JP2015510122A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015510122A5 JP2015510122A5 JP2014556086A JP2014556086A JP2015510122A5 JP 2015510122 A5 JP2015510122 A5 JP 2015510122A5 JP 2014556086 A JP2014556086 A JP 2014556086A JP 2014556086 A JP2014556086 A JP 2014556086A JP 2015510122 A5 JP2015510122 A5 JP 2015510122A5
- Authority
- JP
- Japan
- Prior art keywords
- trail
- crp
- subject
- infection
- saa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 PCT Proteins 0.000 claims 34
- 238000000034 method Methods 0.000 claims 22
- 108700012411 TNFSF10 Proteins 0.000 claims 19
- 102100024598 Tumor necrosis factor ligand superfamily member 10 Human genes 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 claims 16
- 102100031051 Cysteine and glycine-rich protein 1 Human genes 0.000 claims 11
- 101710190759 Serum amyloid A protein Proteins 0.000 claims 11
- 102100032277 Serum amyloid A-1 protein Human genes 0.000 claims 11
- 108091006374 cAMP receptor proteins Proteins 0.000 claims 11
- 208000015181 infectious disease Diseases 0.000 claims 10
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 claims 9
- 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 claims 9
- 102100026016 Interleukin-1 receptor type 1 Human genes 0.000 claims 9
- 102100027314 Beta-2-microglobulin Human genes 0.000 claims 7
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims 7
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 6
- 101000916059 Homo sapiens C-X-C chemokine receptor type 2 Proteins 0.000 claims 6
- 102100022464 5'-nucleotidase Human genes 0.000 claims 5
- 102100038008 60S ribosomal protein L22-like 1 Human genes 0.000 claims 5
- PCLCDPVEEFVAAQ-UHFFFAOYSA-N BCA 1 Chemical compound CC(CO)CCCC(C)C1=CCC(C)(O)C1CC2=C(O)C(O)CCC2=O PCLCDPVEEFVAAQ-UHFFFAOYSA-N 0.000 claims 5
- 102100025277 C-X-C motif chemokine 13 Human genes 0.000 claims 5
- 108010017009 CD11b Antigen Proteins 0.000 claims 5
- 108010066813 Chitinase-3-Like Protein 1 Proteins 0.000 claims 5
- 102000018704 Chitinase-3-Like Protein 1 Human genes 0.000 claims 5
- 102100041022 Coronin-1C Human genes 0.000 claims 5
- 102100023688 Eotaxin Human genes 0.000 claims 5
- 101710139422 Eotaxin Proteins 0.000 claims 5
- 102100030341 Ethanolaminephosphotransferase 1 Human genes 0.000 claims 5
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 5
- 108010075704 HLA-A Antigens Proteins 0.000 claims 5
- 101710121996 Hexon protein p72 Proteins 0.000 claims 5
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 5
- 101000661567 Homo sapiens 60S ribosomal protein L22-like 1 Proteins 0.000 claims 5
- 101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 claims 5
- 101000748856 Homo sapiens Coronin-1C Proteins 0.000 claims 5
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims 5
- 101000926535 Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 claims 5
- 101000663639 Homo sapiens Kunitz-type protease inhibitor 2 Proteins 0.000 claims 5
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 5
- 101000589301 Homo sapiens Natural cytotoxicity triggering receptor 1 Proteins 0.000 claims 5
- 101000589307 Homo sapiens Natural cytotoxicity triggering receptor 3 Proteins 0.000 claims 5
- 101000857759 Homo sapiens Probable G-protein coupled receptor 162 Proteins 0.000 claims 5
- 101000584600 Homo sapiens Ras-related protein Rap-1b Proteins 0.000 claims 5
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 5
- 101000727462 Homo sapiens Reticulon-3 Proteins 0.000 claims 5
- 101100172525 Homo sapiens SELENOI gene Proteins 0.000 claims 5
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims 5
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 5
- 101000942626 Homo sapiens UMP-CMP kinase 2, mitochondrial Proteins 0.000 claims 5
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 claims 5
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 5
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 5
- 102100022338 Integrin alpha-M Human genes 0.000 claims 5
- 102100034170 Interferon-induced, double-stranded RNA-activated protein kinase Human genes 0.000 claims 5
- 102100039020 Kunitz-type protease inhibitor 2 Human genes 0.000 claims 5
- 102100033467 L-selectin Human genes 0.000 claims 5
- 101710125418 Major capsid protein Proteins 0.000 claims 5
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 5
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims 5
- 102100035488 Nectin-2 Human genes 0.000 claims 5
- 102000048238 Neuregulin-1 Human genes 0.000 claims 5
- 108090000556 Neuregulin-1 Proteins 0.000 claims 5
- 102100025358 Probable G-protein coupled receptor 162 Human genes 0.000 claims 5
- 102100030705 Ras-related protein Rap-1b Human genes 0.000 claims 5
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 5
- 102100029832 Reticulon-3 Human genes 0.000 claims 5
- 102100029216 SLAM family member 5 Human genes 0.000 claims 5
- 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 claims 5
- 102100029681 Triggering receptor expressed on myeloid cells 1 Human genes 0.000 claims 5
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 5
