JP2015513528A5 - - Google Patents
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- JP2015513528A5 JP2015513528A5 JP2014556699A JP2014556699A JP2015513528A5 JP 2015513528 A5 JP2015513528 A5 JP 2015513528A5 JP 2014556699 A JP2014556699 A JP 2014556699A JP 2014556699 A JP2014556699 A JP 2014556699A JP 2015513528 A5 JP2015513528 A5 JP 2015513528A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261633287P | 2012-02-07 | 2012-02-07 | |
| US61/633,287 | 2012-02-07 | ||
| PCT/US2013/025234 WO2013119880A1 (en) | 2012-02-07 | 2013-02-07 | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017149223A Division JP6463421B2 (ja) | 2012-02-07 | 2017-08-01 | 核酸送達の区画化方法ならびにその組成物および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513528A JP2015513528A (ja) | 2015-05-14 |
| JP2015513528A5 true JP2015513528A5 (enExample) | 2016-03-24 |
| JP6188728B2 JP6188728B2 (ja) | 2017-08-30 |
Family
ID=47750057
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014556699A Expired - Fee Related JP6188728B2 (ja) | 2012-02-07 | 2013-02-07 | 核酸送達の区画化方法ならびにその組成物および使用 |
| JP2017149223A Expired - Fee Related JP6463421B2 (ja) | 2012-02-07 | 2017-08-01 | 核酸送達の区画化方法ならびにその組成物および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017149223A Expired - Fee Related JP6463421B2 (ja) | 2012-02-07 | 2017-08-01 | 核酸送達の区画化方法ならびにその組成物および使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9821114B2 (enExample) |
| EP (2) | EP3970734A3 (enExample) |
| JP (2) | JP6188728B2 (enExample) |
| KR (1) | KR102063195B1 (enExample) |
| CN (3) | CN104428009A (enExample) |
| AU (1) | AU2013216920B2 (enExample) |
| BR (1) | BR112014019431A8 (enExample) |
| CA (1) | CA2863964C (enExample) |
| EA (1) | EA033803B1 (enExample) |
| HK (1) | HK1204770A1 (enExample) |
| IL (1) | IL233946B (enExample) |
| MX (1) | MX367842B (enExample) |
| NZ (2) | NZ715957A (enExample) |
| SG (3) | SG10201604810UA (enExample) |
| WO (1) | WO2013119880A1 (enExample) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100183558A1 (en) | 2008-10-17 | 2010-07-22 | Zhennan Lai | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| AU2013216920B2 (en) | 2012-02-07 | 2016-09-22 | Global Bio Therapeutics, Inc. | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US11911487B2 (en) | 2012-05-03 | 2024-02-27 | Indiana University Research And Technology Corporation | Hydrodynamic methods for delivering fluids to kidney tissues and related materials and methods |
| EP3622821A1 (en) * | 2013-05-15 | 2020-03-18 | Regents of the University of Minnesota | Adeno-associated virus mediated gene transfer to the central nervous system |
| CA2920261C (en) | 2013-08-08 | 2018-04-03 | Global Bio Therapeutics, Inc. | Clamp device for minimally invasive procedures and uses thereof |
| EA032285B1 (ru) | 2013-08-08 | 2019-05-31 | Глобал Био Терапьютикс, Инк. | Прибор для инъекций с минимальным захватом и его использование |
| EP3039138A4 (en) | 2013-08-30 | 2017-04-26 | Indiana University Research and Technology Corporation | Hydrodynamic method and apparatus for delivering fluids to kidney tissues |
| US10219492B2 (en) * | 2013-11-22 | 2019-03-05 | The Board Of Regents Of The University Of Texas System | Compounds and methods for altering RSV replication rate |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| BR112016019940A2 (pt) * | 2014-03-21 | 2017-10-24 | Univ Leland Stanford Junior | edição de genoma sem nucleases |
| JP6741590B2 (ja) * | 2014-04-25 | 2020-08-19 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | コレステロールレベルを低下させるためのｌｄｌｒ変異体および組成物中でのそれらの使用 |
| CA2948844C (en) * | 2014-05-12 | 2020-06-30 | The Johns Hopkins University | Engineering synthetic brain penetrating gene vectors |
| DE102015201100B4 (de) * | 2015-01-22 | 2018-05-17 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Antivirale Mittel |
