CN105849115A - 制药方法和中间体 - Google Patents
制药方法和中间体 Download PDFInfo
- Publication number
- CN105849115A CN105849115A CN201480069979.6A CN201480069979A CN105849115A CN 105849115 A CN105849115 A CN 105849115A CN 201480069979 A CN201480069979 A CN 201480069979A CN 105849115 A CN105849115 A CN 105849115A
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- salt
- amine
- kilograms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NHHQJBCNYHBUSI-UHFFFAOYSA-N CC(C)(C(N1)=O)Oc(cc2)c1nc2Nc1nc(Nc(cc2OC)cc(OC)c2OC)ncc1F Chemical compound CC(C)(C(N1)=O)Oc(cc2)c1nc2Nc1nc(Nc(cc2OC)cc(OC)c2OC)ncc1F NHHQJBCNYHBUSI-UHFFFAOYSA-N 0.000 description 1
- 0 CC1(C)OC2C=CC(C(C3)C3C3=*C(*C=CC(C(C(OC)=C)O)O)*C=C3C)=*C2*C1=O Chemical compound CC1(C)OC2C=CC(C(C3)C3C3=*C(*C=CC(C(C(OC)=C)O)O)*C=C3C)=*C2*C1=O 0.000 description 1
- GKDRMWXFWHEQQT-UHFFFAOYSA-N CC1(C)Oc2ccc(Nc(nc(Nc(cc3OC)cc(OC)c3OC)nc3)c3F)nc2N(COP(O)(O)=O)C1=O Chemical compound CC1(C)Oc2ccc(Nc(nc(Nc(cc3OC)cc(OC)c3OC)nc3)c3F)nc2N(COP(O)(O)=O)C1=O GKDRMWXFWHEQQT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
Description
Claims (12)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361919671P | 2013-12-20 | 2013-12-20 | |
US61/919,671 | 2013-12-20 | ||
PCT/US2014/071613 WO2015095765A1 (en) | 2013-12-20 | 2014-12-19 | Pharmaceutical process and intermediates |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105849115A true CN105849115A (zh) | 2016-08-10 |
CN105849115B CN105849115B (zh) | 2019-06-11 |
Family
ID=52358996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480069979.6A Active CN105849115B (zh) | 2013-12-20 | 2014-12-19 | 制药方法和中间体 |
Country Status (16)
Country | Link |
---|---|
US (2) | US9388203B2 (zh) |
EP (1) | EP3083648B1 (zh) |
JP (1) | JP6522005B2 (zh) |
CN (1) | CN105849115B (zh) |
CA (2) | CA2934535C (zh) |
CY (1) | CY1121313T1 (zh) |
DK (1) | DK3083648T3 (zh) |
ES (1) | ES2701088T3 (zh) |
HR (1) | HRP20181933T1 (zh) |
HU (1) | HUE042204T2 (zh) |
LT (1) | LT3083648T (zh) |
PL (1) | PL3083648T3 (zh) |
PT (1) | PT3083648T (zh) |
RS (1) | RS58084B1 (zh) |
SI (1) | SI3083648T1 (zh) |
WO (1) | WO2015095765A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109912622A (zh) * | 2019-03-20 | 2019-06-21 | 中国药科大学 | 一种福他替尼关键中间体的制备方法及其中间体和利用中间体制备福他替尼的方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101115761A (zh) * | 2005-01-19 | 2008-01-30 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物的前药及其应用 |
WO2008064274A1 (en) * | 2006-11-21 | 2008-05-29 | Rigel Pharmaceuticals, Inc. | Prodrug salts of 2, 4-pyrimidinediamine compounds and their uses |
CN102482305A (zh) * | 2009-07-02 | 2012-05-30 | 里格尔药品股份有限公司 | N4-(2,2-二甲基-4-[(二氢膦酰氧基)甲基]-3-氧代-5-吡啶并[1,4]噁嗪-6-基)-5-氟-n2-(3,4,5-三甲氧基苯基)-2,4-嘧啶二胺二钠盐的合成 |
US20130150329A1 (en) * | 2009-11-20 | 2013-06-13 | Rigel Pharmaceuticals, Inc. | 2,4-Pyrimidinediamine Compounds and Prodrugs and Their Uses |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4886511B2 (ja) | 2003-07-30 | 2012-02-29 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 2,4−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法 |
-
2014
- 2014-12-19 PL PL14828102T patent/PL3083648T3/pl unknown
- 2014-12-19 RS RS20181453A patent/RS58084B1/sr unknown
- 2014-12-19 LT LTEP14828102.5T patent/LT3083648T/lt unknown
- 2014-12-19 ES ES14828102T patent/ES2701088T3/es active Active
- 2014-12-19 CN CN201480069979.6A patent/CN105849115B/zh active Active
- 2014-12-19 WO PCT/US2014/071613 patent/WO2015095765A1/en active Application Filing
- 2014-12-19 CA CA2934535A patent/CA2934535C/en active Active
- 2014-12-19 EP EP14828102.5A patent/EP3083648B1/en active Active
