JP2014509851A5 - - Google Patents
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- Publication number
- JP2014509851A5 JP2014509851A5 JP2013557704A JP2013557704A JP2014509851A5 JP 2014509851 A5 JP2014509851 A5 JP 2014509851A5 JP 2013557704 A JP2013557704 A JP 2013557704A JP 2013557704 A JP2013557704 A JP 2013557704A JP 2014509851 A5 JP2014509851 A5 JP 2014509851A5
- Authority
- JP
- Japan
- Prior art keywords
- npp1
- fusion protein
- npp1 fusion
- acid residues
- targeting moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34006610P | 2010-03-12 | 2010-03-12 | |
| USPCT/US2011/028233 | 2011-03-11 | ||
| PCT/US2011/028233 WO2011113027A2 (en) | 2010-03-12 | 2011-03-11 | Npp1 fusion proteins |
| PCT/US2011/051858 WO2012125182A1 (en) | 2011-03-11 | 2011-09-15 | Npp1 fusion proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015084216A Division JP6096826B2 (ja) | 2010-03-12 | 2015-04-16 | Ｎｐｐ１融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014509851A JP2014509851A (ja) | 2014-04-24 |
| JP2014509851A5 true JP2014509851A5 (https=) | 2014-11-06 |
| JP5735665B2 JP5735665B2 (ja) | 2015-06-17 |
Family
ID=44564171
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557704A Active JP5735665B2 (ja) | 2010-03-12 | 2011-09-15 | Ｎｐｐ１融合タンパク質 |
| JP2015084216A Active JP6096826B2 (ja) | 2010-03-12 | 2015-04-16 | Ｎｐｐ１融合タンパク質 |
| JP2017026961A Active JP6484905B2 (ja) | 2010-03-12 | 2017-02-16 | Ｎｐｐ１融合タンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015084216A Active JP6096826B2 (ja) | 2010-03-12 | 2015-04-16 | Ｎｐｐ１融合タンパク質 |
| JP2017026961A Active JP6484905B2 (ja) | 2010-03-12 | 2017-02-16 | Ｎｐｐ１融合タンパク質 |
Country Status (10)
| Country | Link |
|---|---|
| US (8) | US8846603B2 (https=) |
| EP (1) | EP2545080B1 (https=) |
| JP (3) | JP5735665B2 (https=) |
| BR (1) | BR112013023010B1 (https=) |
| CL (1) | CL2013002607A1 (https=) |
| ES (2) | ES2628841T3 (https=) |
| NZ (1) | NZ615070A (https=) |
| SG (2) | SG10202100341XA (https=) |
| TR (1) | TR201903573T4 (https=) |
| WO (1) | WO2011113027A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8846603B2 (en) | 2010-03-12 | 2014-09-30 | Synageva Biopharma Corp. | NPP1 fusion proteins |
| KR20150038636A (ko) | 2010-09-09 | 2015-04-08 | 시나게바 바이오파르마, 코포레이션 | 환자에서 리소좀 산 리파제 결핍증의 치료를 위한 리소좀 산 리파제의 용도 |
| WO2012112681A1 (en) | 2011-02-15 | 2012-08-23 | Shire Human Genetic Therapies, Inc. | Methods for treating lysosomal acid lipase deficiency |
| RU2601154C2 (ru) * | 2011-03-11 | 2016-10-27 | Синаджива Байофарма Корп | Гибридные белки npp1 |
| WO2014126965A2 (en) | 2013-02-13 | 2014-08-21 | Yale University | Compositions and methods for treating pathological calcification and ossification |
| WO2014182666A1 (en) * | 2013-05-06 | 2014-11-13 | Bio-Rad Laboratories, Inc. | Stabilization of labile analytes in reference materials |
| EP3967755B1 (en) | 2014-12-19 | 2024-03-27 | Inozyme Pharma, Inc. | Soluble npp1 for use in a method for treating pseudoxanthoma elasticum |
| EP4414028A3 (en) | 2015-05-19 | 2024-11-27 | Yale University | Compositions for treating pathological calcification conditions, and methods using same |
| EP3377105A4 (en) * | 2015-11-20 | 2019-04-24 | Yale University | COMPOSITIONS FOR THE TREATMENT OF ECTOPIC CALIBRATION DISORDERS AND METHODS THEREWITH |
| EP3471747A1 (en) * | 2016-06-16 | 2019-04-24 | Alexion Pharmaceuticals, Inc. | Methods of treating myointimal proliferation |
| CA3032467A1 (en) | 2016-08-05 | 2018-02-08 | Yale University | Compositions and methods for stroke prevention in pediatric sickle cell anemia patients |
| US12134790B2 (en) | 2017-09-27 | 2024-11-05 | Inozyme Pharma, Inc. | Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (NPP1) |
| CN120383683A (zh) * | 2018-08-31 | 2025-07-29 | 耶鲁大学 | Enpp1多肽及其使用方法 |
| JP2023529557A (ja) * | 2020-05-04 | 2023-07-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗ｅｎｐｐ１抗体の阻害 |
| WO2021252549A1 (en) | 2020-06-09 | 2021-12-16 | Inozyme Pharma, Inc. | Soluble enpp1 or enpp3 proteins and uses thereof |
| CA3184349A1 (en) * | 2020-07-02 | 2022-01-06 | Damon BANKS | Compositions and methods for treating allograft vasculopathy, moyamoya disease, moyamoya syndrome and intimal proliferation |