| EP3250279B1 (en) * | 2015-01-30 | 2020-08-19 | The Regents of the University of California | Spinal subpial gene delivery system |
| US10688285B2 (en) | 2015-01-30 | 2020-06-23 | The Regents Of The University Of California | Spinal subpial gene delivery system |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| WO2017007994A1 (en) | 2015-07-08 | 2017-01-12 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| EP3390630B1 (en) | 2015-12-17 | 2025-01-22 | ModernaTX, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| CN116064678A (zh) | 2016-01-15 | 2023-05-05 | 美国基因技术国际有限公司 | 用于活化γ-δT细胞的方法和组合物 |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| WO2017135795A1 (ko) * | 2016-02-04 | 2017-08-10 | 주식회사 에스엘바이젠 | 간세포성장인자를 발현하는 중간엽줄기세포 및 이의 용도 |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| WO2017156311A2 (en) | 2016-03-09 | 2017-09-14 | American Gene Technologies International Inc. | Combination vectors and methods for treating cancer |
| CN108884022B (zh) | 2016-03-28 | 2022-01-28 | 加利福尼亚大学董事会 | 用于治疗神经元的过度兴奋的方法和组合物 |
| IL262211B2 (en) | 2016-04-15 | 2024-01-01 | Univ Pennsylvania | Gene therapy for treating mucopolysaccharidosis type ii |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| EP3896164A1 (en) | 2016-05-18 | 2021-10-20 | ModernaTX, Inc. | Polynucleotides encoding alpha-galactosidase a for the treatment of fabry disease |
| WO2017201347A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis |
| JP7173548B2 (ja) | 2016-06-08 | 2022-11-16 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | 非組み込みウイルス送達系およびその関連方法 |
| US11045557B2 (en) | 2016-06-09 | 2021-06-29 | Queen's University At Kingston | Methods and gene therapy constructs for treating GM2 gangliosidoses |
| IL300730A (en) | 2016-07-08 | 2023-04-01 | American Gene Tech Int Inc | Pre-HIV vaccine and immunotherapy |
| US11583562B2 (en) | 2016-07-21 | 2023-02-21 | American Gene Technologies International Inc. | Viral vectors for treating Parkinson's disease |
| KR101671361B1 (ko) * | 2016-08-08 | 2016-11-01 | 에스씨엠생명과학 주식회사 | TYMP(thymidine phosphorylase) 단백질을 유효성분으로 포함하는 탈모 예방 또는 치료용 약학적 조성물 |
| WO2018056584A1 (ko) | 2016-09-21 | 2018-03-29 | 삼성전자 주식회사 | 피부 상태 측정 방법 및 이를 위한 전자 장치 |
| CN109863243B (zh) * | 2016-09-30 | 2023-07-28 | 埃斯蒂文制药股份有限公司 | 用于治疗粘多糖症的腺相关病毒载体 |
| JP2020513248A (ja) | 2016-10-19 | 2020-05-14 | フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． | 音響による親和性細胞抽出 |
| WO2018187231A2 (en) * | 2017-04-03 | 2018-10-11 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| WO2019014652A1 (en) * | 2017-07-13 | 2019-01-17 | Memphis Meats, Inc. | COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CELL CULTURES USED IN FOOD PRODUCTION |
| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング，インコーポレイテッド | Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療 |
| WO2019039863A2 (ko) * | 2017-08-23 | 2019-02-28 | 주식회사 압타머사이언스 | 대리 바이러스를 이용한 압타머 제조 방법 |
| AU2018327253B2 (en) | 2017-09-08 | 2024-05-16 | The Regents Of The University Of California | Method and composition for treating neuropathic pain |
| TWI835747B (zh) | 2017-09-22 | 2024-03-21 | 賓州大學委員會 | 用於治療黏多醣病 ii 型之基因治療 |
| BR112020006672A2 (pt) * | 2017-10-02 | 2020-09-24 | American Gene Technologies International Inc. | vetores com combinações de promotor e acentuador para tratar fenilcetonúria |
| WO2019079240A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| EP3714048B1 (en) | 2017-11-22 | 2025-04-09 | ModernaTX, Inc. | Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders |
| BR112020009889A2 (pt) | 2017-12-14 | 2020-11-03 | Flodesign Sonics, Inc. | acionador e controlador de transdutor acústico |
