JP2015514072A5 - - Google Patents
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- Publication number
- JP2015514072A5 JP2015514072A5 JP2015501784A JP2015501784A JP2015514072A5 JP 2015514072 A5 JP2015514072 A5 JP 2015514072A5 JP 2015501784 A JP2015501784 A JP 2015501784A JP 2015501784 A JP2015501784 A JP 2015501784A JP 2015514072 A5 JP2015514072 A5 JP 2015514072A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- phenyl
- indazol
- acrylic acid
- vinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613442P | 2012-03-20 | 2012-03-20 | |
| US61/613,442 | 2012-03-20 | ||
| PCT/US2013/031507 WO2013142266A1 (en) | 2012-03-20 | 2013-03-14 | Estrogen receptor modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514072A JP2015514072A (ja) | 2015-05-18 |
| JP2015514072A5 true JP2015514072A5 (enExample) | 2017-02-09 |
| JP6154887B2 JP6154887B2 (ja) | 2017-06-28 |
Family
ID=49223229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501784A Active JP6154887B2 (ja) | 2012-03-20 | 2013-03-14 | エストロゲン受容体モジュレーターおよびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9499538B2 (enExample) |
| EP (1) | EP2828243B1 (enExample) |
| JP (1) | JP6154887B2 (enExample) |
| KR (1) | KR20140138296A (enExample) |
| CN (1) | CN104220426B (enExample) |
| AU (1) | AU2013235499A1 (enExample) |
| CA (1) | CA2866891A1 (enExample) |
| CO (1) | CO7170179A2 (enExample) |
| CR (1) | CR20140479A (enExample) |
| EA (1) | EA201491530A1 (enExample) |
| IL (1) | IL234487A0 (enExample) |
| MX (1) | MX2014011217A (enExample) |
| NZ (1) | NZ630124A (enExample) |
| PE (1) | PE20142461A1 (enExample) |
| PH (1) | PH12014502095A1 (enExample) |
| SG (1) | SG11201405918XA (enExample) |
| WO (1) | WO2013142266A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201491530A1 (ru) | 2012-03-20 | 2015-07-30 | Серагон Фармасьютикалс, Инк. | Модуляторы рецепторов эстрогенов и их применение |
| JP2016517420A (ja) | 2013-03-14 | 2016-06-16 | セラゴン ファーマシューティカルズ， インク． | 多環式エストロゲン受容体モジュレーター及びその使用 |
| US10000459B2 (en) | 2013-03-15 | 2018-06-19 | Epigen Biosciences, Inc. | Heterocyclic compounds useful in the treatment of disease |
| WO2014205136A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Azetidine estrogen receptor modulators and uses thereof |
| BR112015031903A8 (pt) | 2013-06-19 | 2019-12-31 | Seragon Pharmaceuticals Inc | composto, sal farmaceuticamente aceitável, composição farmacêutica e uso de um composto |
| EP3089747A1 (en) | 2013-12-06 | 2016-11-09 | F. Hoffmann-La Roche AG | Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive breast cancer |
| JP2017507964A (ja) | 2014-03-13 | 2017-03-23 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | エストロゲン受容体モジュレーターを用いた治療的組合せ |
| AU2015228860A1 (en) * | 2014-03-13 | 2016-09-08 | F. Hoffmann-La Roche Ag | Methods and compositions for modulating estrogen receptor mutants |
| US9783503B2 (en) | 2014-08-11 | 2017-10-10 | Genentech, Inc. | Crystalline forms of an estrogen receptor modulator |
| CN107531722B (zh) | 2015-05-26 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 杂环雌激素受体调节剂及其用途 |
| PL3302471T3 (pl) | 2015-05-29 | 2022-02-07 | Eisai R&D Management Co., Ltd. | Tetrapodstawione związki alkenowe i ich zastosowanie |
| CN105061316B (zh) * | 2015-07-17 | 2017-12-22 | 苏州大学 | 稠环类化合物、制备方法和用途 |
| CN106518768B (zh) * | 2015-09-15 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 丙烯酸类衍生物、其制备方法及其在医药上的应用 |
| EP3359527A1 (en) | 2015-10-07 | 2018-08-15 | H. Hoffnabb-La Roche Ag | Process for the preparation of (e)-3-(4-((e)-2-(2-chloro-4-fluorophenyl)-1-(1h-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid |
| NZ743651A (en) | 2015-12-09 | 2023-07-28 | Univ Illinois | Benzothiophene-based selective estrogen receptor downregulators |
