KR102057590B1 - 스피로인돌론을 제조하기 위한 화학적 방법 및 그의 중간체 - Google Patents
스피로인돌론을 제조하기 위한 화학적 방법 및 그의 중간체 Download PDFInfo
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- KR102057590B1 KR102057590B1 KR1020147026392A KR20147026392A KR102057590B1 KR 102057590 B1 KR102057590 B1 KR 102057590B1 KR 1020147026392 A KR1020147026392 A KR 1020147026392A KR 20147026392 A KR20147026392 A KR 20147026392A KR 102057590 B1 KR102057590 B1 KR 102057590B1
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- 0 CC*([C@](*)CC(c1c2c(C(C)=I)c(*C)c(*)c1*C)=C*2=C)=C Chemical compound CC*([C@](*)CC(c1c2c(C(C)=I)c(*C)c(*)c1*C)=C*2=C)=C 0.000 description 5
- WLICIRKRCWJTQD-KXFIGUGUSA-N C/C(/[N+]([O-])=O)=C/c(c1c2)c[nH]c1cc(Cl)c2F Chemical compound C/C(/[N+]([O-])=O)=C/c(c1c2)c[nH]c1cc(Cl)c2F WLICIRKRCWJTQD-KXFIGUGUSA-N 0.000 description 1
- HEKMKLXDHREQHI-UHFFFAOYSA-N CC(CC(CNc1c2)c1cc(F)c2Cl)=O Chemical compound CC(CC(CNc1c2)c1cc(F)c2Cl)=O HEKMKLXDHREQHI-UHFFFAOYSA-N 0.000 description 1
- UMWAPELVIFUJEA-UHFFFAOYSA-N CC(CC(c(c(N1)c2)cc(F)c2Cl)(C1=O)O)=O Chemical compound CC(CC(c(c(N1)c2)cc(F)c2Cl)(C1=O)O)=O UMWAPELVIFUJEA-UHFFFAOYSA-N 0.000 description 1
- VECSRFWOHMDQCJ-UHFFFAOYSA-N CC(Cc(c1c2)c[nH]c1cc(Cl)c2F)=O Chemical compound CC(Cc(c1c2)c[nH]c1cc(Cl)c2F)=O VECSRFWOHMDQCJ-UHFFFAOYSA-N 0.000 description 1
- GHBWNCFDSGAFIT-UHFFFAOYSA-N O=C(c(c(N1)c2)cc(F)c2Cl)C1=O Chemical compound O=C(c(c(N1)c2)cc(F)c2Cl)C1=O GHBWNCFDSGAFIT-UHFFFAOYSA-N 0.000 description 1
- XHDJYQWGFIBCEP-UHFFFAOYSA-N O=C(c(cc(cc1)Cl)c1N1)C1=O Chemical compound O=C(c(cc(cc1)Cl)c1N1)C1=O XHDJYQWGFIBCEP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/000359 | 2012-03-23 | ||
| CN2012000359 | 2012-03-23 | ||
| PCT/EP2013/056170 WO2013139987A1 (en) | 2012-03-23 | 2013-03-22 | Chemical process for preparing spiroindolones and intermediates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140137374A KR20140137374A (ko) | 2014-12-02 |
| KR102057590B1 true KR102057590B1 (ko) | 2019-12-19 |
Family
ID=48048006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147026392A Active KR102057590B1 (ko) | 2012-03-23 | 2013-03-22 | 스피로인돌론을 제조하기 위한 화학적 방법 및 그의 중간체 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9598712B2 (https=) |
| EP (2) | EP2828256B1 (https=) |
| JP (1) | JP6117906B2 (https=) |
| KR (1) | KR102057590B1 (https=) |
| AP (1) | AP2014007906A0 (https=) |
| AU (1) | AU2013237330C1 (https=) |
| BR (1) | BR112014022909B1 (https=) |
| CA (1) | CA2866222C (https=) |
| CY (1) | CY1122087T1 (https=) |
| DK (1) | DK2828256T5 (https=) |
| ES (2) | ES2748460T3 (https=) |
| HR (1) | HRP20191632T1 (https=) |
| HU (1) | HUE046421T2 (https=) |
| LT (1) | LT2828256T (https=) |
| MX (1) | MX354023B (https=) |
| PL (1) | PL2828256T3 (https=) |
| PT (1) | PT2828256T (https=) |
| RU (1) | RU2662815C2 (https=) |
| SI (1) | SI2828256T1 (https=) |
| WO (1) | WO2013139987A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI874834B (zh) | 2014-12-18 | 2025-03-01 | 瑞士商赫孚孟拉羅股份公司 | 四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途 |
| JP2017024992A (ja) * | 2015-07-15 | 2017-02-02 | 公益財団法人微生物化学研究会 | 化合物の製造方法 |
| CR20200621A (es) | 2018-06-21 | 2021-02-03 | Hoffmann La Roche | Formas sólidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3 fluoropropil)azetidin-3-il)amino)fenil)-3-(metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos tricíclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos métodos para su uso |
| EP4133064A4 (en) | 2020-04-10 | 2024-07-24 | Codexis, Inc. | Engineered transaminase polypeptides |
| EP4217502A4 (en) * | 2020-09-28 | 2024-12-11 | Codexis, Inc. | Engineered biocatalysts and methods for synthesizing chiral amines |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2947758A (en) * | 1959-04-28 | 1960-08-02 | Searle & Co | 3-(omega-hydrazino) alkylindoles |
| GB974893A (en) | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Amine compounds and means of producing the same |