| RU2762367C1 (ru) * | 2017-12-29 | 2021-12-20 | Ньюромион Инк. | Вектор на основе аденоассоциированного вируса (aav), имеющий гибридный ген hgf, введенный в него |
| WO2019178613A1 (en) * | 2018-03-16 | 2019-09-19 | Immusoft Corporation | B cells genetically engineered to secrete follistatin and methods of using the same to treat follistatin-related diseases, conditions, disorders and to enhance muscle growth and strength |
| CN108576402A (zh) * | 2018-03-22 | 2018-09-28 | 昆明三正生物科技（集团）有限公司 | 一种乳仔猪专用酶生产方法 |
| WO2019210219A1 (en) | 2018-04-27 | 2019-10-31 | Krystal Biotech, Inc. | Recombinant nucleic acids encoding cosmetic protein(s) for aesthetic applications |
| JP7565218B2 (ja) * | 2018-07-02 | 2024-10-10 | ボイジャー セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症および脊髄に関連する障害の治療 |
| US12091675B2 (en) * | 2018-07-16 | 2024-09-17 | Takeda Pharmaceutical Company Limited | Gene therapy of hemophilia a using viral vectors encoding recombinant FVIII variants with increased expression |
| KR20210052469A (ko) * | 2018-08-30 | 2021-05-10 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 갈락토스혈증의 치료를 위한 유전자 요법 |
| AU2019344006B2 (en) * | 2018-09-21 | 2025-11-27 | University Of Connecticut | Compositions and methods to restore paternal UBE3A gene expression in human Angelman Syndrome |
| CN109504709B (zh) * | 2018-11-28 | 2020-07-24 | 上海安民生物技术有限公司 | 白蛋白启动子驱动的白蛋白表达载体 |
| EP3908328A1 (en) * | 2019-01-10 | 2021-11-17 | BioNTech RNA Pharmaceuticals GmbH | Localized administration of rna molecules for therapy |
| CN113260317B (zh) | 2019-01-10 | 2024-05-07 | 加利福尼亚大学董事会 | 软膜下递送系统和使用方法 |
| CN116063505B (zh) | 2019-01-30 | 2024-05-03 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| CN110272810A (zh) * | 2019-07-01 | 2019-09-24 | 广州世赛生物科技有限公司 | 外源物质递送至真核细胞内的装置和方法及其应用 |
| EP4073106A2 (en) * | 2019-12-12 | 2022-10-19 | Takeda Pharmaceutical Company Limited | Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression |
| USD963164S1 (en) | 2020-01-09 | 2022-09-06 | The Regents Of The University Of California | Surgical needle |
| WO2021154414A2 (en) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
| US12071633B2 (en) | 2020-10-13 | 2024-08-27 | Kriya Therapeutics, Inc. | Viral vector constructs for delivery of nucleic acids encoding cytokines and uses thereof for treating cancer |
| EP4100022B1 (en) | 2021-04-09 | 2025-03-12 | Peking University | Sirna, medical compositions, and methods for treating diabetes using the same |
| CN115074344B (zh) * | 2022-06-24 | 2023-09-19 | 徐州医科大学 | 一种多层次严格调控自杀蛋白rCas8活性系统及其应用 |
| WO2024151568A1 (en) * | 2023-01-09 | 2024-07-18 | Biomarin Pharmaceutical Inc. | Epigenetic modifiers improve aav gene therapy durability |
| WO2025038011A1 (en) * | 2023-08-11 | 2025-02-20 | Joint Stock Company «Biocad» | Modified sequence of adenovirus e2a gene for producing vectors based on adeno-associated viruses (aav) (variants) |
| WO2025049818A1 (en) | 2023-08-29 | 2025-03-06 | Enosi Therapeutics Corporation | Tnfr1 antagonists lacking agonist activity and uses thereof |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US567048A (en) | 1896-09-01 | Wedge for filling and tightening wood joints | ||
| US3667471A (en) | 1969-08-15 | 1972-06-06 | Us Army | Surgical clamp |
| US4652525A (en) | 1978-04-19 | 1987-03-24 | The Regents Of The University Of California | Recombinant bacterial plasmids containing the coding sequences of insulin genes |
| US4342832A (en) | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| US4431740A (en) | 1979-09-12 | 1984-02-14 | The Regents Of The University Of California | DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes |
| US4328803B1 (en) | 1980-10-20 | 1994-01-11 | Opthalmic Systems, Inc. | Opthalmological procedures |
