EA201991702A1 - Самосборные белковые наночастицы, инкапсулирующие иммуностимулирующие нуклеиновые кислоты - Google Patents

Самосборные белковые наночастицы, инкапсулирующие иммуностимулирующие нуклеиновые кислоты

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Publication number
EA201991702A1
EA201991702A1 EA201991702A EA201991702A EA201991702A1 EA 201991702 A1 EA201991702 A1 EA 201991702A1 EA 201991702 A EA201991702 A EA 201991702A EA 201991702 A EA201991702 A EA 201991702A EA 201991702 A1 EA201991702 A1 EA 201991702A1
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EA
Eurasian Patent Office
Prior art keywords
nucleic acids
self
mulating
incapsulating
immunities
Prior art date
Application number
EA201991702A
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English (en)
Inventor
Кэролайн Кулангара
Сара Мария Паулильо
Маттео Пьяцца
Сентил Кумар Раман
Питер Буркхард
Original Assignee
Альфа-О Пептидс Аг
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Publication date
Application filed by Альфа-О Пептидс Аг filed Critical Альфа-О Пептидс Аг
Publication of EA201991702A1 publication Critical patent/EA201991702A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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    • C07K2319/00—Fusion polypeptide
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

В настоящем изобретении предложены самосборные белковые наночастицы, инкапсулирующие иммуностимулирующие нуклеиновые кислоты. Настоящее изобретение также относится к применению указанных наночастиц для вакцинации.
EA201991702A 2017-02-23 2018-02-22 Самосборные белковые наночастицы, инкапсулирующие иммуностимулирующие нуклеиновые кислоты EA201991702A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17157687 2017-02-23
PCT/EP2018/054427 WO2018154010A1 (en) 2017-02-23 2018-02-22 Self-assembling protein nanoparticles encapsulating immunostimulatory nucleid acids

Publications (1)

Publication Number Publication Date
EA201991702A1 true EA201991702A1 (ru) 2020-05-14

Family

ID=58185309

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991702A EA201991702A1 (ru) 2017-02-23 2018-02-22 Самосборные белковые наночастицы, инкапсулирующие иммуностимулирующие нуклеиновые кислоты

Country Status (8)

Country Link
US (2) US20200061172A1 (ru)
EP (1) EP3585428A1 (ru)
JP (1) JP2020510650A (ru)
CN (1) CN110621340A (ru)
AU (1) AU2018223890A1 (ru)
CA (1) CA3054172A1 (ru)
EA (1) EA201991702A1 (ru)
WO (1) WO2018154010A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11213582B2 (en) 2018-08-08 2022-01-04 The Regents Of The University Of California Protection against recurrent genital herpes by therapeutic immunization with herpes simplex virus type 2 ribonucleotide reductase protein subunits
JP2022525431A (ja) * 2019-04-02 2022-05-13 サノフイ 抗原性多量体呼吸器合胞体ウイルスポリペプチド
CN114796476A (zh) * 2021-09-24 2022-07-29 中国医学科学院医学生物学研究所 一种亚单位疫苗新型核酸佐剂系统及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581394B1 (fr) 1985-05-02 1988-08-05 Grp Genie Genetique Particules ayant les proprietes immunogenes de l'antigene hbs et portant un site antigenique etranger aux epitopes portes par l'antigene hbs, vecteurs et cellules animales pour la production de telles particules et compositions contenant de telles particules pour la production de vaccins mixtes
JP4085231B2 (ja) 2000-02-28 2008-05-14 株式会社ビークル タンパク質中空ナノ粒子とそれを用いた物質運搬体、ならびに細胞への物質導入方法
EP1594469B1 (en) 2003-02-17 2007-08-29 Peter Burkhard Peptidic nanoparticles as drug delivery and antigen display systems
TW200745158A (en) 2006-03-07 2007-12-16 Vaxinnate Corp Compositions that include hemagglutinin, methods of making and methods of use thereof
CA2713879C (en) 2008-02-01 2020-01-07 Alpha-O Peptides Ag Self-assembling peptide nanoparticles useful as vaccines
AU2015205567B2 (en) * 2014-01-09 2019-04-04 Alpha-O Peptides Ag Flagellin-containing protein nanoparticles as a vaccine platform

Also Published As

Publication number Publication date
AU2018223890A1 (en) 2019-09-05
CN110621340A (zh) 2019-12-27
US20200061172A1 (en) 2020-02-27
US20240075120A1 (en) 2024-03-07
JP2020510650A (ja) 2020-04-09
EP3585428A1 (en) 2020-01-01
CA3054172A1 (en) 2018-08-30
WO2018154010A1 (en) 2018-08-30

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