JP2019503167A5 - - Google Patents
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- Publication number
- JP2019503167A5 JP2019503167A5 JP2018524281A JP2018524281A JP2019503167A5 JP 2019503167 A5 JP2019503167 A5 JP 2019503167A5 JP 2018524281 A JP2018524281 A JP 2018524281A JP 2018524281 A JP2018524281 A JP 2018524281A JP 2019503167 A5 JP2019503167 A5 JP 2019503167A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cdr1
- cdr3
- cdr2
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 35
- 229920001184 polypeptide Polymers 0.000 claims 34
- 102000004196 processed proteins & peptides Human genes 0.000 claims 34
- 125000003275 alpha amino acid group Chemical group 0.000 claims 33
- 150000001413 amino acids Chemical class 0.000 claims 27
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 12
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 11
- 108060003951 Immunoglobulin Proteins 0.000 claims 9
- 102000018358 immunoglobulin Human genes 0.000 claims 9
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 7
- 230000002860 competitive effect Effects 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000015228 acquired partial lipodystrophy Diseases 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 230000002949 hemolytic effect Effects 0.000 claims 1
- 102000052645 human CD38 Human genes 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims 1
- 208000036274 partial acquired susceptibility to lipodystrophy Diseases 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000004565 tumor cell growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562253318P | 2015-11-10 | 2015-11-10 | |
| US62/253,318 | 2015-11-10 | ||
| PCT/EP2016/077361 WO2017081211A2 (en) | 2015-11-10 | 2016-11-10 | Antigen-binding polypeptides directed against cd38 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019503167A JP2019503167A (ja) | 2019-02-07 |
| JP2019503167A5 true JP2019503167A5 (https=) | 2019-12-19 |
Family
ID=57391949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524281A Pending JP2019503167A (ja) | 2015-11-10 | 2016-11-10 | Ｃｄ３８に対する抗原結合性ポリペプチド |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10865249B2 (https=) |
| EP (1) | EP3374397A2 (https=) |
| JP (1) | JP2019503167A (https=) |
| CN (1) | CN108884162A (https=) |
| AU (1) | AU2016352676A1 (https=) |
| CA (1) | CA3004792A1 (https=) |
| MA (1) | MA43219A (https=) |
| WO (1) | WO2017081211A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016357460B2 (en) * | 2015-11-18 | 2023-07-27 | Ablynx Nv | Improved serum albumin binders |
| KR20250175345A (ko) | 2016-06-21 | 2025-12-16 | 테네오바이오, 인코포레이티드 | Cd3 결합 항체 |
| PE20241349A1 (es) | 2016-09-14 | 2024-07-03 | Teneobio Inc | Anticuerpos de union a cd3 |
| IL317134A (en) | 2016-12-21 | 2025-01-01 | Teneobio Inc | An antibody containing only heavy chains that binds a human B-cell maturation antigen, a pharmaceutical composition containing the same, its use in the treatment of B-cell disorders and a method for its preparation |
| CN110945026B (zh) | 2017-06-20 | 2024-03-19 | 特纳奥尼股份有限公司 | 仅有重链的抗bcma抗体 |
| KR20250007003A (ko) | 2017-06-20 | 2025-01-13 | 테네오바이오, 인코포레이티드 | 항-bcma 중쇄-단독 항체 |
| CN109232739B (zh) * | 2017-07-11 | 2021-07-20 | 北京大学深圳研究生院 | 一种抗cd38纳米抗体、编码基因及应用 |
| HUE065510T2 (hu) * | 2017-08-10 | 2024-05-28 | Grifols Diagnostic Solutions Inc | Immunglobulin Fc-régiót és poli-His domént tartalmazó oligomerizációs címke |