| WO2025184419A1 (en) * | 2024-02-29 | 2025-09-04 | Kodiak Sciences Inc. | Engineered complement inhibitor proteins |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US6825396B2 (en) | 1996-06-12 | 2004-11-30 | Board Of Trustees Operating Michigan State University | Methods for tissue specific synthesis of protein in eggs of transgenic hens |
| US6455495B1 (en) | 1997-02-14 | 2002-09-24 | The Salk Institute For Biological Studies | Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents |
| US20040019923A1 (en) | 1997-10-16 | 2004-01-29 | Ivarie Robert D. | Exogenous proteins expressed in avians and their eggs |
| JP2001520009A (ja) | 1997-10-16 | 2001-10-30 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | 鳥の導入遺伝子についてのマグナム特異的プロモーターを含むベクター |
| EP1032662B1 (en) | 1997-11-07 | 2006-03-08 | Trillium Therapeutics Inc. | Methods and compositions for immunomodulation |
| DE20121960U1 (de) * | 2000-04-06 | 2004-01-15 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit Metastase assoziierten Krankheiten |
| US20020108132A1 (en) | 2001-02-02 | 2002-08-08 | Avigenics Inc. | Production of a monoclonal antibody by a transgenic chicken |
| US6875588B2 (en) | 2001-11-30 | 2005-04-05 | Avigenics, Inc. | Ovomucoid promoter and methods of use |
| US7294507B2 (en) | 2001-11-30 | 2007-11-13 | Avigenics, Inc. | Ovomucoid promoters and methods of use |
| US7858297B2 (en) | 2001-12-18 | 2010-12-28 | Centre National De La Recherche Scientifique Cnrs | Chemokine-binding protein and methods of use |
| WO2003072593A2 (en) | 2002-02-21 | 2003-09-04 | University Of Virginia Patent Foundation | Bone targeting peptides |
| US20050090001A1 (en) | 2003-10-07 | 2005-04-28 | Parker Stephen H. | Cell lines and methods for producing proteins |
| CA2559228C (en) | 2004-04-21 | 2016-06-21 | Enobia Pharma Inc. | Bone delivery conjugates and method of using same to target proteins to bone |
| US20060074225A1 (en) * | 2004-09-14 | 2006-04-06 | Xencor, Inc. | Monomeric immunoglobulin Fc domains |
| GB0426397D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| US20090180989A1 (en) * | 2005-10-05 | 2009-07-16 | Synageva Biopharma Corp. | Compositions and methods for delivering nucleotide sequences to vertebrates |
| HUE031655T2 (hu) | 2007-05-11 | 2017-07-28 | Alexion Pharma Inc | Csontot targetáló alkálikus foszfatáz, készletek és eljárások alkalmazásukra |
| PE20100141A1 (es) * | 2008-05-23 | 2010-02-22 | Wyeth Corp | Proteina de union al receptor de interleuquina 21 |
| US8846603B2 (en) | 2010-03-12 | 2014-09-30 | Synageva Biopharma Corp. | NPP1 fusion proteins |
-
2011
- 2011-03-11 US US13/583,973 patent/US8846603B2/en active Active
- 2011-03-11 ES ES11754231.6T patent/ES2628841T3/es active Active
- 2011-03-11 WO PCT/US2011/028233 patent/WO2011113027A2/en not_active Ceased
- 2011-03-11 EP EP11754231.6A patent/EP2545080B1/en active Active
- 2011-09-15 US US14/004,294 patent/US20140154774A1/en not_active Abandoned
- 2011-09-15 NZ NZ615070A patent/NZ615070A/en not_active IP Right Cessation
- 2011-09-15 SG SG10202100341XA patent/SG10202100341XA/en unknown
- 2011-09-15 ES ES11861101T patent/ES2716526T3/es active Active
- 2011-09-15 BR BR112013023010-0A patent/BR112013023010B1/pt active IP Right Grant
- 2011-09-15 SG SG10201500208SA patent/SG10201500208SA/en unknown
- 2011-09-15 TR TR2019/03573T patent/TR201903573T4/tr unknown
- 2011-09-15 JP JP2013557704A patent/JP5735665B2/ja active Active
-
2013
- 2013-09-10 CL CL2013002607A patent/CL2013002607A1/es unknown
-
2014
- 2014-08-01 US US14/449,364 patent/US9540621B2/en active Active
- 2014-10-06 US US14/507,124 patent/US20150024460A1/en not_active Abandoned
-
2015
- 2015-04-16 JP JP2015084216A patent/JP6096826B2/ja active Active
-
2017
- 2017-01-27 US US15/417,590 patent/US20170145393A1/en not_active Abandoned
- 2017-02-16 JP JP2017026961A patent/JP6484905B2/ja active Active
-
2020
- 2020-11-25 US US17/105,245 patent/US20210301268A1/en not_active Abandoned
-
2022
- 2022-08-11 US US17/819,065 patent/US20230129977A1/en not_active Abandoned
-
2025
- 2025-04-18 US US19/183,431 patent/US20260022356A1/en active Pending
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