JP2015511121A - 浸潤性および予後に関する乳がんバイオマーカーシグネチャー - Google Patents

浸潤性および予後に関する乳がんバイオマーカーシグネチャー Download PDF

Info

Publication number
JP2015511121A
JP2015511121A JP2014553510A JP2014553510A JP2015511121A JP 2015511121 A JP2015511121 A JP 2015511121A JP 2014553510 A JP2014553510 A JP 2014553510A JP 2014553510 A JP2014553510 A JP 2014553510A JP 2015511121 A JP2015511121 A JP 2015511121A
Authority
JP
Japan
Prior art keywords
mir
hsa
mirna
expression
mrna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014553510A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015511121A5 (enExample
Inventor
クローセ，カーロ・エム
ヴォリーニャ，ステファノ
Original Assignee
ジ・オハイオ・ステート・ユニバーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジ・オハイオ・ステート・ユニバーシティ filed Critical ジ・オハイオ・ステート・ユニバーシティ
Publication of JP2015511121A publication Critical patent/JP2015511121A/ja
Publication of JP2015511121A5 publication Critical patent/JP2015511121A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/20—Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
    • G06F16/24—Querying
    • G06F16/245—Query processing
    • G06F16/2458—Special types of queries, e.g. statistical queries, fuzzy queries or distributed queries
    • G06F16/2468—Fuzzy queries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mathematical Physics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Fuzzy Systems (AREA)
  • Molecular Biology (AREA)
  • Software Systems (AREA)
  • Probability & Statistics with Applications (AREA)
  • Computational Linguistics (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
JP2014553510A 2012-01-20 2013-01-22 浸潤性および予後に関する乳がんバイオマーカーシグネチャー Pending JP2015511121A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261588790P 2012-01-20 2012-01-20
US61/588,790 2012-01-20
PCT/US2013/022492 WO2013110053A1 (en) 2012-01-20 2013-01-22 Breast cancer biomarker signatures for invasiveness and prognosis

Publications (2)

Publication Number Publication Date
JP2015511121A true JP2015511121A (ja) 2015-04-16
JP2015511121A5 JP2015511121A5 (enExample) 2016-03-03

Family

ID=48797723

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014553510A Pending JP2015511121A (ja) 2012-01-20 2013-01-22 浸潤性および予後に関する乳がんバイオマーカーシグネチャー

Country Status (7)

