RU2537945C2 - Триазиновые, пиримидиновые и пиридиновые аналоги и их применение в качестве терапевтических агентов и диагностических проб - Google Patents

Триазиновые, пиримидиновые и пиридиновые аналоги и их применение в качестве терапевтических агентов и диагностических проб Download PDF

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RU2537945C2
RU2537945C2 RU2011114559/04A RU2011114559A RU2537945C2 RU 2537945 C2 RU2537945 C2 RU 2537945C2 RU 2011114559/04 A RU2011114559/04 A RU 2011114559/04A RU 2011114559 A RU2011114559 A RU 2011114559A RU 2537945 C2 RU2537945 C2 RU 2537945C2
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triazin
compounds
substituted
dimorpholino
unsubstituted
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RU2011114559A (ru
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Владимир ЦМИЛЬЯНОВИЦ
Натаса ЦМИЛЬЯНОВИЦ
Бернд ГИЗЕ
Маттиас ВИМАНН
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Юниверсити Оф Базель
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2754664C2 (ru) * 2016-02-19 2021-09-06 Спринт Биосайенс Аб 6-арил-4-морфолин-1-илпиридоны, пригодные для лечения рака или диабета
US11434232B2 (en) 2018-02-07 2022-09-06 Wuxi Biocity Biopharmaceutics Co., Ltd. ATR inhibitor and application thereof
RU2799047C2 (ru) * 2018-02-07 2023-07-03 Уси Байосити Байофармасьютикс Ко., Лтд. Ингибитор atr и его применение

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3086695B2 (ja) 1990-07-20 2000-09-11 株式会社東芝 ガスタービン制御装置
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
MX2011010105A (es) 2009-03-27 2012-01-12 Pathway Therapeutics Inc Sulfonamidas de pirimidinilo y 1,3,5-triazinilo benzimidazol y su uso en terapia de cancer.
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
AR080945A1 (es) 2009-07-07 2012-05-23 Pathway Therapeutics Inc Pirimidinil y 1,3,5-triazinil benzimidazoles y su uso en la terapia contra el cancer
IN2012DN01325A (enExample) * 2009-08-20 2015-06-05 Karus Therapeutics Ltd
EP2343294A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
WO2011107585A1 (en) 2010-03-04 2011-09-09 Cellzome Limited Morpholino substituted urea derivatives as mtor inhibitors
BR112013006272A2 (pt) 2010-09-17 2019-09-24 Purdue Pharma Lp compostos de piridina e seus usos
JP5775171B2 (ja) * 2010-12-16 2015-09-09 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 三環系pi3k阻害剤化合物及びその使用方法
AU2015268776B2 (en) * 2010-12-16 2017-04-13 Genentech, Inc. Tricyclic PI3k inhibitor compounds and methods of use
KR20130119964A (ko) * 2010-12-22 2013-11-01 퍼듀 퍼머 엘피 나트륨 채널 차단제로서의 치환된 피리딘
EP2667874A4 (en) * 2011-01-27 2014-07-30 Univ Princeton MTOR KINASE HEMMER AS ANTIVIRUS AGENT
WO2012122383A2 (en) * 2011-03-09 2012-09-13 Avila Therapeutics, Inc. Pi3 kinase inhibitors and uses thereof
CA2831582C (en) 2011-03-28 2019-01-08 Mei Pharma, Inc. (alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
CN102389430B (zh) * 2011-09-07 2013-08-28 苏州大学 一种小分子化合物在制备抗肺癌药物中的应用
WO2013041652A1 (en) * 2011-09-21 2013-03-28 Cellzome Limited Morpholino substituted urea or carbamate derivatives as mtor inhibitors
AP3907A (en) 2011-09-27 2016-11-23 Novartis Ag 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
WO2013050508A1 (en) * 2011-10-07 2013-04-11 Cellzome Limited Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mtor inhibitors
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
GB201204125D0 (en) 2012-03-08 2012-04-25 Karus Therapeutics Ltd Compounds
CA2867452C (en) * 2012-03-19 2020-04-14 Council Of Scientific & Industrial Research Boronic acid bearing liphagane compounds as inhibitors of pi3k-.alpha. and/or .beta.
