JP2010535026A5 - - Google Patents
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- Publication number
- JP2010535026A5 JP2010535026A5 JP2010518815A JP2010518815A JP2010535026A5 JP 2010535026 A5 JP2010535026 A5 JP 2010535026A5 JP 2010518815 A JP2010518815 A JP 2010518815A JP 2010518815 A JP2010518815 A JP 2010518815A JP 2010535026 A5 JP2010535026 A5 JP 2010535026A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- influenza
- peptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 101710154606 Hemagglutinin Proteins 0.000 claims 15
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 15
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 15
- 101710176177 Protein A56 Proteins 0.000 claims 15
- 239000000185 hemagglutinin Substances 0.000 claims 15
- 102000011931 Nucleoproteins Human genes 0.000 claims 11
- 108010061100 Nucleoproteins Proteins 0.000 claims 11
- 206010022000 influenza Diseases 0.000 claims 11
- 241000712461 unidentified influenza virus Species 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 238000006116 polymerization reaction Methods 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95349807P | 2007-08-02 | 2007-08-02 | |
| US60/953,498 | 2007-08-02 | ||
| PCT/IL2008/001062 WO2009016639A2 (en) | 2007-08-02 | 2008-08-03 | Multimeric multiepitope influenza vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535026A JP2010535026A (ja) | 2010-11-18 |
| JP2010535026A5 true JP2010535026A5 (https=) | 2011-09-15 |
| JP5654345B2 JP5654345B2 (ja) | 2015-01-14 |
Family
ID=40305020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518815A Expired - Fee Related JP5654345B2 (ja) | 2007-08-02 | 2008-08-03 | 多量体マルチエピトープインフルエンザワクチン |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8747861B2 (https=) |
| EP (1) | EP2173376B1 (https=) |
| JP (1) | JP5654345B2 (https=) |
| KR (1) | KR101580660B1 (https=) |
| CN (1) | CN101795709B (https=) |
| AU (1) | AU2008281384C1 (https=) |
| BR (1) | BRPI0815008B8 (https=) |
| CA (1) | CA2695399C (https=) |
| DK (1) | DK2173376T3 (https=) |
| EA (1) | EA017887B1 (https=) |
| ES (1) | ES2539818T3 (https=) |
| HR (1) | HRP20150479T1 (https=) |
| HU (1) | HUE025149T2 (https=) |
| MX (1) | MX2010001284A (https=) |
| PL (1) | PL2173376T3 (https=) |
| PT (1) | PT2173376E (https=) |
| WO (1) | WO2009016639A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2374474A1 (en) | 2005-01-19 | 2011-10-12 | Vaxinnate Corporation | Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| EP2772267B1 (en) * | 2007-08-27 | 2016-04-27 | Longhorn Vaccines and Diagnostics, LLC | Immunogenic compositions and methods |
| AU2009236585B2 (en) | 2008-04-18 | 2013-03-07 | Vaxinnate Corporation | Deletion mutants of flagellin and methods of use |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| EP2620156B1 (en) | 2010-08-23 | 2019-03-27 | Kang Stem Biotech Co., Ltd. | Pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing stem cells treated with nod2 agonist or cultured product thereof |
| WO2012115715A2 (en) * | 2011-02-21 | 2012-08-30 | Vaxinnate Corporation | Compositions with enhanced immunogenicity and/or reduced reactogenicity and methods of use |
| WO2012114323A1 (en) * | 2011-02-22 | 2012-08-30 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| US9580475B2 (en) * | 2011-06-20 | 2017-02-28 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for H1N1 influenza |
| ES2490915B1 (es) * | 2011-09-12 | 2015-09-17 | Laboratorios Del Dr. Esteve, S.A. | Método para monitorizar las respuestas de linfocitos T citotóxicos (LTC) mediante una reacción de hipersensibilidad de tipo retardado usando epítopos de LTC definidos |
| EP3494989B1 (en) * | 2012-01-26 | 2025-07-16 | Longhorn Vaccines and Diagnostics, LLC | Composite antigenic sequences and vaccines |
| EP2834274A4 (en) * | 2012-04-02 | 2015-11-11 | Folia Biotech Inc | RECOMBINANT PAPAYAMOSA VIRUS WRAPPER PROTEINS AND USES THEREOF IN FLUID VACCINATES |
| CN103055311B (zh) * | 2012-12-28 | 2014-05-21 | 中山大学 | 一种传染性喉气管炎粘膜疫苗及其制备方法和应用 |
| CN109045294A (zh) * | 2013-01-10 | 2018-12-21 | 思齐乐 | 流感病毒免疫原性组合物及其应用 |
| JP6550072B2 (ja) * | 2014-04-03 | 2019-07-24 | バイオンドバックス ファーマシューティカルズ リミテッド | 多量体マルチエピトープインフルエンザポリペプチドの組成物及びそれらの生成 |
| CA3012703A1 (en) * | 2016-02-03 | 2017-08-10 | Cg Discovery, Inc. | Compositions of influenza hemagglutinin with heterologous epitopes and/or altered maturation cleavage sites |
| JP2019064924A (ja) * | 2016-02-24 | 2019-04-25 | Ａｇｃ株式会社 | インフルエンザワクチン |
| KR20190129032A (ko) | 2016-12-28 | 2019-11-19 | 인벡스, 인크. | 인플루엔자 백신 |
| WO2019061297A1 (zh) * | 2017-09-29 | 2019-04-04 | 苏州工业园区唯可达生物科技有限公司 | 一种cd4辅助性t细胞表位融合肽及其疫苗 |
| CA3086456A1 (en) | 2017-12-21 | 2019-06-27 | Kirin Holdings Kabushiki Kaisha | Cross-immunizing antigen vaccine and method for preparation thereof |
| CN119264211A (zh) | 2018-08-27 | 2025-01-07 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| CN111315407B (zh) | 2018-09-11 | 2023-05-02 | 上海市公共卫生临床中心 | 一种广谱抗流感疫苗免疫原及其应用 |
| EP3986447A4 (en) * | 2019-06-18 | 2023-08-16 | Citranvi Biosciences, LLC | RATIONALLY MANIPULATED CARRIER PROTEINS FOR VACCINES |
| WO2021163438A1 (en) * | 2020-02-14 | 2021-08-19 | University Of Washington | Polypeptides, compositions, and their use to treat or limit development of an infection |
