JP2012522529A5 - - Google Patents

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Publication number
JP2012522529A5
JP2012522529A5 JP2012503990A JP2012503990A JP2012522529A5 JP 2012522529 A5 JP2012522529 A5 JP 2012522529A5 JP 2012503990 A JP2012503990 A JP 2012503990A JP 2012503990 A JP2012503990 A JP 2012503990A JP 2012522529 A5 JP2012522529 A5 JP 2012522529A5
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JP
Japan
Prior art keywords
fviii molecule
fviii
antibody
molecule
gpiib
Prior art date
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Application number
JP2012503990A
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English (en)
Japanese (ja)
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JP5770161B2 (ja
JP2012522529A (ja
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Priority claimed from PCT/EP2010/054495 external-priority patent/WO2010115866A1/en
Publication of JP2012522529A publication Critical patent/JP2012522529A/ja
Publication of JP2012522529A5 publication Critical patent/JP2012522529A5/ja
Application granted granted Critical
Publication of JP5770161B2 publication Critical patent/JP5770161B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012503990A 2009-04-06 2010-04-06 血小板への第ｖｉｉｉ因子タンパク質の標的送達 Expired - Fee Related JP5770161B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21200409P 2009-04-06 2009-04-06
US61/212,004 2009-04-06
US18607509P 2009-06-11 2009-06-11
US61/186,075 2009-06-11
PCT/EP2010/054495 WO2010115866A1 (en) 2009-04-06 2010-04-06 Targeted delivery of factor viii proteins to platelets

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015125394A Division JP2015166391A (ja) 2009-04-06 2015-06-23 血小板への第ｖｉｉｉ因子タンパク質の標的送達

Publications (3)

Publication Number Publication Date
JP2012522529A JP2012522529A (ja) 2012-09-27
JP2012522529A5 true JP2012522529A5 (https=) 2013-04-25
JP5770161B2 JP5770161B2 (ja) 2015-08-26

Family

ID=42238764

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012503990A Expired - Fee Related JP5770161B2 (ja) 2009-04-06 2010-04-06 血小板への第ｖｉｉｉ因子タンパク質の標的送達
JP2015125394A Pending JP2015166391A (ja) 2009-04-06 2015-06-23 血小板への第ｖｉｉｉ因子タンパク質の標的送達

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015125394A Pending JP2015166391A (ja) 2009-04-06 2015-06-23 血小板への第ｖｉｉｉ因子タンパク質の標的送達

Country Status (6)

Country Link
US (2) US20120093840A1 (https=)
EP (1) EP2417155B1 (https=)
JP (2) JP5770161B2 (https=)
CN (1) CN102482340B (https=)
ES (1) ES2427627T3 (https=)
WO (1) WO2010115866A1 (https=)

