JP2012508223A5 - - Google Patents
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- Publication number
- JP2012508223A5 JP2012508223A5 JP2011535182A JP2011535182A JP2012508223A5 JP 2012508223 A5 JP2012508223 A5 JP 2012508223A5 JP 2011535182 A JP2011535182 A JP 2011535182A JP 2011535182 A JP2011535182 A JP 2011535182A JP 2012508223 A5 JP2012508223 A5 JP 2012508223A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- triazin
- alkyl
- pyridin
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 25
- 125000000623 heterocyclic group Chemical group 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000001072 heteroaryl group Chemical group 0.000 claims 19
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 16
- 125000004452 carbocyclyl group Chemical group 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 10
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 229910052794 bromium Inorganic materials 0.000 claims 9
- 229910052801 chlorine Inorganic materials 0.000 claims 9
- 229910052731 fluorine Inorganic materials 0.000 claims 9
- 229910052740 iodine Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000005647 linker group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 230000003796 beauty Effects 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 230000003463 hyperproliferative effect Effects 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 2
- 125000003860 C1-C20 alkoxy group Chemical group 0.000 claims 2
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 2
- 208000006029 Cardiomegaly Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 230000006044 T cell activation Effects 0.000 claims 2
- 108090000190 Thrombin Proteins 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 230000001066 destructive effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 208000033065 inborn errors of immunity Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 208000028529 primary immunodeficiency disease Diseases 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003456 sulfonamides Chemical class 0.000 claims 2
- 229960004072 thrombin Drugs 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims 1
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 1
- WMHAVCWMHYZXHG-UHFFFAOYSA-N 3-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenol Chemical compound OC1=CC=CC(C=2N=C(N=C(N=2)N2CCOCC2)N2CCOCC2)=C1 WMHAVCWMHYZXHG-UHFFFAOYSA-N 0.000 claims 1
- CONLCFVHCYLZKW-UHFFFAOYSA-N 3-[4-morpholin-4-yl-6-(pyridin-2-ylmethylamino)-1,3,5-triazin-2-yl]phenol Chemical compound OC1=CC=CC(C=2N=C(N=C(NCC=3N=CC=CC=3)N=2)N2CCOCC2)=C1 CONLCFVHCYLZKW-UHFFFAOYSA-N 0.000 claims 1
- KAMYTFFDGJCUCA-UHFFFAOYSA-N 4-(1h-benzimidazol-4-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=3N=CNC=3C=CC=2)=NC=1N1CCOCC1 KAMYTFFDGJCUCA-UHFFFAOYSA-N 0.000 claims 1
- NNOOIRJOIGXMEE-UHFFFAOYSA-N 4-(1h-indazol-5-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=C3C=NNC3=CC=2)=NC=1N1CCOCC1 NNOOIRJOIGXMEE-UHFFFAOYSA-N 0.000 claims 1
- AZIIYUJTCFFXTJ-UHFFFAOYSA-N 4-(1h-indol-4-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=3C=CNC=3C=CC=2)=NC=1N1CCOCC1 AZIIYUJTCFFXTJ-UHFFFAOYSA-N 0.000 claims 1
- WRVPFLBQQXTMEU-UHFFFAOYSA-N 4-(1h-indol-5-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=C3C=CNC3=CC=2)=NC=1N1CCOCC1 WRVPFLBQQXTMEU-UHFFFAOYSA-N 0.000 claims 1
- MDHMXHNFPXWJEG-UHFFFAOYSA-N 4-(2-aminopyrimidin-5-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C1=NC(N)=NC=C1C1=NC(NCC=2N=CC=CC=2)=NC(N2CCOCC2)=N1 MDHMXHNFPXWJEG-UHFFFAOYSA-N 0.000 claims 1
- VMXPZMLXTHXGLQ-UHFFFAOYSA-N 4-(3h-benzimidazol-5-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C=1C=CC=NC=1CNC(N=C(N=1)C=2C=C3N=CNC3=CC=2)=NC=1N1CCOCC1 VMXPZMLXTHXGLQ-UHFFFAOYSA-N 0.000 claims 1
