JP2015512381A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015512381A5 JP2015512381A5 JP2015500948A JP2015500948A JP2015512381A5 JP 2015512381 A5 JP2015512381 A5 JP 2015512381A5 JP 2015500948 A JP2015500948 A JP 2015500948A JP 2015500948 A JP2015500948 A JP 2015500948A JP 2015512381 A5 JP2015512381 A5 JP 2015512381A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- hydrate
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VECSRFWOHMDQCJ-UHFFFAOYSA-N CC(Cc1c[nH]c(cc2Cl)c1cc2F)=O Chemical compound CC(Cc1c[nH]c(cc2Cl)c1cc2F)=O VECSRFWOHMDQCJ-UHFFFAOYSA-N 0.000 description 2
- NTPLXRHDUXRPNE-UHFFFAOYSA-N CC(c(cc1)ccc1OC)=O Chemical compound CC(c(cc1)ccc1OC)=O NTPLXRHDUXRPNE-UHFFFAOYSA-N 0.000 description 1
- JYAQYXOVOHJRCS-UHFFFAOYSA-N CC(c1cccc(Br)c1)=O Chemical compound CC(c1cccc(Br)c1)=O JYAQYXOVOHJRCS-UHFFFAOYSA-N 0.000 description 1
- GYLDXXLJMRTVSS-UHFFFAOYSA-N CCCCNC(C)=O Chemical compound CCCCNC(C)=O GYLDXXLJMRTVSS-UHFFFAOYSA-N 0.000 description 1
- FNXVEILQGNGZNE-UHFFFAOYSA-N CS(c(cc1)ccc1OC(F)(F)F)(=O)=O Chemical compound CS(c(cc1)ccc1OC(F)(F)F)(=O)=O FNXVEILQGNGZNE-UHFFFAOYSA-N 0.000 description 1
- NLRUCNFHLCYFCM-LURJTMIESA-N C[C@@H](Cc(c1c2)c[nH]c1cc(Cl)c2F)N Chemical compound C[C@@H](Cc(c1c2)c[nH]c1cc(Cl)c2F)N NLRUCNFHLCYFCM-LURJTMIESA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/000359 | 2012-03-23 | ||
| CN2012000359 | 2012-03-23 | ||
| PCT/EP2013/056170 WO2013139987A1 (en) | 2012-03-23 | 2013-03-22 | Chemical process for preparing spiroindolones and intermediates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512381A JP2015512381A (ja) | 2015-04-27 |
| JP2015512381A5 true JP2015512381A5 (https=) | 2017-02-16 |
| JP6117906B2 JP6117906B2 (ja) | 2017-04-19 |
Family
ID=48048006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500948A Active JP6117906B2 (ja) | 2012-03-23 | 2013-03-22 | スピロインドロンおよびこれらの中間体を調製するための化学プロセス |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9598712B2 (https=) |
| EP (2) | EP2828256B1 (https=) |
| JP (1) | JP6117906B2 (https=) |
| KR (1) | KR102057590B1 (https=) |
| AP (1) | AP2014007906A0 (https=) |
| AU (1) | AU2013237330C1 (https=) |
| BR (1) | BR112014022909B1 (https=) |
| CA (1) | CA2866222C (https=) |
| CY (1) | CY1122087T1 (https=) |
| DK (1) | DK2828256T5 (https=) |
| ES (2) | ES2748460T3 (https=) |
| HR (1) | HRP20191632T1 (https=) |
| HU (1) | HUE046421T2 (https=) |
| LT (1) | LT2828256T (https=) |
| MX (1) | MX354023B (https=) |
| PL (1) | PL2828256T3 (https=) |
| PT (1) | PT2828256T (https=) |
| RU (1) | RU2662815C2 (https=) |
| SI (1) | SI2828256T1 (https=) |
| WO (1) | WO2013139987A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI874834B (zh) | 2014-12-18 | 2025-03-01 | 瑞士商赫孚孟拉羅股份公司 | 四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途 |
| JP2017024992A (ja) * | 2015-07-15 | 2017-02-02 | 公益財団法人微生物化学研究会 | 化合物の製造方法 |
