BR112014019733B1 - Método para determinação de um tipo de infecção em um indivíduo - Google Patents

Método para determinação de um tipo de infecção em um indivíduo Download PDF

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Publication number
BR112014019733B1
BR112014019733B1 BR112014019733-4A BR112014019733A BR112014019733B1 BR 112014019733 B1 BR112014019733 B1 BR 112014019733B1 BR 112014019733 A BR112014019733 A BR 112014019733A BR 112014019733 B1 BR112014019733 B1 BR 112014019733B1
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infection
trail
patients
determinants
viral
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BR112014019733-4A
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Portuguese (pt)
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BR112014019733A2 (enExample
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Kfir Oved
Eran Eden
Ilan Ifergan
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Memed Diagnostics
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44717Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44717Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44739Collecting the separated zones, e.g. blotting to a membrane or punching of gel spots
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6866Interferon
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR112014019733-4A 2012-02-09 2013-02-08 Método para determinação de um tipo de infecção em um indivíduo BR112014019733B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261596950P 2012-02-09 2012-02-09
US61/596,950 2012-02-09
US201261652631P 2012-05-29 2012-05-29
US61/652,631 2012-05-29
PCT/EP2013/052619 WO2013117746A1 (en) 2012-02-09 2013-02-08 Signatures and determinants for diagnosing infections and methods of use thereof

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BR112014019733A2 BR112014019733A2 (enExample) 2017-08-22
BR112014019733B1 true BR112014019733B1 (pt) 2022-09-13

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BR112014019733-4A BR112014019733B1 (pt) 2012-02-09 2013-02-08 Método para determinação de um tipo de infecção em um indivíduo

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US (5) US9726668B2 (enExample)
EP (3) EP3367099B1 (enExample)
JP (3) JP6169619B2 (enExample)
CN (2) CN104204803B (enExample)
AU (2) AU2013217935B2 (enExample)
BR (1) BR112014019733B1 (enExample)
CA (2) CA3133249C (enExample)
ES (2) ES2886979T3 (enExample)
IL (3) IL233998A (enExample)
IN (1) IN2014MN01780A (enExample)
WO (1) WO2013117746A1 (enExample)
ZA (1) ZA201405993B (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2387627T3 (pl) 2009-01-15 2016-10-31 Profilowanie odporności adaptacyjnej i wytwarzanie przeciwciał monoklonalnych
US9709565B2 (en) 2010-04-21 2017-07-18 Memed Diagnostics Ltd. Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
US9726668B2 (en) 2012-02-09 2017-08-08 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
ES2662128T3 (es) 2012-03-05 2018-04-05 Adaptive Biotechnologies Corporation Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes
JP5756247B1 (ja) 2012-05-08 2015-07-29 アダプティブ バイオテクノロジーズ コーポレイション マルチプレックスpcr反応における増幅バイアスを測定し校正する組成物及び方法
WO2015160439A2 (en) 2014-04-17 2015-10-22 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
EP3114240B1 (en) 2014-03-05 2019-07-24 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
WO2015138991A2 (en) * 2014-03-13 2015-09-17 Opgen, Inc. Methods of detecting multi-drug resistant organisms
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
CN107077534A (zh) 2014-05-27 2017-08-18 奥普金公司 用于生成和分析耐药基因组概况的系统、装置和方法