- CAVNILDGKKVJSJ-UHFFFAOYSA-N 4-(6-aminopyridin-3-yl)-6-morpholin-4-yl-n-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine Chemical compound C1=NC(N)=CC=C1C1=NC(NCC=2N=CC=CC=2)=NC(N2CCOCC2)=N1 CAVNILDGKKVJSJ-UHFFFAOYSA-N 0.000 claims 1
- BBDMJQBDNFISIX-UHFFFAOYSA-N 4-[4-(1h-benzimidazol-4-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=3N=CNC=3C=CC=2)=NC=1N1CCOCC1 BBDMJQBDNFISIX-UHFFFAOYSA-N 0.000 claims 1
- UPZKDZOZSLCPDX-UHFFFAOYSA-N 4-[4-(1h-indazol-4-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=3C=NNC=3C=CC=2)=NC=1N1CCOCC1 UPZKDZOZSLCPDX-UHFFFAOYSA-N 0.000 claims 1
- AYCPQGCCBNIKNU-UHFFFAOYSA-N 4-[4-(1h-indazol-5-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=C3C=NNC3=CC=2)=NC=1N1CCOCC1 AYCPQGCCBNIKNU-UHFFFAOYSA-N 0.000 claims 1
- BWHGEHLHWRIFSI-UHFFFAOYSA-N 4-[4-(1h-indol-4-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=3C=CNC=3C=CC=2)=NC=1N1CCOCC1 BWHGEHLHWRIFSI-UHFFFAOYSA-N 0.000 claims 1
- DDQOBEBNFDEMIW-UHFFFAOYSA-N 4-[4-(1h-indol-5-yl)-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]morpholine Chemical compound C=1C=CC=NC=1COC(N=C(N=1)C=2C=C3C=CNC3=CC=2)=NC=1N1CCOCC1 DDQOBEBNFDEMIW-UHFFFAOYSA-N 0.000 claims 1
- ADGGYDAFIHSYFI-UHFFFAOYSA-N 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine Chemical compound C1=NC(N)=CC(C(F)(F)F)=C1C1=NC(N2CCOCC2)=NC(N2CCOCC2)=N1 ADGGYDAFIHSYFI-UHFFFAOYSA-N 0.000 claims 1
- IFPHRQQBRZZIOQ-UHFFFAOYSA-N 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine Chemical compound FC(F)(F)C1=NC(N)=NC=C1C1=NC(N2CCOCC2)=NC(N2CCOCC2)=N1 IFPHRQQBRZZIOQ-UHFFFAOYSA-N 0.000 claims 1
- OCKCSFKWKYZXKV-UHFFFAOYSA-N 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-6-(trifluoromethyl)pyridin-2-amine Chemical compound FC(F)(F)C1=NC(N)=CC=C1C1=NC(N2CCOCC2)=NC(N2CCOCC2)=N1 OCKCSFKWKYZXKV-UHFFFAOYSA-N 0.000 claims 1
- WIVHSFPCDNBXSB-UHFFFAOYSA-N 5-[4-morpholin-4-yl-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]pyridin-2-amine Chemical compound C1=NC(N)=CC=C1C1=NC(OCC=2N=CC=CC=2)=NC(N2CCOCC2)=N1 WIVHSFPCDNBXSB-UHFFFAOYSA-N 0.000 claims 1
- HGNGQAXXKVMOMI-UHFFFAOYSA-N 5-[4-morpholin-4-yl-6-(pyridin-2-ylmethoxy)-1,3,5-triazin-2-yl]pyrimidin-2-amine Chemical compound C1=NC(N)=NC=C1C1=NC(OCC=2N=CC=CC=2)=NC(N2CCOCC2)=N1 HGNGQAXXKVMOMI-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- VEFTXXDQMDONGC-UHFFFAOYSA-N C1COCCN1C2N=CN=C(N2C3=CC4=C(C=C3)N=CN4)OCC5=CC=CC=N5 Chemical compound C1COCCN1C2N=CN=C(N2C3=CC4=C(C=C3)N=CN4)OCC5=CC=CC=N5 VEFTXXDQMDONGC-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000002952 polymeric resin Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 229920003002 synthetic resin Polymers 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 0 *C(*1)C(C2N=C(N3C(*)C(*)OC(*)C3*)N=C(*)C2)=C(*)N=C1N* Chemical compound *C(*1)C(C2N=C(N3C(*)C(*)OC(*)C3*)N=C(*)C2)=C(*)N=C1N* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08211219.3 | 2008-11-10 | ||
| GB0821219A GB2465405A (en) | 2008-11-10 | 2008-11-10 | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| PCT/IB2009/007404 WO2010052569A2 (en) | 2008-11-10 | 2009-11-10 | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015020319A Division JP6047184B2 (ja) | 2008-11-10 | 2015-02-04 | トリアジン、ピリミジン、及びピリジン類似体、並びに、治療薬及び診断プローブとしてのそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508223A JP2012508223A (ja) | 2012-04-05 |
| JP2012508223A5 true JP2012508223A5 (enExample) | 2012-12-27 |
| JP5738768B2 JP5738768B2 (ja) | 2015-06-24 |
Family
ID=40230564
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535182A Active JP5738768B2 (ja) | 2008-11-10 | 2009-11-10 | トリアジン、ピリミジン、及びピリジン類似体、並びに、治療薬及び診断プローブとしてのそれらの使用 |
