JP2015513316A - 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法 - Google Patents

向神経活性ステロイド製剤およびｃｎｓ障害の処置方法 Download PDF

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Publication number
JP2015513316A
JP2015513316A JP2014553534A JP2014553534A JP2015513316A JP 2015513316 A JP2015513316 A JP 2015513316A JP 2014553534 A JP2014553534 A JP 2014553534A JP 2014553534 A JP2014553534 A JP 2014553534A JP 2015513316 A JP2015513316 A JP 2015513316A
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Prior art keywords
cyclodextrin
allopregnanolone
captisol
sulfobutyl ether
formulated
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Withdrawn
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JP2014553534A
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English (en)
Japanese (ja)
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JP2015513316A5 (enExample
Inventor
キラン レディ，
キラン レディ，
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Sage Therapeutics, LLC
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Sage Therapeutics, LLC
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Application filed by Sage Therapeutics, LLC filed Critical Sage Therapeutics, LLC
Publication of JP2015513316A publication Critical patent/JP2015513316A/ja
Publication of JP2015513316A5 publication Critical patent/JP2015513316A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014553534A 2012-01-23 2013-01-23 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法 Withdrawn JP2015513316A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261589740P 2012-01-23 2012-01-23
US61/589,740 2012-01-23
PCT/US2013/022772 WO2013112605A2 (en) 2012-01-23 2013-01-23 Neuroactive steroid formulations and methods of treating cns disorders

Related Child Applications (1)

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JP2017236676A Division JP2018076341A (ja) 2012-01-23 2017-12-11 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法

Publications (2)

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JP2015513316A true JP2015513316A (ja) 2015-05-07
JP2015513316A5 JP2015513316A5 (enExample) 2016-03-03

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JP2014553534A Withdrawn JP2015513316A (ja) 2012-01-23 2013-01-23 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法
JP2017236676A Pending JP2018076341A (ja) 2012-01-23 2017-12-11 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法
JP2020082943A Pending JP2020128409A (ja) 2012-01-23 2020-05-11 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法
JP2022072014A Active JP7343651B2 (ja) 2012-01-23 2022-04-26 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法
JP2023140708A Pending JP2023162368A (ja) 2012-01-23 2023-08-31 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法

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JP2017236676A Pending JP2018076341A (ja) 2012-01-23 2017-12-11 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法
JP2020082943A Pending JP2020128409A (ja) 2012-01-23 2020-05-11 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法
JP2022072014A Active JP7343651B2 (ja) 2012-01-23 2022-04-26 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法
JP2023140708A Pending JP2023162368A (ja) 2012-01-23 2023-08-31 向神経活性ステロイド製剤およびｃｎｓ障害の処置方法

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US (5) US20150018327A1 (enExample)
EP (3) EP2806877B2 (enExample)
JP (5) JP2015513316A (enExample)
CN (2) CN104736158A (enExample)
AU (3) AU2013212287B2 (enExample)
BR (1) BR112014018110B1 (enExample)
CA (1) CA2862076C (enExample)
CY (1) CY1122527T1 (enExample)
DK (1) DK2806877T3 (enExample)
ES (1) ES2758446T3 (enExample)
HR (1) HRP20192348T1 (enExample)
HU (1) HUE046800T2 (enExample)
IL (4) IL286348B2 (enExample)
LT (1) LT2806877T (enExample)
MX (3) MX2014008895A (enExample)
NZ (2) NZ627781A (enExample)
PL (1) PL2806877T3 (enExample)
PT (1) PT2806877T (enExample)
RS (1) RS59734B1 (enExample)
RU (2) RU2019104004A (enExample)
SG (2) SG10201606063RA (enExample)
SI (1) SI2806877T1 (enExample)
SM (1) SMT202000008T1 (enExample)
WO (1) WO2013112605A2 (enExample)
ZA (1) ZA201405401B (enExample)

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JP2018521987A (ja) * 2015-06-18 2018-08-09 セージ セラピューティクス， インコーポレイテッド 神経活性ステロイド溶液およびその使用方法
US10251894B2 (en) 2012-11-30 2019-04-09 The Regents Of The University Of California Anticonvulsant activity of steroids
US10478505B2 (en) 2011-09-23 2019-11-19 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids

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WO2014028398A2 (en) 2012-08-13 2014-02-20 The Regents Of The University Of California Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids
PL2887944T3 (pl) * 2012-08-21 2022-02-21 Sage Therapeutics, Inc. Allopregnanolon do leczenia lekoopornego stanu padaczkowego
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WO2023040851A1 (zh) 2021-09-14 2023-03-23 南京迈诺威医药科技有限公司 一种水溶性别孕烷醇酮衍生物及其制备方法和用途
WO2023240100A1 (en) * 2022-06-07 2023-12-14 Clarkson Clay Carew A method to encapsulate non-polar compounds to achieve extended thermal stability and attenuate/prevent thermal and redox isomerization
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MX2019009739A (es) 2019-11-11
EP2806877B2 (en) 2025-01-29
JP7343651B2 (ja) 2023-09-12
PL2806877T3 (pl) 2020-06-01
JP2020128409A (ja) 2020-08-27
EP4295908A3 (en) 2024-03-20
PT2806877T (pt) 2019-12-06
IL276403B (en) 2021-10-31
MX2014008895A (es) 2014-11-25
WO2013112605A3 (en) 2015-01-22
EP2806877A2 (en) 2014-12-03
US20150018327A1 (en) 2015-01-15
CY1122527T1 (el) 2021-01-27
JP2023162368A (ja) 2023-11-08
RU2019104004A (ru) 2019-03-07
NZ627781A (en) 2016-10-28
IL233744A0 (en) 2014-09-30
CN104736158A (zh) 2015-06-24
EP3650027A1 (en) 2020-05-13
SMT202000008T1 (it) 2020-03-13

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