| CA3018801C (en) * | 2016-03-25 | 2020-06-23 | Luoxin Biotechnology (Shanghai) Co., Ltd | Substituted-indole compounds as estrogen receptor down-regulators |
| CA3017388C (en) | 2016-04-01 | 2024-03-12 | Zeno Royalties & Milestones, LLC | Estrogen receptor modulators |
| HUE057289T2 (hu) | 2016-08-31 | 2022-05-28 | Jiangsu Hengrui Medicine Co | Oxopikolinamid-származék, annak elõállítási módszere és gyógyszerészeti felhasználása |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| WO2018098305A1 (en) * | 2016-11-24 | 2018-05-31 | Eisai R&D Management Co., Ltd. | Tetrasubstituted alkene compounds and their use for the treatment of breast cancer |
| EP3544967B1 (en) | 2016-11-28 | 2023-06-28 | Eisai R&D Management Co., Ltd. | Salts of indazole derivative and crystals thereof |
| TWI823845B (zh) | 2017-01-06 | 2023-12-01 | 美商G1治療公司 | 用於治療癌症的組合療法 |
| WO2018148576A1 (en) | 2017-02-10 | 2018-08-16 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
| CN108976187B (zh) * | 2017-06-02 | 2021-11-26 | 上海青东生物科技有限公司 | 一种取代苯并呋喃衍生物及其制备与在制备抗肿瘤药物中的应用 |
| WO2019225552A1 (en) * | 2018-05-22 | 2019-11-28 | Eisai R&D Management Co., Ltd. | Salts of indazole derivative and crystals thereof |
| KR102754524B1 (ko) | 2018-08-17 | 2025-01-13 | 제넨테크, 인크. | 유방암 치료를 위한 진단 및 치료 방법들 |
| MX2021007088A (es) * | 2018-12-17 | 2021-09-08 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Antagonista del receptor de estrogeno. |
| KR20220024476A (ko) * | 2019-06-19 | 2022-03-03 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 인다졸 유도체, 이의 제조 방법, 및 이의 약제학적 적용 |
| US11278532B2 (en) | 2019-08-06 | 2022-03-22 | Recurium Ip Holdings, Llc | Estrogen receptor modulators for treating mutants |
| JP2024502270A (ja) | 2020-12-23 | 2024-01-18 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | エストロゲン受容体調節薬 |
| CN115745895A (zh) * | 2021-11-13 | 2023-03-07 | 温州奥洋科技有限公司 | 一种紫外线吸收剂二苯嘧啶乙烯的结构与合成路线 |
| CN116239562B (zh) * | 2021-12-07 | 2024-12-31 | 江苏师范大学 | 一种以苯并呋喃酮为原料合成盐酸多塞平的方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002097B1 (en) * | 1977-08-22 | 1981-08-05 | Imperial Chemical Industries Plc | Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them |
| US4229447A (en) | 1979-06-04 | 1980-10-21 | American Home Products Corporation | Intraoral methods of using benzodiazepines |
| US4596795A (en) | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| JPH0778017B2 (ja) | 1985-12-28 | 1995-08-23 | 住友製薬株式会社 | パルス的かつ持続放出性製剤 |
| US4755386A (en) | 1986-01-22 | 1988-07-05 | Schering Corporation | Buccal formulation |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5739136A (en) | 1989-10-17 | 1998-04-14 | Ellinwood, Jr.; Everett H. | Intraoral dosing method of administering medicaments |
| US5017381A (en) | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
| US5229135A (en) | 1991-11-22 | 1993-07-20 | Prographarm Laboratories | Sustained release diltiazem formulation |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| JP3409366B2 (ja) | 1993-06-18 | 2003-05-26 | 東洋インキ製造株式会社 | 有機エレクトロルミネッセンス素子 |
| US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| DE19807760A1 (de) | 1997-02-27 | 1998-09-03 | Fuji Electric Co Ltd | Elektrofotografischer Fotoleiter |
| US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| CZ300929B6 (cs) | 1997-08-15 | 2009-09-16 | Duke University | Sloucenina pro použití pri lécení nebo prevenci estrogenem stimulované rakoviny |
| DE19801597C2 (de) | 1998-01-17 | 2001-05-03 | Aventis Res & Tech Gmbh & Co | Basenkatalysierte Synthese von 1-Aryl-4-(arylethyl)piperazinen aus aromatischen Olefinen und 1-Arylpiperazinen |
| DE19801598C2 (de) | 1998-01-17 | 2000-05-11 | Aventis Res & Tech Gmbh & Co | Katalytische Synthese von N-alkylierten Anilinen aus Olefinen und Anilinen |
| TW593256B (en) | 1999-11-16 | 2004-06-21 | Hormos Medical Oy Ltd | Triphenylalkene derivatives and their use as selective estrogen receptor modulators |