US10308989B2 (en) 2014-06-13 2019-06-04 North Carolina State University Aptamers with binding affinity to norovirus
CA3190715A1 (en) 2014-08-14 2016-02-18 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016059636A1 (en) * 2014-10-14 2016-04-21 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
AU2015339191A1 (en) 2014-10-29 2017-05-18 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
WO2016079219A1 (en) * 2014-11-19 2016-05-26 Koninklijke Philips N.V. Diagnostic method employing hnl
CN107209184B (zh) * 2014-12-11 2020-04-24 米密德诊断学有限公司 用于诊断多种感染的标记组合及其使用方法
WO2016138122A1 (en) * 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
EP3139171B1 (en) * 2015-09-02 2020-02-12 Labsystems Diagnostics Oy Novel methods and kits for detecting of urea cycle disorders using mass spectrometry
US11884978B2 (en) 2015-09-30 2024-01-30 Immunexpress Pty Ltd Pathogen biomarkers and uses therefor
CN106918698B (zh) * 2015-12-25 2019-11-22 广州瑞博奥生物科技有限公司 一种检测人受体酪氨酸激酶的磷酸化抗体芯片试剂盒
CN108699609A (zh) 2016-03-03 2018-10-23 米密德诊断学有限公司 分析rna用于诊断感染类型
WO2017149548A1 (en) * 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Rna determinants for distinguishing between bacterial and viral infections
CN106053831A (zh) * 2016-06-05 2016-10-26 潘时辉 一种用于自身免疫病检测的试剂盒
AU2017278254A1 (en) * 2016-06-07 2018-11-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosis of bacterial and viral infections
CN109642900A (zh) * 2016-06-23 2019-04-16 米密德诊断学有限公司 通过侧流免疫测定测量trail
EP4141448A1 (en) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
EP3482201B1 (en) * 2016-07-10 2022-12-14 Memed Diagnostics Ltd. Early diagnosis of infections
WO2018029690A1 (en) 2016-08-10 2018-02-15 Memed Diagnostics Ltd. System and method for analysis of biological data
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
EP3519834A4 (en) * 2016-09-29 2020-06-17 MeMed Diagnostics Ltd. RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS
WO2018060998A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of prognosis and treatment
JP6903494B2 (ja) * 2017-06-09 2021-07-14 シスメックス株式会社 感染症を識別するための粒子分析方法
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
CA3070522A1 (en) * 2017-07-31 2019-02-07 University Health Network Biomarkers in ex vivo lung perfusion (evlp) perfusate
WO2019092703A1 (en) * 2017-11-07 2019-05-16 Memed Diagnostics Ltd. Anti-trail antibodies and methods of use
WO2019107370A1 (ja) * 2017-11-28 2019-06-06 国立大学法人三重大学 検出方法
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
CN108039206B (zh) * 2017-12-21 2021-11-09 北京大学深圳研究生院 一种传染病的诊治方法及系统
EP3743719A4 (en) * 2018-01-27 2021-11-03 Becton, Dickinson and Company MULTIPLEX SIDE FLOW ASSAY TO DIFFERENTIATE BACTERIAL INFECTIONS FROM VIRAL INFECTIONS
US11484273B2 (en) * 2018-03-06 2022-11-01 International Business Machines Corporation Determining functional age indices based upon sensor data
WO2019236768A1 (en) * 2018-06-05 2019-12-12 Washington University Nasal genes used to identify, characterize, and diagnose viral respiratory infections
CN108486246B (zh) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 子痫前期的诊治标志物
TWI819049B (zh) * 2018-08-02 2023-10-21 香港商布萊特臨床研究有限公司 對正在運行中的臨床試驗進行動態數據監測和實時優化的系統,方法及實施過程
EA202092684A1 (ru) 2018-08-27 2021-03-11 Ридженерон Фармасьютикалз, Инк. Применение рамановской спектроскопии для последующей очистки
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
US20210389329A1 (en) * 2018-10-29 2021-12-16 Thomas Jefferson University Compositions and Methods for Discriminating Infectious from Non-Infectious CNS Disorders