Country Link
US (3) US8859202B2 (enExample)
EP (1) EP2804960A4 (enExample)
JP (1) JP2015511121A (enExample)
CN (2) CN105936932A (enExample)
AU (1) AU2013209477B2 (enExample)
CA (1) CA2866052A1 (enExample)
WO (1) WO2013110053A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2484782B1 (en) 2006-01-05 2015-11-18 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
JP2015511121A (ja) 2012-01-20 2015-04-16 ジ・オハイオ・ステート・ユニバーシティ 浸潤性および予後に関する乳がんバイオマーカーシグネチャー
ES2548299B2 (es) * 2014-03-13 2016-05-13 Universidad De Málaga Firma de microARN como indicador del riesgo de recurrencia temprana en pacientes con cáncer de mama
CN105586390B (zh) * 2014-10-23 2019-01-22 王辉云 一种用于乳腺癌预后判断的试剂盒
WO2016115572A1 (en) * 2015-01-16 2016-07-21 City Of Hope Markers of breast cancer and methods for the use thereof
WO2016150475A1 (en) * 2015-03-22 2016-09-29 Universite De Liege Circulating micrornas for the diagnosis of breast cancer
CN105200043B (zh) * 2015-06-26 2018-08-03 宋尔卫 一种用于评估乳腺癌预后风险的试剂盒
KR101903838B1 (ko) 2015-09-07 2018-10-02 동국대학교 산학협력단 유방암 관련 stk32c 유전자 및 이의 용도
CN108367995B (zh) * 2015-10-06 2021-08-27 安大略省癌症研究所 靶向组蛋白途径以检测和克服蒽环类抗生素耐受性
MX390160B (es) * 2015-12-04 2025-03-20 Instituto Nac De Medicina Genomica Método de pronóstico en cáncer de mama.
CN105483254A (zh) * 2015-12-31 2016-04-13 高勇 乳腺癌的诊断标记物
CN107299129B (zh) * 2016-04-15 2021-07-27 昆山市工业技术研究院小核酸生物技术研究所有限责任公司 循环核酸作为乳腺癌生物标志物的应用
EP3481941A4 (en) * 2016-07-06 2020-04-15 Youhealth Biotech, Limited METHYLIZATION MARKERS FOR BREAST AND OVARIAL CANCER AND THEIR USE
WO2018125011A1 (en) * 2016-12-29 2018-07-05 Istanbul Universitesi Rektorlugu Early diagnosis method and kit for breast cancer
EP3366780B1 (en) 2017-02-23 2020-05-06 Siemens Healthcare GmbH Single-molecule sequence and high sensitivity methylation analysis for tissue-specific analysis
CN107025387B (zh) * 2017-03-29 2020-09-18 电子科技大学 一种用于癌症生物标志物识别的方法
CN107543926A (zh) * 2017-08-25 2018-01-05 复旦大学附属金山医院 一种新的诊断乳腺浸润性导管癌的应用
CN108504555B (zh) * 2018-04-16 2021-08-03 图灵人工智能研究院（南京）有限公司 鉴别及评价肿瘤进展的装置和方法
CN109745335B (zh) * 2019-03-26 2021-03-16 南京医科大学 miR-218在制备乳腺癌化疗药物增敏剂中的应用
WO2020242857A1 (en) * 2019-05-24 2020-12-03 Lunella Biotech, Inc. Therapeutics and methods for predicting and overcoming endocrine resistance in breast cancer
JP7299765B2 (ja) * 2019-06-14 2023-06-28 株式会社東芝 マイクロｒｎａ測定方法およびキット
CN111312330A (zh) * 2020-02-13 2020-06-19 兰州理工大学 一种基于蛋白质节点特性的关键蛋白质识别方法及系统
CN112035421B (zh) * 2020-11-02 2021-01-19 杭州优云科技有限公司 一种基于数据积累的idc调度优化系统
CN112301133B (zh) * 2020-12-01 2021-07-27 江门市中心医院 胆固醇生成基因标签在年轻乳腺癌患者预后预测中的应用
CA3210972A1 (en) * 2021-02-12 2022-08-18 Mammogen, Inc. Biomarkers for the diagnosis of breast cancer
CN117098853A (zh) * 2021-02-12 2023-11-21 麻摩根公司 用于诊断乳腺癌的生物标记物
CN113140258B (zh) * 2021-04-28 2024-03-19 上海海事大学 基于肿瘤浸润性免疫细胞筛选肺腺癌的潜在预后生物标志物的方法
CN113355419B (zh) * 2021-06-28 2022-02-18 广州中医药大学(广州中医药研究院) 一种乳腺癌预后风险预测标志组合物及应用
CN113702635B (zh) * 2021-07-23 2024-11-26 深圳市罗湖区人民医院 Birc6作为三阴性乳腺癌诊断和治疗靶标
CN115058513A (zh) * 2022-01-26 2022-09-16 河南牧业经济学院 一种犬乳腺浸润性导管癌组织差异表达miRNA的分析方法及应用
CN121794400A (zh) 2023-06-22 2026-04-03 宗教与信仰基金会"苦难慰藉之家"-圣庇奥·达·彼得雷尔奇纳创立的机构 非转移性女性乳腺癌的预后方法
CN119517424B (zh) * 2024-11-13 2025-10-03 吉林大学 一种评估消化系统癌恶性程度的试剂盒和方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005519624A (ja) * 2002-03-13 2005-07-07 ジェノミック ヘルス， インコーポレイテッド 生検腫瘍組織での遺伝子発現プロファイリング
WO2007081740A2 (en) * 2006-01-05 2007-07-19 The Ohio State University Research Foundation Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers
JP2008508895A (ja) * 2004-08-10 2008-03-27 ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド 乳癌の予後診断方法およびキット
WO2008089577A1 (en) * 2007-01-26 2008-07-31 Vm Institute Of Resaerch Breast cancer gene array
JP2009505639A (ja) * 2005-08-01 2009-02-12 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 乳癌の診断、予後及び治療のためのマイクロｒｎａに基づいた方法及び組成物
JP2009507918A (ja) * 2005-09-12 2009-02-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法
JP2010518878A (ja) * 2007-02-26 2010-06-03 アンセルム （アンスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） 乳癌患者における転移発生の予測方法
US20100210738A1 (en) * 2009-02-09 2010-08-19 Vm Institute Of Research Prognostic biomarkers to predict overall survival and metastatic disease in patients with triple negative breast cancer
WO2011088137A2 (en) * 2010-01-12 2011-07-21 H. Lee Moffitt Cancer Center & Research Institute Bad pathway gene signature
US20110195848A1 (en) * 2010-01-08 2011-08-11 Roopra Avtar S Gene expression and breast cancer
WO2011107819A1 (en) * 2010-03-01 2011-09-09 Adelbio Methods for predicting outcome of breast cancer, and/or risk of relapse, response or survival of a patient suffering therefrom