| CR20200621A (es) | 2018-06-21 | 2021-02-03 | Hoffmann La Roche | Formas sólidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3 fluoropropil)azetidin-3-il)amino)fenil)-3-(metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos tricíclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos métodos para su uso |
| EP4133064A4 (en) | 2020-04-10 | 2024-07-24 | Codexis, Inc. | Engineered transaminase polypeptides |
| EP4217502A4 (en) * | 2020-09-28 | 2024-12-11 | Codexis, Inc. | Engineered biocatalysts and methods for synthesizing chiral amines |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2947758A (en) * | 1959-04-28 | 1960-08-02 | Searle & Co | 3-(omega-hydrazino) alkylindoles |
| GB974893A (en) | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Amine compounds and means of producing the same |
| GB974895A (en) | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Process for the production of amine compounds |
| US3183170A (en) * | 1961-10-03 | 1965-05-11 | Sanraku Ocean Kabushiki Kaisha | Method of l-amino acid manufacture |
| BE795457A (fr) * | 1972-02-16 | 1973-08-16 | Clin Midy | Amines indoliques, leur preparation et leur application en therapeutiques |
| US4073795A (en) * | 1976-06-22 | 1978-02-14 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
| US4331818A (en) * | 1980-03-19 | 1982-05-25 | The Procter & Gamble Company | Chiral phospine ligand |
| DE3307095A1 (de) | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung |
| US4518692A (en) * | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
| HU193902B (en) * | 1983-09-01 | 1987-12-28 | Genetics Inst | Process for preparing l-amino acids by means of transamination |
| US4859591A (en) | 1984-07-05 | 1989-08-22 | W. R. Grace & Co.-Conn. | Transamination process for producing amino acids |
| US4826766A (en) | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
| JP2007502124A (ja) | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド |
| US7541091B2 (en) | 2004-05-18 | 2009-06-02 | M & G Usa Corporation | Compartmentalized resin pellets for oxygen scavenging |
| ATE554178T1 (de) * | 2004-10-05 | 2012-05-15 | Ajinomoto Kk | Verfahren zur herstellung von aminosäurederivaten aus hydroxyiminosäuren |
| WO2008050207A1 (en) * | 2006-10-25 | 2008-05-02 | Pfizer Limited | Heterocyclic compounds useful as anabolic agents for livestock animals |
| EP2132322A4 (en) | 2007-03-02 | 2013-02-20 | Richmond Chemical Corp | METHOD FOR INCREASING YIELD AND IMPROVING PURIFICATION OF PRODUCTS FROM REACTIONS WITH TRANSAMINASE |
| CN102015711B (zh) * | 2008-04-29 | 2013-05-01 | 诺瓦提斯公司 | 用于治疗寄生虫病的螺-吲哚衍生物 |
| AT507050B1 (de) | 2008-06-17 | 2010-06-15 | Angewandte Biokatalyse Kompete | Verfahren zur herstellung von aminen unter verwendung von omega-transaminasen |
| HUE052297T2 (hu) * | 2009-01-08 | 2021-04-28 | Codexis Inc | Transzamináz polipeptidek |
| ES2650245T3 (es) * | 2010-07-14 | 2018-01-17 | Dpx Holdings B.V. | Método enzimático para aminación (R)-selectiva |
