JP2017535256A5 - - Google Patents
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- JP2017535256A5 JP2017535256A5 JP2017518977A JP2017518977A JP2017535256A5 JP 2017535256 A5 JP2017535256 A5 JP 2017535256A5 JP 2017518977 A JP2017518977 A JP 2017518977A JP 2017518977 A JP2017518977 A JP 2017518977A JP 2017535256 A5 JP2017535256 A5 JP 2017535256A5
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- Japan
- Prior art keywords
- substitution
- histidine
- substituted
- helicase
- iii
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1417712.5A GB201417712D0 (en) | 2014-10-07 | 2014-10-07 | Method |
| GB1417712.5 | 2014-10-07 | ||
| PCT/GB2015/051291 WO2015166276A1 (en) | 2014-05-02 | 2015-05-01 | Method of improving the movement of a target polynucleotide with respect to a transmembrane pore |
| GBPCT/GB2015/051291 | 2015-05-01 | ||
| PCT/GB2015/052916 WO2016055777A2 (en) | 2014-10-07 | 2015-10-06 | Modified enzymes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017535256A JP2017535256A (ja) | 2017-11-30 |
| JP2017535256A5 true JP2017535256A5 (https=) | 2018-11-15 |
| JP6843042B2 JP6843042B2 (ja) | 2021-03-17 |
Family
ID=51946970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518977A Active JP6843042B2 (ja) | 2014-10-07 | 2015-10-06 | 修飾酵素 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11180741B2 (https=) |
| EP (2) | EP3204406B1 (https=) |
| JP (1) | JP6843042B2 (https=) |
| KR (1) | KR102436445B1 (https=) |
| CN (3) | CN116622671A (https=) |
| GB (1) | GB201417712D0 (https=) |
| WO (1) | WO2016055777A2 (https=) |
Families Citing this family (78)
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| EP4737389A2 (en) | 2011-05-27 | 2026-05-06 | Oxford Nanopore Technologies PLC | Coupling method |
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| CN104039979B (zh) | 2011-10-21 | 2016-08-24 | 牛津纳米孔技术公司 | 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法 |
| AU2012360244B2 (en) | 2011-12-29 | 2018-08-23 | Oxford Nanopore Technologies Limited | Enzyme method |
| CA2879261C (en) | 2012-07-19 | 2022-12-06 | Oxford Nanopore Technologies Limited | Modified helicases |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| CA2901545C (en) | 2013-03-08 | 2019-10-08 | Oxford Nanopore Technologies Limited | Use of spacer elements in a nucleic acid to control movement of a helicase |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CN117947149A (zh) | 2013-10-18 | 2024-04-30 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| CN111534504B (zh) | 2014-01-22 | 2024-06-21 | 牛津纳米孔科技公开有限公司 | 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法 |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| GB201502810D0 (en) * | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| US10640822B2 (en) * | 2016-02-29 | 2020-05-05 | Iridia, Inc. | Systems and methods for writing, reading, and controlling data stored in a polymer |
| CN109196116B (zh) | 2016-05-25 | 2022-09-27 | 牛津纳米孔科技公开有限公司 | 一种表征靶多核苷酸的方法 |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201616590D0 (en) | 2016-09-29 | 2016-11-16 | Oxford Nanopore Technologies Limited | Method |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| CN108101962B (zh) * | 2017-11-10 | 2021-06-04 | 浙江美保龙生物技术有限公司 | 一种特异性提高猪繁殖与呼吸综合征疫苗免疫效果的小分子多肽及其应用 |