EP2874632B1 (en) * 2012-07-23 2020-06-17 Sphaera Pharma Pte. Ltd Triazine compound having pi3k-alpha and mtor inhibiting activity
CN107573363A (zh) 2012-09-20 2018-01-12 Udc 爱尔兰有限责任公司 供电子应用的氮杂二苯并呋喃和包含氮杂二苯并呋喃的电子器件
CN102875558A (zh) * 2012-11-05 2013-01-16 贵州大学 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途
NZ707366A (en) 2012-11-07 2018-11-30 Karus Therapeutics Ltd Novel histone deacetylase inhibitors and their use in therapy
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
CN105050602B (zh) * 2013-01-12 2018-05-25 张大为 作为pi3激酶抑制剂的吡啶化合物
WO2014141104A1 (en) 2013-03-14 2014-09-18 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
WO2014177060A1 (en) 2013-05-01 2014-11-06 F.Hoffmann-La Roche Ag Biheteroaryl compounds and uses thereof
NZ714283A (en) 2013-05-10 2020-04-24 Karus Therapeutics Ltd Novel histone deacetylase inhibitors
CN103483345B (zh) * 2013-09-25 2016-07-06 中山大学 Pi3k激酶抑制剂、包含其的药物组合物及其应用
WO2015088564A1 (en) * 2013-12-13 2015-06-18 Sunovion Pharmaceuticals Inc. P2x4 receptor modulating compounds
WO2015088565A1 (en) * 2013-12-13 2015-06-18 Sunovion Pharmaceuticals Inc. P2x4 receptor modulating compounds and methods of use thereof
GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
US9982123B2 (en) 2014-04-02 2018-05-29 Ineos Styrolution Group Gmbh Process for producing thermoplastic moulding compositions with improved mechanical properties
CN106458968B (zh) 2014-04-22 2019-06-25 巴塞尔大学 三嗪、嘧啶和吡啶衍生物的新制备方法
KR102287012B1 (ko) * 2014-05-28 2021-08-09 덕산네오룩스 주식회사 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치
US10689383B2 (en) 2014-08-04 2020-06-23 Nuevolution A/S Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
CN104151256B (zh) * 2014-08-14 2016-08-24 西安交通大学 二取代苯甲酰胺类化合物及其合成方法和应用
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
MA40933A (fr) * 2014-11-11 2017-09-19 Piqur Therapeutics Ag Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines
CN104473923B (zh) * 2014-12-29 2016-08-17 巩春智 一种防治慢性心力衰竭的药物组合物及其应用
SG11201706146UA (en) 2015-02-02 2017-08-30 Forma Therapeutics Inc 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors
US10183934B2 (en) 2015-02-02 2019-01-22 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors
CN104860956B (zh) * 2015-04-30 2017-05-10 华南师范大学 一种荧光多功能单体及其合成方法与应用
CN106279211B (zh) * 2015-06-03 2020-09-15 北京大学 一种噻唑并嘧啶酮化合物及其制备方法和应用
GB201514760D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
MX391850B (es) 2015-12-10 2025-03-19 Ptc Therapeutics Inc Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington
CN113999249B (zh) * 2015-12-16 2025-03-25 基因泰克公司 用于制备三环pi3k抑制剂化合物的方法及用其治疗癌症的方法
GB201602527D0 (en) * 2016-02-12 2016-03-30 Glaxosmithkline Ip Dev Ltd Chemical compounds
KR101919189B1 (ko) * 2016-02-18 2018-11-15 경북대학교 산학협력단 다중치환 4H-티아졸로[4,5-e][1,4]다이아제핀-5,8-다이온 유도체 및 이의 용도
AU2017219847B2 (en) 2016-02-19 2021-02-04 Sprint Bioscience Ab 6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
WO2017198346A1 (en) * 2016-05-18 2017-11-23 Piqur Therapeutics Ag Treatment of neurological disorders
EP3458035A1 (en) * 2016-05-18 2019-03-27 PIQUR Therapeutics AG Treatment of skin lesions