- 102100032947 UMP-CMP kinase 2, mitochondrial Human genes 0.000 claims 5
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 claims 5
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 5
- 208000036142 Viral infection Diseases 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 5
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 5
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 5
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 5
- 238000011269 treatment regimen Methods 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 208000035143 Bacterial infection Diseases 0.000 claims 4
- 101710098272 C-X-C motif chemokine 11 Proteins 0.000 claims 4
- 102100025279 C-X-C motif chemokine 11 Human genes 0.000 claims 4
- 102000026633 IL6 Human genes 0.000 claims 4
- 102000003815 Interleukin-11 Human genes 0.000 claims 4
- 108090000177 Interleukin-11 Proteins 0.000 claims 4
- 108090001005 Interleukin-6 Proteins 0.000 claims 4
- 108090001007 Interleukin-8 Proteins 0.000 claims 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims 4
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 3
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims 3
- 102100024573 Macrophage-capping protein Human genes 0.000 claims 3
- 102100040952 Tetraspanin-7 Human genes 0.000 claims 3
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 3
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 208000003322 Coinfection Diseases 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 210000000440 neutrophil Anatomy 0.000 claims 2
- 102100027621 2'-5'-oligoadenylate synthase 2 Human genes 0.000 claims 1
- YMZPQKXPKZZSFV-CPWYAANMSA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-2-[(1r)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H]([C@H]2C=CCCC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 YMZPQKXPKZZSFV-CPWYAANMSA-N 0.000 claims 1
- GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 claims 1
- 102100033497 Adiponectin receptor protein 1 Human genes 0.000 claims 1
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 1
- 102100029602 Eukaryotic translation initiation factor 4B Human genes 0.000 claims 1
- 101001008910 Homo sapiens 2'-5'-oligoadenylate synthase 2 Proteins 0.000 claims 1
- 101001135206 Homo sapiens Adiponectin receptor protein 1 Proteins 0.000 claims 1
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 1
- 101000840282 Homo sapiens Eukaryotic translation initiation factor 4B Proteins 0.000 claims 1
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 1
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 claims 1
- 101001082060 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 3 Proteins 0.000 claims 1
- 101001034844 Homo sapiens Interferon-induced transmembrane protein 1 Proteins 0.000 claims 1
- 101001034846 Homo sapiens Interferon-induced transmembrane protein 3 Proteins 0.000 claims 1
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 claims 1
- 101000957316 Homo sapiens Lysophospholipid acyltransferase 2 Proteins 0.000 claims 1
- 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 1
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 claims 1
- 102100027302 Interferon-induced protein with tetratricopeptide repeats 3 Human genes 0.000 claims 1
- 102100040021 Interferon-induced transmembrane protein 1 Human genes 0.000 claims 1
- 102100040035 Interferon-induced transmembrane protein 3 Human genes 0.000 claims 1
- 102100020881 Interleukin-1 alpha Human genes 0.000 claims 1
- 102000000704 Interleukin-7 Human genes 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 102100038805 Lysophospholipid acyltransferase 2 Human genes 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229940109239 creatinine Drugs 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000009871 nonspecific binding Effects 0.000 claims 1
- 238000010606 normalization Methods 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261596950P | 2012-02-09 | 2012-02-09 | |
| US61/596,950 | 2012-02-09 | ||
| US201261652631P | 2012-05-29 | 2012-05-29 | |
| US61/652,631 | 2012-05-29 | ||
| PCT/EP2013/052619 WO2013117746A1 (en) | 2012-02-09 | 2013-02-08 | Signatures and determinants for diagnosing infections and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017126712A Division JP6725456B2 (ja) | 2012-02-09 | 2017-06-28 | 対象における細菌感染または細菌／ウイルス混合感染を除外するためのキット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510122A JP2015510122A (ja) | 2015-04-02 |
| JP2015510122A5 true JP2015510122A5 (enExample) | 2016-03-31 |
| JP6169619B2 JP6169619B2 (ja) | 2017-07-26 |
Family
ID=47678877
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014556086A Active JP6169619B2 (ja) | 2012-02-09 | 2013-02-08 | 細菌感染または細菌とウイルスの同時感染を検出するためのキット |
| JP2017126712A Active JP6725456B2 (ja) | 2012-02-09 | 2017-06-28 | 対象における細菌感染または細菌／ウイルス混合感染を除外するためのキット |
| JP2020109710A Pending JP2020180975A (ja) | 2012-02-09 | 2020-06-25 | 複数の抗体を含むキット |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017126712A Active JP6725456B2 (ja) | 2012-02-09 | 2017-06-28 | 対象における細菌感染または細菌／ウイルス混合感染を除外するためのキット |