| US4738927A (en) | 1982-03-31 | 1988-04-19 | Ajinomoto Co. Inc. | Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4517295A (en) | 1983-02-18 | 1985-05-14 | Diagnostic, Inc. | Hyaluronic acid from bacterial culture |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| US6696420B1 (en) | 1984-11-20 | 2004-02-24 | Institut Pasteur | Adenoviral vector with a deletion in the E1A coding region expressing a hetorologous protein |
| FR2573436B1 (fr) | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| EP0275598B1 (en) | 1986-12-16 | 1998-01-07 | Gist-Brocades N.V. | Molecular cloning and expression of human IL-3 |
| OA09736A (en) | 1987-02-18 | 1993-11-30 | Schering Biotech Corp | "Human interleukin-3 and muteins thereof". |
| US5282851A (en) | 1987-07-07 | 1994-02-01 | Jacob Labarre Jean | Intraocular prostheses |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US5229127A (en) | 1989-03-03 | 1993-07-20 | Mckinzie James W | Rapid miosis with control of intraocular pressure using a mixture of a cetylcholine and carbachol derivatives |
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| US5292362A (en) | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
| WO1992009616A1 (en) | 1990-12-03 | 1992-06-11 | THE UNITED OF AMERICA, represented by THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE | Enhancement of musculature in animals |
| US5203786A (en) | 1991-06-19 | 1993-04-20 | Thomas Jefferson University | Hepatic resection clamp |
| JPH07503372A (ja) | 1992-01-23 | 1995-04-13 | バイカル・インコーポレイテッド | 生体外遺伝子導入 |
| US5273056A (en) | 1992-06-12 | 1993-12-28 | Alcon Laboratories, Inc. | Use of combinations of viscoelastics during surgery |
| US5846945A (en) | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| JPH08511423A (ja) * | 1993-06-10 | 1996-12-03 | ジェネティック セラピー，インコーポレイテッド | 血友病治療のためのアデノウイルスベクター |
| US5919676A (en) | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| US5543328A (en) | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
| WO1995026411A2 (en) | 1994-03-25 | 1995-10-05 | The Uab Research Foundation | Composition and methods for creating syngeneic recombinant virus-producing cells |
| CA2189067A1 (en) | 1994-04-28 | 1995-11-09 | Gary J. Nabel | Gene delivery vector using plasmid dna packaged into an adenovirus and a packaging cell line |
| WO1995034671A1 (en) | 1994-06-10 | 1995-12-21 | Genvec, Inc. | Complementary adenoviral vector systems and cell lines |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| WO1996008563A1 (en) | 1994-09-12 | 1996-03-21 | Schering Aktiengesellschaft | Process for manufacture of a modified collagen-induced platelet aggregation inhibitor pallidipin |
| US5998205A (en) | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
| US6638762B1 (en) | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| US5792453A (en) | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| US5869230A (en) | 1995-03-30 | 1999-02-09 | Beth Israel Hospital Association | Gene transfer into the kidney |
| DE69638058D1 (de) | 1995-06-15 | 2009-11-26 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie |
| US6001650A (en) | 1995-08-03 | 1999-12-14 | Avigen, Inc. | High-efficiency wild-type-free AAV helper functions |
| US5622856A (en) | 1995-08-03 | 1997-04-22 | Avigen | High efficiency helper system for AAV vector production |
| US20020001574A1 (en) * | 1995-12-13 | 2002-01-03 | Jon A. Woiff | Process of delivering a polynucleotide to a muscle cell via the vascular system |
| US20010009904A1 (en) * | 1997-12-30 | 2001-07-26 | Jon A. Wolff | Process of delivering a polynucleotide to a cell via the vascular system |
| DE19600328C1 (de) | 1996-01-08 | 1997-02-13 | Zimmermann Jos Gmbh & Co Kg | Tuftingnadeln für ein Nadelmodul |
| US6121247A (en) * | 1996-03-29 | 2000-09-19 | The Johns Hopkins University | Therapy for allergic diseases |