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ES2427627T3 (es) * 2009-04-06 2013-10-31 Novo Nordisk A/S Entrega dirigida de proteínas de Factor VIII a plaquetas
CN102812039B (zh) 2010-02-16 2016-01-20 诺沃—诺迪斯克有限公司 缀合蛋白质
EP2536753B1 (en) * 2010-02-16 2017-12-20 Novo Nordisk A/S Factor viii molecules with reduced vwf binding
TW201217527A (en) 2010-07-09 2012-05-01 Biogen Idec Hemophilia Inc Processable single chain molecules and polypeptides made using same
WO2012117091A1 (en) 2011-03-02 2012-09-07 Novo Nordisk A/S Coagulation factor-targeting to tlt-1 on activated platelets
CA2875247A1 (en) 2012-06-08 2013-12-12 Biogen Idec Ma Inc. Chimeric clotting factors
WO2013185113A1 (en) 2012-06-08 2013-12-12 Biogen Idec Ma Inc. Procoagulant compounds
EP2897634B1 (en) * 2012-09-12 2018-03-21 Centre for Bioseparation Technology-VIT Double mutant coagulation factor viii and methods thereof
CN104661685A (zh) 2012-10-15 2015-05-27 诺和诺德保健Ag（股份有限公司） 因子vii缀合物
HK1214539A1 (zh) 2012-10-30 2016-07-29 Bioverativ Therapeutics Inc. 應用viii因子多肽的方法
WO2014127215A1 (en) * 2013-02-15 2014-08-21 Biogen Idec Ma Inc. Optimized factor viii gene
WO2014144549A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Factor ix polypeptide formulations
EP4122487A1 (en) * 2013-03-15 2023-01-25 Bioverativ Therapeutics Inc. Factor viii polypeptide formulations
US10364288B2 (en) 2013-05-24 2019-07-30 Biogen Ma Inc. Anti-GPIIB/IIIA antibodies or uses thereof
CA2927756A1 (en) 2013-10-15 2015-04-23 Novo Nordisk Health Care Ag Coagulation factor vii polypeptides
US10325687B2 (en) 2013-12-06 2019-06-18 Bioverativ Therapeutics Inc. Population pharmacokinetics tools and uses thereof
RU2695428C2 (ru) * 2014-01-20 2019-07-23 Октафарма Аг СПОСОБ ПРОИЗВОДСТВА ФАКТОРА VIII, ИМЕЮЩЕГО УЛУЧШЕННОЕ СООТНОШЕНИЕ FVIII:C/FVIII:Ag
US11008561B2 (en) 2014-06-30 2021-05-18 Bioverativ Therapeutics Inc. Optimized factor IX gene
CN106687126B (zh) 2014-08-04 2020-07-28 杰特有限公司 因子viii制剂
MA40835A (fr) 2014-10-23 2017-08-29 Biogen Ma Inc Anticorps anti-gpiib/iiia et leurs utilisations
ES2772933T3 (es) 2015-03-06 2020-07-08 CSL Behring Lengnau AG Factor de von Willebrand modificado que tiene una semivida mejorada
JP2018533017A (ja) * 2015-10-02 2018-11-08 ティージーアール バイオサイエンシス ピーティーワイ エルティーディー． 多基体による検体検出
EA202190827A1 (ru) 2015-11-13 2021-11-30 Баксалта Инкорпорейтед Вирусные векторы, кодирующие рекомбинантные варианты fviii с повышенной экспрессией для генной терапии гемофилии a
CA3012695A1 (en) 2016-02-01 2017-08-10 Bioverativ Therapeutics Inc. Optimized factor viii genes
EP3205665A1 (en) * 2016-02-11 2017-08-16 Octapharma AG Method of separating factor viii from blood products
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
US12091675B2 (en) 2018-07-16 2024-09-17 Takeda Pharmaceutical Company Limited Gene therapy of hemophilia a using viral vectors encoding recombinant FVIII variants with increased expression
TWI851647B (zh) 2019-01-16 2024-08-11 日商武田藥品工業股份有限公司 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
WO2021001522A1 (en) 2019-07-04 2021-01-07 CSL Behring Lengnau AG A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii
KR20220097891A (ko) 2019-09-30 2022-07-08 바이오버라티브 테라퓨틱스 인크. 렌티바이러스 벡터 제형
US20220348637A1 (en) 2019-11-11 2022-11-03 CSL Behring Lengnau AG Polypeptides for inducing tolerance to factor viii
MX2023000156A (es) 2020-06-24 2023-02-16 Bioverativ Therapeutics Inc Metodos para la eliminacion de factor viii libre de preparaciones de vectores lentivirales modificados para expresar dicha proteina.
CN113248594B (zh) * 2021-04-26 2022-08-30 北京美康基免生物科技有限公司 一种重组凝血因子viii及其应用
EP4662240A2 (fr) 2023-02-09 2025-12-17 Commissariat à l'Energie Atomique et aux Energies Alternatives Fragment fab mutant pour l'obtention de conjugués mono- ou bi-fonctionnalisés site-spécifiques

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CA2673459C (en) * 2006-12-22 2016-09-13 Stefan Schulte Modified coagulation factors with prolonged in vivo half-life
PL2257311T3 (pl) * 2008-02-27 2014-09-30 Novo Nordisk As Koniugaty cząsteczek czynnika VIII
CN102112144A (zh) * 2008-05-16 2011-06-29 拜耳医药保健有限公司 靶向性凝固因子及其使用方法
ES2427627T3 (es) * 2009-04-06 2013-10-31 Novo Nordisk A/S Entrega dirigida de proteínas de Factor VIII a plaquetas

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