Family Cites Families (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4172124A (en) 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
US4608337A (en) 1980-11-07 1986-08-26 The Wistar Institute Human hybridomas and the production of human monoclonal antibodies by human hybridomas
US4701409A (en) 1984-11-15 1987-10-20 The Wistar Institute Detection of B-cell neoplasms
US4693975A (en) 1984-11-20 1987-09-15 The Wistar Institute Human hybridroma fusion partner for production of human monoclonal antibodies
US4666099A (en) 1985-11-15 1987-05-19 Scott Paper Company Apparatus for dispensing sheet material
US5015568A (en) 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5202429A (en) 1986-07-09 1993-04-13 The Wistar Institute DNA molecules having human BCL-2 gene sequences
US5198338A (en) 1989-05-31 1993-03-30 Temple University Molecular probing for human t-cell leukemia and lymphoma
JPH05500302A (ja) 1989-07-03 1993-01-28 テンプル・ユニバーシティ Ｔ細胞性白血病及び黒色腫に伴うｔｃｌ―５遺伝子の転位
US5149628A (en) 1989-11-15 1992-09-22 Temple University Methods for detecting bcl-3 gene in human leukemias
US6040140A (en) 1991-12-11 2000-03-21 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
US5633135A (en) 1991-12-11 1997-05-27 Thomas Jefferson University Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities
WO1993012136A1 (en) 1991-12-11 1993-06-24 Thomas Jefferson University Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region
EP0667920B1 (en) 1992-10-29 2003-01-15 Thomas Jefferson University Methods of detecting micrometastasis of prostate cancer
US5674682A (en) 1992-10-29 1997-10-07 Thomas Jefferson University Nucleic acid primers for detecting micrometastasis of prostate cancer
GB9307754D0 (en) 1993-04-15 1993-06-02 Perry Robert E Diagnostic probes and therapeutic products
WO1994026930A1 (en) 1993-05-14 1994-11-24 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
US7175995B1 (en) 1994-10-27 2007-02-13 Thomas Jefferson University TCL-1 protein and related methods
US5985598A (en) 1994-10-27 1999-11-16 Thomas Jefferson University TCL-1 gene and protein and related methods and compositions
US5695944A (en) 1995-05-05 1997-12-09 Thomas Jefferson University Modulation of bcl-2 phosphorylation
US5567586A (en) 1995-05-18 1996-10-22 Thomas Jefferson University Methods of indentifying solid tumors with chromosome abnormalities in the ALL-1 region
US5928884A (en) 1996-02-09 1999-07-27 Croce; Carlo M. FHIT proteins and nucleic acids and methods based thereon
US6242212B1 (en) 1996-02-09 2001-06-05 Thomas Jefferson University Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins
AU4003597A (en) 1996-09-04 1998-03-26 Howard Florey Institute Of Experimental Physiology And Medicine Methods of diagnosing and treating cancer
WO1998035707A1 (en) 1997-02-18 1998-08-20 Thomas Jefferson University Compositions that bind to pancreatic cancer cells and methods of using the same
AU6951098A (en) 1997-04-04 1998-10-30 The Texas A & M University System Noninvasive detection of colonic biomarkers using fecal messenger rna
JP2000511291A (ja) 1997-10-21 2000-08-29 キャンサー リサーチ キャンペーン テクノロジー リミティド 細胞の増殖異常の測定
US6303323B1 (en) 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
EP1098968A4 (en) 1998-07-20 2002-01-02 Univ Jefferson NITRILASE APPROVALS
US6255293B1 (en) 1998-07-24 2001-07-03 Yeda Research And Development Co., Ltd. Prevention of metastasis with 5-aza-2′-deoxycytidine
US6649396B1 (en) 1999-02-05 2003-11-18 Uab Research Foundation Fiber receptor-independent system for the propagation of adenoviral vectors
WO2000050565A2 (en) 1999-02-25 2000-08-31 Thomas Jefferson University Compositions, kits, and methods relating to the human fez1 gene, a novel tumor suppressor gene
US7141417B1 (en) 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
EP1165586A4 (en) 1999-03-15 2003-05-28 Univ Jefferson TCL-1B GENES AND PROTEINS AND RELATED METHODS AND METHODS
US6579857B1 (en) 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
AU6227400A (en) 1999-07-26 2001-02-13 Childrens Hospital Los Angeles Research Institute Fenretinide increases antibody cellular toxicity
US7163801B2 (en) 1999-09-01 2007-01-16 The Burnham Institute Methods for determining the prognosis for cancer patients using tucan
US20040132017A1 (en) 1999-12-16 2004-07-08 Robert Richards Oxidoreductase gene associated with the fra16d fragile site
US20030206958A1 (en) 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
US6891031B2 (en) 2000-02-18 2005-05-10 The Regents Of The University Of California Coordinate cytokine regulatory sequences
US20010026796A1 (en) 2000-03-14 2001-10-04 Croce Carlo M. TCL1 enhances Akt kinase activity and mediates its nuclear translocation
CA2406366A1 (en) 2000-04-11 2001-10-18 Thomas Jefferson University Muir-torre-like syndrome infhit deficient mice
US20020086331A1 (en) 2000-05-16 2002-07-04 Carlo Croce Crystal structure of worm NitFhit reveals that a Nit tetramer binds two Fhit dimers
US7060811B2 (en) 2000-10-13 2006-06-13 Board Of Regents, The University Of Texas System WWOX: a tumor suppressor gene mutated in multiple cancers
WO2002064172A2 (en) 2001-02-12 2002-08-22 Thomas Jefferson University Fhit gene therapy prevents tumor development in fhit-deficient mice
WO2002064171A1 (en) 2001-02-12 2002-08-22 Thomas Jefferson University Adenoviral transduction of fragile histidine triad (fhit) into cancer cells
US20040033502A1 (en) 2001-03-28 2004-02-19 Amanda Williams Gene expression profiles in esophageal tissue
US20050176025A1 (en) 2001-05-18 2005-08-11 Sirna Therapeutics, Inc. RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
EP2428570B1 (en) 2001-09-28 2018-05-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Microrna molecules
US7371736B2 (en) 2001-11-07 2008-05-13 The Board Of Trustees Of The University Of Arkansas Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss
WO2003040347A2 (en) 2001-11-09 2003-05-15 The Ohio State University Research Foundation Baalc expression as a diagnostic marker for acute leukemia
GB0128898D0 (en) 2001-12-03 2002-01-23 Biotech Res Ventures Pte Ltd Materials and methods relating to the stabilization and activation of a tumour suppressor protein
WO2003069853A1 (en) 2002-02-12 2003-08-21 Nokia Corporation Method for controlling data transmission, and data transmission system
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
EP1442143A4 (en) 2002-02-20 2005-02-16 Sirna Therapeutics Inc INHIBITION OF BCL2 GENE EXPRESSION MEDIATED BY RNA INTERFERENCE USING siNA (SHORT INTERFERING NUCLEIC ACID)
CA2478065C (en) 2002-03-08 2013-01-08 Eisai Co. Ltd. Macrocyclic compounds useful as pharmaceuticals
WO2003083710A2 (en) 2002-03-27 2003-10-09 Universiity Of Southern California Phrase- based joint probability model for statistical machine translation