| JP2015020319A Active JP6047184B2 (ja) | 2008-11-10 | 2015-02-04 | トリアジン、ピリミジン、及びピリジン類似体、並びに、治療薬及び診断プローブとしてのそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015020319A Active JP6047184B2 (ja) | 2008-11-10 | 2015-02-04 | トリアジン、ピリミジン、及びピリジン類似体、並びに、治療薬及び診断プローブとしてのそれらの使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8921361B2 (enExample) |
| EP (1) | EP2364302B1 (enExample) |
| JP (2) | JP5738768B2 (enExample) |
| KR (1) | KR101749192B1 (enExample) |
| CN (1) | CN102209714B (enExample) |
| AU (1) | AU2009312464B2 (enExample) |
| BR (1) | BRPI0921709B1 (enExample) |
| CA (1) | CA2741990C (enExample) |
| CY (1) | CY1118438T1 (enExample) |
| DK (1) | DK2364302T3 (enExample) |
| ES (1) | ES2609296T3 (enExample) |
| GB (1) | GB2465405A (enExample) |
| HR (1) | HRP20161769T1 (enExample) |
| IL (1) | IL212726A (enExample) |
| LT (1) | LT2364302T (enExample) |
| MX (1) | MX2011004889A (enExample) |
| NZ (1) | NZ592617A (enExample) |
| RU (1) | RU2537945C2 (enExample) |
| SI (1) | SI2364302T1 (enExample) |
| SM (1) | SMT201700006B (enExample) |
| WO (1) | WO2010052569A2 (enExample) |
| ZA (1) | ZA201104298B (enExample) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3086695B2 (ja) | 1990-07-20 | 2000-09-11 | 株式会社東芝 | ガスタービン制御装置 |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| AU2010229468A1 (en) | 2009-03-27 | 2011-10-13 | Vetdc, Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
| UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| US8486939B2 (en) | 2009-07-07 | 2013-07-16 | Pathway Therapeutics Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
| AU2010286168B2 (en) * | 2009-08-20 | 2014-05-15 | Karus Therapeutics Limited | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors |
| EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| EP2542536B1 (en) | 2010-03-04 | 2015-01-21 | Cellzome Limited | Morpholino substituted urea derivatives as mtor inhibitors |
| EP2616441B1 (en) | 2010-09-17 | 2019-08-07 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| AU2011343712B2 (en) | 2010-12-16 | 2015-09-17 | Genentech, Inc. | Tricyclic PI3k inhibitor compounds and methods of use |
| AU2015268776B2 (en) * | 2010-12-16 | 2017-04-13 | Genentech, Inc. | Tricyclic PI3k inhibitor compounds and methods of use |
| JP2014500303A (ja) * | 2010-12-22 | 2014-01-09 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としての置換ピリジン |
| EA201300867A1 (ru) * | 2011-01-27 | 2014-03-31 | Дзе Трастиз Оф Принстон Юнивесити | ИНГИБИТОРЫ КИНАЗЫ mTOR В КАЧЕСТВЕ АНТИВИРУСНЫХ АГЕНТОВ |
| WO2012122383A2 (en) * | 2011-03-09 | 2012-09-13 | Avila Therapeutics, Inc. | Pi3 kinase inhibitors and uses thereof |
| EP2691384B1 (en) | 2011-03-28 | 2016-10-26 | MEI Pharma, Inc. | (alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
| CN102389430B (zh) * | 2011-09-07 | 2013-08-28 | 苏州大学 | 一种小分子化合物在制备抗肺癌药物中的应用 |
| CA2849189A1 (en) * | 2011-09-21 | 2013-03-28 | Cellzome Limited | Morpholino substituted urea or carbamate derivatives as mtor inhibitors |
| AU2012313888B2 (en) | 2011-09-27 | 2016-03-31 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH |
| JP5995977B2 (ja) * | 2011-10-07 | 2016-09-21 | セルゾーム リミテッド | Ｍｔｏｒ阻害剤としてのモルホリノ置換二環式ピリミジン尿素またはカルバメート誘導体 |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
| IN2012DE00794A (enExample) * | 2012-03-19 | 2015-08-21 | Council Scient Ind Res | |
| US9630958B2 (en) | 2012-07-23 | 2017-04-25 | Sphaera Pharma Pte. Ltd. | Triazine compounds |
| WO2014044722A1 (en) | 2012-09-20 | 2014-03-27 | Basf Se | Azadibenzofurans for electronic applications |
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