KR102483630B1 (ko) * 2016-05-18 2023-01-02 토르쿠르 아게 피부 병변의 치료
WO2017210545A1 (en) 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
WO2017218950A1 (en) 2016-06-17 2017-12-21 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
KR20190049691A (ko) 2016-07-07 2019-05-09 카듀리온 파마슈티칼스, 엘엘씨 심부전의 치료 방법
EP3548035A4 (en) 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
US10829452B2 (en) 2016-12-22 2020-11-10 Global Blood Therapeutics, Inc. Histone methyltransferase inhibitors
PL3571193T3 (pl) 2017-01-23 2022-04-25 Cadent Therapeutics, Inc. Modulatory kanału potasowego
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
GB201702938D0 (en) 2017-02-23 2017-04-12 Univ Southampton Methods of generating and screening compartmentalised peptides libraries
CN117860758A (zh) 2017-05-23 2024-04-12 梅制药公司 联合疗法
CN107216344B (zh) * 2017-05-27 2019-06-21 无锡捷化医药科技有限公司 一种5-溴-噻唑并[4,5-d]嘧啶的制备方法
SG11201911615WA (en) 2017-06-05 2020-01-30 Ptc Therapeutics Inc Compounds for treating huntington's disease
US11111243B2 (en) 2017-06-09 2021-09-07 Global Blood Therapeutics, Inc. Azaindole compounds as histone methyltransferase inhibitors
CN107266422A (zh) * 2017-06-12 2017-10-20 西安交通大学 2‑(5‑嘧啶基)‑4‑吗啉基‑6‑取代均三嗪类化合物及其盐、制备方法和应用
MX2019015580A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
WO2019005980A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
KR20200041358A (ko) 2017-08-14 2020-04-21 메이 파마, 아이엔씨. 병용 요법
CN109651341A (zh) * 2017-10-11 2019-04-19 上海医药工业研究院 二吗啉氰基嘧(吡)啶类衍生物及作为抗肿瘤药物应用
CN111315384A (zh) 2017-11-23 2020-06-19 皮奎尔治疗公司 皮肤病的治疗
AU2019243048A1 (en) * 2018-03-27 2020-10-15 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
CN112189012B (zh) * 2018-04-10 2024-02-13 神经孔疗法股份有限公司 作为pi3激酶和自噬途径的调节剂的三取代芳基和杂芳基衍生物
BR112020021153A2 (pt) 2018-04-17 2021-03-23 Cardurion Pharmaceuticals, Llc sais de meglumina de tienopirimidinas
EP3814360B8 (en) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
BR112020026534A2 (pt) 2018-06-27 2021-03-23 Ptc Therapeutics, Inc. Compostos de heteroarila para o tratamento da doença de huntington
MX2020014098A (es) 2018-06-27 2021-05-27 Ptc Therapeutics Inc Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington.
WO2020030708A1 (en) 2018-08-07 2020-02-13 Piqur Therapeutics Ag Treatment of squamous cell carcinoma
BR112021007552A2 (pt) 2018-10-22 2021-07-27 Cadent Therapeutics, Inc. formas cristalinas de moduladores de canal de potássio
CN113507931B (zh) 2018-11-21 2025-05-27 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
JP7458406B2 (ja) 2018-12-21 2024-03-29 セルジーン コーポレーション Ripk2のチエノピリジン阻害剤
CA3125625A1 (en) * 2019-01-04 2020-07-09 Bellbrook Labs, Llc Inhibitors of cgas activity as therapeutic agents
MA54907A (fr) * 2019-02-06 2022-05-11 Venthera Inc Inhibiteurs de phosphoinositide 3-kinase topiques
CN109942562B (zh) * 2019-02-27 2022-02-08 江西科技师范大学 含芳基结构的五元杂环联三嗪类化合物及其制备方法和应用
US12358932B2 (en) * 2019-07-03 2025-07-15 Borah, Inc. Chemical compounds
MX2022007265A (es) 2019-12-20 2022-09-09 Nuevolution As Compuestos activos frente a receptores nucleares.