EP1496928A4 (en) 2002-04-08 2005-08-10 Ciphergen Biosystems Inc SERUM BIOMARKERS IN HEPATOCELLULAR CARCINOMA
CA2484920A1 (en) 2002-04-29 2003-11-13 Thomas Jefferson University Human chronic lymphocytic leukemia modeled in mouse by targeted tcl1 expression
AU2003273542A1 (en) 2002-05-31 2003-12-19 The Board Of Trustees Of The Leland Stanford Junior University Methods of identifying and isolating stem cells and cancer stem cells
US20050260639A1 (en) 2002-09-30 2005-11-24 Oncotherapy Science, Inc. Method for diagnosing pancreatic cancer
WO2004033659A2 (en) 2002-10-11 2004-04-22 Thomas Jefferson University Novel tumor suppressor gene and compositions and methods for making and using the same
US20050266443A1 (en) 2002-10-11 2005-12-01 Thomas Jefferson University Novel tumor suppressor gene and compositions and methods for making and using the same
CN1719973A (zh) 2002-11-13 2006-01-11 托马斯杰斐逊大学 用于癌症诊断和治疗的组合物和方法
ATE546528T1 (de) 2002-11-13 2012-03-15 Univ Jefferson Zusammensetzungen und verfahren zur diagnose und behandlung von krebs
US7250496B2 (en) 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US20040102421A1 (en) 2002-11-21 2004-05-27 Children's Hospital Research Center At Oakland Tocopherol and tocotrienol anti-inflammatory medicaments
WO2004071464A2 (en) 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
WO2004079013A1 (en) 2003-03-03 2004-09-16 Arizona Board Of Regents On Behalf Of The University Of Arizona Ecto-5’-nucleotidase (cd73) used in the diagnosis and the treatment of pancreatic cancer
US7183384B2 (en) 2003-03-06 2007-02-27 A & G Pharmaceutical, Inc. Monoclonal antibody 7H11 reactive with human cancer
WO2004081196A2 (en) 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
WO2004098377A2 (en) 2003-05-02 2004-11-18 Thomas Jefferson University Methods and compositions for diagnosis and therapy of parkin-associated disorders
WO2006031210A1 (en) 2003-05-29 2006-03-23 Board Of Regents, The University Of Texas Systems Jabi as a prognostic marker and a therapeutic target for human cancer
MXPA05013879A (es) 2003-06-18 2006-06-27 Genelux Corp Virus de la vaccinia recombinantes modificados y otros microorganismos, y usos de los mismos.
WO2005013901A2 (en) 2003-07-31 2005-02-17 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for use in modulation of small non-coding rnas
US8106180B2 (en) 2003-08-07 2012-01-31 Whitehead Institute For Biomedical Research Methods and products for expression of micro RNAs
US20050037362A1 (en) 2003-08-11 2005-02-17 Eppendorf Array Technologies, S.A. Detection and quantification of siRNA on microarrays
US8412541B2 (en) 2003-08-14 2013-04-02 Edda Technology, Inc. Method and system for intelligent qualitative and quantitative analysis for medical diagnosis
US20050084883A1 (en) 2003-08-25 2005-04-21 The Johns Hopkins University School Of Medicine Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differential gene expression analysis
EP1670955A2 (en) 2003-09-22 2006-06-21 Rosetta Inpharmatics LLC. Synthetic lethal screen using rna interference
EP1676914A4 (en) 2003-09-22 2007-10-10 Aichi Prefecture TYPE OF PATHOLOGICAL LYMPHOMA AND DIAGNOSTIC EVALUATION METHOD
WO2005028675A2 (en) 2003-09-24 2005-03-31 Oncotherapy Science, Inc. Methods for detecting, diagnosing and treating hepatocellular carcinomas (hcc)
US20050186589A1 (en) 2003-11-07 2005-08-25 University Of Massachusetts Interspersed repetitive element RNAs as substrates, inhibitors and delivery vehicles for RNAi
US20050164252A1 (en) 2003-12-04 2005-07-28 Yeung Wah Hin A. Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell
EP2299266A1 (en) 2003-12-19 2011-03-23 The Regents of the University of California Methods and materials for assessing prostate cancer therapies
JP4120002B2 (ja) 2004-01-07 2008-07-16 愛知県 ｍｉＲＮＡを用いた癌の予後判定方法、癌の遺伝子治療ベクター及び癌治療用医薬組成物
WO2005078096A2 (en) 2004-02-09 2005-08-25 University Of Massachusetts Dual functional oligonucleotides for use in repressing mutant gene expression
EP1713938A2 (en) 2004-02-09 2006-10-25 Thomas Jefferson University DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
CA2556435C (en) 2004-02-13 2014-08-12 The Rockefeller University Anti-microrna oligonucleotide molecules
EP1723257B1 (en) 2004-02-23 2019-01-09 Erasmus University Medical Center Rotterdam Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profiling
WO2005094263A2 (en) 2004-03-23 2005-10-13 Pintex Pharmaceuticals, Inc. Methods of determining the prognosis and treatment of subjects with colon cancer
US20060134639A1 (en) 2004-04-06 2006-06-22 Huffel Christophe V Method for the determination of cellular transcriptional regulation
US7365058B2 (en) 2004-04-13 2008-04-29 The Rockefeller University MicroRNA and methods for inhibiting same
CN101056991A (zh) 2004-04-20 2007-10-17 基因耐克生物医学制品有限公司 检测ncRNA的方法
CA2566519C (en) 2004-05-14 2020-04-21 Rosetta Genomics Ltd. Micrornas and uses thereof
EP2471924A1 (en) 2004-05-28 2012-07-04 Asuragen, INC. Methods and compositions involving microRNA
US7635563B2 (en) 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
WO2006007529A2 (en) 2004-07-01 2006-01-19 University Of Pittsburgh Of The Commonwealth System For Higher Education Immunosuppressive exosomes
US20060037088A1 (en) 2004-08-13 2006-02-16 Shulin Li Gene expression levels as predictors of chemoradiation response of cancer
DK1797183T3 (da) 2004-09-02 2012-10-01 Univ Yale Regulering af onkogener med mikrornas
US7642348B2 (en) 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
US7592441B2 (en) 2004-10-04 2009-09-22 Rosetta Genomics Ltd Liver cancer-related nucleic acids
FR2877350B1 (fr) 2004-11-03 2010-08-27 Centre Nat Rech Scient IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE
ES2534300T3 (es) 2004-11-12 2015-04-21 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
EP1662259A1 (en) 2004-11-25 2006-05-31 Cellzome Ag Use of Eph receptor inhibitors for the treatment of neurodegenerative diseases
EP1824872B1 (en) 2004-12-14 2012-02-08 Alnylam Pharmaceuticals Inc. Rnai modulation of mll-af4 and uses thereof
US20060185027A1 (en) 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
US20070099196A1 (en) 2004-12-29 2007-05-03 Sakari Kauppinen Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs
JP2008528003A (ja) 2005-01-25 2008-07-31 ロゼッタ インファーマティックス エルエルシー 小ｒｎａ分子の定量方法
US8071306B2 (en) 2005-01-25 2011-12-06 Merck Sharp & Dohme Corp. Methods for quantitating small RNA molecules
CA2597767A1 (en) 2005-02-11 2006-08-17 Wisconsin Alumni Research Foundation Mir-155 assay
RS53128B (sr) 2005-02-23 2014-06-30 Genentech Inc. Produžavanje vremena progresije bolesti ili preživljavanja kod pacijenata obolelih od kancera jajnika korišćenjem pertuzumaba