WO2021057986A1 (zh) * 2019-09-27 2021-04-01 成都中医药大学 检测粪钙卫蛋白含量的试剂在制备卵巢病变筛查试剂盒中的用途
CN110923333B (zh) * 2019-12-11 2020-09-29 湖北省农业科学院畜牧兽医研究所 山羊zbp1基因第一内含子内与产羔数关联的单倍型标记及其应用
US20230016954A1 (en) 2019-12-11 2023-01-19 Ichilov Tech Ltd. Non-invasive assay for differentiating between bacterial and viral infections
US20230094142A1 (en) * 2020-01-29 2023-03-30 Memed Diagnostics Ltd. Methods of diagnosing and classifying viral infections
KR20220151168A (ko) * 2020-02-09 2022-11-14 엔엘씨 파르마 엘티디 Sars-cov-2에 대한 신속한 검출 테스트
JP2023520813A (ja) 2020-04-09 2023-05-19 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 気道感染症の診断のためのバイオマーカー
CN113533170A (zh) * 2020-04-21 2021-10-22 贝克曼考尔特公司 病毒感染的血液学参数
WO2022004730A1 (ja) * 2020-06-30 2022-01-06 株式会社堀場製作所 体液分析装置、体液検体を判定するための方法、および、コンピュータープログラム
CN111816245B (zh) * 2020-07-20 2022-09-09 成都博欣医学检验实验室有限公司 结合mNGS和临床知识库的病原微生物检测方法及系统
WO2022153323A1 (en) * 2021-01-18 2022-07-21 Memed Diagnostics Ltd. Markers for diagnosing infections
US20220298572A1 (en) * 2021-03-16 2022-09-22 Cepheid Compositions and methods for discriminating bacterial and viral infections in a human subject
EP4388136A4 (en) * 2021-08-17 2025-07-23 Biomeme Inc METHODS FOR CHARACTERIZING INFECTIONS AND METHODS FOR DEVELOPING CORRESPONDING TESTS
CN113945712A (zh) * 2021-12-21 2022-01-18 山东中鸿特检生物科技有限公司 一种区别细菌、病毒感染的检测方法及检测试剂盒
CN114441506B (zh) * 2022-04-08 2022-06-21 港湾之星健康生物(深圳)有限公司 量子磁光传感器
EP4357778A1 (en) 2022-10-20 2024-04-24 Heraeus Medical GmbH Treatment of microbial infections diagnosed using the biomarker d-lactate
CN119913247B (zh) * 2025-01-21 2025-12-19 浙江大学医学院附属邵逸夫医院 单核细胞和淋巴细胞cd45分子表达相对变化在诊断感染和炎症中的应用

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1178414A (en) 1978-02-08 1984-11-27 Toyo Boseki Kabushiki Kaisha (Trading Under The Name Of Toyobo Co., Ltd.) Packaging material having excellent seal packaging property
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
US4727022A (en) 1984-03-14 1988-02-23 Syntex (U.S.A.) Inc. Methods for modulating ligand-receptor interactions and their application
US5018067A (en) 1987-01-12 1991-05-21 Iameter Incorporated Apparatus and method for improved estimation of health resource consumption through use of diagnostic and/or procedure grouping and severity of illness indicators
DE4322330A1 (de) 1992-08-31 1994-03-03 Behringwerke Ag Verwendung des IL-4-Rezeptors zur Therapie, Prophylaxe und Diagnose von allergischen, viralen, parasitären und bakteriellen Erkrankungen sowie von Pilzinfektionen
DE4227454C1 (de) 1992-08-19 1994-02-03 Henning Berlin Gmbh Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens
SE9401351D0 (sv) 1994-04-21 1994-04-21 Venge A method for diagnosis
US5910421A (en) 1995-12-21 1999-06-08 University Of Florida Rapid diagnostic method for distinguishing allergies and infections
US6077665A (en) 1996-05-07 2000-06-20 The Board Of Trustees Of The Leland Stanford Junior University Rapid assay for infection in neonates
EP1042459A4 (en) 1997-12-24 2003-07-23 Diatech Pty Ltd BIFUNCTIONAL MOLECULES
JP2002515267A (ja) 1998-05-18 2002-05-28 アポトーシス テクノロジー・インコーポレーテッド 抗アポトーシス遺伝子及び遺伝子産物に関する化合物、スクリーニング方法並びに用途
DE19847690A1 (de) 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen
US6709855B1 (en) 1998-12-18 2004-03-23 Scios, Inc. Methods for detection and use of differentially expressed genes in disease states
WO2000040749A2 (en) 1999-01-06 2000-07-13 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
MXPA02001977A (es) 1999-08-24 2002-09-18 Glycozym Aps Udp-n-acetilglucosamina: galactosa-beta1, 3-n-acetil-galactosamina-alfa-r/(gicnac a galnac) beta1, 6-n-acetilglucosaminiltransferasa, c2gnt3.