| CN104508126B (zh) * | 2012-03-23 | 2017-06-30 | 科德克希思公司 | 用于合成色胺和色胺类似物的衍生物的生物催化剂和方法 |
-
2013
- 2013-03-22 EP EP13714246.9A patent/EP2828256B1/en active Active
- 2013-03-22 SI SI201331580T patent/SI2828256T1/sl unknown
- 2013-03-22 HU HUE13714246A patent/HUE046421T2/hu unknown
- 2013-03-22 MX MX2014011489A patent/MX354023B/es active IP Right Grant
- 2013-03-22 AU AU2013237330A patent/AU2013237330C1/en active Active
- 2013-03-22 DK DK13714246T patent/DK2828256T5/da active
- 2013-03-22 PT PT137142469T patent/PT2828256T/pt unknown
- 2013-03-22 KR KR1020147026392A patent/KR102057590B1/ko active Active
- 2013-03-22 BR BR112014022909-0A patent/BR112014022909B1/pt active IP Right Grant
- 2013-03-22 WO PCT/EP2013/056170 patent/WO2013139987A1/en not_active Ceased
- 2013-03-22 HR HRP20191632 patent/HRP20191632T1/hr unknown
- 2013-03-22 LT LTEP13714246.9T patent/LT2828256T/lt unknown
- 2013-03-22 ES ES13714246T patent/ES2748460T3/es active Active
- 2013-03-22 ES ES19182727T patent/ES2962530T3/es active Active
- 2013-03-22 CA CA2866222A patent/CA2866222C/en active Active
- 2013-03-22 JP JP2015500948A patent/JP6117906B2/ja active Active
- 2013-03-22 PL PL13714246T patent/PL2828256T3/pl unknown
- 2013-03-22 US US14/384,233 patent/US9598712B2/en active Active
- 2013-03-22 RU RU2014142621A patent/RU2662815C2/ru active
- 2013-03-22 EP EP19182727.8A patent/EP3578557B1/en active Active
- 2013-03-22 AP AP2014007906A patent/AP2014007906A0/xx unknown
-
2019
- 2019-10-02 CY CY20191101024T patent/CY1122087T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101934096B1 (ko) | 이델라리십의 제조방법 | |
| US9550716B2 (en) | Process for treprostinil salt preparation | |
| JP2010513494A5 (https=) | ||
| CN111362881A (zh) | 一种化合物及其制备方法 | |
| JP2015512381A5 (https=) | ||
| JP2013523700A (ja) | アミノベンゾフラン誘導体の製造方法 | |
| JP2013531054A (ja) | アミノベンゾイルベンゾフラン誘導体を調製する方法 | |
| KR102266680B1 (ko) | 벨리노스테트의 다형태 및 이의 제조 방법 | |
| RU2014142621A (ru) | Химический способ получения спироиндолонов и их промежуточных соединений | |
| CN100519512C (zh) | 2-[2-(2,2,2-三氟乙氧基)]苯氧基乙胺的制备方法 | |
| JP6228210B2 (ja) | フルボキサミン遊離塩基の精製方法およびそれを用いた高純度フルボキサミンマレイン酸塩の製造方法 | |
| KR102453655B1 (ko) | 아코티아미드의 개선된 제조방법 | |
| TW212181B (https=) | ||
| JP6248202B2 (ja) | シロドシン及びその中間体の製造方法 | |
| CN103087080B (zh) | 一种盐酸头孢卡品酯的制备方法及其合成中间体 | |
| WO2010018895A1 (en) | Process for the preparation of n-phenyl-2-pyrimidine-amine derivatives | |
| JP2015511578A (ja) | 置換フェニルプロパノンを調製するためのプロセス | |
| RU2013110311A (ru) | Синтез соединений тиазолидиндиона | |
| CN107586267B (zh) | 一种牛磺酰胺盐酸盐(2-氨基乙基磺酰胺盐酸盐)的合成方法 | |
| JP2016510063A (ja) | （２ｓ，５ｒ）−硫酸モノ−｛［（４−アミノピペリジン−４−イル）カルボニル］−７−オキソ−１，６−ジアザ−ビシクロ［３．２．１］オクタ−６−イル｝エステルを調製するための方法 | |
| JP6211711B2 (ja) | アゾ色素組成物及びその製造方法 | |
| CN101146768B (zh) | 氨磺酰羧酸衍生物的制备方法 | |
| CA2608087A1 (en) | Methods for synthesizing heterocyclic compounds | |
| CN105849115A (zh) | 制药方法和中间体 | |
| CN110734430A (zh) | 用于合成取代的γ内酰胺的方法 |