JP2019527200A5 - - Google Patents
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- JP2019527200A5 JP2019527200A5 JP2018566552A JP2018566552A JP2019527200A5 JP 2019527200 A5 JP2019527200 A5 JP 2019527200A5 JP 2018566552 A JP2018566552 A JP 2018566552A JP 2018566552 A JP2018566552 A JP 2018566552A JP 2019527200 A5 JP2019527200 A5 JP 2019527200A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- polypeptide
- scil
- monomer subunit
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662353478P | 2016-06-22 | 2016-06-22 | |
| US62/353,478 | 2016-06-22 | ||
| PCT/US2017/038747 WO2018005226A2 (en) | 2016-06-22 | 2017-06-22 | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527200A JP2019527200A (ja) | 2019-09-26 |
| JP2019527200A5 true JP2019527200A5 (https=) | 2020-07-30 |
| JP7084881B2 JP7084881B2 (ja) | 2022-06-15 |
Family
ID=60674961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566552A Expired - Fee Related JP7084881B2 (ja) | 2016-06-22 | 2017-06-22 | Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10335459B2 (https=) |
| EP (1) | EP3474884A4 (https=) |
| JP (1) | JP7084881B2 (https=) |
| AU (2) | AU2017291321B2 (https=) |
| CA (1) | CA3026393C (https=) |
| WO (1) | WO2018005226A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| RU2593715C2 (ru) | 2010-09-15 | 2016-08-10 | Рэндэлл Дж. МРСНИ | Системы и способы доставки биоактивных средств с применением транспортных последовательностей, происходящих от бактериального токсина |
| CN106470707A (zh) | 2014-05-07 | 2017-03-01 | 应用分子运输有限责任公司 | 用于口服递送生物活性货物的cholix毒素衍生的融合分子 |
| AU2015364396B2 (en) * | 2014-12-19 | 2018-08-09 | Alkermes, Inc. | Single chain Fc fusion proteins |
| WO2018005226A2 (en) | 2016-06-22 | 2018-01-04 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
| AU2019240370B2 (en) * | 2018-03-23 | 2024-03-07 | Gavish-Galilee Bio Applications Ltd. | Genetically reprogrammed Tregs expressing membrane-bound IL-10 |
| EP4083058A3 (en) | 2018-11-07 | 2023-01-11 | Applied Molecular Transport Inc. | Delivery constructs for transcytosis and related methods |
| EP3927728A2 (en) * | 2019-02-21 | 2021-12-29 | Xencor, Inc. | Untargeted and targeted il-10 fc-fusion proteins |
| MX2022001975A (es) | 2019-08-16 | 2022-03-11 | Applied Molecular Transport Inc | Composiciones, formulaciones y produccion y purificacion de interleucinas. |
| EP3795583A1 (en) * | 2019-09-19 | 2021-03-24 | Ecole Polytechnique Federale de Lausanne (EPFL) | Il10/fc fusion proteins useful as enhancers of immunotherapies |
| CN112625137B (zh) * | 2019-10-08 | 2021-10-08 | 北京东方百泰生物科技股份有限公司 | 一种人白细胞介素10-Fc融合蛋白及其医药用途 |
| FI4065585T3 (fi) | 2019-11-25 | 2025-09-26 | Alkermes Inc | Substituoituja makrosyklisiä yhdisteitä ja niihin liittyviä hoitomenetelmiä |
| EP4126017A4 (en) * | 2020-04-03 | 2024-05-22 | Baylor College of Medicine | Tnf-alpha signaling triggers tumor-promoting inflammation that can be targeted to therapy |
| WO2021231447A1 (en) | 2020-05-12 | 2021-11-18 | Regeneron Pharmaceuticals, Inc. | Novel il10 agonists and methods of use thereof |
| CA3180304A1 (en) * | 2020-05-28 | 2021-12-02 | Kenan Christopher GARCIA | Engineered interleukin-10 polypeptides and uses thereof |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| EP4612165A1 (en) * | 2022-11-02 | 2025-09-10 | Synerkine Pharma B.V. | Engineered immunocytokines, fusion polypeptides, and il10 polypeptides |
| CN118221829A (zh) * | 2022-12-21 | 2024-06-21 | 广东菲鹏制药股份有限公司 | 一种il-10单体融合蛋白 |
| WO2024144336A1 (ko) * | 2022-12-30 | 2024-07-04 | 주식회사 프로젠 | 신규 이중 특이성 융합단백질 및 그의 용도 |
| EP4719457A2 (en) * | 2023-06-02 | 2026-04-08 | Synthekine, Inc. | Fused il10 polypeptides |
| WO2025247362A1 (zh) * | 2024-05-31 | 2025-12-04 | 江苏先声生物制药有限公司 | 抗cdh17抗体、缀合物及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0939121B2 (de) | 1989-09-12 | 2007-12-26 | AHP Manufacturing B.V. | TFN-bindende Proteine |
| WO2000029447A1 (en) | 1998-11-19 | 2000-05-25 | Smithkline Beecham Corporation | Rhamm antagonist antibodies |