IL132687A0 (en) 1999-11-01 2001-03-19 Keren Mechkarim Ichilov Pnimit System and method for evaluating body fluid samples
US20020038227A1 (en) 2000-02-25 2002-03-28 Fey Christopher T. Method for centralized health data management
US7668661B2 (en) 2000-04-28 2010-02-23 Siemens Healthcare Diagnostics Inc. Liver disease-related methods and systems
US20020059030A1 (en) 2000-07-17 2002-05-16 Otworth Michael J. Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities
US20020055176A1 (en) 2000-11-08 2002-05-09 Ray Robert A. Diagnostic assay system
KR100461715B1 (ko) 2001-03-27 2004-12-17 가부시끼가이샤 도시바 질환과 관련된 핵산의 검출 방법
US7713705B2 (en) 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
DE10119804A1 (de) 2001-04-23 2002-10-24 Brahms Ag Entzündungsspezifische Peptide und deren Verwendungen
CA2447602C (en) 2001-05-18 2011-11-01 Kirin Beer Kabushiki Kaisha Anti-trail-r antibodies
FI115165B (fi) 2001-06-04 2005-03-15 Aboatech Ab Oy Menetelmä infektion laadun määrittämiseksi
DE10130985B4 (de) 2001-06-27 2004-03-18 B.R.A.H.M.S Ag Verfahren zur Diagnose von Sepsis und schweren Infektionen unter Bestimmung löslicher Cytokeratin-1-Fragmente
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
EP1318407B1 (de) 2001-12-07 2004-09-29 B.R.A.H.M.S Aktiengesellschaft Verwendungen der Aldose-1-Epimerase (Mutarotase) für die Diagnose von Entzündungserkrankungen und Sepsis
EP1317902B1 (en) 2001-12-10 2005-11-09 Kabushiki Gaisha K-and-S Biological data observation apparatus
US20040038201A1 (en) 2002-01-22 2004-02-26 Whitehead Institute For Biomedical Research Diagnostic and therapeutic applications for biomarkers of infection
US20040122296A1 (en) 2002-12-18 2004-06-24 John Hatlestad Advanced patient management for triaging health-related data
US7468032B2 (en) 2002-12-18 2008-12-23 Cardiac Pacemakers, Inc. Advanced patient management for identifying, displaying and assisting with correlating health-related data
WO2003081240A1 (fr) 2002-03-22 2003-10-02 Kyowa Medex Co., Ltd. Procede de recherche d'infection virale
US7485298B2 (en) * 2002-05-23 2009-02-03 Michael Powell Diagnosis and treatment of human dormancy-related sequellae
EP1552021A4 (en) 2002-06-11 2006-06-14 Idaho Res Foundation INTERFERON TYPE I INDUCIBLE PROTEINS FOR THE DETECTION OF VIRUS INFECTION
BR0315935A (pt) 2002-10-31 2005-09-20 Health Research Inc Teste de diagnóstico para o vìrus do nilo ocidental
US8563476B2 (en) 2002-11-15 2013-10-22 Morehouse School Of Medicine Anti-CXCL9, anti-CXCL10, anti-CXCL11, anti-CXCL13, anti-CXCR3 and anti-CXCR5 agents for inflammatory disorders
AU2004245998A1 (en) 2003-06-04 2004-12-16 The Government of the United States as represented by The Secretary of the Department of Health and Human Services, Centres for Disease Control and Prevention PNI microarray and uses
CA2537668A1 (en) 2003-09-29 2005-04-14 Biosite Incorporated Methods and compositions for the diagnosis of sepsis
JP2005106694A (ja) 2003-09-30 2005-04-21 Mochida Pharmaceut Co Ltd 敗血症早期検出及び重篤度評価
GB0401730D0 (en) 2004-01-27 2004-03-03 Bioxell Spa Diagnosis method
US8906630B2 (en) 2004-02-27 2014-12-09 The Trustees Of The University Of Pennsylvania Assays for detecting pathogenic respiratory bacteria
US7892539B2 (en) * 2004-03-24 2011-02-22 The Regents Of The University Of California Modulation of an innate immune response by altering TRIAL-R signaling
US8155993B2 (en) 2004-06-15 2012-04-10 Janssen Pharmaceutica, N.V. Apparatus and methods for assessing a pharmaceutical product
EP1787128A2 (en) 2004-07-09 2007-05-23 Amaox, Inc. Immune cell biosensors and methods of using same
WO2006023312A2 (en) 2004-08-20 2006-03-02 Carl Deirmengian Diagnostic assay for source of inflammation
WO2006036182A2 (en) 2004-09-28 2006-04-06 Singulex, Inc. System and method for spectroscopic analysis of single particles
