 2022-02-11 | Cisbio Bioassays | Anticorps anti-protéine G alpha |
| EP4204460A4 (en) | 2020-08-26 | 2024-09-25 | Twist Bioscience Corporation | METHODS AND COMPOSITIONS RELATING TO GLP1R VARIANTS |
| US20230340461A1 (en) * | 2022-02-14 | 2023-10-26 | Twist Bioscience Corporation | Combinatorial dna assembly for multispecific antibodies |
| WO2023159144A2 (en) * | 2022-02-17 | 2023-08-24 | The Regents Of The University Of Michigan | G-protein coupled receptor assay |
| CN114702570B (zh) * | 2022-03-23 | 2022-12-06 | 山东大学 | aGPCR拮抗剂 |
| EP4605077A1 (en) | 2022-10-18 | 2025-08-27 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
| US11862295B1 (en) | 2022-11-08 | 2024-01-02 | United Arab Emirates University | Method of classifying conformers |
| CN116425888B (zh) * | 2023-04-24 | 2024-11-05 | 徐州医科大学 | 一种多肽tat-v2r1c及其应用 |
| US12176075B1 (en) | 2023-11-14 | 2024-12-24 | United Arab Emirates University | Method of matching conformers of different molecules |
| WO2025129064A1 (en) * | 2023-12-15 | 2025-06-19 | Eve Bio, Llc | Spliced rna barcodes for multiplexed cell-based high throughput screening |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| EP4620523A1 (en) * | 2024-03-22 | 2025-09-24 | Genome Research Limited | Mutants of the beta2-adrenergic receptor with altered activity and their use in disease treatment. |
| JP2025167890A (ja) * | 2024-04-26 | 2025-11-07 | 国立大学法人 東京大学 | 標的タンパク質に付加されるためのタンパク質 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1621554T4 (da) | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
| AU3596599A (en) | 1998-01-26 | 1999-08-09 | Unilever Plc | Method for producing antibody fragments |
| DK1144616T4 (da) | 1999-01-19 | 2009-03-30 | Unilever Nv | Fremgangsmåde til fremstilling af antistoffragmenter |
| US20030190598A1 (en) | 2000-05-26 | 2003-10-09 | Jasmid Tanha | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| US7208279B2 (en) | 2001-03-14 | 2007-04-24 | Caden Biosciences, Inc. | Method for identifying inhibitors of G protein coupled receptor signaling |
| US7294472B2 (en) * | 2001-03-14 | 2007-11-13 | Caden Biosciences | Method for identifying modulators of G protein coupled receptor signaling |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| WO2004035614A1 (en) * | 2001-07-11 | 2004-04-29 | Karo Bio Ab | Synthetic or partially purified peptides which can bind to specific subunits of g proteins and uses thereof |
| JP4213586B2 (ja) | 2001-09-13 | 2009-01-21 | 株式会社抗体研究所 | ラクダ抗体ライブラリーの作製方法 |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| MXPA05007151A (es) | 2002-12-31 | 2005-09-21 | Nektar Therapeutics Al Corp | Polimeros terminados en maleimida hidroliticamente estables. |
| WO2006086883A1 (en) * | 2005-02-16 | 2006-08-24 | Universite De Montreal | Biosensors for monitoring receptor-mediated g-protein activation |
| WO2008020079A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| US7947807B2 (en) | 2007-10-15 | 2011-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3) |
| EP2285833B1 (en) * | 2008-05-16 | 2014-12-17 | Ablynx N.V. | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
| WO2009147196A1 (en) | 2008-06-04 | 2009-12-10 | Vib Vzw | Hiv-rev-multimerization inhibiting nanobodies |
| US9005963B2 (en) * | 2008-10-14 | 2015-04-14 | Ablynx N.V. | Amino acid sequences directed against cellular receptors for viruses and bacteria |
| WO2010066740A1 (en) | 2008-12-08 | 2010-06-17 | Complix Nv | Single-chain antiparallel coiled coil proteins |
| GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| US8765414B2 (en) | 2011-03-15 | 2014-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | GPCR fusion protein containing an N-terminal autonomously folding stable domain, and crystals of the same |
| NO2723764T3 (https=) | 2011-09-15 | 2018-05-26 |
-
2012
- 2012-06-21 NO NO12730478A patent/NO2723764T3/no unknown
- 2012-06-21 HU HUE12730478A patent/HUE036982T2/hu unknown
- 2012-06-21 EP EP23193788.9A patent/EP4282882A3/en active Pending
- 2012-06-21 EP EP12730478.0A patent/EP2723764B1/en active Active
- 2012-06-21 EP EP17209368.4A patent/EP3345919B1/en active Active
- 2012-06-21 CN CN201280040585.9A patent/CN104053667B/zh active Active
- 2012-06-21 PT PT127304780T patent/PT2723764T/pt unknown
- 2012-06-21 HR HRP20180443TT patent/HRP20180443T1/hr unknown
- 2012-06-21 CN CN201710728087.8A patent/CN107857810A/zh active Pending
- 2012-06-21 ES ES12730478.0T patent/ES2662372T3/es active Active
- 2012-06-21 PL PL12730478T patent/PL2723764T3/pl unknown
- 2012-06-21 DK DK12730478.0T patent/DK2723764T3/en active
- 2012-06-21 AU AU2012273987A patent/AU2012273987B2/en active Active
- 2012-06-21 JP JP2014516358A patent/JP6164535B2/ja active Active
- 2012-06-21 US US14/129,100 patent/US9695227B2/en active Active
- 2012-06-21 WO PCT/EP2012/062036 patent/WO2012175643A2/en not_active Ceased
- 2012-06-21 CA CA2839834A patent/CA2839834A1/en active Pending
-
2017
- 2017-02-16 JP JP2017026632A patent/JP2017127306A/ja active Pending
- 2017-05-01 US US15/583,540 patent/US10626154B2/en active Active
-
2020
- 2020-04-17 US US16/852,235 patent/US12252521B2/en active Active
-
2024
- 2024-11-26 US US18/960,784 patent/US20250171510A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014525735A5 (https=) | ||
| HRP20180443T1 (hr) | Povezujuće domene usmjerene protiv gpcr-a: g proteinski kompleksi i njihove derivirane uporabe | |
| JP2017529067A5 (https=) | ||
| JP2020501532A5 (https=) | ||
| RU2017105515A (ru) | Сигнальная система | |
| JP2016026215A5 (https=) | ||
| RU2016124179A (ru) | СКОНСТРУИРОВАННЫЕ ВЫСОКОАФФИННЫЕ T-клеточные рецепторы человека | |
| JP2020515518A5 (https=) | ||
| JP2016536322A5 (https=) | ||
| RU2016106577A (ru) | САЙТЫ АНТИТЕЛ, СПЕЦИФИЧНО СВЯЗЫВАЮЩИЕ EGFRvIII | |
| JP2012531922A5 (ja) | Ｔｏｌｌ様受容体２へのヒト化抗体またはその抗原結合部位 | |
| RU2016151265A (ru) | Антитела, направленные на cd127 | |
| JP2017522903A5 (https=) | ||
| JP2016196468A5 (https=) | ||
| JP2020500510A5 (https=) | ||
| JP2014158485A5 (https=) | ||
| JP2014518883A5 (https=) | ||
| JP2016185981A5 (https=) | ||
| JP2014515602A5 (https=) | ||
| JP2016511277A5 (https=) | ||
| JP2018537421A5 (https=) | ||
| JP2016539096A5 (https=) | ||
| JP2016527314A5 (https=) | ||
| JP2019503167A5 (https=) | ||
| JP2018535196A5 (https=) |