PE20230240A1 (es) 2019-12-20 2023-02-07 Nuevolution As Compuestos activos frente a receptores nucleares
EP4090426B1 (en) 2020-01-13 2025-12-31 Verge Analytics, Inc. Substitutes for pyrazolos and pyrimidines and their uses
JP7713954B2 (ja) 2020-03-31 2025-07-28 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
AU2021245397A1 (en) 2020-03-31 2022-10-20 Nuevolution A/S Compounds active towards nuclear receptors
CN117255687A (zh) 2020-11-25 2023-12-19 德西费拉制药有限责任公司 吗啉衍生物作为vsp34抑制剂用于治疗病毒感染
US20250188062A1 (en) * 2021-01-25 2025-06-12 Athos Therapeutics, Inc. Triazine compounds and methods of making and using the same
CN117396470A (zh) * 2021-04-09 2024-01-12 巴塞尔大学 作为pi3k的可逆和不可逆共价抑制剂的三嗪衍生物
WO2022214701A1 (en) * 2021-04-09 2022-10-13 Universität Basel Triazine derivative as covalent inhibitors of pi3k
KR20240008312A (ko) * 2021-04-09 2024-01-18 유니버시타트 바셀 Pi3k의 가역적 및 비가역적 공유 억제제로서의 트리아진 유도체
CN117751127A (zh) * 2021-08-20 2024-03-22 南京大美生物制药有限公司 一种五元含氮杂环并杂芳基类衍生物及其用途
MX2024007010A (es) * 2021-12-08 2024-08-26 Kineta Inc Pirimidinas y metodos para su uso.
WO2024015531A2 (en) * 2022-07-13 2024-01-18 University Of Kentucky Research Foundation Triazine lipids, lipid synthesis, and methods for inhibiting canonical nf kb transcriptional activity
CN114933594A (zh) * 2022-07-20 2022-08-23 北京科翔中升医药科技有限公司 一种氟代三嗪类化合物、药物组合物及用途
CN116003448B (zh) * 2022-11-07 2024-06-11 淮阴工学院 一种含吲哚啉多烯键识别Aβ纤维的BODIPY近红外荧光探针及其制备方法
WO2024187321A1 (zh) * 2023-03-10 2024-09-19 甫康(上海)健康科技有限责任公司 含有egfr抑制剂的药物组合物及其制备方法和应用
US20250206729A1 (en) * 2023-12-22 2025-06-26 Deciphera Pharmaceuticals, Llc Dual raf and tubulin inhibitors and methods of use thereof
WO2025181366A1 (en) * 2024-03-01 2025-09-04 Torqur Ag Topical formulations of dual pi3k/mtor inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7173029B2 (en) * 2000-04-27 2007-02-06 Astellas Pharma Inc. Fused heteroaryl derivatives
EP1864665A1 (en) * 2005-03-11 2007-12-12 Zenyaku Kogyo Kabushiki Kaisha Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient
RU2312859C2 (ru) * 2002-05-30 2007-12-20 Солвей Фармасьютикалс Б.В. Производные 1,3,5-триазина, фармацевтическая композиция на их основе и их применение

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670550B2 (de) * 1967-02-17 1973-04-26 Deutsche Gold und Silber Scheide anstalt vormals Roessler, 6000 Frank fürt Substituierte 2-amino-4-hydrazino6-piperazino-s-triazine
DE2013357A1 (en) * 1970-03-20 1971-10-07 Farbenfabriken Bayer AG,5O9O Lever kusen Iminocarboxylic acid derivs in prepn of s-triazines
DE2712686C2 (de) * 1977-03-23 1986-09-04 Bayer Ag, 5090 Leverkusen 4-Triazinyl-4'-benzoxazolyl- bzw. 4'-phenyl-stilben-derivate
JPS59145250A (ja) * 1983-02-04 1984-08-20 Mitsubishi Chem Ind Ltd アントラキノン化合物及びアントラキノン染料
GB8612062D0 (en) * 1986-05-17 1986-06-25 Fbc Ltd Herbicides
WO1993017009A1 (fr) * 1992-02-28 1993-09-02 Zenyaku Kogyo Kabushiki Kaisha DERIVE DE s-TRIAZINE ET REMEDE CONTRE DES MALADIES DEPENDENTES DE L'×STROGENE LE CONTENANT COMME INGREDIENT ACTIF
BR9508539A (pt) * 1994-08-08 1997-10-28 Nippon Shinyaku Co Ltd Derivado de triazina e medicamento
EP1126843A4 (en) * 1998-10-29 2005-06-15 Bristol Myers Squibb Co AMINO-CELL DERIVATIVE COMPOUNDS INHIBITORS OF ENZYME IMPDH
JP4709388B2 (ja) * 1999-01-25 2011-06-22 全薬工業株式会社 複素環式化合物及びそれを有効成分とする抗腫瘍剤
CA2445395C (en) * 2001-04-27 2010-03-30 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent comprising the same as effective component