| US6428985B1 (en) * | 1998-12-02 | 2002-08-06 | The Regents Of The University Of Michigan | Immunosuppressive structural definition of IL-10 |
| US7754855B1 (en) | 1999-07-13 | 2010-07-13 | Bolder Biotechnology, Inc. | Immunoglobulin fusion proteins |
| WO2001058950A1 (en) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | Improved interleukin 10 |
| AU2003280315A1 (en) * | 2002-11-14 | 2004-06-03 | Maxygen, Inc. | Conjugates of interleukin-10 and polymers |
| PL2298347T3 (pl) | 2003-05-06 | 2016-03-31 | Bioverativ Therapeutics Inc | Białka chimeryczne czynnika krzepnięcia do leczenia zaburzenia hemostazy |
| US7696322B2 (en) | 2003-07-28 | 2010-04-13 | Catalent Pharma Solutions, Inc. | Fusion antibodies |
| US20150071948A1 (en) | 2003-09-26 | 2015-03-12 | Gregory Alan Lazar | Novel immunoglobulin variants |
| WO2008140595A2 (en) | 2006-12-01 | 2008-11-20 | President And Fellows Of Harvard College | Synthetic trivalent haptens, complexes thereof, and uses therefor |
| BR112012017164A2 (pt) | 2009-12-22 | 2019-09-24 | Novartis Ag | proteína de fusão de região constante de anticorpo-cd47 tetravalente |
| CA2785907A1 (en) | 2009-12-29 | 2011-07-28 | Emergent Product Development Seattle, Llc | Ron binding constructs and methods of use thereof |
| AR080993A1 (es) | 2010-04-02 | 2012-05-30 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de interferon beta donde se usa un fragmento de inmunoglobulina |
| BR112012028893A2 (pt) | 2010-05-10 | 2017-12-12 | Ascend Biopharmaceuticals Pty Ltd | composições imunoestimuladoras e de vacina |
| CN101962413B (zh) * | 2010-09-21 | 2013-03-13 | 中国科学技术大学 | 具有透皮能力和白细胞介素-10活性的融合蛋白及其编码基因与应用 |
| US8883134B2 (en) | 2010-10-20 | 2014-11-11 | Handok Pharmaceuticals, Inc. | Human interleukin-1 receptor antagonist—hybrid Fc fusion protein |
| EP2457579A1 (en) * | 2010-11-26 | 2012-05-30 | Technische Universität Dresden | Covalently linked interleukin -10 |
| TWI743461B (zh) | 2011-03-28 | 2021-10-21 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| EA201892619A1 (ru) * | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| EP2723380B1 (en) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| NO2748201T3 (https=) | 2011-08-23 | 2018-05-12 | ||
| US9062120B2 (en) | 2012-05-02 | 2015-06-23 | Janssen Biotech, Inc. | Binding proteins having tethered light chains |
| US9156897B2 (en) | 2012-06-08 | 2015-10-13 | Alkermes, Inc. | Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide |
| IN2015DN01299A (https=) | 2012-07-23 | 2015-07-03 | Zymeworks Inc | |
| PE20150645A1 (es) * | 2012-08-08 | 2015-05-11 | Roche Glycart Ag | Proteinas de fusion de interleuquina 10 y usos de las mismas |
| US11634502B2 (en) | 2013-03-15 | 2023-04-25 | Amgen Inc. | Heterodimeric bispecific antibodies |
| EP2989240A4 (en) | 2013-04-24 | 2016-10-19 | Armo Biosciences Inc | INTERLEUKIN-10 COMPOSITIONS AND USES THEREOF |
| CA2919076C (en) | 2013-07-31 | 2024-01-30 | Amgen Inc. | Stabilization of fc-containing polypeptides |
| WO2015117930A1 (en) | 2014-02-06 | 2015-08-13 | F. Hoffmann-La Roche Ag | Interleukine 10 immunoconjugates |
| CN104403004B (zh) | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
| AU2015364396B2 (en) * | 2014-12-19 | 2018-08-09 | Alkermes, Inc. | Single chain Fc fusion proteins |
| WO2017165464A1 (en) | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| WO2018005226A2 (en) | 2016-06-22 | 2018-01-04 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
-
2017
- 2017-06-22 WO PCT/US2017/038747 patent/WO2018005226A2/en not_active Ceased
- 2017-06-22 AU AU2017291321A patent/AU2017291321B2/en not_active Ceased
- 2017-06-22 JP JP2018566552A patent/JP7084881B2/ja not_active Expired - Fee Related
- 2017-06-22 EP EP17820960.7A patent/EP3474884A4/en not_active Withdrawn
- 2017-06-22 CA CA3026393A patent/CA3026393C/en active Active
- 2017-06-22 US US15/630,341 patent/US10335459B2/en active Active
-
2019
- 2019-05-16 US US16/414,223 patent/US11534480B2/en active Active
-
2020
- 2020-07-03 AU AU2020204457A patent/AU2020204457A1/en not_active Abandoned
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