| JP2020109710A Pending JP2020180975A (ja) | 2012-02-09 | 2020-06-25 | 複数の抗体を含むキット |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US9726668B2 (enExample) |
| EP (3) | EP3367099B1 (enExample) |
| JP (3) | JP6169619B2 (enExample) |
| CN (2) | CN108802385B (enExample) |
| AU (2) | AU2013217935B2 (enExample) |
| BR (1) | BR112014019733B1 (enExample) |
| CA (2) | CA2863819C (enExample) |
| ES (2) | ES2886979T3 (enExample) |
| IL (3) | IL233998A (enExample) |
| IN (1) | IN2014MN01780A (enExample) |
| WO (1) | WO2013117746A1 (enExample) |
| ZA (1) | ZA201405993B (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3059337T3 (da) | 2009-01-15 | 2019-07-22 | Adaptive Biotechnologies Corp | Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier |
| US9709565B2 (en) | 2010-04-21 | 2017-07-18 | Memed Diagnostics Ltd. | Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof |
| CA2863819C (en) | 2012-02-09 | 2021-11-23 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| DK2823060T3 (en) | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
| EP3091089B1 (en) | 2012-05-08 | 2019-01-23 | Adaptive Biotechnologies Corporation | Method for measuring and calibrating amplification bias in multiplexed pcr reactions |
| US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| CA2942405A1 (en) | 2014-03-13 | 2015-09-17 | Opgen, Inc. | Methods of detecting multi-drug resistant organisms |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| CA2950327A1 (en) | 2014-05-27 | 2015-12-03 | Opgen, Inc. | Systems, apparatus, and methods for generating and analyzing resistome profiles |
| WO2015192050A1 (en) * | 2014-06-13 | 2015-12-17 | North Carolina State University | Aptamers with binding affinity to norovirus |
| US10303846B2 (en) | 2014-08-14 | 2019-05-28 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
| US20170234873A1 (en) | 2014-10-14 | 2017-08-17 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| WO2016079219A1 (en) * | 2014-11-19 | 2016-05-26 | Koninklijke Philips N.V. | Diagnostic method employing hnl |
| US20170269081A1 (en) * | 2014-12-11 | 2017-09-21 | Memed Diagnostics Ltd. | Marker combinations for diagnosing infections and methods of use thereof |
| US11047008B2 (en) | 2015-02-24 | 2021-06-29 | Adaptive Biotechnologies Corporation | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
| WO2016161273A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| EP3139171B1 (en) * | 2015-09-02 | 2020-02-12 | Labsystems Diagnostics Oy | Novel methods and kits for detecting of urea cycle disorders using mass spectrometry |
| AU2016331663B2 (en) * | 2015-09-30 | 2022-04-07 | Immunexpress Pty Ltd | Pathogen biomarkers and uses therefor |
| CN106918698B (zh) * | 2015-12-25 | 2019-11-22 | 广州瑞博奥生物科技有限公司 | 一种检测人受体酪氨酸激酶的磷酸化抗体芯片试剂盒 |
| WO2017149548A1 (en) * | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Rna determinants for distinguishing between bacterial and viral infections |
| CN108699609A (zh) | 2016-03-03 | 2018-10-23 | 米密德诊断学有限公司 | 分析rna用于诊断感染类型 |
| CN106053831A (zh) * | 2016-06-05 | 2016-10-26 | 潘时辉 | 一种用于自身免疫病检测的试剂盒 |
| KR102515555B1 (ko) * | 2016-06-07 | 2023-03-28 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 세균성 감염 및 바이러스성 감염의 진단 방법 |
| CN109642900A (zh) * | 2016-06-23 | 2019-04-16 | 米密德诊断学有限公司 | 通过侧流免疫测定测量trail |
| CA3027341A1 (en) * | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| US11340223B2 (en) | 2016-07-10 | 2022-05-24 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| WO2018029690A1 (en) | 2016-08-10 | 2018-02-15 | Memed Diagnostics Ltd. | System and method for analysis of biological data |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| EP3519833B1 (en) | 2016-09-29 | 2024-08-14 | MeMed Diagnostics Ltd. | Methods of prognosis and treatment |
| US11353456B2 (en) | 2016-09-29 | 2022-06-07 | Memed Diagnostics Ltd. | Methods of risk assessment and disease classification for appendicitis |
| JP6903494B2 (ja) * | 2017-06-09 | 2021-07-14 | シスメックス株式会社 | 感染症を識別するための粒子分析方法 |
| US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| EP3662285A4 (en) * | 2017-07-31 | 2021-04-28 | University Health Network | Biomarkers in ex vivo lung perfusion (evlp) perfusate |
| EP3707161A4 (en) * | 2017-11-07 | 2021-10-27 | Memed Diagnostics Ltd. | ANTI-TRAIL ANTIBODIES AND METHOD OF USING THEM |
| JP7267606B2 (ja) * | 2017-11-28 | 2023-05-02 | 国立大学法人三重大学 | 検出方法 |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CN108039206B (zh) * | 2017-12-21 | 2021-11-09 | 北京大学深圳研究生院 | 一种传染病的诊治方法及系统 |
| CN111801575B (zh) * | 2018-01-27 | 2024-01-12 | 贝克顿·迪金森公司 | 区分细菌感染和病毒感染的多重横向流测定物 |
| US11484273B2 (en) * | 2018-03-06 | 2022-11-01 | International Business Machines Corporation | Determining functional age indices based upon sensor data |
| WO2019236768A1 (en) * | 2018-06-05 | 2019-12-12 | Washington University | Nasal genes used to identify, characterize, and diagnose viral respiratory infections |
| CN108486246B (zh) * | 2018-06-06 | 2020-06-09 | 青岛泱深生物医药有限公司 | 子痫前期的诊治标志物 |