| EP3681908A1 (en) * | 2017-09-13 | 2020-07-22 | Teneobio, Inc. | Heavy chain antibodies binding to ectoenzymes |
| AU2019235626A1 (en) * | 2018-03-13 | 2020-10-08 | Pfizer Inc. | Combination of CD47 blockade therapy and a CD38 antibody |
| KR20210086651A (ko) * | 2018-10-26 | 2021-07-08 | 테네오바이오, 인코포레이티드 | Cd38에 결합하는 중쇄 항체 |
| KR20210104736A (ko) | 2018-12-14 | 2021-08-25 | 모르포시스 아게 | 항체 제형 |
| WO2020206330A1 (en) | 2019-04-05 | 2020-10-08 | Teneobio, Inc. | Heavy chain antibodies binding to psma |
| CR20210622A (es) | 2019-06-14 | 2022-06-27 | Teneobio Inc | Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3 |
| EP3999540A1 (en) * | 2019-07-16 | 2022-05-25 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Antibodies having specificity for cd38 and uses thereof |
| JP7561364B2 (ja) * | 2020-04-30 | 2024-10-04 | 国立大学法人東北大学 | 蛍光偏光免疫分析法 |
| WO2021229104A1 (en) * | 2020-05-15 | 2021-11-18 | Université de Liège | Anti-cd38 single-domain antibodies in disease monitoring and treatment |
| CN112457401B (zh) * | 2020-10-21 | 2023-02-24 | 上海交通大学医学院附属仁济医院 | 一种诊断多发性骨髓瘤的分子影像探针 |
| EP4236997A4 (en) * | 2020-10-28 | 2024-10-09 | City of Hope | BISPECIFIC ANTI-CD38-CD3 BINDERS |
| US20240261446A1 (en) * | 2021-05-17 | 2024-08-08 | Université de Liège | Anti-cd38 single domain antibodies in disease monitoring and treatment |
| WO2022271987A1 (en) * | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
| US20250277051A1 (en) * | 2021-08-02 | 2025-09-04 | Hangzhou Unogen Biotech, Ltd | Anti-cd38 antibodies, anti-cd3 antibodies, and bispecific antibodies, and uses thereof |
| CN115174413B (zh) | 2022-07-07 | 2024-08-30 | 苏州磐联集成电路科技股份有限公司 | 网状网络系统的配对切换方法 |
| AR131494A1 (es) | 2022-12-23 | 2025-03-26 | Ablynx Nv | Vehículos de conjugación a base de proteína |
| TW202448926A (zh) | 2023-02-17 | 2024-12-16 | 比利時商艾伯霖克斯公司 | 結合新生兒fc受體之多肽 |
| WO2025058962A1 (en) * | 2023-09-11 | 2025-03-20 | Absci Corporation | High-throughput methods for kinetic characterization, quantifying and optimizing antibodies and antibody fragments expression in bacteria |
| WO2026026938A1 (zh) * | 2024-08-01 | 2026-02-05 | 原启生物科技(上海)有限责任公司 | 靶向cd38的抗原结合蛋白及其应用 |
| CN120737203B (zh) * | 2025-09-08 | 2026-01-23 | 南昌大学 | 抗cd38蛋白抗体及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006323415A1 (en) * | 2005-12-06 | 2007-06-14 | Domantis Limited | Bispecific ligands with binding specificity to cell surface targets and methods of use therefor |
| CN103421115B (zh) * | 2013-09-02 | 2015-06-03 | 东南大学 | 一种cd38纳米抗体及应用 |
-
2016
- 2016-11-10 AU AU2016352676A patent/AU2016352676A1/en not_active Abandoned
- 2016-11-10 WO PCT/EP2016/077361 patent/WO2017081211A2/en not_active Ceased
- 2016-11-10 MA MA043219A patent/MA43219A/fr unknown
- 2016-11-10 US US15/774,919 patent/US10865249B2/en active Active
- 2016-11-10 CN CN201680078361.5A patent/CN108884162A/zh not_active Withdrawn
- 2016-11-10 JP JP2018524281A patent/JP2019503167A/ja active Pending
- 2016-11-10 CA CA3004792A patent/CA3004792A1/en active Pending
- 2016-11-10 EP EP16800902.5A patent/EP3374397A2/en active Pending
-
2020
- 2020-12-11 US US17/119,073 patent/US12018088B2/en active Active
-
2024
- 2024-06-24 US US18/752,283 patent/US20240336700A1/en active Pending
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