| DE19620687A1 (de) * | 1996-05-22 | 1997-11-27 | Centeon Pharma Gmbh | Neuer adenoviraler Vektor für den Transfer humaner Gene in vivo |
| US5785689A (en) | 1996-07-18 | 1998-07-28 | Act Medical, Inc. | Endoscopic catheter sheath position control |
| DE69725878T2 (de) | 1996-08-13 | 2004-07-29 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Zusammensetzungen zur polynukleotidabgabe |
| US5704908A (en) | 1996-10-10 | 1998-01-06 | Genetronics, Inc. | Electroporation and iontophoresis catheter with porous balloon |
| US20080305999A1 (en) | 1996-11-01 | 2008-12-11 | John Francis Martin | Therapeutic use of growth factor, and delivery device, especially for the treatment of intimal hyperplasia |
| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6183444B1 (en) | 1998-05-16 | 2001-02-06 | Microheart, Inc. | Drug delivery module |
| JP2002501032A (ja) | 1998-01-27 | 2002-01-15 | ヘム−バイオテック エイ／エス | 急性間欠性ポルフィリン症（ａｉｐ）及び他のポルフィリン症の治療方法 |
| US5997509A (en) | 1998-03-06 | 1999-12-07 | Cornell Research Foundation, Inc. | Minimally invasive gene therapy delivery device and method |
| ATE312641T1 (de) | 1998-05-21 | 2005-12-15 | Us Gov Health & Human Serv | Kanüle zur selektiven, druckabhängigen verabreichung von therapeutischen substanzen |
| JP2002517519A (ja) | 1998-06-08 | 2002-06-18 | バレンティス・インコーポレーテッド | エレクトロポレーション用製剤 |
| AU748523B2 (en) | 1998-08-14 | 2002-06-06 | Aventis Pharmaceuticals Inc. | Adenovirus formulations for gene therapy |
| JP2002528128A (ja) | 1998-11-02 | 2002-09-03 | ユニバーシティ オブ サスカチュワン | 組換えアデノウイルスベクターの増殖のためのアデノウイルス必須機能を発現するウシ細胞 |
| GB9824437D0 (en) | 1998-11-06 | 1999-01-06 | Ylo Herttuala Seppo | Gene therapy |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| PT1200117E (pt) | 1999-06-24 | 2008-11-26 | Univ British Columbia | Tratamento à base de variantes da lipoproteína lipase |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| US7329728B1 (en) | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| US6218186B1 (en) | 1999-11-12 | 2001-04-17 | Trustees Of The University Of Pennsylvania | HIV-MSCV hybrid viral vector for gene transfer |
| DK2796553T3 (da) | 2000-03-30 | 2019-09-30 | Whitehead Inst Biomedical Res | Rna-sekvensspecifikke formidlere af rna-interferens |
| GB0013105D0 (en) * | 2000-05-30 | 2000-07-19 | Univ Bristol | Therapeutic compounds |
| EP1290161B1 (en) | 2000-05-30 | 2011-06-22 | Johnson & Johnson Research Pty Limited | METHODS FOR MEDIATING GENE SUPPRESION BY USING FACTORS THAT ENHANCE RNAi |
| US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
| US6821264B1 (en) | 2000-11-27 | 2004-11-23 | Gautam Khurana | Gene delivery device and gene delivery method |
| IL152420A0 (en) | 2001-02-23 | 2003-05-29 | Novartis Ag | Novel oncolytic adenoviral vectors |
| US20040009151A1 (en) | 2002-04-04 | 2004-01-15 | Kay Mark A. | Methods for delivering recombinant adeno-associated virus virions to the liver of a mammal |
| US20070015238A1 (en) | 2002-06-05 | 2007-01-18 | Snyder Richard O | Production of pseudotyped recombinant AAV virions |
| WO2004001049A1 (en) | 2002-06-24 | 2003-12-31 | Genzyme Corporation | Methods of delivering gene therapy agents |
| JP5051679B2 (ja) | 2003-08-29 | 2012-10-17 | 日本パーカライジング株式会社 | アルミニウムまたはアルミニウム合金製ｄｉ缶のアルカリ洗浄方法 |
| WO2005049094A1 (en) | 2003-11-13 | 2005-06-02 | Advantagene, Inc. | A mixed complementary viral vector for gene therapy |
| US20050129660A1 (en) | 2003-12-11 | 2005-06-16 | Hagstrom James E. | Process of delivering a virally encapsulated polynucleotide or viral vector to a parenchymal cell via the vascular system |
| WO2005060746A1 (en) * | 2003-12-11 | 2005-07-07 | Mirus Corporation | Delivery of viral vectors to extravascular parenchymal cells |