| EP3830685A4 (en) * | 2018-08-02 | 2022-04-27 | Bright Clinical Research Limited | SYSTEMS, METHODS, AND PROCESSES FOR DYNAMIC DATA MONITORING AND REAL-TIME OPTIMIZATION OF ONGOING CLINICAL RESEARCH TRIALS |
| CN120795059A (zh) | 2018-08-27 | 2025-10-17 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020092443A1 (en) * | 2018-10-29 | 2020-05-07 | Thomas Jefferson University | Compositions and methods for discriminating infectious from non-infectious cns disorders |
| CN112578125B (zh) * | 2019-09-27 | 2022-10-25 | 成都中医药大学 | 检测粪钙卫蛋白含量的试剂在制备卵巢病变筛查试剂盒中的用途 |
| CN110923333B (zh) * | 2019-12-11 | 2020-09-29 | 湖北省农业科学院畜牧兽医研究所 | 山羊zbp1基因第一内含子内与产羔数关联的单倍型标记及其应用 |
| WO2021117044A1 (en) | 2019-12-11 | 2021-06-17 | Ichilov Tech Ltd. | Non-invasive assay for differentiating between bacterial and viral infections |
| US20230094142A1 (en) | 2020-01-29 | 2023-03-30 | Memed Diagnostics Ltd. | Methods of diagnosing and classifying viral infections |
| EP4097244A2 (en) | 2020-02-09 | 2022-12-07 | NLC Pharma Ltd | Rapid detection test for sars-cov-2 |
| CN115136009A (zh) | 2020-04-09 | 2022-09-30 | B.R.A.H.M.S有限公司 | 用于呼吸道感染诊断的生物标志物 |
| CN113533170A (zh) * | 2020-04-21 | 2021-10-22 | 贝克曼考尔特公司 | 病毒感染的血液学参数 |
| JPWO2022004730A1 (enExample) * | 2020-06-30 | 2022-01-06 | ||
| CN111816245B (zh) * | 2020-07-20 | 2022-09-09 | 成都博欣医学检验实验室有限公司 | 结合mNGS和临床知识库的病原微生物检测方法及系统 |
| WO2022153323A1 (en) * | 2021-01-18 | 2022-07-21 | Memed Diagnostics Ltd. | Markers for diagnosing infections |
| EP4308729B1 (en) * | 2021-03-16 | 2025-10-29 | Cepheid | Methods for discriminating bacterial and viral infections in a human subject |
| CN117280218A (zh) * | 2021-04-30 | 2023-12-22 | 豪夫迈·罗氏有限公司 | 用于脓毒症的早期检测的strem1标志物组 |
| CA3227382A1 (en) * | 2021-08-17 | 2023-02-23 | Ephraim L. TSALIK | Methods for characterizing infections and methods for developing tests for the same |
| CN113945712A (zh) * | 2021-12-21 | 2022-01-18 | 山东中鸿特检生物科技有限公司 | 一种区别细菌、病毒感染的检测方法及检测试剂盒 |
| CN114441506B (zh) * | 2022-04-08 | 2022-06-21 | 港湾之星健康生物(深圳)有限公司 | 量子磁光传感器 |
| EP4357778A1 (en) | 2022-10-20 | 2024-04-24 | Heraeus Medical GmbH | Treatment of microbial infections diagnosed using the biomarker d-lactate |
| CN119913247B (zh) * | 2025-01-21 | 2025-12-19 | 浙江大学医学院附属邵逸夫医院 | 单核细胞和淋巴细胞cd45分子表达相对变化在诊断感染和炎症中的应用 |
| CN121595402B (zh) * | 2026-01-28 | 2026-04-17 | 信纳克(北京)生化标志物检测医学研究有限责任公司 | 用于鉴别异基因造血干细胞移植后腹泻致病成因的试剂盒与鉴别系统 |
Family Cites Families (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1178414A (en) | 1978-02-08 | 1984-11-27 | Toyo Boseki Kabushiki Kaisha (Trading Under The Name Of Toyobo Co., Ltd.) | Packaging material having excellent seal packaging property |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
| US4727022A (en) | 1984-03-14 | 1988-02-23 | Syntex (U.S.A.) Inc. | Methods for modulating ligand-receptor interactions and their application |
| US5018067A (en) | 1987-01-12 | 1991-05-21 | Iameter Incorporated | Apparatus and method for improved estimation of health resource consumption through use of diagnostic and/or procedure grouping and severity of illness indicators |
| DE4322330A1 (de) | 1992-08-31 | 1994-03-03 | Behringwerke Ag | Verwendung des IL-4-Rezeptors zur Therapie, Prophylaxe und Diagnose von allergischen, viralen, parasitären und bakteriellen Erkrankungen sowie von Pilzinfektionen |
| DE4227454C1 (de) | 1992-08-19 | 1994-02-03 | Henning Berlin Gmbh | Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens |
| SE9401351D0 (sv) | 1994-04-21 | 1994-04-21 | Venge | A method for diagnosis |
| US5910421A (en) | 1995-12-21 | 1999-06-08 | University Of Florida | Rapid diagnostic method for distinguishing allergies and infections |
| US6077665A (en) | 1996-05-07 | 2000-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Rapid assay for infection in neonates |
| WO1999033965A1 (en) | 1997-12-24 | 1999-07-08 | Diatech Pty. Ltd. | Bifunctional molecules |
| EP1080233A4 (en) | 1998-05-18 | 2003-02-05 | Apoptosis Technology Inc | COMPOUNDS, SCREENING METHODS, AND USES USING ANTI-APOPTIC GENES AND GENE PRODUCTS |
| DE19847690A1 (de) | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
| US6709855B1 (en) | 1998-12-18 | 2004-03-23 | Scios, Inc. | Methods for detection and use of differentially expressed genes in disease states |
| WO2000040749A2 (en) | 1999-01-06 | 2000-07-13 | Genenews Inc. | Method for the detection of gene transcripts in blood and uses thereof |
| CA2384978C (en) | 1999-08-24 | 2012-10-23 | Glycozym Aps | Udp-n-acetylglucosamine: galactose-.beta.1,3-n-acetylgalactosamine-.alpha.-r/(glcnac to galnac) .beta.1,6-n-acetylglucosaminyltransferase, c2gnt3 |
| IL132687A0 (en) | 1999-11-01 | 2001-03-19 | Keren Mechkarim Ichilov Pnimit | System and method for evaluating body fluid samples |
| US20020038227A1 (en) | 2000-02-25 | 2002-03-28 | Fey Christopher T. | Method for centralized health data management |
| US7668661B2 (en) | 2000-04-28 | 2010-02-23 | Siemens Healthcare Diagnostics Inc. | Liver disease-related methods and systems |
| US20020059030A1 (en) | 2000-07-17 | 2002-05-16 | Otworth Michael J. | Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities |
| US20020055176A1 (en) | 2000-11-08 | 2002-05-09 | Ray Robert A. | Diagnostic assay system |
| RU2229719C2 (ru) | 2001-03-27 | 2004-05-27 | Кабусики Кайся Тосиба | Обнаружение имеющей отношение к заболеванию нуклеиновой кислоты |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| DE10119804A1 (de) | 2001-04-23 | 2002-10-24 | Brahms Ag | Entzündungsspezifische Peptide und deren Verwendungen |
| AU2002256895B2 (en) | 2001-05-18 | 2008-09-18 | Kirin Beer Kabushiki Kaisha | Anti-TRAIL-R antibodies |
| FI115165B (fi) | 2001-06-04 | 2005-03-15 | Aboatech Ab Oy | Menetelmä infektion laadun määrittämiseksi |
| DE10130985B4 (de) | 2001-06-27 | 2004-03-18 | B.R.A.H.M.S Ag | Verfahren zur Diagnose von Sepsis und schweren Infektionen unter Bestimmung löslicher Cytokeratin-1-Fragmente |
| US20040209307A1 (en) * | 2001-08-20 | 2004-10-21 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| EP1318407B1 (de) | 2001-12-07 | 2004-09-29 | B.R.A.H.M.S Aktiengesellschaft | Verwendungen der Aldose-1-Epimerase (Mutarotase) für die Diagnose von Entzündungserkrankungen und Sepsis |
| DE60207183T2 (de) | 2001-12-10 | 2006-08-10 | Kabushiki Gaisha K-And-S | Vorrichtung zur Beobachtung biologischer Daten |
| US20040038201A1 (en) | 2002-01-22 | 2004-02-26 | Whitehead Institute For Biomedical Research | Diagnostic and therapeutic applications for biomarkers of infection |
| US20040122296A1 (en) | 2002-12-18 | 2004-06-24 | John Hatlestad | Advanced patient management for triaging health-related data |
| US7468032B2 (en) | 2002-12-18 | 2008-12-23 | Cardiac Pacemakers, Inc. | Advanced patient management for identifying, displaying and assisting with correlating health-related data |
| US7351547B2 (en) | 2002-10-31 | 2008-04-01 | Health Research, Inc. | Diagnostic test for West Nile virus |
| WO2003081240A1 (fr) | 2002-03-22 | 2003-10-02 | Kyowa Medex Co., Ltd. | Procede de recherche d'infection virale |
| US7485298B2 (en) * | 2002-05-23 | 2009-02-03 | Michael Powell | Diagnosis and treatment of human dormancy-related sequellae |
| US7629116B2 (en) | 2002-06-11 | 2009-12-08 | Idaho Research Foundation | Type I interferon-inducible proteins to detect viral infection |
| US8563476B2 (en) | 2002-11-15 | 2013-10-22 | Morehouse School Of Medicine | Anti-CXCL9, anti-CXCL10, anti-CXCL11, anti-CXCL13, anti-CXCR3 and anti-CXCR5 agents for inflammatory disorders |
| WO2004108899A2 (en) | 2003-06-04 | 2004-12-16 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Pni microarray and uses |
| JP2007518062A (ja) | 2003-09-29 | 2007-07-05 | バイオサイト インコーポレイテッド | 敗血症を診断する方法および診断するための組成物 |
| JP2005106694A (ja) | 2003-09-30 | 2005-04-21 | Mochida Pharmaceut Co Ltd | 敗血症早期検出及び重篤度評価 |
| GB0401730D0 (en) | 2004-01-27 | 2004-03-03 | Bioxell Spa | Diagnosis method |
| US8906630B2 (en) | 2004-02-27 | 2014-12-09 | The Trustees Of The University Of Pennsylvania | Assays for detecting pathogenic respiratory bacteria |
| US7892539B2 (en) * | 2004-03-24 | 2011-02-22 | The Regents Of The University Of California | Modulation of an innate immune response by altering TRIAL-R signaling |
| US8155993B2 (en) | 2004-06-15 | 2012-04-10 | Janssen Pharmaceutica, N.V. | Apparatus and methods for assessing a pharmaceutical product |
| EP1787128A2 (en) | 2004-07-09 | 2007-05-23 | Amaox, Inc. | Immune cell biosensors and methods of using same |
| WO2006023312A2 (en) | 2004-08-20 | 2006-03-02 | Carl Deirmengian | Diagnostic assay for source of inflammation |
| US7572640B2 (en) | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
| WO2006036182A2 (en) | 2004-09-28 | 2006-04-06 | Singulex, Inc. | System and method for spectroscopic analysis of single particles |
| AU2005334466B2 (en) | 2004-11-05 | 2011-05-26 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Diagnosis and prognosis of infectious disease clinical phenotypes and other physiologic states using host gene expression biomarkers in blood |
| US20060099628A1 (en) | 2004-11-10 | 2006-05-11 | Wei-Mei Ching | Diagnostic assay for rickettsia prowazekii disease by detection of responsive gene expression |
| KR20080006617A (ko) | 2005-04-15 | 2008-01-16 | 백톤 디킨슨 앤드 컴퍼니 | 패혈증의 진단 |
| CN101208602A (zh) | 2005-04-15 | 2008-06-25 | 贝克顿迪金森公司 | 脓毒症的诊断 |
| US20070015172A1 (en) | 2005-06-01 | 2007-01-18 | Z-Biomed, Inc. | Expression profiles for microbial infection |
| UA78641C2 (en) | 2005-08-29 | 2007-04-10 | Open Joint Stock Company Conce | A process for the preparation of carbamide-formaldehyde resin |
| DE102005050933A1 (de) | 2005-10-21 | 2007-04-26 | Justus-Liebig-Universität Giessen | Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen |
| CN101378764A (zh) | 2005-12-09 | 2009-03-04 | 贝勒研究院 | 通过血液白细胞微阵列分析对系统性红斑狼疮的诊断、预后和疾病发展的监测 |
| GB0601959D0 (en) | 2006-01-31 | 2006-03-15 | King S College London | Sepsis test |
| US20070184460A1 (en) | 2006-02-09 | 2007-08-09 | Wei-Mei Ching | Diagnostic assay for Orientia tsutsugamushi by detection of responsive gene expression |
| NZ573052A (en) | 2006-04-26 | 2012-03-30 | Vertex Pharma | Hepatitis c virus infection biomarkers |