US20070065840A1 (en) 2005-03-23 2007-03-22 Irena Naguibneva Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS
GB2425311A (en) 2005-04-15 2006-10-25 Ist Superiore Sanita Micro RNA against kit protein
EP2631292A3 (en) 2005-04-29 2013-11-20 The Rockefeller University Human microRNAs and methods for inhibiting same
WO2006119365A2 (en) 2005-05-02 2006-11-09 Cold Spring Harbor Laboratory Composition and methods for cancer diagnosis utilizing the mir 17-92 cluster
US20090209621A1 (en) 2005-06-03 2009-08-20 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
US20070065844A1 (en) 2005-06-08 2007-03-22 Massachusetts Institute Of Technology Solution-based methods for RNA expression profiling
US20060292616A1 (en) 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods
AU2006279906B2 (en) 2005-08-10 2012-05-10 Alnylam Pharmaceuticals, Inc. Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
US20070213292A1 (en) 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
CA2624531A1 (en) 2005-10-05 2007-04-19 Carlo M. Croce Wwox gene, vectors containing the same, and uses in treatment of cancer
US20070092882A1 (en) 2005-10-21 2007-04-26 Hui Wang Analysis of microRNA
US8445198B2 (en) 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
US7390792B2 (en) 2005-12-15 2008-06-24 Board Of Regents, The University Of Texas System MicroRNA1 therapies
US20100286044A1 (en) 2005-12-29 2010-11-11 Exiqon A/S Detection of tissue origin of cancer
AU2007205234B2 (en) 2006-01-05 2012-07-12 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
WO2007081680A2 (en) 2006-01-05 2007-07-19 The Ohio State University Research Foundation Microrna expression abnormalities in pancreatic endocrine and acinar tumors
CA2636990A1 (en) 2006-01-13 2007-07-26 Battelle Memorial Institute Animal model for assessing copd-related diseases
ES2446362T3 (es) 2006-03-20 2014-03-07 The Ohio State University Research Foundation Huellas de microARN durante megacariocipoyesis humana
WO2007112097A2 (en) 2006-03-24 2007-10-04 Children's Medical Center Corporation Novel signature self renewal gene expression programs
EP2013016B8 (en) 2006-03-29 2014-10-08 Wayne State University Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery
CA3042781C (en) 2006-04-03 2021-10-19 Roche Innovation Center Copenhagen A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
CN101472470B (zh) 2006-04-24 2013-07-24 俄亥俄州立大学研究基金会 miR155转基因小鼠中前B细胞增殖和淋巴母细胞性白血病/高度淋巴瘤
WO2008002672A2 (en) 2006-06-28 2008-01-03 The Cleveland Clinic Foundation Targets for use in diagnosis, prognosis and therapy of cancer
WO2008029295A2 (en) 2006-06-30 2008-03-13 Rosetta Genomics Ltd A method for detecting nucleic acids
ES2425387T3 (es) 2006-07-13 2013-10-15 The Ohio State University Research Foundation Mir-106a para diagnosticar adenocarcinoma de colon de pronóstico de supervivencia pobre
US20080029279A1 (en) 2006-08-01 2008-02-07 Louis Zuccarello Ground-working tool
CA2661354C (en) 2006-08-30 2012-12-18 The Regents Of The University Of Michigan New small molecule inhibitors of mdm2 and the uses thereof
US20080193943A1 (en) 2006-09-05 2008-08-14 Abbott Laboratories Companion diagnostic assays for cancer therapy
EP2145001A2 (en) 2006-09-19 2010-01-20 Asuragen, Inc. Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
WO2008036741A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-200 regulated genes and pathways as targets for therapeutic intervention
US8071292B2 (en) 2006-09-19 2011-12-06 The Ohio State University Research Foundation Leukemia diagnostic methods
CA2664383C (en) 2006-09-19 2017-08-22 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
JP2008086201A (ja) 2006-09-29 2008-04-17 Gifu Prefecture Kenkyu Kaihatsu Zaidan マイクロｒｎａ生成の検出方法と癌の診断・治療およびマイクロｒｎａ生成調整剤
WO2008070301A2 (en) 2006-10-20 2008-06-12 Washington University In St. Louis Predicting lung cancer survival using gene expression
WO2008054828A2 (en) 2006-11-01 2008-05-08 The Ohio State University Research Foundation Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma
JP2010510769A (ja) 2006-11-28 2010-04-08 キャピタルバイオ コーポレーション 食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物
US8293684B2 (en) 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
WO2008070082A2 (en) 2006-12-04 2008-06-12 The Johns Hopkins University Stem-progenitor cell specific micro-ribonucleic acids and uses thereof
GB0624302D0 (en) 2006-12-05 2007-01-17 Istituto Superiore Di Sanito Micro RNA
CN101622348A (zh) 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-20调节的基因和途径
WO2008073919A2 (en) 2006-12-08 2008-06-19 Asuragen, Inc. Mir-20 regulated genes and pathways as targets for therapeutic intervention
EP2104737B1 (en) 2006-12-08 2013-04-10 Asuragen, INC. Functions and targets of let-7 micro rnas
EP2104735A2 (en) 2006-12-08 2009-09-30 Asuragen, INC. Mir-21 regulated genes and pathways as targets for therapeutic intervention
CA2671270A1 (en) 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
JP2010516291A (ja) 2007-01-31 2010-05-20 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 急性骨髄性白血病（ａｍｌ）の診断、予後及び治療のためのマイクロｒｎａに基づく方法及び組成物
WO2008104974A2 (en) 2007-02-27 2008-09-04 Rosetta Genomics Ltd. Composition and methods for modulating cell proliferation and cell death
JP5331714B2 (ja) 2007-03-16 2013-10-30 コヴァルクス・アーゲー タンパク質複合体をターゲティングする薬物候補の直接質量分析
CN101688240A (zh) 2007-04-10 2010-03-31 国立台湾大学 通过微rna预测癌症患者的治疗后存活预期
CN101827941B (zh) 2007-04-30 2014-07-16 俄亥俄州立大学研究基金会 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法
US20090005336A1 (en) 2007-05-08 2009-01-01 Zhiguo Wang Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions
US20090232893A1 (en) 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090131354A1 (en) 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
WO2008154098A2 (en) 2007-06-07 2008-12-18 Wisconsin Alumni Research Foundation Reagents and methods for mirna expression analysis and identification of cancer biomarkers
US8465917B2 (en) 2007-06-08 2013-06-18 The Ohio State University Research Foundation Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells
AU2008261951A1 (en) 2007-06-08 2008-12-18 Asuragen, Inc. miR-34 regulated genes and pathways as targets for therapeutic intervention
US8053186B2 (en) 2007-06-15 2011-11-08 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing
GB2459228B (en) 2007-07-25 2012-06-20 Univ Louisville Res Found Exosome-associated microrna as a diagnostic marker
EP2173911B1 (en) 2007-07-31 2014-06-18 The Ohio State University Research Foundation Methods for reverting methylation by targeting dnmt3a and dnmt3b
EP2653561B1 (en) 2007-08-03 2016-03-02 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
EP3028708A1 (en) 2007-08-22 2016-06-08 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