| GB0406728D0 (en) * | 2004-03-25 | 2004-04-28 | Hydrodynamic Gene Delivery Ltd | Gene therapy |
| US7645285B2 (en) | 2004-05-26 | 2010-01-12 | Idx Medical, Ltd | Apparatus and methods for occluding a hollow anatomical structure |
| WO2006060641A2 (en) | 2004-12-01 | 2006-06-08 | Genzyme Corporation | Methods for targeted delivery of genetic material to the liver |
| EP1831382B1 (en) | 2004-12-31 | 2023-01-18 | Per Sonne Holm | Method for reversing multiple resistance in animal cells |
| US8092464B2 (en) | 2005-04-30 | 2012-01-10 | Warsaw Orthopedic, Inc. | Syringe devices and methods useful for delivering osteogenic material |
| EP1928504B1 (en) | 2005-08-19 | 2013-04-24 | University of Technology, Sydney | Liver-directed gene therapy |
| WO2008108890A2 (en) * | 2006-10-18 | 2008-09-12 | University Of Rochester | Conditionally replicating viruses for cancer therapy |
| US8196905B2 (en) | 2006-10-25 | 2012-06-12 | Pi-Design Ag | Electric milk frother |
| US20080119880A1 (en) | 2006-11-16 | 2008-05-22 | Chu David Z J | Laparoscopic surgical clamp |
| WO2008122048A2 (en) * | 2007-04-02 | 2008-10-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Removal of contrast agents from blood |
| JP2010538675A (ja) | 2007-09-19 | 2010-12-16 | アムステルダム モレキュラー セラピューティクス ビー．ブイ． | タンパク質産生の改善のためのａａｖ複製機構の使用 |
| EP2068294A1 (en) | 2007-12-03 | 2009-06-10 | Endosim Limited | Laparoscopic training apparatus |
| US20100234862A1 (en) | 2007-12-06 | 2010-09-16 | Manoj Patel | Surgical clamp and method of clamping an organ |
| EA201170506A1 (ru) | 2008-09-29 | 2011-12-30 | Амстердам Молекьюлар Терапьютикс (Амт) Б.В. | Генная терапия порфобилиногендезаминазой |
| EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| WO2010099383A2 (en) | 2009-02-26 | 2010-09-02 | The Johns Hopkins University | Compositions and methods for ex vivo hepatic nucleic acid delivery |
| EP2432497A1 (en) | 2009-05-18 | 2012-03-28 | Amsterdam Molecular Therapeutics (AMT) IP B.V. | Use of lipoprotein lipase (lpl) in therapy |
| AU2013216920B2 (en) | 2012-02-07 | 2016-09-22 | Global Bio Therapeutics, Inc. | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
| CA2920261C (en) | 2013-08-08 | 2018-04-03 | Global Bio Therapeutics, Inc. | Clamp device for minimally invasive procedures and uses thereof |
| EA032285B1 (ru) | 2013-08-08 | 2019-05-31 | Глобал Био Терапьютикс, Инк. | Прибор для инъекций с минимальным захватом и его использование |
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2013
- 2013-02-07 AU AU2013216920A patent/AU2013216920B2/en not_active Ceased
- 2013-02-07 EA EA201400871A patent/EA033803B1/ru not_active IP Right Cessation
- 2013-02-07 BR BR112014019431A patent/BR112014019431A8/pt not_active IP Right Cessation
- 2013-02-07 HK HK15105338.3A patent/HK1204770A1/xx unknown
- 2013-02-07 NZ NZ715957A patent/NZ715957A/en not_active IP Right Cessation
- 2013-02-07 WO PCT/US2013/025234 patent/WO2013119880A1/en not_active Ceased
- 2013-02-07 SG SG10201604810UA patent/SG10201604810UA/en unknown
- 2013-02-07 MX MX2014009480A patent/MX367842B/es active IP Right Grant
- 2013-02-07 JP JP2014556699A patent/JP6188728B2/ja not_active Expired - Fee Related
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- 2013-02-07 CN CN201380018970.8A patent/CN104428009A/zh active Pending
- 2013-02-07 CN CN201711235370.3A patent/CN107982548A/zh active Pending
- 2013-02-07 EP EP21167237.3A patent/EP3970734A3/en not_active Withdrawn
- 2013-02-07 SG SG10201609345QA patent/SG10201609345QA/en unknown
- 2013-02-07 CN CN201910870752.6A patent/CN110917362A/zh active Pending
- 2013-02-07 SG SG11201404741VA patent/SG11201404741VA/en unknown
- 2013-02-07 EP EP13706130.5A patent/EP2812012A1/en not_active Withdrawn
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