| GB9929988D0 (en) | 1999-12-17 | 2000-02-09 | Celltech Therapeutics Ltd | Chemical compounds |
| US6528681B2 (en) * | 2000-04-05 | 2003-03-04 | Bristol-Meyers Squibb Pharma Company | Halogenated triphenylethylene derivatives as selective estrogen receptor modulators |
| AU2002323098A1 (en) | 2001-08-11 | 2003-03-03 | Bristol-Myers Squibb Pharma Company | Selective estrogen receptor modulators |
| US7414040B2 (en) | 2002-06-06 | 2008-08-19 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| ATE399775T1 (de) * | 2003-10-08 | 2008-07-15 | Smithkline Beecham Corp | Triphenylethyleneverbindungen als selektive modulatoren des östrogenrezeptors |
| DE102004028862A1 (de) * | 2004-06-15 | 2005-12-29 | Merck Patent Gmbh | 3-Aminoindazole |
| US20070292545A1 (en) | 2005-10-18 | 2007-12-20 | Aaron Monte | Anti-infective agents and methods of use |
| CN101146796A (zh) * | 2005-01-26 | 2008-03-19 | 先灵公司 | 作为蛋白激酶抑制剂用于治疗癌症的3-(吲唑-5-基)-(1,2,4)三嗪衍生物及相关化合物 |
| JP2009504872A (ja) | 2005-08-15 | 2009-02-05 | テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド | 印刷可能な材料 |
| JP2010508358A (ja) | 2006-11-01 | 2010-03-18 | ブリストル−マイヤーズ スクイブ カンパニー | グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の調節剤、並びにその使用 |
| JP2008156313A (ja) | 2006-12-26 | 2008-07-10 | Fyuuensu:Kk | アミロイド疾患の治療およびモニタリングのための薬剤 |
| GB0704407D0 (en) | 2007-03-07 | 2007-04-18 | Glaxo Group Ltd | Compounds |
| DE102007049451A1 (de) * | 2007-10-16 | 2009-04-23 | Merck Patent Gmbh | 5-Cyano-thienopyridine |
| JP5223362B2 (ja) | 2008-02-07 | 2013-06-26 | コニカミノルタビジネステクノロジーズ株式会社 | 光電変換素子及び太陽電池 |
| WO2009131654A2 (en) | 2008-04-21 | 2009-10-29 | North Carolina State University | Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives |
| US8697685B2 (en) | 2008-11-20 | 2014-04-15 | Glaxosmithkline Llc | Chemical compounds |
| WO2010077603A1 (en) | 2008-12-08 | 2010-07-08 | North Carolina State University | Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives |
| WO2010107474A1 (en) | 2009-03-16 | 2010-09-23 | The Research Foundation Of State University Of New York | Antiestrogens for breast cancer therapy |
| WO2010144959A1 (en) | 2009-06-18 | 2010-12-23 | Fibrotech Therapeutics Pty Ltd | Analogues of anti-fibrotic agents |
| GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| EA201491530A1 (ru) | 2012-03-20 | 2015-07-30 | Серагон Фармасьютикалс, Инк. | Модуляторы рецепторов эстрогенов и их применение |
| JP6126562B2 (ja) * | 2014-08-27 | 2017-05-10 | 三星ダイヤモンド工業株式会社 | 光ファイバ装置 |
-
2013
- 2013-03-14 EA EA201491530A patent/EA201491530A1/ru unknown
- 2013-03-14 KR KR1020147028984A patent/KR20140138296A/ko not_active Withdrawn
- 2013-03-14 PE PE2014001451A patent/PE20142461A1/es not_active Application Discontinuation
- 2013-03-14 AU AU2013235499A patent/AU2013235499A1/en not_active Abandoned
- 2013-03-14 EP EP13763661.9A patent/EP2828243B1/en active Active
- 2013-03-14 CN CN201380019700.9A patent/CN104220426B/zh active Active
- 2013-03-14 NZ NZ630124A patent/NZ630124A/en not_active IP Right Cessation
- 2013-03-14 MX MX2014011217A patent/MX2014011217A/es unknown
- 2013-03-14 SG SG11201405918XA patent/SG11201405918XA/en unknown
- 2013-03-14 WO PCT/US2013/031507 patent/WO2013142266A1/en not_active Ceased
- 2013-03-14 CA CA2866891A patent/CA2866891A1/en not_active Abandoned
- 2013-03-14 US US14/386,313 patent/US9499538B2/en active Active
- 2013-03-14 JP JP2015501784A patent/JP6154887B2/ja active Active
-
2014
- 2014-09-07 IL IL234487A patent/IL234487A0/en unknown
- 2014-09-22 PH PH12014502095A patent/PH12014502095A1/en unknown
- 2014-10-15 CR CR20140479A patent/CR20140479A/es not_active Application Discontinuation
- 2014-10-17 CO CO14230728A patent/CO7170179A2/es unknown
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