| GB2569977A (en) | 2018-01-05 | 2019-07-10 | Oxford Nanopore Tech Ltd | Method |
| GB201801768D0 (en) | 2018-02-02 | 2018-03-21 | Oxford Nanopore Tech Ltd | Synthesis method |
| GB201808556D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| GB201808554D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| GB201821155D0 (en) | 2018-12-21 | 2019-02-06 | Oxford Nanopore Tech Ltd | Method |
| CN110004074B (zh) * | 2019-02-28 | 2021-06-18 | 北京蛋白质组研究中心 | 一种利用silac标记耻垢分枝杆菌蛋白质的方法及其专用培养基 |
| GB201907244D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| GB201907246D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| CN112079903B (zh) * | 2019-06-14 | 2022-11-18 | 中国科学院青岛生物能源与过程研究所 | 一种错配结合蛋白的突变体及其编码基因 |
| GB201917060D0 (en) | 2019-11-22 | 2020-01-08 | Oxford Nanopore Tech Ltd | Method |
| CN114761799A (zh) | 2019-12-02 | 2022-07-15 | 牛津纳米孔科技公开有限公司 | 使用纳米孔表征靶多肽的方法 |
| GB201917742D0 (en) | 2019-12-04 | 2020-01-15 | Oxford Nanopore Tech Ltd | Method |
| GB202004944D0 (en) | 2020-04-03 | 2020-05-20 | King S College London | Method |
| GB202009349D0 (en) | 2020-06-18 | 2020-08-05 | Oxford Nanopore Tech Ltd | Method |
| JP2023530155A (ja) | 2020-06-18 | 2023-07-13 | オックスフォード ナノポール テクノロジーズ ピーエルシー | ナノポアを通って移動するポリヌクレオチドを特徴付ける方法 |
| US20230295712A1 (en) | 2020-06-18 | 2023-09-21 | Oxford Nanopore Technologies Plc | A method of selectively characterising a polynucleotide using a detector |
| WO2021253410A1 (zh) | 2020-06-19 | 2021-12-23 | 北京齐碳科技有限公司 | 一种Pif1-like解旋酶及其应用 |
| CN113930406B (zh) * | 2021-12-17 | 2022-04-08 | 北京齐碳科技有限公司 | 一种Pif1-like解旋酶及其应用 |
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| KR102398032B1 (ko) * | 2020-09-22 | 2022-05-19 | 비피진 주식회사 | 암 치료를 위한 5''-뉴클레오티다아제 변이체 |
| GB202015993D0 (en) | 2020-10-08 | 2020-11-25 | Oxford Nanopore Tech Ltd | Method |
| WO2022126304A1 (zh) * | 2020-12-14 | 2022-06-23 | 北京齐碳科技有限公司 | 一种经修饰的解旋酶及其应用 |
| US20240368568A1 (en) | 2021-04-06 | 2024-11-07 | Qitan Technology Ltd., Chengdu | Modified prp43 helicase and use thereof |
| EP4341433A1 (en) | 2021-05-19 | 2024-03-27 | Oxford Nanopore Technologies PLC | Methods for complement strand sequencing |
| GB202107192D0 (en) | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| GB202107354D0 (en) | 2021-05-24 | 2021-07-07 | Oxford Nanopore Tech Ltd | Method |
| GB202118906D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| GB202118908D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| US20250066748A1 (en) * | 2021-12-31 | 2025-02-27 | Bgi Shenzhen | Helicase bch2x and use thereof |
| CN118355130A (zh) * | 2021-12-31 | 2024-07-16 | 深圳华大生命科学研究院 | 解旋酶bch1x及其用途 |
| EP4482855A4 (en) * | 2022-02-22 | 2026-03-04 | Peter Biotherapeutics Inc | GENE MODIFICATION TECHNOLOGIES |
| GB202205617D0 (en) | 2022-04-14 | 2022-06-01 | Oxford Nanopore Tech Plc | Novel modified protein pores and enzymes |
| WO2023215603A1 (en) | 2022-05-06 | 2023-11-09 | 10X Genomics, Inc. | Methods and compositions for in situ analysis of v(d)j sequences |