| GB974895A (en) | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Process for the production of amine compounds |
| US3183170A (en) * | 1961-10-03 | 1965-05-11 | Sanraku Ocean Kabushiki Kaisha | Method of l-amino acid manufacture |
| BE795457A (fr) * | 1972-02-16 | 1973-08-16 | Clin Midy | Amines indoliques, leur preparation et leur application en therapeutiques |
| US4073795A (en) * | 1976-06-22 | 1978-02-14 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
| US4331818A (en) * | 1980-03-19 | 1982-05-25 | The Procter & Gamble Company | Chiral phospine ligand |
| DE3307095A1 (de) | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung |
| US4518692A (en) * | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
| HU193902B (en) * | 1983-09-01 | 1987-12-28 | Genetics Inst | Process for preparing l-amino acids by means of transamination |
| US4859591A (en) | 1984-07-05 | 1989-08-22 | W. R. Grace & Co.-Conn. | Transamination process for producing amino acids |
| US4826766A (en) | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
| JP2007502124A (ja) | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド |
| US7541091B2 (en) | 2004-05-18 | 2009-06-02 | M & G Usa Corporation | Compartmentalized resin pellets for oxygen scavenging |
| ATE554178T1 (de) * | 2004-10-05 | 2012-05-15 | Ajinomoto Kk | Verfahren zur herstellung von aminosäurederivaten aus hydroxyiminosäuren |
| WO2008050207A1 (en) * | 2006-10-25 | 2008-05-02 | Pfizer Limited | Heterocyclic compounds useful as anabolic agents for livestock animals |
| EP2132322A4 (en) | 2007-03-02 | 2013-02-20 | Richmond Chemical Corp | METHOD FOR INCREASING YIELD AND IMPROVING PURIFICATION OF PRODUCTS FROM REACTIONS WITH TRANSAMINASE |
| CN102015711B (zh) * | 2008-04-29 | 2013-05-01 | 诺瓦提斯公司 | 用于治疗寄生虫病的螺-吲哚衍生物 |
| AT507050B1 (de) | 2008-06-17 | 2010-06-15 | Angewandte Biokatalyse Kompete | Verfahren zur herstellung von aminen unter verwendung von omega-transaminasen |
| HUE052297T2 (hu) * | 2009-01-08 | 2021-04-28 | Codexis Inc | Transzamináz polipeptidek |
| ES2650245T3 (es) * | 2010-07-14 | 2018-01-17 | Dpx Holdings B.V. | Método enzimático para aminación (R)-selectiva |
| CN104508126B (zh) * | 2012-03-23 | 2017-06-30 | 科德克希思公司 | 用于合成色胺和色胺类似物的衍生物的生物催化剂和方法 |
-
2013
- 2013-03-22 EP EP13714246.9A patent/EP2828256B1/en active Active
- 2013-03-22 SI SI201331580T patent/SI2828256T1/sl unknown
- 2013-03-22 HU HUE13714246A patent/HUE046421T2/hu unknown
- 2013-03-22 MX MX2014011489A patent/MX354023B/es active IP Right Grant
- 2013-03-22 AU AU2013237330A patent/AU2013237330C1/en active Active
- 2013-03-22 DK DK13714246T patent/DK2828256T5/da active
- 2013-03-22 PT PT137142469T patent/PT2828256T/pt unknown
- 2013-03-22 KR KR1020147026392A patent/KR102057590B1/ko active Active
- 2013-03-22 BR BR112014022909-0A patent/BR112014022909B1/pt active IP Right Grant
- 2013-03-22 WO PCT/EP2013/056170 patent/WO2013139987A1/en not_active Ceased
- 2013-03-22 HR HRP20191632 patent/HRP20191632T1/hr unknown
- 2013-03-22 LT LTEP13714246.9T patent/LT2828256T/lt unknown
- 2013-03-22 ES ES13714246T patent/ES2748460T3/es active Active
- 2013-03-22 ES ES19182727T patent/ES2962530T3/es active Active
- 2013-03-22 CA CA2866222A patent/CA2866222C/en active Active
- 2013-03-22 JP JP2015500948A patent/JP6117906B2/ja active Active
- 2013-03-22 PL PL13714246T patent/PL2828256T3/pl unknown
- 2013-03-22 US US14/384,233 patent/US9598712B2/en active Active
- 2013-03-22 RU RU2014142621A patent/RU2662815C2/ru active
- 2013-03-22 EP EP19182727.8A patent/EP3578557B1/en active Active
- 2013-03-22 AP AP2014007906A patent/AP2014007906A0/xx unknown
-
2019
- 2019-10-02 CY CY20191101024T patent/CY1122087T1/el unknown
Non-Patent Citations (1)
| Title |
|---|
| Tetrahedron letters, v.28, no.32, pp.3745-6* |
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