JP2019527200A5 - - Google Patents
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- JP2019527200A5 JP2019527200A5 JP2018566552A JP2018566552A JP2019527200A5 JP 2019527200 A5 JP2019527200 A5 JP 2019527200A5 JP 2018566552 A JP2018566552 A JP 2018566552A JP 2018566552 A JP2018566552 A JP 2018566552A JP 2019527200 A5 JP2019527200 A5 JP 2019527200A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- polypeptide
- scil
- monomer subunit
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662353478P | 2016-06-22 | 2016-06-22 | |
| US62/353,478 | 2016-06-22 | ||
| PCT/US2017/038747 WO2018005226A2 (en) | 2016-06-22 | 2017-06-22 | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527200A JP2019527200A (ja) | 2019-09-26 |
| JP2019527200A5 true JP2019527200A5 (https=) | 2020-07-30 |
| JP7084881B2 JP7084881B2 (ja) | 2022-06-15 |
Family
ID=60674961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566552A Expired - Fee Related JP7084881B2 (ja) | 2016-06-22 | 2017-06-22 | Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10335459B2 (https=) |
| EP (1) | EP3474884A4 (https=) |
| JP (1) | JP7084881B2 (https=) |
| AU (2) | AU2017291321B2 (https=) |
| CA (1) | CA3026393C (https=) |
| WO (1) | WO2018005226A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2616045B1 (en) | 2010-09-15 | 2017-10-25 | Randall J. Mrsny | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| PL3139965T3 (pl) | 2014-05-07 | 2022-01-31 | Applied Molecular Transport Inc. | Cząsteczki fuzyjne pochodzące z toksyny cholix do doustnego dostarczania ładunku biologicznie czynnego |
| AU2015364396B2 (en) * | 2014-12-19 | 2018-08-09 | Alkermes, Inc. | Single chain Fc fusion proteins |
| JP7084881B2 (ja) | 2016-06-22 | 2022-06-15 | アルカームス インコーポレーテッド | Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法 |
| EP3768699B1 (en) * | 2018-03-23 | 2025-11-12 | Gavish-Galilee Bio Applications Ltd. | Genetically reprogrammed tregs expressing membrane-bound il-10 |
| KR20210110294A (ko) | 2018-11-07 | 2021-09-07 | 어플라이드 몰레큘라 트랜스포트 인크. | 통과세포외배출용 전달 구조체 및 관련 방법 |
| US12006345B2 (en) | 2019-02-21 | 2024-06-11 | Xencor, Inc. | Untargeted and targeted IL-10 Fc-fusion proteins |
| CN114599665A (zh) | 2019-08-16 | 2022-06-07 | 应用分子转运公司 | 组合物、制剂及白细胞介素产生和纯化 |
| EP3795583A1 (en) * | 2019-09-19 | 2021-03-24 | Ecole Polytechnique Federale de Lausanne (EPFL) | Il10/fc fusion proteins useful as enhancers of immunotherapies |
| CN112625137B (zh) * | 2019-10-08 | 2021-10-08 | 北京东方百泰生物科技股份有限公司 | 一种人白细胞介素10-Fc融合蛋白及其医药用途 |
| EP4065585B1 (en) | 2019-11-25 | 2025-08-20 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| EP4126017A4 (en) * | 2020-04-03 | 2024-05-22 | Baylor College of Medicine | Tnf-alpha signaling triggers tumor-promoting inflammation that can be targeted to therapy |
| MX2022014239A (es) | 2020-05-12 | 2023-02-09 | Regeneron Pharma | Nuevos agonistas de il10 y metodos para su uso. |
| KR20230017840A (ko) * | 2020-05-28 | 2023-02-06 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 조작된 인터루킨-10 폴리펩타이드 및 이의 용도 |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| WO2024094755A1 (en) * | 2022-11-02 | 2024-05-10 | Synerkine Pharma B.V. | Engineered immunocytokines, fusion polypeptides, and il10 polypeptides |
| WO2024131864A1 (zh) * | 2022-12-21 | 2024-06-27 | 广东菲鹏制药股份有限公司 | 一种il-10单体融合蛋白 |
| WO2024144336A1 (ko) * | 2022-12-30 | 2024-07-04 | 주식회사 프로젠 | 신규 이중 특이성 융합단백질 및 그의 용도 |
| EP4719457A2 (en) * | 2023-06-02 | 2026-04-08 | Synthekine, Inc. | Fused il10 polypeptides |
| WO2025247362A1 (zh) * | 2024-05-31 | 2025-12-04 | 江苏先声生物制药有限公司 | 抗cdh17抗体、缀合物及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE194384T1 (de) | 1989-09-12 | 2000-07-15 | Hoffmann La Roche | Tnf-bindende proteine |
| JP2002530066A (ja) | 1998-11-19 | 2002-09-17 | スミスクライン・ビーチャム・コーポレイション | Ｒｈａｍｍアンタゴニスト抗体 |
| US6428985B1 (en) * | 1998-12-02 | 2002-08-06 | The Regents Of The University Of Michigan | Immunosuppressive structural definition of IL-10 |