- 2014-12-19 US US14/576,544 patent/US9388203B2/en active Active
- 2014-12-19 HU HUE14828102A patent/HUE042204T2/hu unknown
- 2014-12-19 SI SI201430992T patent/SI3083648T1/sl unknown
- 2014-12-19 JP JP2016560869A patent/JP6522005B2/ja active Active
- 2014-12-19 DK DK14828102.5T patent/DK3083648T3/en active
- 2014-12-19 CA CA3186267A patent/CA3186267A1/en active Pending
- 2014-12-19 PT PT14828102T patent/PT3083648T/pt unknown
-
2016
- 2016-06-10 US US15/178,967 patent/US9695204B2/en active Active
-
2018
- 2018-11-20 HR HRP20181933TT patent/HRP20181933T1/hr unknown
- 2018-12-04 CY CY20181101287T patent/CY1121313T1/el unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101115761A (zh) * | 2005-01-19 | 2008-01-30 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物的前药及其应用 |
WO2008064274A1 (en) * | 2006-11-21 | 2008-05-29 | Rigel Pharmaceuticals, Inc. | Prodrug salts of 2, 4-pyrimidinediamine compounds and their uses |
CN102482305A (zh) * | 2009-07-02 | 2012-05-30 | 里格尔药品股份有限公司 | N4-(2,2-二甲基-4-[(二氢膦酰氧基)甲基]-3-氧代-5-吡啶并[1,4]噁嗪-6-基)-5-氟-n2-(3,4,5-三甲氧基苯基)-2,4-嘧啶二胺二钠盐的合成 |
US20130150329A1 (en) * | 2009-11-20 | 2013-06-13 | Rigel Pharmaceuticals, Inc. | 2,4-Pyrimidinediamine Compounds and Prodrugs and Their Uses |
Non-Patent Citations (2)
Title |
---|
MCADOO, S. P. ET AL: "Fostamatinib disodium: tyrosine-protein kinase SYK/FLT3 inhibitor treatment of rheumatoid arthritis oncolytic", 《DRUGS OF THE FUTURE》 * |
郭宝国,赵文献主编: "《有机合成重要单元反应》", 31 December 2009 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109912622A (zh) * | 2019-03-20 | 2019-06-21 | 中国药科大学 | 一种福他替尼关键中间体的制备方法及其中间体和利用中间体制备福他替尼的方法 |
Also Published As
Publication number | Publication date |
---|---|
JP2017503018A (ja) | 2017-01-26 |
US9695204B2 (en) | 2017-07-04 |
ES2701088T3 (es) | 2019-02-20 |
DK3083648T3 (en) | 2019-01-07 |
US20150175639A1 (en) | 2015-06-25 |
EP3083648B1 (en) | 2018-09-12 |
CA3186267A1 (en) | 2015-06-25 |
HRP20181933T1 (hr) | 2019-01-11 |
RS58084B1 (sr) | 2019-02-28 |
US9388203B2 (en) | 2016-07-12 |
CA2934535C (en) | 2023-03-28 |
CY1121313T1 (el) | 2020-05-29 |
SI3083648T1 (sl) | 2019-02-28 |
LT3083648T (lt) | 2019-01-25 |
CN105849115B (zh) | 2019-06-11 |
JP6522005B2 (ja) | 2019-05-29 |
PL3083648T3 (pl) | 2019-05-31 |
EP3083648A1 (en) | 2016-10-26 |
PT3083648T (pt) | 2018-12-14 |
CA2934535A1 (en) | 2015-06-25 |
HUE042204T2 (hu) | 2019-06-28 |
WO2015095765A1 (en) | 2015-06-25 |
US20160355531A1 (en) | 2016-12-08 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20170519 Address after: California, USA Applicant after: RIGEL PHARMACEUTICALS, Inc. Address before: California, USA Applicant before: RIGEL PHARMACEUTICALS, Inc. Applicant before: ASTRAZENECA AB Effective date of registration: 20170519 Address after: California, USA Applicant after: RIGEL PHARMACEUTICALS, Inc. Applicant after: ASTRAZENECA AB Address before: California, USA Applicant before: RIGEL PHARMACEUTICALS, Inc. Applicant before: Astrazeneca UK Ltd. Effective date of registration: 20170519 Address after: California, USA Applicant after: RIGEL PHARMACEUTICALS, Inc. Applicant after: AstraZeneca UK Ltd. Address before: California, USA Applicant before: RIGEL PHARMACEUTICALS, Inc. Applicant before: MCKEEVER BENEDICT Applicant before: DIORAZIO LOUIS JOSEPH Applicant before: JONES MARTIN FRANCIS Applicant before: FERRIS LEIGH Applicant before: JANBON SOPHIE LAURE MARIE Applicant before: SIEDLECKI PAWEL STANISLAW Applicant before: CHURCHILL GWYDION HUW Applicant before: CRAFTS PETER ALAN |
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