| JP2025517736A (ja) | 2022-05-17 | 2025-06-10 | オックスフォード ナノポール テクノロジーズ ピーエルシー | 方法及びアダプター |
| CN117384867B (zh) * | 2022-09-16 | 2024-06-07 | 北京普译生物科技有限公司 | 一种经修饰的Cas3移位酶及其应用 |
| CN117721101B (zh) * | 2022-09-16 | 2024-09-20 | 北京普译生物科技有限公司 | 一种经修饰的CaPif1解旋酶及其应用 |
| GB202216162D0 (en) | 2022-10-31 | 2022-12-14 | Oxford Nanopore Tech Plc | Method |
| WO2024138422A1 (zh) * | 2022-12-28 | 2024-07-04 | 深圳华大生命科学研究院 | 一种销结构域、含其的解旋酶及制备方法和应用 |
| WO2024138574A1 (zh) * | 2022-12-29 | 2024-07-04 | 深圳华大生命科学研究院 | 解旋酶及其应用 |
| CN120435549A (zh) * | 2022-12-30 | 2025-08-05 | 深圳华大生命科学研究院 | 一种解旋酶及其制备方法和在高通量测序中的应用 |
| WO2024138701A1 (zh) * | 2022-12-30 | 2024-07-04 | 深圳华大生命科学研究院 | 一种解旋酶突变体及其制备方法和在高通量测序中的应用 |
| GB202304324D0 (en) | 2023-03-24 | 2023-05-10 | Oxford Nanopore Tech Plc | Method and kits |
| GB202307486D0 (en) | 2023-05-18 | 2023-07-05 | Oxford Nanopore Tech Plc | Method |
| WO2025067293A1 (zh) * | 2023-09-27 | 2025-04-03 | 北京齐碳科技有限公司 | 解旋酶及其应用 |
| GB202315935D0 (en) | 2023-10-18 | 2023-11-29 | Oxford Nanopore Tech Ltd | Novel enzymes |
| GB202317028D0 (en) | 2023-11-06 | 2023-12-20 | Oxford Nanopore Tech Ltd | Method |
| CN118126983B (zh) * | 2024-02-22 | 2025-09-02 | 北京普译生物科技有限公司 | 一种修饰的mpk2解旋酶及其应用 |
| CN117964713B (zh) * | 2024-02-26 | 2024-07-30 | 江苏省疾病预防控制中心(江苏省公共卫生研究院) | 一种t4gp32蛋白突变体及其应用 |
| GB202407247D0 (en) | 2024-05-21 | 2024-07-03 | Oxford Nanopore Tech Plc | Method |
| GB202407228D0 (en) | 2024-05-21 | 2024-07-03 | Oxford Nanopore Tech Plc | Method |
| WO2025241113A1 (zh) * | 2024-05-22 | 2025-11-27 | 深圳华大生命科学研究院 | 控制多核苷酸移动的方法及解旋酶变体 |
| WO2026052811A2 (en) | 2024-09-06 | 2026-03-12 | Oxford Nanopore Technologies Plc | Method |
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| WO2026057755A1 (en) | 2024-09-13 | 2026-03-19 | Oxford Nanopore Technologies Plc | Adaptors and kits for rna molecules labelling and characterising |
| CN119192309B (zh) * | 2024-10-25 | 2025-09-30 | 新镁(上海)生物技术有限公司 | 高耐盐单链结合蛋白突变体及其应用 |
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| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
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2014
- 2014-10-07 GB GBGB1417712.5A patent/GB201417712D0/en not_active Ceased
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2015
- 2015-10-06 US US15/517,592 patent/US11180741B2/en active Active
- 2015-10-06 CN CN202310481939.3A patent/CN116622671A/zh active Pending
- 2015-10-06 CN CN201580066254.6A patent/CN107109380A/zh active Pending
- 2015-10-06 KR KR1020177011707A patent/KR102436445B1/ko active Active
- 2015-10-06 JP JP2017518977A patent/JP6843042B2/ja active Active
- 2015-10-06 CN CN202310481940.6A patent/CN117089536A/zh active Pending
- 2015-10-06 EP EP15784740.1A patent/EP3204406B1/en active Active
- 2015-10-06 WO PCT/GB2015/052916 patent/WO2016055777A2/en not_active Ceased
- 2015-10-06 EP EP22175638.0A patent/EP4108679A1/en active Pending
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2021
- 2021-10-13 US US17/500,831 patent/US11965183B2/en active Active
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2024
- 2024-03-05 US US18/596,176 patent/US20240287485A1/en active Pending
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