US20090061424A1 (en) 2007-08-30 2009-03-05 Sigma-Aldrich Company Universal ligation array for analyzing gene expression or genomic variations
EP3138926A3 (en) 2007-09-06 2017-04-05 The Ohio State University Research Foundation Microrna signatures in human ovarian cancer
US20090239818A1 (en) 2007-09-07 2009-09-24 Cheng Jin Q Effective treatment of ovarian cancer using triciribine and related compounds
BRPI0816852A2 (pt) 2007-09-14 2017-06-06 Univ Ohio State Res Found método de diagnosticar ou prognosticar doença ou desordem em sujeito, biomarcador, método para determinar e/ou prever se sujeito tem diferenciação da desordem, biomarcador para desordem pulmonar, método para diagnosticar se sujeito tem, ou está em risco de desenvolver doença ou desordem, método de inibir a proliferação de doença ou desordem e método para identificar agente terapêutico do câncer.
US7993831B2 (en) * 2007-09-14 2011-08-09 Asuragen, Inc. Methods of normalization in microRNA detection assays
US20100305188A1 (en) * 2007-10-03 2010-12-02 Kyowa Hakko Kirin Co., Ltd. Nucleic acid capable of regulating the proliferation of cell
DK2205737T3 (da) 2007-10-04 2013-05-21 Santaris Pharma As Mikromirer
EP2212440A4 (en) 2007-10-11 2011-04-06 Univ Ohio State Res Found METHOD AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF ADENOCARCINOMES OF DISHES
WO2009055773A2 (en) 2007-10-26 2009-04-30 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (fhit) interaction and uses thereof
CN101980712B (zh) 2007-10-29 2015-02-18 雷古拉斯治疗公司 用于肝癌治疗的靶向微小rna
US20090123933A1 (en) 2007-11-12 2009-05-14 Wake Forest University Health Sciences Microrna biomarkers in lupus
WO2009064590A2 (en) 2007-11-12 2009-05-22 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
EP2225396A4 (en) 2007-11-30 2011-03-02 Univ Ohio State Res Found PROFILING AND SCREENING OF MICRO-RNA EXPRESSION IN PERIPHERAL BLOOD IN LUNG CANCER
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
US20090192114A1 (en) 2007-12-21 2009-07-30 Dmitriy Ovcharenko miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
CN101215560B (zh) 2007-12-26 2010-09-29 暨南大学 一种具有抗白血病作用的miR-21反义寡核苷酸及其应用
AU2009212543B2 (en) 2008-02-01 2015-07-09 The General Hospital Corporation Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions
WO2009100430A2 (en) 2008-02-08 2009-08-13 Asuragen, Inc miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
JP5662166B2 (ja) 2008-02-28 2015-01-28 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 胃癌の診断、予後診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物
JP2011517932A (ja) 2008-02-28 2011-06-23 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション ヒト慢性リンパ球性白血病（ｃｃｌ）と関連するマイクロｒｎａシグネチャーおよびその使用
CN102007408A (zh) 2008-02-28 2011-04-06 俄亥俄州立大学研究基金会 与急性髓性白血病(aml)中的细胞遗传学和预后相关的微rna特征及其用途
US20110054009A1 (en) 2008-02-28 2011-03-03 The Ohio State University Research Foundation MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders
WO2009111375A2 (en) 2008-03-01 2009-09-11 Abraxis Bioscience, Llc Treatment, diagnostic, and method for discovering antagonist using sparc specific mirnas
US20090233297A1 (en) 2008-03-06 2009-09-17 Elizabeth Mambo Microrna markers for recurrence of colorectal cancer
US20090253780A1 (en) 2008-03-26 2009-10-08 Fumitaka Takeshita COMPOSITIONS AND METHODS RELATED TO miR-16 AND THERAPY OF PROSTATE CANCER
US20110166200A1 (en) 2008-04-24 2011-07-07 Zhan Zhang Methods of using mir210 as a biomarker for hypoxia and as a therapeutic agent for treating cancer
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
US20110107440A1 (en) 2008-06-04 2011-05-05 Andor Pivarcsi Skin cancer associated micrornas
WO2009149418A2 (en) 2008-06-06 2009-12-10 Asuragen, Inc. Novel compositions for the in vivo delivery of rnai agents
WO2009152300A1 (en) 2008-06-11 2009-12-17 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
US20100021734A1 (en) 2008-07-22 2010-01-28 Covalent Materials Corporation Ceramic particles and producing method thereof
KR101031305B1 (ko) 2008-07-23 2011-04-29 국립암센터 마이크로ｒｎａ-21 저해제를 포함하는 방사선 민감성증진용 조성물
US8492357B2 (en) 2008-08-01 2013-07-23 Santaris Pharma A/S Micro-RNA mediated modulation of colony stimulating factors
CA2734179A1 (en) 2008-08-12 2010-02-18 The Ohio State University Research Foundation Micro-rna-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma
US8728745B2 (en) 2008-09-04 2014-05-20 Ventana Medical Sysems, Inc. Method for prediction of the progression risk of tumors
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
AU2009316584A1 (en) 2008-11-21 2010-05-27 The Ohio State University Research Foundation Tcl1 as a transcriptional regulator
WO2010065156A1 (en) 2008-12-05 2010-06-10 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis and treatment of ovarian cancer
JP2012518997A (ja) 2009-02-26 2012-08-23 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 喫煙未経験者におけるマイクロｒｎａ、ならびに関連する材料および方法
CA2715518A1 (en) 2009-09-23 2011-03-23 Wilson Roa Microrna expression profiles associated with lung cancer
US20130012591A1 (en) 2009-10-28 2013-01-10 Revision Therapeutics, Inc. Prophylaxis of skin cancer with retinamides
US20120219958A1 (en) 2009-11-09 2012-08-30 Yale University MicroRNA Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors
EP2504452A4 (en) 2009-11-23 2014-06-11 Univ Ohio State Res Found MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS
EP2354246A1 (en) 2010-02-05 2011-08-10 febit holding GmbH miRNA in the diagnosis of ovarian cancer
US8709732B2 (en) 2010-02-11 2014-04-29 The Hong Kong Polytechnic University Biomarkers of gastric cancer and use thereof
EP2552547A4 (en) 2010-03-26 2014-08-27 Univ Ohio State Res Found MATERIALS AND METHODS RELATED TO THE MODULATION OF INCORPORATION AND GENERAL STABILITY BY ME-155
AU2011271218A1 (en) 2010-06-24 2013-01-10 The Ohio State University Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression
US20130150430A1 (en) 2010-08-04 2013-06-13 The Ohio State University Methods for Impairing the P53/HDM2 Auto-Regulatory Loop in Multiple Myeloma Development Using mIR-192, mIR-194 and mIR-215
WO2012065049A1 (en) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Materials and methods related to microrna-21, mismatch repair, and colorectal cancer
US20130017964A1 (en) 2011-01-11 2013-01-17 Croce Carlo M Methods to Identify Chronic Lymphocytic Leukemia Disease Progression
JP2014509852A (ja) 2011-03-07 2014-04-24 ジ・オハイオ・ステート・ユニバーシティ マイクロＲＮＡ−１５５（ｍｉＲ−１５５）により誘導される変異誘発活性は炎症および癌を結び付ける
CA2852066A1 (en) 2011-10-14 2013-04-18 The Ohio State University Methods and materials related to ovarian cancer
JP2015511121A (ja) 2012-01-20 2015-04-16 ジ・オハイオ・ステート・ユニバーシティ 浸潤性および予後に関する乳がんバイオマーカーシグネチャー
US20130236453A1 (en) 2012-03-12 2013-09-12 The Ohio State University Methods and Compositions for Modulating Acute Graft-versus-Host Disease using miR-155 Specific Inhibitors