US7572640B2 (en) 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
WO2007011412A2 (en) 2004-11-05 2007-01-25 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Diagnosis and prognosis of infectious diesease clinical phenotypes and other physiologic states using host gene expresion biomarkers in blood
WO2007018574A2 (en) 2004-11-10 2007-02-15 The United States Of America As Represented By The Secretary Of The Navy Diagnostic assay for rickettsia prowazekii disease by detection of responsive gene expression
WO2006113529A2 (en) 2005-04-15 2006-10-26 Becton, Dickinson And Company Diagnosis of sepsis
CN101208602A (zh) 2005-04-15 2008-06-25 贝克顿迪金森公司 脓毒症的诊断
US20070015172A1 (en) 2005-06-01 2007-01-18 Z-Biomed, Inc. Expression profiles for microbial infection
UA78641C2 (en) 2005-08-29 2007-04-10 Open Joint Stock Company Conce A process for the preparation of carbamide-formaldehyde resin
DE102005050933A1 (de) 2005-10-21 2007-04-26 Justus-Liebig-Universität Giessen Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen
US20070231816A1 (en) 2005-12-09 2007-10-04 Baylor Research Institute Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles
GB0601959D0 (en) 2006-01-31 2006-03-15 King S College London Sepsis test
US20070184460A1 (en) 2006-02-09 2007-08-09 Wei-Mei Ching Diagnostic assay for Orientia tsutsugamushi by detection of responsive gene expression
RU2008146518A (ru) 2006-04-26 2010-06-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Биомаркеры инфекции, вызываемой вирусом гепатита с
SG177956A1 (en) 2006-08-11 2012-02-28 Baylor Res Inst Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections
ATE504000T1 (de) 2006-09-05 2011-04-15 Hvidovre Hospital Auf ip-10 basierende immunologische überwachung
AU2012244350B2 (en) 2006-09-05 2013-08-15 Statens Serum Institut Ip-10 based immunological monitoring
JP2010506166A (ja) 2006-10-05 2010-02-25 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ デング熱の診断及び治療
RU2527068C2 (ru) 2006-12-06 2014-08-27 Медиммун, Ллк Фармакодинамические маркеры, индуцированные интерфероном альфа
DE102006060112A1 (de) 2006-12-20 2008-06-26 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM
WO2008076077A1 (en) 2006-12-21 2008-06-26 Innogene Kalbiotech Pte Ltd Method of early diagnosis of epstein-barr virus-related cancer and respective reagents and kits
EP2102370A4 (en) * 2007-01-11 2010-01-13 Univ Duke METHOD FOR MONITORING HIV INFECTION
US8293489B2 (en) 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
DE102007009751A1 (de) * 2007-02-28 2008-09-04 B.R.A.H.M.S Aktiengesellschaft Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens
WO2008104953A2 (en) 2007-02-28 2008-09-04 The Procter & Gamble Company Methods and targets for identifying compounds for regulating rhinovirus infection
JP5718049B2 (ja) 2007-06-01 2015-05-13 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチCouncil Of Scientific & Industrial Research 眼および中枢神経系の細菌、真菌、寄生虫およびウイルス感染の同時検出と識別のための新規な方法
RU2352948C1 (ru) 2007-06-15 2009-04-20 Государственное образовательное учреждение высшего профессионального образования "КРАСНОЯРСКАЯ ГОСУДАРСТВЕННАЯ МЕДИЦИНСКАЯ АКАДЕМИЯ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" Способ прогноза исхода заболевания пациентов с ургентной хирургической патологией органов брюшной полости
IL184478A (en) 2007-07-08 2017-07-31 Hadasit Medical Res Services & Development Ltd Preparations, methods and kits for identifying carriers of mutations in genes 1brca and 2brca and for the early detection of cancers associated with mutations in these genes
DE102007035640A1 (de) 2007-07-27 2009-01-29 Lkh-Kunststoffwerk Gmbh & Co. Kg Tauchkolben
CN101790687A (zh) * 2007-08-03 2010-07-28 B.R.A.H.M.S有限公司 降钙素原(pct)在患原发性非传染疾病的患者的风险分级和预后中的应用