| AU2007286915B2 (en) | 2006-08-11 | 2014-05-15 | Baylor Research Institute | Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections |
| ATE504000T1 (de) | 2006-09-05 | 2011-04-15 | Hvidovre Hospital | Auf ip-10 basierende immunologische überwachung |
| AU2012244350B2 (en) | 2006-09-05 | 2013-08-15 | Statens Serum Institut | Ip-10 based immunological monitoring |
| US20100068147A1 (en) | 2006-10-05 | 2010-03-18 | Agency for Science , Technology and Research | Dengue diagnosis and treatment |
| JP2010512315A (ja) | 2006-12-06 | 2010-04-22 | メディミューン，エルエルシー | インターフェロンα誘導性薬力学的マーカー |
| DE102006060112A1 (de) | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| CN101617056A (zh) | 2006-12-21 | 2009-12-30 | 伊诺基因卡尔生物技术私人有限公司 | Eb病毒相关癌症的早期诊断方法及各自的试剂和试剂盒 |
| CN101622364A (zh) * | 2007-01-11 | 2010-01-06 | 杜克大学 | 监测hiv感染的方法 |
| WO2008095136A2 (en) | 2007-01-31 | 2008-08-07 | Henkin Robert I | Methods for detection of biological substances |
| JP2010519898A (ja) | 2007-02-28 | 2010-06-10 | ザ プロクター アンド ギャンブル カンパニー | ライノウイルス感染を制御するための化合物の同定方法及び標的 |
| DE102007009751A1 (de) * | 2007-02-28 | 2008-09-04 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens |
| JP5718049B2 (ja) | 2007-06-01 | 2015-05-13 | カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチＣｏｕｎｃｉｌ Ｏｆ Ｓｃｉｅｎｔｉｆｉｃ ＆ Ｉｎｄｕｓｔｒｉａｌ Ｒｅｓｅａｒｃｈ | 眼および中枢神経系の細菌、真菌、寄生虫およびウイルス感染の同時検出と識別のための新規な方法 |
| RU2352948C1 (ru) | 2007-06-15 | 2009-04-20 | Государственное образовательное учреждение высшего профессионального образования "КРАСНОЯРСКАЯ ГОСУДАРСТВЕННАЯ МЕДИЦИНСКАЯ АКАДЕМИЯ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" | Способ прогноза исхода заболевания пациентов с ургентной хирургической патологией органов брюшной полости |
| IL184478A (en) | 2007-07-08 | 2017-07-31 | Hadasit Medical Res Services & Development Ltd | Preparations, methods and kits for identifying carriers of mutations in genes 1brca and 2brca and for the early detection of cancers associated with mutations in these genes |
| DE102007035640A1 (de) | 2007-07-27 | 2009-01-29 | Lkh-Kunststoffwerk Gmbh & Co. Kg | Tauchkolben |
| EP2174143B1 (en) * | 2007-08-03 | 2011-06-22 | B.R.A.H.M.S GmbH | Use of procalcitonin (pct) in risk stratification and prognosis of patients with a primary, non-infectious disease |
| EP2020603A1 (en) | 2007-08-03 | 2009-02-04 | BRAHMS Aktiengesellschaft | Method for risk stratification in stable coronary artery disease |
| TW200920358A (en) | 2007-08-13 | 2009-05-16 | Lundbeck & Co As H | Method of treating stress-mediated depression |
| WO2009025743A2 (en) * | 2007-08-17 | 2009-02-26 | University Of Massachusetts Medical School | Use of trail compositions as antiviral agents |
| ATE463700T1 (de) | 2007-09-24 | 2010-04-15 | Bmdsys Production Gmbh | Kryostat mit stabilisiertem aussengefäss |
| EP2071334A1 (en) | 2007-12-14 | 2009-06-17 | Transmedi SA | Compositions and methods of detecting TIABS |
| WO2009100907A1 (en) | 2008-02-14 | 2009-08-20 | Dianeering Diagnostics Engineering And Research Gmbh | Means and methods for assessing the risk of patients presenting to emergency departments based on very low concentrations of troponin i or t or using a combination of markers |
| US8293880B2 (en) | 2008-03-25 | 2012-10-23 | University Of Southern California | Prognostic panel for urinary bladder cancer |
| AU2009240021B2 (en) | 2008-04-21 | 2013-01-10 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Antiviral therapy |
| US9910036B2 (en) | 2008-05-20 | 2018-03-06 | Rapid Pathogen Screening, Inc. | Method and device for combined detection of viral and bacterial infections |
| US8697370B2 (en) | 2008-05-23 | 2014-04-15 | Pronota N.V. | Biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof |
| PE20110386A1 (es) | 2008-06-25 | 2011-07-03 | Baylor Res Inst | Patron de transcripcion sanguinea de la infeccion por mycobacterium tuberculosis |
| WO2010046136A1 (en) | 2008-10-24 | 2010-04-29 | B.R.A.H.M.S. Ag | Prognosis and risk assessment in stroke patients by determining the level of marker peptides |
| TW201021778A (en) | 2008-11-12 | 2010-06-16 | Alcon Res Ltd | Intraocular lens delivery device with a multi-part plunger tip |
| US20160041153A1 (en) | 2008-11-12 | 2016-02-11 | Kirk Brown | Biomarker compositions and markers |
| CA2743211A1 (en) | 2008-11-12 | 2010-05-20 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Methods and systems of using exosomes for determining phenotypes |
| UA92843C2 (ru) | 2009-05-21 | 2010-12-10 | Институт Технической Теплофизики Национальной Академии Наук Украины | Способ получения порошкообразного пищевого красителя из столовой свеклы |
| WO2011008349A2 (en) | 2009-05-26 | 2011-01-20 | Duke University | Methods of identifying infectious disease and assays for identifying infectious disease |
| WO2010139475A1 (en) | 2009-06-05 | 2010-12-09 | B.R.A.H.M.S Gmbh | Detection of bacterial infections in subjects suffering from dyspnea |
| WO2011017683A1 (en) | 2009-08-07 | 2011-02-10 | Rules-Based Medicine, Inc. | Methods and devices for detecting kidney damage |
| JP5667353B2 (ja) | 2009-09-25 | 2015-02-12 | シスメックス株式会社 | 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム |
| ES2601104T3 (es) | 2009-10-13 | 2017-02-14 | B.R.A.H.M.S Gmbh | Procalcitonina para el diagnóstico de infecciones bacterianas y la guía del tratamiento antibiótico en pacientes con apoplejía aguda o accidente isquémico transitorio |
| EP2488659B1 (en) | 2009-10-15 | 2019-12-11 | Crescendo Bioscience, Inc. | Biomarkers and methods for measuring and monitoring inflammatory disease activity |
| US20110144914A1 (en) | 2009-12-09 | 2011-06-16 | Doug Harrington | Biomarker assay for diagnosis and classification of cardiovascular disease |
| US20110312534A1 (en) | 2010-03-05 | 2011-12-22 | Erasmus University Medical Center Rotterdam | Method for prediction of human iris color |
| EP2365456B1 (en) | 2010-03-11 | 2016-07-20 | CompuGroup Medical SE | Data structure, method and system for predicting medical conditions |
| US9709565B2 (en) | 2010-04-21 | 2017-07-18 | Memed Diagnostics Ltd. | Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof |
| EP2579037B1 (en) | 2010-05-31 | 2015-08-12 | The University of Tokushima | Method for testing the severity of an illness |
| GB2482187A (en) | 2010-07-23 | 2012-01-25 | Univ Exeter | Predicting response to surgery |
| US8877212B2 (en) | 2011-02-07 | 2014-11-04 | Trudeau Institute | Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis |
| RU2476887C2 (ru) | 2011-03-29 | 2013-02-27 | Учреждение Российской академии медицинских наук Дальневосточный научный центр физиологии и патологии дыхания Сибирского отделения РАМН | Способ прогнозирования развития осложнений у больных внебольничной пневмонией |
| KR20140033152A (ko) | 2011-06-20 | 2014-03-17 | 교와 핫꼬 기린 가부시키가이샤 | 항erbB3 항체 |
| HK1200496A1 (en) | 2011-09-12 | 2015-08-07 | Vanderbilt University | Characterizing multiple sclerosis |
| JP5842107B2 (ja) | 2011-10-19 | 2016-01-13 | パナソニックＩｐマネジメント株式会社 | 循環動態測定装置 |
| EP2592421B1 (en) | 2011-11-14 | 2017-08-30 | Universitätsklinikum Jena | Diagnosis of sepsis and systemic inflammatory response syndrome |
| US10152702B2 (en) | 2012-02-07 | 2018-12-11 | Michael Ingber | Apparatus and methods for analyzing a medical condition |
| CA2863819C (en) | 2012-02-09 | 2021-11-23 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| US9669111B2 (en) | 2012-03-08 | 2017-06-06 | Thommen Medical Ag | Device for the diagnosis of inflammatory tissues in dental applications |
| EP2637023A1 (en) | 2012-03-08 | 2013-09-11 | B.R.A.H.M.S GmbH | Prediction of outcome in patients with chronic obstructive pulmonary disease |
| CN104245954A (zh) | 2012-03-30 | 2014-12-24 | 文森医学公司 | 细菌成像剂及其使用方法 |
| GB201211982D0 (en) | 2012-07-05 | 2012-08-22 | Isis Innovation | Biomarker |
| AU2013289854B2 (en) | 2012-07-10 | 2016-03-24 | Nepean Blue Mountains Local Health District | Risk stratification in influenza |
| FR2996003B1 (fr) | 2012-09-25 | 2014-10-17 | Commissariat Energie Atomique | Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active |
| US20140127827A1 (en) | 2012-11-05 | 2014-05-08 | Gwangju Institute Of Science And Technology | Method for detection of antigen using fluorescence resonance energy transfer immunoassay |
| CA2893158A1 (en) | 2012-11-30 | 2014-06-05 | Applied Proteomics, Inc. | Method for evaluation of presence of or risk of colon tumors |
| BR112015017473A2 (pt) | 2013-01-22 | 2017-07-11 | Imicroq S L | método para detectar um agente patogênico em uma amostra, e, kit de análise de agente patogênico |
| CA2899263A1 (en) | 2013-01-29 | 2014-08-07 | Molecular Health Ag | Systems and methods for clinical decision support |
| EP2968952B1 (en) | 2013-03-15 | 2018-07-11 | Boston Scientific Neuromodulation Corporation | Clinical response data mapping |
| US10689701B2 (en) | 2013-03-15 | 2020-06-23 | Duke University | Biomarkers for the molecular classification of bacterial infection |
| CN105556308B (zh) | 2013-09-20 | 2018-05-29 | 阿斯图特医药公司 | 用于阑尾炎的诊断和预后及腹痛病因的区分的方法和组合物 |
| WO2015048098A1 (en) | 2013-09-24 | 2015-04-02 | Washington University | Diagnostic methods for infectious disease using endogenous gene expression |
| US10303846B2 (en) | 2014-08-14 | 2019-05-28 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
| US20170234873A1 (en) | 2014-10-14 | 2017-08-17 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
| WO2016079219A1 (en) | 2014-11-19 | 2016-05-26 | Koninklijke Philips N.V. | Diagnostic method employing hnl |
| US20170269081A1 (en) * | 2014-12-11 | 2017-09-21 | Memed Diagnostics Ltd. | Marker combinations for diagnosing infections and methods of use thereof |
| KR20160072626A (ko) | 2014-12-15 | 2016-06-23 | 전북대학교산학협력단 | 패혈증 인자 il-6 간이 진단 키트 |
| EP3367895A4 (en) | 2015-11-01 | 2019-07-03 | Elminda Ltd. | METHOD AND SYSTEM FOR CALCULATING THE POTENTIAL DISTRIBUTION ON A CORTICAL SURFACE |
| WO2017149548A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Rna determinants for distinguishing between bacterial and viral infections |
| CN108699609A (zh) | 2016-03-03 | 2018-10-23 | 米密德诊断学有限公司 | 分析rna用于诊断感染类型 |
| CN109642900A (zh) | 2016-06-23 | 2019-04-16 | 米密德诊断学有限公司 | 通过侧流免疫测定测量trail |