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005519624A (ja) * 2002-03-13 2005-07-07 ジェノミック ヘルス， インコーポレイテッド 生検腫瘍組織での遺伝子発現プロファイリング
JP2008508895A (ja) * 2004-08-10 2008-03-27 ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド 乳癌の予後診断方法およびキット
JP2009505639A (ja) * 2005-08-01 2009-02-12 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 乳癌の診断、予後及び治療のためのマイクロｒｎａに基づいた方法及び組成物
JP2009507918A (ja) * 2005-09-12 2009-02-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法
WO2007081740A2 (en) * 2006-01-05 2007-07-19 The Ohio State University Research Foundation Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers
WO2008089577A1 (en) * 2007-01-26 2008-07-31 Vm Institute Of Resaerch Breast cancer gene array
JP2010518878A (ja) * 2007-02-26 2010-06-03 アンセルム （アンスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） 乳癌患者における転移発生の予測方法
US20100210738A1 (en) * 2009-02-09 2010-08-19 Vm Institute Of Research Prognostic biomarkers to predict overall survival and metastatic disease in patients with triple negative breast cancer
US20110195848A1 (en) * 2010-01-08 2011-08-11 Roopra Avtar S Gene expression and breast cancer
WO2011088137A2 (en) * 2010-01-12 2011-07-21 H. Lee Moffitt Cancer Center & Research Institute Bad pathway gene signature
WO2011107819A1 (en) * 2010-03-01 2011-09-09 Adelbio Methods for predicting outcome of breast cancer, and/or risk of relapse, response or survival of a patient suffering therefrom