| ATE407697T1 (de) | 1999-07-13 | 2008-09-15 | Bolder Biotechnology Inc | Erythropoietin immunglobulin fusionsproteine |
| EP1257574A1 (en) | 2000-02-11 | 2002-11-20 | Maxygen Aps | Improved interleukin 10 |
| WO2004044006A1 (en) * | 2002-11-14 | 2004-05-27 | Maxygen, Inc. | Conjugates of interleukin-10 and polymers |
| PT1624891E (pt) | 2003-05-06 | 2010-01-05 | Syntonix Pharmaceuticals Inc | Proteínas quiméricas de factor de coagulação-fc destinadas ao tratamento da hemofilia |
| US7696322B2 (en) | 2003-07-28 | 2010-04-13 | Catalent Pharma Solutions, Inc. | Fusion antibodies |
| US20150071948A1 (en) | 2003-09-26 | 2015-03-12 | Gregory Alan Lazar | Novel immunoglobulin variants |
| WO2008140595A2 (en) | 2006-12-01 | 2008-11-20 | President And Fellows Of Harvard College | Synthetic trivalent haptens, complexes thereof, and uses therefor |
| AU2010334974A1 (en) | 2009-12-22 | 2012-07-12 | Novartis Ag | Tetravalent CD47-antibody constant region fusion protein for use in therapy |
| CN102958942A (zh) | 2009-12-29 | 2013-03-06 | 新兴产品开发西雅图有限公司 | 异二聚体结合蛋白及其应用 |
| AR080993A1 (es) | 2010-04-02 | 2012-05-30 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de interferon beta donde se usa un fragmento de inmunoglobulina |
| AU2011226992B2 (en) | 2010-05-10 | 2012-03-22 | Ascend Biopharmaceuticals Pty Ltd | Immunostimulatory and vaccine compositions |
| CN101962413B (zh) | 2010-09-21 | 2013-03-13 | 中国科学技术大学 | 具有透皮能力和白细胞介素-10活性的融合蛋白及其编码基因与应用 |
| KR101333958B1 (ko) | 2010-10-20 | 2013-11-27 | 주식회사 한독 | 인간 인터루킨-1 수용체 길항제-하이브리드 Ｆｃ 융합단백질 |
| EP2457579A1 (en) | 2010-11-26 | 2012-05-30 | Technische Universität Dresden | Covalently linked interleukin -10 |
| TWI588156B (zh) | 2011-03-28 | 2017-06-21 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| EP2723380B1 (en) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| MY169358A (en) | 2011-08-23 | 2019-03-26 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| US9062120B2 (en) | 2012-05-02 | 2015-06-23 | Janssen Biotech, Inc. | Binding proteins having tethered light chains |
| RS61391B1 (sr) * | 2012-06-08 | 2021-02-26 | Alkermes Pharma Ireland Ltd | Ligandi modifikovani primenom cirkularnog permutiranja kao agonisti i antagonisti |
| US20140072581A1 (en) | 2012-07-23 | 2014-03-13 | Zymeworks Inc. | Immunoglobulin Constructs Comprising Selective Pairing of the Light and Heavy Chains |
| CA2876285A1 (en) * | 2012-08-08 | 2014-02-13 | Roche Glycart Ag | Interleukin-10 fusion proteins and uses thereof |
| AU2014236769B2 (en) | 2013-03-15 | 2018-09-27 | Amgen Inc. | Heterodimeric bispecific antibodies |
| US20160068583A1 (en) * | 2013-04-24 | 2016-03-10 | Armo Biosciences, Inc. | Interleukin-10 Compositions and Uses Thereof |
| SG11201600734YA (en) * | 2013-07-31 | 2016-02-26 | Amgen Inc | Stabilization of fc-containing polypeptides |
| WO2015117930A1 (en) | 2014-02-06 | 2015-08-13 | F. Hoffmann-La Roche Ag | Interleukine 10 immunoconjugates |
| CN104403004B (zh) | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
| AU2015364396B2 (en) | 2014-12-19 | 2018-08-09 | Alkermes, Inc. | Single chain Fc fusion proteins |
| WO2017165464A1 (en) | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| JP7084881B2 (ja) | 2016-06-22 | 2022-06-15 | アルカームス インコーポレーテッド | Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法 |
-
2017
- 2017-06-22 JP JP2018566552A patent/JP7084881B2/ja not_active Expired - Fee Related
- 2017-06-22 EP EP17820960.7A patent/EP3474884A4/en not_active Withdrawn
- 2017-06-22 US US15/630,341 patent/US10335459B2/en active Active
- 2017-06-22 WO PCT/US2017/038747 patent/WO2018005226A2/en not_active Ceased
- 2017-06-22 AU AU2017291321A patent/AU2017291321B2/en not_active Ceased
- 2017-06-22 CA CA3026393A patent/CA3026393C/en active Active
-
2019
- 2019-05-16 US US16/414,223 patent/US11534480B2/en active Active
-
2020
- 2020-07-03 AU AU2020204457A patent/AU2020204457A1/en not_active Abandoned
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