EP2020603A1 (en) 2007-08-03 2009-02-04 BRAHMS Aktiengesellschaft Method for risk stratification in stable coronary artery disease
TW200920358A (en) 2007-08-13 2009-05-16 Lundbeck & Co As H Method of treating stress-mediated depression
WO2009025743A2 (en) * 2007-08-17 2009-02-26 University Of Massachusetts Medical School Use of trail compositions as antiviral agents
DE502007003414D1 (de) 2007-09-24 2010-05-20 Bmdsys Production Gmbh Kryostat mit stabilisiertem Aussengefäss
EP2071334A1 (en) 2007-12-14 2009-06-17 Transmedi SA Compositions and methods of detecting TIABS
WO2009100907A1 (en) 2008-02-14 2009-08-20 Dianeering Diagnostics Engineering And Research Gmbh Means and methods for assessing the risk of patients presenting to emergency departments based on very low concentrations of troponin i or t or using a combination of markers
WO2009120800A2 (en) 2008-03-25 2009-10-01 University Of Southern California Prognostic panel for urinary bladder cancer
KR20110014979A (ko) 2008-04-21 2011-02-14 노파르티스 포르슝스티프퉁 쯔바이크니덜라쑹 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 항바이러스 요법
US9910036B2 (en) 2008-05-20 2018-03-06 Rapid Pathogen Screening, Inc. Method and device for combined detection of viral and bacterial infections
EP2796878A1 (en) 2008-05-23 2014-10-29 Biocartis NV New biomarkers for diagnosis, prediction and/or prognosis of sepsis and uses thereof
EA201170088A1 (ru) 2008-06-25 2011-10-31 Бейлор Рисёч Инститьют Транскрипционная сигнатура крови инфекции mycobacterium tuberculosis
ES2724478T3 (es) 2008-10-24 2019-09-11 Brahms Gmbh Pronóstico y evaluación del riesgo en pacientes con accidente cerebrovascular determinando el nivel de péptidos marcadores
TW201021778A (en) 2008-11-12 2010-06-16 Alcon Res Ltd Intraocular lens delivery device with a multi-part plunger tip
US20160041153A1 (en) 2008-11-12 2016-02-11 Kirk Brown Biomarker compositions and markers
CN102301002A (zh) 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
UA92843C2 (ru) 2009-05-21 2010-12-10 Институт Технической Теплофизики Национальной Академии Наук Украины Способ получения порошкообразного пищевого красителя из столовой свеклы
WO2011008349A2 (en) 2009-05-26 2011-01-20 Duke University Methods of identifying infectious disease and assays for identifying infectious disease
JP5731489B2 (ja) 2009-06-05 2015-06-10 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸困難を起こした患者における細菌感染の検出
US20110065593A1 (en) 2009-08-07 2011-03-17 Rules-Based Medicine, Inc. Computer Methods and Devices for Detecting Kidney Damage
JP5667353B2 (ja) 2009-09-25 2015-02-12 シスメックス株式会社 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム
US8383332B2 (en) 2009-10-13 2013-02-26 B.R.A.H.M.S. Gmbh Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack
KR20120105444A (ko) 2009-10-15 2012-09-25 오클라호마 메디컬 리써치 화운데이션 염증성 질병의 활성 측정 및 모니터링을 위한 바이오마커 및 방법
WO2011072177A2 (en) 2009-12-09 2011-06-16 Aviir, Inc. Biomarker assay for diagnosis and classification of cardiovascular disease
US20110312534A1 (en) 2010-03-05 2011-12-22 Erasmus University Medical Center Rotterdam Method for prediction of human iris color
EP2365456B1 (en) 2010-03-11 2016-07-20 CompuGroup Medical SE Data structure, method and system for predicting medical conditions
US9709565B2 (en) 2010-04-21 2017-07-18 Memed Diagnostics Ltd. Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
EP2579037B1 (en) 2010-05-31 2015-08-12 The University of Tokushima Method for testing the severity of an illness
GB2482187A (en) 2010-07-23 2012-01-25 Univ Exeter Predicting response to surgery
US8877212B2 (en) 2011-02-07 2014-11-04 Trudeau Institute Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis
RU2476887C2 (ru) 2011-03-29 2013-02-27 Учреждение Российской академии медицинских наук Дальневосточный научный центр физиологии и патологии дыхания Сибирского отделения РАМН Способ прогнозирования развития осложнений у больных внебольничной пневмонией
KR20140033152A (ko) 2011-06-20 2014-03-17 교와 핫꼬 기린 가부시키가이샤 항erbB3 항체
EP2756103A4 (en) 2011-09-12 2015-06-03 Univ Vanderbilt CHARACTERIZATION OF MULTIPLE SCLEROSIS
JP5842107B2 (ja) 2011-10-19 2016-01-13 パナソニックIpマネジメント株式会社 循環動態測定装置
EP2592421B1 (en) 2011-11-14 2017-08-30 Universitätsklinikum Jena Diagnosis of sepsis and systemic inflammatory response syndrome
WO2013119632A1 (en) 2012-02-07 2013-08-15 Ingber Michael Apparatus and methods for analyzing a medical condition
US9726668B2 (en) 2012-02-09 2017-08-08 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
EP2822602B1 (en) 2012-03-08 2020-06-03 Thommen Medical Ag Chewing gum for the diagnosis of inflammatory tissues in dental applications
EP2637023A1 (en) 2012-03-08 2013-09-11 B.R.A.H.M.S GmbH Prediction of outcome in patients with chronic obstructive pulmonary disease
CN104245954A (zh) 2012-03-30 2014-12-24 文森医学公司 细菌成像剂及其使用方法
GB201211982D0 (en) 2012-07-05 2012-08-22 Isis Innovation Biomarker
CN104769430B (zh) 2012-07-10 2018-12-14 尼平蓝山地方医疗区 流感中的风险分层
FR2996003B1 (fr) 2012-09-25 2014-10-17 Commissariat Energie Atomique Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active
US20140127827A1 (en) 2012-11-05 2014-05-08 Gwangju Institute Of Science And Technology Method for detection of antigen using fluorescence resonance energy transfer immunoassay
CN110596385A (zh) 2012-11-30 2019-12-20 迪森德克斯公司 用于评估结肠肿瘤的存在或风险的方法
RU2015135359A (ru) 2013-01-22 2017-03-02 Имикрок, С.Л. Быстрый способ детекции патогенов
BR112015017954A2 (pt) 2013-01-29 2017-07-11 Molecular Health Gmbh sistemas e métodos para o suporte de decisão clínica
EP2968952B1 (en) 2013-03-15 2018-07-11 Boston Scientific Neuromodulation Corporation Clinical response data mapping
US10689701B2 (en) 2013-03-15 2020-06-23 Duke University Biomarkers for the molecular classification of bacterial infection
EP3047270A4 (en) 2013-09-20 2017-07-19 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
WO2015048098A1 (en) 2013-09-24 2015-04-02 Washington University Diagnostic methods for infectious disease using endogenous gene expression
CA3190715A1 (en) 2014-08-14 2016-02-18 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016059636A1 (en) 2014-10-14 2016-04-21 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
WO2016079219A1 (en) 2014-11-19 2016-05-26 Koninklijke Philips N.V. Diagnostic method employing hnl
CN107209184B (zh) 2014-12-11 2020-04-24 米密德诊断学有限公司 用于诊断多种感染的标记组合及其使用方法
KR20160072626A (ko) 2014-12-15 2016-06-23 전북대학교산학협력단 패혈증 인자 il-6 간이 진단 키트
US20180310854A1 (en) 2015-11-01 2018-11-01 Elminda Ltd. Method and system for estimating potential distribution on cortical surface
WO2017149548A1 (en) 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Rna determinants for distinguishing between bacterial and viral infections
CN108699609A (zh) 2016-03-03 2018-10-23 米密德诊断学有限公司 分析rna用于诊断感染类型
CN109642900A (zh) 2016-06-23 2019-04-16 米密德诊断学有限公司 通过侧流免疫测定测量trail
EP4141448A1 (en) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
EP3482201B1 (en) 2016-07-10 2022-12-14 Memed Diagnostics Ltd. Early diagnosis of infections
CN116429665A (zh) 2016-09-16 2023-07-14 芯片生物技术株式会社 微粒分注装置、微粒分析装置、反应检测装置、以及使用它们的方法
EP3519834A4 (en) 2016-09-29 2020-06-17 MeMed Diagnostics Ltd. RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS
WO2018060998A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of prognosis and treatment
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
US12348304B2 (en) 2021-04-08 2025-07-01 Infinidome Ltd. Adjustable null steering in a stationary network

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