| US11149286B1 (en) | 2020-08-17 | 2021-10-19 | Mayo Foundation For Medical Education And Research | Adenovirus vectors and methods for using adenovirus vectors |
| EP4199907A4 (en) * | 2020-09-21 | 2024-10-09 | SRI International | Targeted antigen delivery system and uses thereof |
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| IL61904A (en) * | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
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| US4539205A (en) * | 1982-11-09 | 1985-09-03 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
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| US5093318A (en) * | 1983-11-01 | 1992-03-03 | Scripps Clinic And Research Foundation | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
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| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
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| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| US5837268A (en) * | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| GB9201139D0 (en) | 1992-01-20 | 1992-03-11 | Connaught Lab | Synthetic peptides for a rubella vaccine |
| IL101639A0 (en) | 1992-04-17 | 1992-12-30 | Yeda Res & Dev | Recombinant influenza vaccines |
| CA2138997C (en) * | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Vaccine composition containing adjuvants |
| DE69331733T2 (de) * | 1992-09-16 | 2002-08-22 | The University Of Tennessee Research Corp., Knoxville | Rekombinantes vielwertiges m-protein-vakzin |
| US5683695A (en) * | 1993-02-10 | 1997-11-04 | United Biomedical, Inc. | Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains |
| US5776468A (en) * | 1993-03-23 | 1998-07-07 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A |
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| EP1167379A3 (en) | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| RS50101B (sr) | 1996-02-24 | 2009-01-22 | Boehringer Ingelheim International Gmbh., | Farmaceutski preparati za imunomodulaciju |
| US6355257B1 (en) * | 1997-05-08 | 2002-03-12 | Corixa Corporation | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
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| CA2297786C (en) | 1997-08-05 | 2011-06-14 | Vlaams Interuniversitair Instituut Voor Biotechnologie | New immunoprotective influenza antigen and its use in vaccination |
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| KR20050114225A (ko) * | 2003-03-07 | 2005-12-05 | 머크 앤드 캄파니 인코포레이티드 | 인플루엔자 바이러스 백신 |
| US7108679B2 (en) * | 2004-03-11 | 2006-09-19 | Becton, Dickinson And Company | Intradermal syringe and needle assembly |
| EP1827489B1 (en) * | 2004-12-16 | 2012-10-31 | Wake Forest University Health Sciences | Use of flagellin in tumor immunotherapy |
| NZ556004A (en) | 2004-12-21 | 2010-05-28 | Vaxinnate Corp | Compositions of influenza viral proteins comprising at least one flagellin and at least one influenza M2 protein |
| EP2374474A1 (en) | 2005-01-19 | 2011-10-12 | Vaxinnate Corporation | Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response |
| MX2007015105A (es) * | 2005-06-01 | 2008-03-18 | Variation Biotechnologies Inc | Formulacion de vacuna de influenza a base de peptido. |
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| GB0613977D0 (en) | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
| AU2007300663A1 (en) * | 2006-07-21 | 2008-04-03 | Pharmexa Inc. | Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions |
| PE20090146A1 (es) * | 2007-04-20 | 2009-03-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenica contra el virus influenza |
| US20090196915A1 (en) | 2007-08-21 | 2009-08-06 | Gary Van Nest | Composition and methods of making and using influenza proteins |
-
2008
- 2008-08-03 EA EA201070219A patent/EA017887B1/ru not_active IP Right Cessation
- 2008-08-03 JP JP2010518815A patent/JP5654345B2/ja not_active Expired - Fee Related
- 2008-08-03 KR KR1020107003351A patent/KR101580660B1/ko not_active Expired - Fee Related
- 2008-08-03 PT PT87897385T patent/PT2173376E/pt unknown
- 2008-08-03 US US12/671,617 patent/US8747861B2/en active Active
- 2008-08-03 DK DK08789738.5T patent/DK2173376T3/en active
- 2008-08-03 BR BRPI0815008A patent/BRPI0815008B8/pt not_active IP Right Cessation
- 2008-08-03 HR HRP20150479TT patent/HRP20150479T1/hr unknown
- 2008-08-03 MX MX2010001284A patent/MX2010001284A/es active IP Right Grant
- 2008-08-03 ES ES08789738.5T patent/ES2539818T3/es active Active
- 2008-08-03 PL PL08789738T patent/PL2173376T3/pl unknown
- 2008-08-03 EP EP08789738.5A patent/EP2173376B1/en active Active
- 2008-08-03 CA CA2695399A patent/CA2695399C/en not_active Expired - Fee Related
- 2008-08-03 CN CN2008801015810A patent/CN101795709B/zh not_active Expired - Fee Related
- 2008-08-03 WO PCT/IL2008/001062 patent/WO2009016639A2/en not_active Ceased
- 2008-08-03 HU HUE08789738A patent/HUE025149T2/hu unknown
- 2008-08-03 AU AU2008281384A patent/AU2008281384C1/en not_active Ceased
-
2014
- 2014-04-28 US US14/263,359 patent/US9353159B2/en not_active Expired - Fee Related
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