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ROTHE, F. ET AL.: ""Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasi", PLOS ONE, vol. Vol. 6: e20980, JPN6016044549, 2011, pages 1 - 13, XP055200959, ISSN: 0003442933, DOI: 10.1371/journal.pone.0020980 *
YAN, L.-X. ET AL.: ""MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, l", RNA, vol. 14, JPN6016044548, 2008, pages 2348 - 2360, XP055038607, ISSN: 0003442932, DOI: 10.1261/rna.1034808 *

Also Published As

Publication number Publication date
US8859202B2 (en) 2014-10-14
US20160265066A1 (en) 2016-09-15
CN104685065A (zh) 2015-06-03
CN105936932A (zh) 2016-09-14
EP2804960A4 (en) 2015-08-19
AU2013209477B2 (en) 2016-12-08
WO2013110053A1 (en) 2013-07-25
US9434995B2 (en) 2016-09-06
CA2866052A1 (en) 2013-07-25
US20140378535A1 (en) 2014-12-25
CN104685065B (zh) 2017-02-22
AU2013209477A1 (en) 2014-09-11
US20130190386A1 (en) 2013-07-25
EP2804960A1 (en) 2014-11-26

Similar Documents

Publication Publication Date Title
US9434995B2 (en) Breast cancer biomarker signatures for invasiveness and prognosis
US12129522B2 (en) MicroRNA assay for detection and management of pancreatic cancer precursors
Chebouti et al. EMT-like circulating tumor cells in ovarian cancer patients are enriched by platinum-based chemotherapy
Wach et al. MicroRNA profiles of prostate carcinoma detected by multiplatform microRNA screening
Jamieson et al. MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma
Nadal et al. A MicroRNA cluster at 14q32 drives aggressive lung adenocarcinoma
Bansal et al. Feasibility of microRNAs as biomarkers for Barrett's esophagus progression: a pilot cross-sectional, phase 2 biomarker study
Permuth-Wey et al. A genome-wide investigation of microRNA expression identifies biologically-meaningful microRNAs that distinguish between high-risk and low-risk intraductal papillary mucinous neoplasms of the pancreas
JP2012510813A (ja) 卵巣癌の診断および治療のためのマイクロｒｎａに基づく方法および組成物
D'aiuto et al. miR-30e* is an independent subtype-specific prognostic marker in breast cancer
JP2011516033A (ja) 急性骨髄性性白血病（ａｍｌ）における細胞遺伝学および予後と関連するマイクロｒｎａシグネチャーおよびその使用
JP2013176370A (ja) 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物
US11993816B2 (en) Circulating microRNA as biomarkers for endometriosis
WO2014085906A1 (en) Microrna biomarkers for prostate cancer
Tao et al. Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection
US10059998B2 (en) Microrna signature as an indicator of the risk of early recurrence in patients with breast cancer
Oh et al. Clinical applications of circulating biomarkers in non-small cell lung cancer
Ding et al. A Potential Four‐Gene Signature and Nomogram for Predicting the Overall Survival of Papillary Thyroid Cancer
Doğan et al. Candidate biomarkers associated with circulating tumor cell status in metastatic colorectal cancer
US12592321B2 (en) Cancer detection and classification using methylome analysis
WO2014201542A1 (en) Prognostic micro-rna signature for sarcoma
Sehovic Analysis of Circulating Biomarkers for Minimally Invasive Early Detection of Breast Cancer
Webster Circulating microRNA expression in canine apocrine gland anal sac adenocarcinoma
Stigliani et al. miRNA expression profile of bone marrow resident cells from children with neuroblastoma is not significantly different from that of healthy children
HK40049419A (en) Circulating micrornas as biomarkers for endometriosis

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160115

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160115

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161118

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170613