| CA3027341A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| US11340223B2 (en) | 2016-07-10 | 2022-05-24 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| CN109716102B (zh) | 2016-09-16 | 2023-05-16 | 芯片生物技术株式会社 | 微粒分注装置、微粒分析装置、反应检测装置、以及使用它们的方法 |
| EP3519833B1 (en) | 2016-09-29 | 2024-08-14 | MeMed Diagnostics Ltd. | Methods of prognosis and treatment |
| US11353456B2 (en) | 2016-09-29 | 2022-06-07 | Memed Diagnostics Ltd. | Methods of risk assessment and disease classification for appendicitis |
| US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| US12348304B2 (en) | 2021-04-08 | 2025-07-01 | Infinidome Ltd. | Adjustable null steering in a stationary network |
-
2013
- 2013-02-08 CA CA2863819A patent/CA2863819C/en active Active
- 2013-02-08 US US14/377,887 patent/US9726668B2/en active Active
- 2013-02-08 ES ES18162713T patent/ES2886979T3/es active Active
- 2013-02-08 AU AU2013217935A patent/AU2013217935B2/en active Active
- 2013-02-08 CA CA3133249A patent/CA3133249C/en active Active
- 2013-02-08 CN CN201810781584.9A patent/CN108802385B/zh active Active
- 2013-02-08 IN IN1780MUN2014 patent/IN2014MN01780A/en unknown
- 2013-02-08 BR BR112014019733-4A patent/BR112014019733B1/pt active IP Right Grant
- 2013-02-08 EP EP18162713.4A patent/EP3367099B1/en active Active
- 2013-02-08 CN CN201380019055.0A patent/CN104204803B/zh active Active
- 2013-02-08 JP JP2014556086A patent/JP6169619B2/ja active Active
- 2013-02-08 EP EP13703112.6A patent/EP2812700B1/en active Active
- 2013-02-08 ES ES13703112.6T patent/ES2679107T3/es active Active
- 2013-02-08 WO PCT/EP2013/052619 patent/WO2013117746A1/en not_active Ceased
- 2013-02-08 EP EP21170448.1A patent/EP3882633A1/en not_active Withdrawn
-
2014
- 2014-08-07 IL IL233998A patent/IL233998A/en active IP Right Grant
- 2014-08-15 ZA ZA2014/05993A patent/ZA201405993B/en unknown
-
2016
- 2016-08-16 US US15/237,728 patent/US10502739B2/en active Active
-
2017
- 2017-06-28 JP JP2017126712A patent/JP6725456B2/ja active Active
- 2017-08-22 IL IL254095A patent/IL254095B/en unknown
-
2018
- 2018-03-29 AU AU2018202302A patent/AU2018202302C1/en active Active
-
2019
- 2019-11-19 US US16/687,726 patent/US11175291B2/en active Active
-
2020
- 2020-06-25 JP JP2020109710A patent/JP2020180975A/ja active Pending
-
2021
- 2021-06-30 IL IL284506A patent/IL284506B/en unknown
- 2021-10-22 US US17/507,994 patent/US12188934B2/en active Active
-
2024
- 2024-12-24 US US19/000,814 patent/US20250189526A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ryan et al. | Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection | |
| Sparks et al. | Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19 | |
| RU2017121108A (ru) | Способ диагностики с использованием hnl | |
| US10859574B2 (en) | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof | |
| JP6725456B2 (ja) | 対象における細菌感染または細菌／ウイルス混合感染を除外するためのキット | |
| Vanwolleghem et al. | Re‐evaluation of hepatitis B virus clinical phases by systems biology identifies unappreciated roles for the innate immune response and B cells | |
| Kuri-Cervantes et al. | Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection | |
| Ford et al. | Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19 | |
| Schulte-Schrepping et al. | Suppressive myeloid cells are a hallmark of severe COVID-19 | |
| DeBerg et al. | Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling | |
| Riou et al. | Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2-specific T-cells | |
| Wei et al. | Regulation network of serum cytokines induced by tuberculosis-specific antigens reveals biomarkers for tuberculosis diagnosis | |
| Paczesny | Post‐haematopoietic cell transplantation outcomes: why ST2 became a ‘golden nugget’biomarker | |
| Shrestha et al. | Sensitivity and specificity of lateral flow antigen test kits for COVID-19 in asymptomatic population of quarantine centre of Province 3 | |
| Zhou et al. | Host biomarkers other than interferon gamma in QFT-TB supernatants for identifying active tuberculosis | |
| Yang et al. | Evaluation of IFIT3 and ORM1 as biomarkers for discriminating active tuberculosis from latent infection | |
| Li et al. | Improved diagnosis of systemic lupus erythematosus with human-derived double-stranded DNA antigen | |
| Ioannidis et al. | Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever | |
| Sacco et al. | Multi-omics approach identifies novel age-, time-and treatment-related immunopathological signatures in MIS-C and pediatric COVID-19 | |
| Wang et al. | Clinicopathologic characteristics of pediatric tuberculous pleural effusion: a retrospective analysis of 112 consecutive cases | |
| JP2020526745A5 (enExample) | ||
| Bortolin et al. | Multiplex analysis of blood cytokines as a prognostic tool in HIV related non-Hodgkin lymphoma patients: a potential role of interleukin-7 | |
| CN109752548B (zh) | 评估慢性淋巴细胞白血病预后的组合试剂及系统 | |
| Yang et al. | Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection | |
| Ford et al. | CD8+ T cell clonotypes from prior SARS-CoV-2 infection predominate during the cellular immune response to mRNA vaccination |