WO2003078427A1 (en) * 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Azolylaminoazines as inhibitors of protein kinases
WO2004000820A2 (en) * 2002-06-21 2003-12-31 Cellular Genomics, Inc. Certain aromatic monocycles as kinase modulators
WO2004072063A1 (en) * 2003-02-07 2004-08-26 Vertex Pharmaceuticals Incorporated Heteroaryl substituted pyrolls useful as inhibitors of protein kinases
WO2005011703A1 (en) * 2003-08-04 2005-02-10 Akzo Nobel N.V. 2-cyano-1,3,5-triazine-4,6-diamine derivatives
PE20050952A1 (es) * 2003-09-24 2005-12-19 Novartis Ag Derivados de isoquinolina como inhibidores de b-raf
KR20080063809A (ko) * 2005-09-30 2008-07-07 버텍스 파마슈티칼스 인코포레이티드 야누스 키나아제의 억제제로서 유용한 데아자퓨린
GB0520657D0 (en) * 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds
CL2007001167A1 (es) * 2006-04-26 2008-01-25 Genentech Inc Compuestos derivados de pirimidina condensada, inhibidores de p13-quinasa; procesos para preparar los compuestos; composicion farmaceutica que los comprende; uso de los compuestos en la preparacion de medicamentos; proceso para preparar la composicion farmaceutica; y kit que incluye a la composicionfarmaceutica.
CA2659604C (en) 2006-08-08 2015-04-28 Chugai Seiyaku Kabushiki Kaisha Pyrimidine derivative as pi3k inhibitor and use thereof
WO2008032033A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
WO2008072850A1 (en) * 2006-12-11 2008-06-19 Amorepacific Corporation Triazine derivatives having inhibitory activity against acetyl-coa carboxylase
AU2008213808B2 (en) * 2007-02-06 2011-11-10 Novartis Ag PI 3-kinase inhibitors and methods of their use
WO2009093981A1 (en) * 2008-01-23 2009-07-30 S Bio Pte Ltd Triazine compounds as kinase inhibitors
EP2082777A1 (en) * 2008-01-27 2009-07-29 Oncotherm Kft. Flexible and porous large-area electrode for heating
DE202008001253U1 (de) * 2008-01-28 2008-04-10 Mirror Image Ag Bildanzeigegerät
EP2294072B1 (en) * 2008-05-23 2017-03-29 Wyeth LLC Triazine compounds as p13 kinase and mtor inhibitors
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7173029B2 (en) * 2000-04-27 2007-02-06 Astellas Pharma Inc. Fused heteroaryl derivatives
RU2312859C2 (ru) * 2002-05-30 2007-12-20 Солвей Фармасьютикалс Б.В. Производные 1,3,5-триазина, фармацевтическая композиция на их основе и их применение
EP1864665A1 (en) * 2005-03-11 2007-12-12 Zenyaku Kogyo Kabushiki Kaisha Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MENICAGLI R ET AL: "2-Alkyl-4,6-dialkylamino-1,3,5-triazines via Grignard Alkylation of Cyanuric Chloride: An Aged Reaction Revisited", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol.56, no.49, p.p.9705-9711, 2000. MATSUNO T ET AL:"SYNTHESIS AND ANTITUMOR ACTIVITY OF BENZIMIDAZOLYL-1,3,5- TRIAZINE AND BENZIMIDAZOLYLPYRIMIDINE DERIVATIVES", Chemical and pharmaceutical bulletin, Pharmaceutical society of Japan, TOKYO, vol.48, no.11, p.p.1778-1781, 2000. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2754664C2 (ru) * 2016-02-19 2021-09-06 Спринт Биосайенс Аб 6-арил-4-морфолин-1-илпиридоны, пригодные для лечения рака или диабета
RU2803158C2 (ru) * 2017-08-23 2023-09-07 Спринт Биосайенс Аб Морфолинилпиридоны
US11434232B2 (en) 2018-02-07 2022-09-06 Wuxi Biocity Biopharmaceutics Co., Ltd. ATR inhibitor and application thereof
RU2799047C2 (ru) * 2018-02-07 2023-07-03 Уси Байосити Байофармасьютикс Ко., Лтд. Ингибитор atr и его применение

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